Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial...
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Transcript of Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial...
![Page 1: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/1.jpg)
Laser Intervention in Early Age Related Macular Degeneration
Emily Caruso – LEAD trial Coordinator
![Page 2: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/2.jpg)
AMD
Macular degeneration is one of the leading causes of blindness in Australia.
![Page 3: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/3.jpg)
Stages of AMD
• Early AMD
• Wet AMD Dry AMD
![Page 4: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/4.jpg)
• Currently there is only treatment for WET macular degeneration.
• Lucentis• Eylea
Treatment
![Page 5: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/5.jpg)
Early AMD
• Vision is good• Drusen present• Diagnosis usually picked
up on routine visit to the Optometrist.
• No signs of any late AMD progression
![Page 6: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/6.jpg)
2RT nanosecond laser- Ellex
• Speckled effect Laser– Killing sick RPE cells
• Healthy cells will divide, and bridge over the gap the laser has left
• New cells will function to clear away the debris in Bruch's Membrane.
• Gentle laser• Doesn’t leave burns(like current lasers do)• Painless.
![Page 7: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/7.jpg)
2RT Pilot study
• The world first Pilot study of the Ellex nanosecond laser in the treatment of Early AMD ran for 3 years.
• 50 Participants• All had 1 eye treated with the2RT nanosecond laser
![Page 8: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/8.jpg)
2RT Pilot study results
• Reduction in Drusen• Improved Macular Function–We are seeing these results in not only the
treated eye but in some cases the fellow non-treated eye
![Page 9: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/9.jpg)
Drusen Regression• Baseline 9 months
![Page 10: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/10.jpg)
Bilateral Effect
• Right Eye Baseline RE 3 months post laser to LE
![Page 11: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/11.jpg)
Bilateral Effect • Before Treatment to LE 3 months post laser to LE
![Page 12: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/12.jpg)
Bilateral Effect
• Before laser to RE
• 12 months afterLaser to RE
![Page 13: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/13.jpg)
LEAD STUDY
• With positive results from the Pilot study, we received an NHMRC grant to conduct the worlds first multi centred randomised control trial of nanosecond laser in the treatment of early AMD. (LEAD Trial)
![Page 14: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/14.jpg)
LEAD Study
Aim: To provide an Early intervention, which may slow or partially reverse the progression of the disease, before any late changes develop.
![Page 15: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/15.jpg)
LEAD Update
• Recruitment will finish at the end of 2014.
• Aiming to have 150 participants at the RVEEH site.
• Overall recruitment aim is 350 participants.
• Multiple sites recruiting.– Melbourne (2 sites)– Sydney– Adelaide– Perth– Northern Ireland
![Page 16: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/16.jpg)
LEAD Inclusion criteria
• Bilateral high-risk early AMD
• Best corrected VA 6/12 or better in each eye
• 50-95 years of age• MAIA perimetry result
of <25 dB in one eye in the same area on 2 tests
![Page 17: Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.](https://reader038.fdocuments.us/reader038/viewer/2022103021/56649c735503460f94924e44/html5/thumbnails/17.jpg)
THANK YOU!
• Any Questions