Lecture 15. Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep...
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Transcript of Lecture 15. Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep...
![Page 1: Lecture 15. Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep blood glucose level constant Not taking in Glc Blood.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649f0e5503460f94c22741/html5/thumbnails/1.jpg)
Lecture 15
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Maintaining blood Glc levels
Glucose is the energy source for many tissuesNeed to keep blood glucose level constantNot taking in Glc Blood glucose fallsHow to put Glc into blood?
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Carbon sources for Gluconeogeneis: Cori cycle
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Carbon sources for Gluconeogeneis
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Gluconeogenesis
Gluconeogenesis
Reverse of glycolysis
What step/s have to be different?
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Cellular compartments
Where does Glycolysis occur?
Where does TCA occur?
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Compartmentalization
http://www.sabiosciences.com/pathwaymagazine/minireview/mitchondrial_energy_metabolism.php
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1: How to make PEP?
Cannot directly convert Pyruvate to PEPSo, make Oxaloacetate
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1: How to make PEP?
Metabolite compartmentalization must be overcome
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1: How to make PEP?
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2: If you don’t like it!
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2: If you don’t like it!
Remember Fru 2,6-bis-PO4?
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3. If you really don’t like it!
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Reversing Glycolysis
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Reversing Glycolysis
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Avoiding “futile” cycles
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Signaling cascade recap
LIVER
Example 2: Phosphofructokinase 2
Pancreas
Low Glc
?? Fru 2,6 bis-PO4
Adenylate cyclase↑? PKA?
? PFK1; ? FBPase1? GLYCOLYSIS? GLUCONEOGENESIS
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Coordinating metabolism: Recap
Decreased Blood sugarMake hormone: ___________________
Effect on liver: ___________________
Effect on muscle: ___________________
Effect on adipose tissue: ___________________
Increase Blood sugarMake hormone: ___________________
Effect on liver: ___________________
Effect on muscle: ___________________
Effect on adipose tissue: ___________________