Leptospirose final
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Transcript of Leptospirose final
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LEPTOSPIROSE
DR IRIS RICARDO ROSSIN
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LEPTOSPIROSE
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LEPTOSPIROSE
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LEPTOSPIROSE
A falta de infraestrutura facilita a proliferação
de ratos e a disseminação. A ausência de
saneamento básico é o principal fator
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LEPTOSPIROSE
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LEPTOSPIROSE
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LEPTOSPIROSE
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LEPTOSPIROSE
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LEPTOSPIROSE
FASE PRECOCE
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LEPTOSPIROSEFASE PRECOCE
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LEPTOSPIROSE
FASE IMUNOLÓGICA
Cerca de 10% com evolução mais grave:
insuficiência renal aguda , hemorragias, insuficiência hepática e insuficiência respiratória.
Ocorre uma reação imunitária análoga aquela gerada pela reação do sistema de defesa face as bactérias responsáveis pela doença.
Podem surgir novas manifestações:• Icterícia, a coloração amarela da pele provocada por uma insuficiência
hepática• Sinais e sintomas de meningite
FASE TARDIA
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LEPTOSPIROSEFASE IMUNOLOGICA - MecanismosA liberação de componentes bacterianos como LPS e fração glicolipoprotéicacausam ativação da resposta imune com agravamento do quadro clínico do paciente.
Além destes componentes bacterianos a bactéria apresenta moléculas de superfície celular (OMPs) como a lipoproteína LIPL32, também reconhecida pelo TLR2, encontra-se aumentada durante o curso da infecção
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LEPTOSPIROSE
Diagnósticos
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LEPTOSPIROSE
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LEPTOSPIROSE
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LEPTOSPIROSE
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Obrigado