Lecture 14/15 – Inflamation & Stress Signaling

Lecture 14/15 – Inflamation & Stress Signaling

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Module 11: Inflamatory responses

Inflammatory responses• The innate immune system is our first line of defense against invading pathogens. • Initiates a vigorous and rapid inflammatory response to attack foreign pathogens• Plays a key role in activating the more slowly developing adaptive immune response.

o Activation of specific B and T cells to extend the host defense system• Innate response is carried out by a complex series of cellular interactions, collectively

known as the inflammatory response.

• Cellular players in the innate immune response/inflamatory response are:o Blood plateletso Macrophageso Mast cellso Neutrophilso Endothelial cells


Module 11: Inflamation


Module 11: Platelet Structure & Thrombus formation(A)

(B)


Module 11 Figure platelet activation


Module 11: Endothelial Cell Permeability


Module 11: Cell Proliferation

Platlet-derived growth factor – PDGFTransforming growth factor b (TGF-b)Angiogenesis

Vascular endothelial growth factor (VEGF)


Module 11: Sphingomyellin Signaling


Module 11: Formation and Action of PAMPs


Module 2: Toll Receptor Signalling


Module 2: Virus Recognition


Module 1: Cytokines


Module 11: TNFα apoptotic signalling


Module 11: Apoptosis


Module 11: Figure Bcl-2 family functions


Module 2: NF-κB activation


Module 11: Macrophage Signalling


Module 11: Mast Cell Signalling


Module 11: Cell Proliferation

Lecture 14/15 – Inflamation & Stress Signaling

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