Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling
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Transcript of Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling
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Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling
BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy
Last modified -13F
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CSB Fig 02:01 Cell signalling pathways
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
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Transducers Second Messengers II
1. Cyclic ADPribose• ADP Ribosyl cyclase
2. Inositol phosphate & other lipid signaling• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:22 cADPR metabolism
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:26 NAADP structure
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:23 cADPR/NAADP function
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Transducers Second Messengers II
1. Calcium signaling • 1. Cyclic ADPribose
• 2. Inositol phosphate &
other lipid signaling• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:30 Phosphoinositide signalling systems
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:27 Phosphoinositide metabolism
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:28 PtdIns structure
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:29 PI 3-K family
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:31 Inositol phosphate metabolism
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:32 InsP3 and DAG formation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:33 InsP3 and DAG formation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:34 InsP3/Ca2+ signalling functions
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:35 InsP3/DAG recycling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:36 PLC structure and function
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:37 PKC structure and activation
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:38 Localized inositol lipid signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:39 PtdIns4,5P2 signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:42 PtdIns 3-kinase signalling
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:43 Insulin receptor
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Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:44 PIKfyve activation