Laser and its medical Laser and its medical applicationsapplications

S.SELVAKUMARS.SELVAKUMARASSISTANT PROFESSORASSISTANT PROFESSOR

THAMIRABHARANI ENGINEERING THAMIRABHARANI ENGINEERING COLLEGECOLLEGE

TIRUNELVELITIRUNELVELI 9042474329(MOBILE) 9042474329(MOBILE)

kumartvl88@gmail.com(E- kumartvl88@gmail.com(E-MAIL)MAIL)

A wide application of laser in medicine and beauty therapyA wide application of laser in medicine and beauty therapy

Surgical laser: removing tumors, making incisions.

Cosmetic treatments: resurfacing, removal of birth

mark, age spots, spider veins, hair, tattoos,

Ophthalmology: inner eye surgery in removing

cataract, repairing retina, correct nearsightedness.

Laser Laser repairing retinarepairing retina

Laser removal of port-wine stainLaser removal of port-wine stain

Laser skin rejuvenationLaser skin rejuvenation

Laser = Light Amplification by Stimulated Emission of Radiation

•The physics of laser •The interaction of laser light with human tissue

What is a laser?What is a laser?

•Simple atomic structure

•Light emission

•Characteristic of laser

•Laser power and intensity

•Mechanisms of laser interaction

with human tissues

•Selective absorption of laser light

by human tissues

•Applications of lasers in

healthcare and beauty therapy

Outline of the unit 11Outline of the unit 11

1. 1. Summary about atomSummary about atom

Atom is the smallest building block of matters, including body tissue and fluids,

•it is electrically neutral, it contains three elementary particles: the electron , the proton, and the neutron. •electrons make circular motion around the nucleus (containing proton and neutron) in different level of orbits, called stationary orbits, they correspond to different energy levels.•the number of electrons is equals to the number of protons in an atom,•a nucleus counts for vast majority of the atomic mass.•The so-called atomic number (Z number) is the proton number (also electron number) in an atom. Ions are formed when atoms obtained extra electrons or loose electrons.

2. 2. Light emissionLight emission

•electron orbits displayed as an energy level diagram• energy is plotted vertically with the lowest (n=1) , or ground stat, and with exited states (n=2, 3,4,…) above.• n is called orbit number and can be only positive integer.

(a) The electron can absorb energy and jump to a higher level, the process is called excitation.

(b) A photon is emitted when an electron change from a higher orbit to a lower orbit with a characteristic emission spectrum. This process is called de-excitation.

(c) If an atom absorbs a photon, an electron jumps from a lower orbit to a higher orbit with a characteristic absorption spectrum.

Atom will absorb and emit light photons at particular wavelength corresponding to the energy differences between orbits. The wavelength of emitted or absorbed photon can be obtained by the formula:

hfhc

E

where E is the change in energy between the initial and final orbits.

A variety of biological molecules have notable absorption spectra in the visible, IR, and UV. This has many clinical application. e.g. Oximeter.

3. 3. How laser workHow laser workss

Spontaneous emission and stimulated emissionSpontaneous emission and stimulated emission

An excited electron may gives off a photon and decay to the ground state by two processes:

•stimulated emission : the excited atoms interact with a pre-existing photon that passes by. If the incoming photon has the right energy, it induces the electron to decay and gives off a new photon. Ex. Laser.

•spontaneous emission: neon light, light bulb

Optical pumpingOptical pumping

many electrons must be previously excited and held in an excited state without massive spontaneous emission: this is called population inversion. The process is called optical pumping. Example of Ruby laser.

Optical pumpingOptical pumping

Only those perpendicular to the mirrors will be reflected back to the active medium, They travel together with incoming photons in the same direction, this is the directionality of the laser.

Characteristics of laser

• The second photon has the same energy, i.e. the same wavelength and color as the first – laser has a pure color

• It travels in the same direction and exactly in the same step with the first photon – laser has temporal coherence

Comparing to the conventional light, a laser is differentiated by three characteristics. They are:

Directionality,pure color, temporal coherence.

Characteristics of laser

Directionality

Temporal coherence

Pure color

where the unit of power is Joules/s or W.

The power and intensity of a laserThe power P is a measure of energy transfer rate;

The energy encountered by a particular spot area in a unit time is measured by the intensity (or power density):

)22

(cmarea spot

(W) Power) (W/cmIntensity

(s)time exposurte

(J) outputenergy TotalPower(W)

laser versus ordinary lights:

The directionality of laser beam offers a great advantage over ordinary lights since it can be concentrate its energy onto a very small spot area. This is because the laser rays can be considered as almost parallel and confined to a well-defined circular spot on a distant object.

Sample problem: we compare the intensity of the light of a bulb of 10 W and that of a laser with output power of 1mW (10-3 W). For calculation, we consider an imagery sphere of radius R of 1m for the light spreading of the bulb, laser beams illuminate a spot of circular area with a radius r = 1mm.

2522

/108)100(4

10

4

10cmW

cm

W

R

W

A

PI bulb

bulb

222

3

2

3

/103)1.0(

1010cmW

cm

W

r

W

A

PI laser

laser

400/108

/10325

22

cmW

cmW

I

I

bulb

laser

Fluence, F is defined as the total energy delivered by a laser on an unit area during an expose time TE,F(J/cm2)=I(watts/cm2) x TE(s)

The advantage of directionality of a laser : we can focus or defocus a laser beam using a lens. This can be used to vary the intensity of the laser.

Incoming parallel ray

f

Focused spotDiverged beam

continuous wave (CW) lasers versus pulsed lasers

• CW lasers has a constant power output during whole operation time.

• pulsed lasers emits light in strong bursts periodically with no light between pulses

usually T>>Tw

• The tw may vary from milliseconds (1ms=10-3 s) to femtoseconds (1fs=10-15s), but typically at nanoseconds (1ns=10-9s).

• energy is stored up and emitted during a brief time tw,

• this results in a very high instantaneous power Pi • the average power Pave delivered by a pulsed laser is low.

Instantaneous power Pi

w

pulsei t

EP

Average power Pave

RET

EP pulse

pulseave

Where R is the repetition rate

Example A pulsed laser emits 1 milliJoule (mJ) energy that lasts for 1 nanoseconds (ns), if the repetition rate R is 5 Hz, comparing their instantaneous power and average power. (The repetition rate is the number of pulses per second, so the repetition rate is related to the time interval by R=1/T).

Ws

J

ns

mlliJoule

t

EP

w

pulsei

69

3

1010

10

1

1

WHzJHzRJET

EP pulse

pulseave

33 105510)()(

4. 4. Mechanisms of laser Mechanisms of laser interaction with human tissuesinteraction with human tissues

When a laser beam projected to tissueWhen a laser beam projected to tissue

•reflection,•transmission, •scattering, •re-emission, •absorption.

Five phenomena:

Laser light interacts with tissue and transfers energy of photons to tissue because absorption occurs.

PhotocoagulationPhotocoagulation

What is a coagulation? • A slow heating of muscle and other tissues is like a

cooking of meat in everyday life. • The heating induced the destabilization of the proteins,

enzymes.• This is also called coagulation. • Like egg whites coagulate when cooked, red meat turns

gray because coagulation during cooking.

A Laser heating of tissues above 50 oC but below 100oC induces disordering of proteins and other bio-molecules, this process is called photocoagulation.

Consequence of photocoagulationConsequence of photocoagulation

When lasers are used to photocoagulate tissues during surgery, tissues essentially becomes cooked:

• they shrink in mass because water is expelled, • the heated region change color and loses its mechanical

integrity • cells in the photocoagulated region die and a region of

dead tissue called photocoagulation burn develops • can be removed or pull out,

Applications of photocoagulationApplications of photocoagulation

• destroy tumors• treating various eye conditions like retinal disorders

caused by diabetes• hemostatic laser surgery - bloodless incision, excision:

due to its ability to stop bleeding during surgery. A blood vessel subjected to photocoagulation develops a pinched point due to shrinkage of proteins in the vessel’s wall. The coagulation restriction helps seal off the flow, while damaged cells initiate clotting.

Photo-vaporizationPhoto-vaporization

With very high power densities, instead of cooking, lasers will quickly heat the tissues to above 100o C , water within the tissues boils and evaporates. Since 70% of the body tissue is water, the boiling change the tissue into a gas. This phenomenon is called photo-vaporization.

Photo- vaporization results in complete removal of the tissue, making possible for :

• hemostatic incision,or excision.

• complete removal of thin layer of tissue. Skin rejuvenation, resurfacing

Conditions for photo-vaporizationConditions for photo-vaporization

1.the tissue must be heated quickly to above the boiling point of the water, this require very high intensity lasers,

2.a very short exposure time TE, so no time for heat to flow away while delivering enough energy,

highly spatial coherence (directionality) of lasers over other light sources is responsible for providing higher intensities

Intensity requirementIntensity requirement

Intensity (W/cm2) Resulting processes

Low (<10) General heatingModerate (10 – 100) PhotocoagulationHigh (>100) Photo-vaporization

Photochemical ablationPhotochemical ablation

When using high power lasers of ultraviolet wavelength, some chemical bonds can be broken without causing local heating; this process is called photo-chemical ablation.

The photo-chemical ablation results in clean-cut incision. The thermal component is relatively small and the zone of thermal interaction is limited in the incision wall.

5. Selective absorption of laser 5. Selective absorption of laser light by human tissueslight by human tissues

Selective absorption

Selective absorption occurs when a given color of light is strongly absorbed by one type of tissue, while transmitted by another. Lasers’ pure color is responsible for selective absorption. The main absorbing components of tissues are:

• Oxyhemoglobin (in blood): the blood’s oxygen carrying protein, absorption of UV and blue and green light,

• Melanin (a pigment in skin, hair, moles, etc): absorption in visible and near IR light (400nm – 1000nm),

• Water (in tissues): transparent to visible light but strong absorption of UV light below 300nm and IR over 1300nm

Selective absorption

6. Applications of lasers6. Applications of lasers

Lasers in beauty therapy

Lasers application in beauty therapy are based on:

• selective absorption of absorbing components.• photo-vaporization process for removal of the treated components.

• pulsed lasers are used.

Laser skin rejuvenationLaser skin rejuvenation

IR lasers are used to remove extremely thin layer of skin (<0.1 mm). In the absence of pigment in general, they take advantage of the presence of water in the skin to provide an ability to remove skin and body tissue.

Laser hair removalLaser hair removal

selective absorption : absorbing component being melanin pigment in hair and follicle, it is best worked with a red light ruby laser. White hair can not be treated with any laser due to the lack of absorbing component.

Laser removal of port-wine stainLaser removal of port-wine stain

Yellow laser is absorbed by the presence of hemoglobin in blood vessels.

Laser removal of tattooLaser removal of tattoo

tattoo can be removed with variety of laser depending on the presence of inks in the tattoo.

Lasers in ophthalmology

For retina operation, visible laser can be used. Visible light is transparent to the cornea and crystalline lens, and can be focused with eye’s lens on the retina. The most popular visible laser is the green argon laser. • Treatment of glaucoma: Argon laser is

focused externally on iris to make incision, creating drainage holes for excess aqueous humors to release pressure,

• Retina tear: photocoagulation burn to repair retina tears due to trauma to the head.

• Diabetic retinopathy: inadequate blood supply to the retina due to diabetes. Small photocoagulation burn by green argon laser to repair the retina due to vessels leakage.

Lasers in ophthalmology

For cornea and lens, UV light emitted by the excimer laser is strongly absorbed by water and proteins, so their energy can be absorbed by transparent cornea and lens, permitting laser surgery on these areas.

• Cataracts: a milky structure in the lens of the eye. Photo-vaporization by using UV laser to remove the obaque regions.

• Correction of myopia: over focusing of the lens. Excimer laser removal of surface of cornea to make it flatten.

7. Laser hazards and protections7. Laser hazards and protections

Absorption of the eye

Hazards to the eye

The retinaThe directionality of a laser beam permits the ray to be focused to an extremely small spot on the retina. A collimated laser will be concentrated by a factor of 100,000 when passing from cornea to retina.

Visible or near IR lasers (400 nm to 1400nm) are particularly dangerous to the retina and always requires eye-protection when working with these kind of lasers.

Hazards to the eye

The cornea and lens•Cornea is accessible to danger of UV and most of IR lasers,•UV-A, UV-B (between 295nm and 320 nm) and IR-A (between 1 to 2 mm) are dangerous for lens,•308-nm (UV-B) excimer XeCl laser is particular dangerous because of it can simultaneously damage the lens, the cornea and the retina.

Protection to the eye

Eye protectionEyewear (goggles) is the most common laser protective measure, especially for open laser beams. It should be good design with all around shielding and adequate visible light transmission.

Identification of the eyewear : All laser protective eyewear shall be clearly labelled with information adequate to ensure the proper choice of eyewear with particular lasers.