Lesson 18 Using Punnett Squares and Pedigrees
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Transcript of Lesson 18 Using Punnett Squares and Pedigrees
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Lesson 18 Using Punnett Squares and Pedigrees
Bb x Bbmale / sperm
fem
ale
/ eg
gs
X
BB
Bb bb
BbB
b
B b
Remember this?
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A Punnett Square is a diagram used to identify possible combinations resulting from a mating.
This married couple is considering having their first baby.
The man is heterozygous for a disease. The woman is also heterozygous for the disease.
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The couple comes to you for counseling. They want you to know the chances they will have a healthy baby.
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You know that the disease they carry is a recessive trait and that both parents are heterozygous.
RR Rr rrWhich of the above genotypes will you need to use?
Man x Woman
Rr RrRrR r
RR
r
r
RR rR
Rr rr?
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Man x Woman
Rr RrR r
R
r
RR rR
Rr rr
Genotype %RR =Rr =rr =
25%50%25%
Phenotype %Healthy =Carrier =Diseased =
25%50%25%
The chance that the couple will have a baby that has the disease is 25%.
Let’s Practice!
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HUNTINGTON’S DISEASE: dominantly inherited disease
Man x Woman
Rr rr
R r
r
r
Rr r r
Rr rr
A man has Huntington’s disease. He does not know this because Huntington’s doesn’t show symptoms until later in life, after children have been produced.
His wife does not have Huntington’s and knows that it has never been diagnosed in her family pedigree.
What are the chances their first born child will have the disease?
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Dihybrid Crosses = mating of two individuals involving two traits.
Heterozygous for both traits:
AaBb x AaBbAB Ab aB ab
AB
Ab
aB
ab
A = talla = shortB = brown hairb = blond hair
Tall/Brown
Tall/blond
Short/Brown
Short/blond 9:3:3:1
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Testcrossunknown x aa
www.zamzows.com
static.howstuffworks.comwww.vetnetwork.net
R? rr
‘ello, my name is
Reginald.I am a
magnificent red canary.
I want to make ‘de beautiful red beebies like me.
But I do not know my genetics. How can I know if my beebies
will be red?
Hi there handsome! My name’s
Gloria and I’m a purely recessive
white gal.
Maybe I can help you with
a testcross!
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www.zamzows.com
static.howstuffworks.comwww.vetnetwork.net
R? rr
‘Dees TESTCROSS…What is it?
Hmm… I think this TESTCROSS is a good
idea.
It’s when you cross an
unknown genotype with a
homozygous recessive.
If you get any homozygous recessive babies, you know you carry the
recessive gene!
TESTCROSS = a cross between any gene pair and the homozygous recessive condition for that trait.
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animal-world.com
www.zamzows.com
static.howstuffworks.comwww.vetnetwork.net
R? rr
‘Eeet worked!
Now I know that I carry
the rare white gene!
Congratulations handsome!
You’re a carrier!
www.sandsexoticanimals.com www.lorislittlecritters.comaaawebmaster.com
I’m the jailbird.
Rr rrThe twinsRr and RrRr Rr
Later that year the babies were born…
www.stuff4birds.com
R?Rr
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What would be the genotype needed to testcross a heterozygous purple-flowering pea plant?
a. PPb. Ppc. pp
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Pedigree = family record for one specific trait.
Sex-linked traits = genes for these traits are carried on the sex chromosomes.
The gene for Red-Green colorblindness is carried on the X chromosome.
Female must get two (XX) X’s to have colorblindness.
Male must get one (XY) X to have colorblindness.
Why are most sex-linked traits carried on the X chromosome?
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Analyzing a Pedigree Interactivehttp://highered.mcgraw-hill.com/sites/0072485949/student_view0/chapter3/interactive_activity.html
Reading a Pedigree
= male carrier = female carrier
= male without trait
= male with trait
= female without trait
= female with trait
= two parents
= three children
I
II
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Remember this?
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Another view of a pedigree…
This one is for Huntington’s Disease
Let’s Practice!
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These people all have Down’s Syndrome
farm1.static.flickr.com
www.thejakartapost.com
blogs.reuters.com
cdn.24.com
Any Questions?
Assignment:Coach Book L18Textbook pg 201 Read and Summarize