Laparoscopic Adjustable Gastric Band in Super Morbidly Obese Patients (BMI > 50)
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Transcript of Laparoscopic Adjustable Gastric Band in Super Morbidly Obese Patients (BMI > 50)
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LaparoscopicAdjustable Gastric Bandin Super Morbidly Obese Patients (BMI >50):A Prospective,Comparative Analysis
GreeceMay 2005
Wilbur B. Bowne MD, Kell Julliard MS, Armando E. Castro MD, Palak Shah MD, Craig B. Morgenthal MD, Emad Kandil MD,Abel Gonzalez MD, Anthony J. Acinapura MD, George S. Ferzli MD, FACS
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Disclosure of Interest Declaration
None
Laparoscopic Adjustable Gastric Band inSuper Morbidly Obese Patients (BMI >50):
A Prospective, Comparative Analysis
GreeceMay 2005
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Background:
1 Hedley AA. JAMA 2002; 2847-2850.2 Mason, EE. Gastroent Clin of North Am 1987;16:495-502.
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
Super- morbid obesity– increasing prevalence in United States1
– body mass index (BMI ≥ 50 kg/m2) 1,2
– ≥ 225 % ideal body weight1,2
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Background:
1 Hedley AA. JAMA 2002; 2847-2850.2 Mason, EE. Gastroent Clin of North Am 1987;16:495-502.
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
Surgeon’s perspective – substantial co-morbidity 1,2
– technically challenging 1,2
– associated with worse outcome 1,2
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Background:
1 Ren, CJ. J. Gastrointest Surg 2004; 396-340.2 Fielding, GA, Ren, CJ Surg Endosc 2003;17:1541-1545.
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
Laparoscopic adjustable gastric band (LAGB)
– most common in Europe and
Australia (1993)1,2
– approved by FDA in 20011,2
– alternative treatment
strategy
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Background:
Incidence of complications and failure following LAGB
YEAR # PATIENTSAUTHOR
Suter et al. 2001 272 20 7
Biertho et al. 2003 805 74 9
Suter et al. 2000 150 24 16 Chevallier et al. 2004 378 91 24
Holéczy et al. 2001 36 11 31
Gustavson et al. 2002 90 52 58
# FAILURES %
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Background:
Lack of outcome data comparing to laparoscopic
Roux- en-Y gastric bypass (LRYGB)
Role of LAGB in super-morbidly obese patients
not well defined
Clarification of safety, feasiblity, and effectiveness
of LAGB
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Purpose:
To determine and compare weight loss, change in BMI, incidence of complications, and patient satisfaction after LAGB and LRYGB
To establish the effectiveness of LAGB and LRYGB on concomitant medical co-morbidity
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Retrospective review Super-morbidly obese patients
(BMI ≥ 50 mg/kg2) treated between
2001 and 2004
Outcomes analysis— Patient (Age, gender, BMI and weight loss)— Perioperative (Complications and reoperations)— Co-morbidity (Hypertension, diabetes, dyslipidemia,
respiratory, and degenerative arthritis)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
Methods:
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Methods:
Laparoscopic adjustable gastric bandOperative conduct (Pars flaccida technique)1,2
1 Belachew M. Surg Endosc 1994;8:1354-1356.2 Shapiro K. Surg Endosc 2004;18:48-50.
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Background:
1 Bowne, W. J Am Coll Surg (submitted) 2005.2 Feng, JJ. Surg Endosc 2003;17:1055-1060.3 Himpens, J. Sem Laparosc Surg 2004;11:171-177.
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
Laparoscopic
Roux-en-Y gastric bypass: – creation of a 30-cc gastric pouch 1
– extended Roux limb (150 cm) 1,2
– intracorporeal-sutured
gastrojejunostomy 1-3
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Morbid ObesityN = 315 patients
Super-Morbid ObesityN = 106 Patients (34%)
LAGBN = 60 Patients (57%)
LRYGBN = 46 Patients (43%)
Results: Surgical Pathway
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Results: Preoperative characteristics of patients
LRYGB (N=46) P-value 1 Characteristic
Age 43 (21-65) 42 (18-63) 0.45
Gender (female/male) 35/11 50/10 0.35
BMI (Kg/ m2) 57 (50-70) 55 (50-68) 0.18
Weight (Kg) 157 (120-195) 150 (124-209) 0.07
Excess weight (Kg) 92 (62 -124) 86 (66 -130) 0.08
1 Independent t-test
LAGB (N=60)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Results: Preoperative co-morbidity of patients
LRYGB (N=46) P-value 1
Co-morbidity
Hypertension 26 (57%) 24 (40%) 0.07
Diabetes mellitus II 8 (18%) 11 (18%) 0.55
Respiratory (asthma) 15 (33%) 17 (28%) 0.75
Sleep Apnea 25 (54%) 28 (47%) 0.27
Degenerative arthritis 21 (46 %) 14 (23%) 0.13
Dyslipidemia 17 (37%) 17 (18%) 0.03
1 Pearson
LAGB (N=60)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
2
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Results: Perioperative data
Operation time (min) 75 ± 22 (50-180) 121 ± 45 (70-210) < 0.001
Hospital stay (days) 1.8 ± 1.9 (1-11) 3.5 ± 3.4 (1-18) < 0.002
Conversion to open 1 0
LAGB (N=60) LRYGB (N=46) P1
1 Independent t-test
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Adequate follow-up available for 106 patients identified
Results:
LAGBmedian = 17 months
LRYGBmedian = 13 months
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Results: Early complications ( < 30 days)
N (%) P= 0.33 1
LAGB (N=60)
Emesis/Dehydration 7 (12) Emesis/Dehydration 4 (9)
Food impaction 1 (2) Pneumonia 1 (2)
*Port displacement 1 (2) Anastomotic bleed 1 (2)
Wound infection 1 (2) * Anastomotic leak 1 (2)
Myocardial infarction 1 (2) * Abscess 1 (2)
1 Pearson
LRYGB (N=46)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
2
N (%)
*Reoperation
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Results: Late complications ( ≥ 30 days)
N (%) (%) P < 0.05 1
LAGB (N=55)
Emesis/Dehydration 24 (44) Emesis/Dehydration 5 (13)
*Port displacement 11 (20) *Bowel Obstruction 3 (8)
Food impaction 1 (2) Anastomotic stenosis 2 (5)
Reflux 1 (2) Gastritis 1 (2)
*Bland slippage 1 (2)
*Abscess 1 (2)
Wound infection 1 (2)
†Aspiration Pneumonia 1 (2)1 Pearson
LRYGB (N=39)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
2
*Reoperation
†Postoperative death
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Results:
LAGB N= 15 (83%)
LRYGB N=3 (17%)
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
*P < 0.04 N = 18
* Pearson 2
Reoperations
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0
10
20
30
40
50
60
70
Preop Postop
BMI
LAGB
LRYGB
p < 0.001
Results:
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
(N = 60)
(N = 46)
Change in BMI
1 Independent t-test
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Results:
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
N = 55
Number of band adjustments
0
5
10
15
20
24 18 5 4 1 1 1 1
No. of Patients
No.
of A
djus
tmen
ts
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Percent excess weight loss
Results:
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
N = 106
0
10
20
30
40
50
60
LAGB LRYGB
Pe
rce
nt
p < 0.001
1 Independent t-test
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Preoperative co-morbidity
Results:
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
(N = 60)(N = 46)
0
10
20
30
40
50
60
Perc
ent
LAGB
LRYGB
* P < 0.05* Pearson 2
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Postoperative co-morbidity at last follow-up
Results:
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
(N = 55)(N = 39)
*
* P < 0.05
0
5
10
15
20
25
30
35
Perc
ent
LAGB
LRYGB
*
* Pearson 2
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0102030405060708090
Verysatisfied
Satisfied Notsatisfied
Regret
Pe
rce
nt LAGB
LRYGB
p = 0.006
Patient satisfaction
Results: Quality of Life
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
(N = 55)(N = 39)
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Summary:
LAGB is associated with shorter operative time and hospital stay
LAGB patients experience greater incidence of
late complicatons resulting in more reoperations
LAGB patients have less weight loss and reduction of comorbidities
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese
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Conclusion: LRYGB is associated with greater weight loss,
reduction of co-morbidity, less complications, and fewer reoperations compared to LAGB
Quality of life of LRYGB patients is significantly
better compared to LAGB patients
Further evaluation of LAGB in super-morbidly obese patient population appears warranted
Laparoscopic Adjustable Gastric Band in Super- Morbidly Obese