Large Intes-ne Feces - philipdarrenjones.com–Pass through the rectum and exit via the anus Large...

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1 A major func-on of the colon is to recover water that has entered the alimentary canal Feces Wastes of the diges-ve tract Become more solid as they move through the colon Pass through the rectum and exit via the anus Large Intes-ne The colon houses strains of the bacterium Escherichia coli, some of which produce vitamins Vitamin K Rectum Feces are stored in the un-l they can be eliminated Two sphincters between the rectum and anus control bowel movements Internal/external anal sphincter Colon

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• Amajorfunc-onofthecolonistorecoverwaterthathasenteredthealimentarycanal

• Feces

– Wastesofthediges-vetract

– Becomemoresolidastheymovethroughthecolon

– Passthroughtherectumandexitviatheanus

LargeIntes-ne

• ThecolonhousesstrainsofthebacteriumEscherichiacoli,someofwhichproducevitamins

– VitaminK

• Rectum

– Fecesarestoredintheun-ltheycanbeeliminated

• Twosphinctersbetweentherectumandanuscontrolbowelmovements

– Internal/externalanalsphincter

Colon

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Evolu-onaryadapta-ons

• Diges-vesystemsofvertebratesarevaria-onsonacommonplan

• However,thereareintriguingadapta-ons,oHenrelatedtodiet

– Sizeandtypeofteeth

– Lengthofintes-nes

– Numberofstomachs

SomeDentalAdapta-ons

• Den--on

– Animal’sassortmentofteeth

– Mammalshavevaryingden--onthatisadaptedtotheirusualdiet

• Theteethofpoisonoussnakesaremodifiedasfangsforinjec-ngvenom

• Allsnakescanunhingetheirjawstoswallowpreywhole

Fig. 41-18

Incisors

(c) Omnivore

Molars

(b) Herbivore

(a) Carnivore

Canines Premolars

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StomachandIntes-nalAdapta-ons

• Herbivores

– Generallyhavelongeralimentarycanalsthancarnivores

• Indica-veofthelonger-meneededtodigestvegeta-on

Cecum

Small intestine

HerbivoreCarnivore

Colon(largeintestine)

StomachSmall intestine

Mutualis-cAdapta-ons

• Manyherbivoreshavefermenta-onchambers

– Wheresymbio-cmicroorganismsdigestcellulose

• Crop,cecum,rumen

– Coprophagy?!

• Ruminants

– Themostelaborateadapta-onsforanherbivorousdiet

– Deer,sheep,caUle

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Esophagus

OmasumAbomasum

Intestine

Rumen Reticulum1 2

4 3

EnergySourcesandStores

• Nearlyallofananimal’sATPgenera-onisbasedonoxida-onofenergy‐richmolecules:carbohydrates,proteins,andfats

• Animalsstoreexcesscaloriesprimarilyasglycogenintheliverandmuscles

• Energyissecondarilystoredasadipose,orfat,cells

• Whenfewercaloriesaretakeninthanareexpended,fuelistakenfromstorageandoxidized

Homeostasis:90 mg glucose/100 mL blood

Stimulus:Blood glucose

level risesafter eating.

Stimulus:Blood glucose

level dropsbelow set point.

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OvernourishmentandObesity

• Overnourishment

– Causesobesity

– Resultsfromexcessiveintakeoffoodenergywiththeexcessstoredasfat

• Obesity

– Contributestodiabetes(type2)

– Cancerofthecolonandbreasts

– HeartaUacks,andstrokes

100 µm

• Researchershavediscoveredseveralofthemechanismsthathelpregulatebodyweight

• Homeosta-cmechanismsarefeedbackcircuitsthatcontrolthebody’sstorageandmetabolismoffatoverthelong‐term

• Hormonesregulatelong‐termandshort‐termappe-tebyaffec-nga“sa-etycenter”inthebrain

OvernourishmentandObesity

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LeptinPYY

Insulin

Ghrelin

• Lep-n

– Producedbyfatcells

– Appe-tesuppresant

• Micethatinheritadefectinthegeneforlep-nbecomeveryobese

OvernourishmentandObesity

Obese mouse with mutantob gene (left) next to wild-typemouse.

EXPERIMENT

RESULTS

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ObesityandEvolu-on

• Theproblemofmaintainingweight

– partlystemsfromourevolu-onarypast

• fathoardingwasameansofsurvival

• Petrelsbecomeobeseaschicks

– Inordertoconsumeenoughproteinfromhigh‐fatfood,chicksneedtoconsumemorecaloriesthantheyburn

Youshouldnowbeableto:

1. Namethethreenutri-onalneedsthatmustbemetbyananimal’sdiet

2. Describethefourclassesofessen-alnutrients

3. Dis-nguishamongundernourishment,overnourishment,andmalnourishment

4. Describethefourmainstagesoffoodprocessing

5. Dis-nguishbetweenacompletediges-vetractandagastrovascularcavity

6. Followamealthroughthemammaliandiges-vesystem:

– Listimportantenzymesanddescribetheirroles

– Comparewhereandhowthemajortypesofmacromoleculesaredigestedandabsorbed

7. Relatevaria-onsinden--onwithdifferentdiets

8. Explainwhereandinwhatformenergy‐richmoleculesmaybestoredinthehumanbody