Kumar Sharma, M.D. April, 2016

Page1

KUMAR SHARMA, MD, FAHA University of California at San Diego, La Jolla, CA

--------------------------------------------------------- Office Address: Suite 406, Stein Building 9500 Gilman Drive, #0711 University of California, San Diego La Jolla, CA 92093-0711 Office Phone No.: Tel: (858) 822-0860/0870 Office Fax No.: Fax: (858) 822-7483 E-Mail Address: KumarSharma@ucsd.edu kssharma_family@yahoo.com Education: 1978-81 B.A. in Biology (with Distinction), Boston University, Boston, MA 1981-85 M.D. Albert Einstein College of Medicine, Bronx, NY Postgraduate Training and Fellowship Appointments: 1985-86 Internship in Internal Medicine, Temple University Hospital, Philadelphia, PA 1986-88 Resident in Internal Medicine, Bronx Municipal Hospital Center, Bronx, NY

1988-89 Chief Resident, Bronx Municipal Hospital Center, Bronx, NY 1990-94 Clinical and Research Fellowship in Nephrology, University of

Pennsylvania School of Medicine, Philadelphia, PA

Faculty Appointments: 1989-90 Instructor, Internal Medicine, Cornell Medical

Practice, New York Hospital, New York, NY 1994-99 Assistant Professor of Medicine, Thomas Jefferson University

Hospital, Philadelphia, PA 1999-04 Associate Professor of Medicine, Thomas Jefferson University 2004-07 Professor of Medicine, Thomas Jefferson University 2006-07 Genzyme Endowed Chaired Professor of Medicine, Thomas

Jefferson University 2000-07 Director of Center for Novel Therapies for Kidney Disease,

Thomas Jefferson University 2007- Professor of Medicine, Division of Nephrology, Department of

Medicine, University of California at San Diego 2007- Professor of Medicine, San Diego VA Medical Center 2007- Director, Center for Renal Translational Medicine, UCSD/VA 2010- Professor of Medicine, Division of Medical Genetics, UCSD 2011- Director, Translational Applications, Biochemical Genetics,

UCSD 2013- Director, Institute of Metabolomic Medicine, UCSD

Hospital and Administrative Appointments:

1994-07 Attending Physician, Nephrology, TJU Hospital

Kumar Sharma, M.D. April, 2016

Page2

1994-07 Active Medical Staff, Wills Eye Hospital, Philadelphia, PA 1995-07 Director of Cell and Molecular Biology of Kidney Disease, TJU 1996-07 Director of Center for Diabetic Kidney Disease and Early Renal

Insufficiency, TJU Hospital 1997-07 Member of residency review committee at TJU Hospital 1997-99 TJU Institutional Review Board Member 1997-07 Director of Nephrology Research fellowship, TJU 2002-07 Director of CME for Renal Grand Rounds, Nephrology, TJU 2004-07 Member of Committee for Research, TJU 2005-07 Member of President Barchis Strategic Planning Committee for

Cardiovascular and Hypertension at TJU 2005-06 Member of President Barchis Strategic Planning Committee for

Translational Research and Core Facilities at TJU 2005-07 Appointed Nephrology liason for faculty mentoring at TJU 2008-09 Young Investigator Award Committee-UCSD 2008-09 Search Committee for Vice Chair of Clinical Operations-UCSD 2008-11 OBrien Research Center for Kidney Disease, Core Director,

UAB/UCSD 2009- MSTP Clinical Re-Immersion Course (clinical course for MD/PhD

students) 2009-12 Department of Medicine Committee on Advancement and

Promotion, (DOMCAP)-UCSD 2009- Diabetes Education and Research (DERC), UCSD/USC 2010- MSTP Admissions Committee for MD-PhD applicants, UCSD 2010- Clinical Operations and Research Committee (CORE), UCSD 2010-12 KDOQI, Member of National Kidney Foundation Diabetes in CKD

Workgroup 2011- Residency Admissions Committee, UCSD 2011-12 Member, International Society of Nephrology Education Task

Force 2011- Member, ASN Task Force for Research Funding 2011- Research Council, UCSD 2011- Research Budget and Equipment Committee, VA San Diego

HealthCare System 2012- Executive Research Council Committee, UCSD 2012- Research Committee for Department of Medicine, UCSD 2012- Search Committee for Endocrinology Chief, UCSD 2013-14 Member of CTRI/GEM Study Section

Leadership Role in Clinical and Academic Programs: 1996-2006 Center for Diabetic Kidney Disease (CDKD)-Novel

multidisciplinary clinical center with team approach. Involvement of endocrinology, nutrition, cardiology and nephrology

1997-98 Initiated syllabus for Nephrology fellowship at TJU 1997 Initiated summer lecture series for Nephrology fellowship at TJU 1999-2001 Initiated basic science research seminar series for fellows and

Nephrology attendings at TJU 1999-3 Member of Board for Kibow, Inc 2001-4 Member of Board for Delaware Valley American Diabetes

Association and co-organizer of ADA Annual Expo for 3 consecutive years

Kumar Sharma, M.D. April, 2016

Page3

2002-03 Initiated electronic clinical database at Center for Diabetic Kidney Disease and Early Renal Insufficiency

2004 TJU nephrology representative for clinical outcomes of dialysis population in Delaware Valley (RMS Disease Management/ Independence Blue Cross)

2005 Represented TJU at Bio2005 meeting for academic-industry partnerships

2005 Member of Dialysis Leaders, Strategies for the Future-Davita 2006 Invited TJU representative for BioAsia 2006-Hyderabad, India 2006 Advisory Board Member for Davita Research 2006 Director of new Center for Novel Therapies for Kidney Disease

(multi-disciplinary center focused on molecular biology, biomarkers and translating new therapies for patients with kidney disease and cardiovascular complications)

2006 Chairman of NIH-AMDCC Nephropathy Group, 2006-7 2007- Director, Center for Renal Translational Medicine, UCSD 2009-10 President, American Diabetes Association Community Board,

San Diego 2009-10 Chair, AMDCC Executive Committee, NIDDK, NHLBI 2010- Chair of Core Committee, International Society of Nephrology

Nexus Translational Symposia 2010- Research Council, American Diabetes Association 2010-11 President, American Diabetes Association Community Board,

San Diego 2011-2016 Member of Research Advocacy Group for the American Society

of Nephrology (ASN) 2011-12 Leader of successful Research Program Proposal for UCSD

partnership application with Khalifa University, Abu Dhabi 2012- Director, Institute of Metabolomic Medicine, UCSD 2013 Chair, NIDDK Ad Hoc Study Sections 2013- Co-Chair, ISN North American Regional Council 2013- Member, Awards Committee of the ASN for selection of Peters,

Smith, Narins awards 2014- Memorandum of Understanding between Chang Gung University

and UCSD Center for Renal Translational Medicine and Institute for Metabolomic Medicine

2015- Member of KDIGO for Diabetic Kidney Disease 2015- ISN North American and Caribbean Regional Board 2015- Member of USA-Mexico Collaboration for Diabetic Kidney

Disease (University of Washington, UCSD and Mexico City) 2015-19 Standing member of PBKD Study Section, NIDDK 2015-19 NIDDK Expert Evaluation Panel for the Chronic Kidney

Disease Biomarkers Consortium - 2 - study 2015-16 Co-chair of ISN Forefronts Symposium for Metabolomics and

Microbiome in Kidney Disease, San Diego September 2016 2015-17 Scientific program committee for World Congress in Nephrology,

ISN for Mexico City WCN 2017 2015-16 Scientific organizer of NIDDK Workshop on Mitochondria and

Diseases Related to NIDDK, Bethesda, MD May 2016 2016-17 Scientific Program Committee for American Society of

Nephrology Annual Meeting for November 2017, New Orleans

Kumar Sharma, M.D. April, 2016

Page4

Mentoring and Teaching: 1996-2007 Mentor for 2nd-3rd year medical residents and 4th yr medical

students 1996-1997 Mentor based Central PA Specter Award-Tracy McGowan 1997-1998 Mentor-based NKF Fellowship Award-Tracy McGowan, now

Clinical director at Janssen Labs 1999 Mentor for visiting PhD candidate from Netherlands/Groningen

University-Leo Deelman-Awarded PhD in 2000, presently Assistant Professor in Pharmacology, Groningen University

2000-2 Mentor based JDRF Award-Ken-ichi Tsuchida, M.D., PhD, presently Assistant Professor of Medicine, Hokkaido University School of Medicine, Sapporo, Japan

2001-2 Mentor for MD student from Goettingen University, Germany-Bernd Kurz

2001-6 Mentor for junior faculty in nephrology (Tracy McGowan, John Freidewald), endocrinology (Intekhab Ahmad), rheumatology (Nora Sandorfi)

2004-6 Member of Advisory Committee for PhD candidate, Zachary Schug, expected thesis defense in 2007

2004-6 Mentor for Masters student in clinical/translational-Dayra Perez, thesis defended successfully 2005

2005-6 Invited Mentor/Judge for Fellow based research-East Coast Nephrology programs

2006 Mentor for Visiting Scholar from Okayama, Japan- Hitomi Kataoka

2007 Mentor based Central PA Specter Award- Nidhi Garg 2007-9 Co-Mentor for Sheena Singh 2nd year nephrology fellow in

translational research project, UCSD, now Assistant Professor of Medicine, UCSD

2008-10 Mentor for Shinichi Okada, Post-doc, MD/PhD from Okayama, Japan

2008-10 Mentor for Amber Sanchez 2nd year nephrology fellow in translational research, UCSD (supported by NIH training grant), now Assistant Professor of Medicine, UCSD

2009 Mentor for Bernardo Lara, Howard Hughes Minority Scholar (now applying for PhD graduate program in Biological Sciences)

2009-12 Mentor for Anne-Emilie Decleves, Post-doc PhD from Belgium 2009-11 Mentor for Anna Mathew 3rd year pediatrics/adult nephrology

fellow (supported by NIH training grant), now a junior faculty member pursuing academic research at the University of Michigan, Ann Arbor

2010 Mentor for Maria Schenk, Groningen University, Graduate student

2010 Invited as opposition to PhD thesis of Ville-Petteri Makinen, Helsinki, Finland

2010-11 Mentor for San Li, UCSD undergraduate student in Pharmacy 2011- Mentor for Bethany Karl, MD (nephrology fellow), UCSD

(supported by NIH T32 training grant) 2012- Mentor for Natalie Sweiss, MD (nephrology fellow), UCSD

Kumar Sharma, M.D. April, 2016

Page5

(supported by NIH T32 training grant) 2012- Mentor for post-doc Satoshi Miyamoto, MD/PhD (visiting scholar

from Okayama University) 2012- Mentor for post-doc Emma Borgeson, PhD (visiting scholar from

Ireland). Supported by a Marie Curie Fellowship. 2013 Mentor for Svetlana Kozlovich, summer medical student from

University of Chicago, supported by DERC grant 2013 Mentorship program for Harsha Vishwanathan, BioEngineering 2013-14 Adviser to PhD candidate Alex Thomas, BioEngineering 2014 Mentorship program for Lauren Liu, BioEngineering 2014 Mentorship of K. Sheng, Chang Gung University, Taiwan 2014-15 Mentor for Sabbatical for Stein Hallan, visiting nephrologist from

Norway 2015 Mentor for visiting MD/PhD student Marius Ovrehus 2015 Mentor for Anshika Gupta, Undergrad student from IIT Delhi 2015 Mentor for DRC UCSD Medical student Yasmin Aghajan

Specialty Certification: 1989 American Board of Internal Medicine, Diplomate 1992 American Board of Internal Medicine, Diplomate, Subspecialty:

Nephrology 2002 American Board of Internal Medicine, Re-certified, Subspecialty:

Nephrology 2003 Invited Inaugural Fellow of the American Heart Association

(FAHA) 2013 American Board of Internal Medicine, Recertified, Subspecialty:

Nephrology Licensure: 1988 New York and Pennsylvania 2007 California Major Research, Teaching and Clinical Interests

1. Metabolomics in health and disease 2. Systems biology approaches for chronic disease 3. Novel therapies for progressive kidney disease 4. Biomarkers in kidney disease 5. Cytokine signaling in diabetic kidney disease 6. Vascular injury in obesity and diabetes-related kidney disease 7. Transcription factors involved in glucose toxicity 8. Innovative health care delivery systems for diabetes, obesity and CKD

Present Active Grants: Basic/Clinical/Translational Research

NIDDK, DP3 Award, (Sharma, PI), Novel Paradigms in Diabetic Complications, 2011-2016

NIDDK, U24 Coordinating Unit, (Martone, PI), Establish NIDDK Interconnectivity Network Coordinating Center for NIDDK Consortia, 2012-2017

Kumar Sharma, M.D. April, 2016

Page6

NASA, NNJ13ZSA002N-TWINS (Lee, PI) Metabolomic And Genomic Markers Of Atherosclerosis As Related To Oxidative Stress, Inflammation, And Vascular Function In Twin Astronauts, 2014-2017 VA Merit Award, Mitochondrial Superoxide in Diabetic Kidney Disease, (PI: Sharma, K.), 2015-2019 JDRF Network Grant: Discovery and Validation of Prognostic Biomarkers of Renal Function Decline in Type 1 Diabetes, (PI: Sharma, K.), 2015-2018 Boerhinger-Ingelheim Research Agreement, Novel Therapies in Models of DKD (PI: Sharma, K.), 2015-2017

Merck Research Agreement, Novel Therapies in Diabetic Kidney Disease

(PI:Sharma, K.), 2015-2017

Recently Completed Grants (in last 5 years)

NIDDK, SBIR Phase I and Phase II, (Sharma, PI) of Academic Contract, Ultrasound mediated targeted delivery for kidney disease, Targeson, Inc. Academic PI 2008-2014 VA Merit Grant, (Sharma, PI), Adiponectin and Podocytes 1/10-6/14 NIH U01, Adiponectin and Nox4 in Diabetic Kidney Disease, Animal Models for Diabetic Complications Consortium -NHLBI/NIDDK, Principal Investigator 2006-11 Paricalcitol and Diabetic Nephropathy, (Sharma, PI), Abbott, Investigator Initiated, 2007-14

The Genetic Basis of Obesity/Diabetes in Saudi Population, King Abdullah University of Science and Technology (KAUST) (Sharma, PI, Co-PI: Jerry Olefsky) 2010-2014

Novel mitochondrial treatment for diabetic kidney disease. Stealth

Peptides, Inc., (Sharma, PI), 2013-2014 Exosomes as Biomarkers in Diabetic Nephropathy, Juvenile Diabetes Research Foundation, Principal Investigator, 2009-2012 Metabolomics in Diabetic Kidney Disease, PI, Innovative Grant, Juvenile Diabetes Research Foundation, Principal Investigator, 2011-2012 Mitochondrial Dysfunction and NADPH Oxidase in Diabetic Complications, Juvenile Diabetes Research Foundation, Principal Investigator, 2008-11 OBrien Kidney Disease Center, Core Director, Biomarkers, NIDDK, 2008-11

Kumar Sharma, M.D. April, 2016

Page7

TGF-b signaling in diabetic kidney disease NIH/NIDDK 7 R01 DK053867-07, 05/01/2006 - 04/30/2010 Role of USF1 in Diabetic Induced Renal and Vascular Disease American Diabetes Association (PI:Sharma, Kumar) 07/01/2007 - 06/30/2010

Pending Grants DP3, NIDDK, Biochemical Contribution to Epigenetic Changes in

Metabolic Memory, (PI: Sharma, K.), 2016-2019

R01, NIDDK, Fumaric Acid Regulation in Diabetic Kidney Disease, (PI: Sharma, K.), 2016-2020 (first submission-20th percentile, to be resubmitted 2016) R24, NIDDK, Integrated Systems Biology Approach to Diabetic Microvascular Complications (PI: Brosius, F. UMich, UCSD PI for Sub-contract)

Grants, Awards, and Honors:

1977 Regents Scholarship Award Newtown H.S., New York, NY 1977-81 Deans Honor List, Boston University 1981 B.A. in Biology with Distinction Boston University 1988-89 Chief Resident Bronx Municipal Hospital Corporation 1992-4 National Research Service Award, NIH 1994-6 Young Investigator Grant, National Kidney Foundation 1996-01 K08 Clinical Investigator Award, NIH 1997-9 Fellow Award (Mentor), National Kidney Foundation 1997-01 Research Award, American Diabetes Association 2000 Merck Young Investigator Award 2000-2 Fellow Award (Mentor), JDRF-I 2001 Mary Jane Kugel Award, Juvenile Diabetes Research

Foundation 2001-5 R01 Grant, NIH-NIDDK 2001-4 Research Award, Juvenile Diabetes Research Foundation-

International 2001-6 UO1 Genotype-Phenotype Unit for Animal Mouse Models for

Diabetic Complications Consortium-PI for Sub-Contract from Albert Einstein College of Medicine NIDDK

2002-6 Standing member of NIH study section (GMB, PBKD) 2002-4 R01-Novel Therapy for Diabetic Nephropathy, NIH-NIDDK 2004-6 R01-Novel Therapy for Diabetic Nephropathy, NIH-NIDDK-Comp

renewal 2005-6 JDRF Innovative Grant 2005-10 RO1 Grant-NIH-NIDDK-Comp renewal 2006-11 UO1 Genotype-Phenotype Unit for Animal Mouse Models for

Diabetic Complications Consortium-NIH-NIDDK (received top score)

2007-13 Associate Editor, American Journal of Physiology-Renal 2007- Advisory Member for JDRF Complications Review Board

Kumar Sharma, M.D. April, 2016

Page8

2008- Ad Hoc NIDDK Study Section PBKD, U01, Training grants, SBIR 2009- Study section for NephCure (Foundation for research in Focal

Sclerosis) 2009 Outstanding Investigator Award in Diabetes Complications,

Japan 2013 Robert Hearin Distinguished lecture for University of Mississippi 2014 Plenary Lecture for Australian Society of Diabetes, Melbourne,

Australia Investigator-Initiated Industry Grants

1997-8 Bristol-Myers Squibb-Clinical, Investigator Initiated 1999-0 Creative Biomolecules-Basic, Investigator Initiated 2001-2 Glaxo-Smith Kline Beecham-Basic, Investigator Initiated 2001-2 Marnac-Clinical, Investigator Initiated 2001-2 Genentech-Basic, Investigator Initiated 2002-4 Merck-Clinical Investigator Initiated 2001-4 Biogen, Ross-Basic, Investigator Initiated 2002-8 Intermune-Clinical, Investigator Initiated 2003-4 Novartis-Clinical, Investigator Initiated 2004-5 Keryx-Basic, Investigator Initiated 2004-5 Eli Lilly-Basic, Investigator Initiated 2006-7 Davita-Clinical, Investigator Initiated 2007-12 Abbott-Translational, Investigator Initiated 2009-10 Concert Pharmaceuticals 2011-13 Johnson and Johnson, Anti-Inflammatory Treatment for Diabetic

Kidney Disease 2011-13 Abbott, Atrasentan for Diabetic Kidney Disease 2013-14 Stealth Peptides, Inc. for diabetic kidney disease

Reviewer/Committees Extramural (in last 9 years)

New England Journal of Medicine Nature Medicine Journal of Clinical Investigation American Journal of Physiology-Renal-Associate Editor FASEB J Diabetes-Associate Editor Diabetologia Diabetes Care Kidney International, Editorial Board Journal of the American Society of Nephrology, Editorial Board American Journal of Pathology American Journal of Kidney Disease PlOS One VA Merit Grant-Ad Hoc Reviewer, British Diabetic Association, Washington University, NY/NJ American Society of Nephrology-Abstract reviewer (2003, Chair 2005). Selected as writer/reviewer for Board questions in Nephrology for ABIM American Diabetes Association-Board Member 1999-2000, Volunteer for EXPO, 2002,

Kumar Sharma, M.D. April, 2016

Page9

2003, 2004 Served as Advisory Member for Markers of Chronic Kidney Disease-NIDDK 2003 Member of ASN committee to organize Chronic Kidney Disease initiatives for ASN meeting and primary care providers-2003-6 Diabetes Research Retreat, formulate initiatives for NIDDK funding 2004, ASN JDRF/ADA joint strategic meeting for joint funding opportunities, 2005 Reviewer Ireland Industry-Academic Partnership Grant, 2005 Chairman of abstracts for Diabetic Nephropathy-Basic, ASN 2005 Ad Hoc reviewer for NIDDK-Rapid Access to Development, 2006 Ad Hoc reviewer for JDRF-I, 2006-9 Member of Strategic Committee for NIDDK Pilot and Feasibility Clinical Grants, 2006 American Diabetes Association, Abstract reviewer for national meeting, 2007 Program Committee for American Diabetes Association Annual Meeting, 2009, 2013 JDRF Innovative Grants, 2010 ASN Course Committee Chair for all abstracts in Chronic Kidney Disease, 2011 ADA Research Study Section, 2010, 2011 ASN Chair/Reviwer for abstracts in Diabetic Kidney Disease, 2013, 2014, 2015

Study Sections/Editorial Board: Scientific Review Council of the Juvenile Diabetes Research Foundation-I (1999-2001). Study section of NY/NJ National Kidney Foundation (2001-2002). Study section for Mid-Atlantic American Heart Association (2002-3). NIH General Medicine B Study Section member (2002-2003) NIH Pathobiology of Kidney Disease Study Section Member (2003-2006) Editorial Board Member for Diabetes (2002-2005) Editorial Board for American Journal of Physiology-Renal and Electrolyte (2002-2007) Editorial Board for Journal of the American Society of Nephrology (2005-present) Honorary Editorial Board for Perspectives in Medicinal Chemistry (2006-present) Ad Hoc Reviewer, NIDDK, Kidney Disease (2007-present) National Kidney Foundation-Study section member, 2007-10 Associate Editor for American Journal of Physiology-Renal Physiology (2007-2013) Editorial Board for Journal of Clinical Investigation (2008-2012) Editorial Board for Journal of the American Society of Nephrology (2008-2013) American Diabetes Association Study Section (2011-2014) Chair, Ad-Hoc NIDDK Study Section for Ancillary Studies (2013) Ad Hoc, PBKD Study Section (2014)

Kumar Sharma, M.D. April, 2016

Page10

NIH Pathobiology of Kidney Disease (2015-2019) Invited Lectures (selected):

National Kidney Foundation Annual Meeting (New Orleans) 1996 American Society of Nephrology (New Orleans) 1996 European Dialysis and Transplantation Association Satellite Meeting (Montreux, Switzerland) 1997 Forefronts in Nephrology Meeting (Berlin, Germany) 1997 Annual Nephrology Meeting of South America, Mexico 1998 TGF-b Meeting, NIH (Bethesda, MD) 1999 South Indian Regional Chapter of the Indian Society of Nephrology Chennai, Tamil Nadu, India 1999 Korean Society of Nephrology 2000 Renal Fibrosis Meeting Goettingen, Germany 2000 Japanese Society of Nephrology 2000 Japanese Society of Diabetes 2001 Merck Hypertension Meeting 2001 International Physiology Congress-Australia 2001 Renal Grand Rounds-Hershey Medical Center, Temple University Hospital, MCP-Hahnemann Hospital, Nassau County Medical Center (2000-2001) Medical Grand Rounds-Thomas Jefferson University-2001 Medical Grand Rounds- Lehigh Hospital-2002 Renal Grand Rounds-Goettingen, Germany-2002 Juvenile Diabetes Research Foundation Workshop-Oxford Meeting, 2003 British Society of Matrix and Fibrosis-2003 American Society of Nephrology-2003 Renal Grand Rounds-AECOM 2003 Philadelphia Endocrine Society-2004 American Diabetes Association, Delaware Valley chapter-2004 Medical Grand Rounds-Methodist Hospital-2004 Diabetes Technology Society-2004 American Society of Nephrology, Annual Meeting-Metabolic Syndrome and the Kidney-2004 Toronto Meeting of Diabetes Complications-2004 University of Pittsburgh-Renal Grand Rounds-2004 TJU Cardiology Translational Research Seminar Series-2005 Pediatric Academy Societies Annual Meeting-Symposium speaker-2005 Baylor College of Medicine, Renal GR-2005 Northwestern University, Renal GR-2005 Hahnemann Hospital, Renal GR 2005 University of Texas, San Antonio, Renal GR-2005 Case Western, Renal GR-2006 University of Alabama, Renal GR-2006 National Kidney Foundation Annual Meeting-Podocytes in Diabetic Nephropathy-2006 Beth Israel-Deaconess Nephrology, Harvard Medical School-2006 UCSD/VA Nephrology Grand Rounds-2006 Am Soc of Nephrology Annual Meeting, San Diego-Novel Treatments for Diabetic Nephropathy-2006 University of Oklahoma-Endocrine Grand Rounds-2006 Pennington Diabetes Complications Symposium, Lousiana-2007 Inter Soc of Nephrology Annual Meeting, Rio de Janiero, Brazil-Novel Anti-Fibrotic

Kumar Sharma, M.D. April, 2016

Page11

Treatments for CKD-2007 Groningen, the Netherlands-Clinical Pharmacology-2007 University of Hong Kong, China-2007 ISN COMGAN, Institute of Nephrology, 2nd Military Medical University- Shanghai, China-2007 Egyptian Nephrology Annual Meeting, Cairo, Egypt, 2008 American Diabetes Association Annual Meeting, San Francisco, 2008 D.E.V.E.N.I.R. Group 6th annual meeting, Quebec City, Quebec, Canada, 2008 German Nephrology Society Annual Meeting, Tubingen, Germany, 2008 UCSD Medical Grand Rounds, 2008 Association of Indian Physicians Meeting, Chennai, India, 2009 Keystone Meeting, Diabetes Complications and Vascular Biology, Vancouver, Canada, 2009 Latin American Nephrology Society Meeting, ISN COMGAN Mexico City, Mexico City, Mexico, 2009 American Association of Clinical Endocrinologists, Annual Meeting, Houston, Texas, 2009 Outstanding Foreign Investigator Award, Japanese Society of Diabetic Complications, Okayama, Japan, October 2009 American Society of Nephrology Annual Meeting, San Diego, November 2009 Invited Plenary Lecture, Tokyo, Japan 2009 Diabetes Grand Rounds, University of Michigan, Ann Arbor, MI, January 2010 ISN Nexus Program Committee, Kyoto, Japan April 2010 Stereology Meeting, UCLA, May 2010 FASEB Meeting, Renal Hemodynamics, Saxtons River, Vermont, June 2010 ISN Nexus Co-Chair, Geneva, Switzerland, June 2010 Taiwan Society of Nephrology, July 2010 Latin American Society of Nephrology, Cardoba, Argentina, October, 2010 Case Western Medical Center/MetroHealth Renal Grand Rounds, November 2010 ISN World Congress of Nephrology, Vancouver, Canada, April 2011 United Mitochondrial Disease Foundation, Illinois, June 2011 European Renal Association/European Society of Dialysis and Transplantation, XLVIII ERA-EDTA Congress (Prague, Czech Republic June 23-26, 2011) American Diabetes Association, Annual Meeting, June 2011 JDRF Resistors/Progressors, New York, January 2012 Vanderbilt University Renal Grand Rounds, February 2012 Georgia Health Sciences University, Medical Grand Rounds, Augusta, GA February, 2012 Experimental Biology, San Diego, April 2012 ISN Forefronts Meeting on Systems Biology and the Kidney, Ann Arbor, MI, June 2012 ASN Annual Meeting, San Diego, November 2012 University of Mississippi, Pharmacology and Physiology, Jackson, Miss., March 2013 University of Washington, Seattle, Diabetes Education Research Center (DERC Annual Symposium), Seattle, WA., May 2013 University of Washington, Seattle, Renal Grand Rounds, Seattle, WA., May 2013 Chongqing Hospital, Renal Grand Rounds, Chongqing, China, May, 2013 ISN Satellite Meeting on Renal Fibrosis, Guangzhou, China, June 2013 Latin American College of Nephrologists, Obesity and Inflammation, Novel Treatments for Diabetic Nephropathy, Guadelajara, Mexico, September 2013 European Diabetes Society, Biomarkers of Diabetic Kidney Disease, Barcelona, Spain, September, 2013

Kumar Sharma, M.D. April, 2016

Page12

NY Academy of Sciences, October 2013 ASN Annual Meeting, Atlanta, November 2013 University of California, Riverside, February 2014 Fibrosis Seminar Series, University of California, San Diego February 2014 International Society of Nephrology Nexus Meeting, Bergamo, Italy, April 2014 Nephrology Grand Rounds, Mt. Sinai/Icahn School of Medicine, April 2014 Experimental Biology Meeting, San Diego, April 2014 American Society of Hypertension Annual Meeting, NYC, May 2014 American Diabetes Association Annual Meeting, June 2014 Plenary Lecture, Australian Diabetes Society, Melbourne, August 2014 ISN Nexus HTN meeting, Brisbane, Australia, September, 2014 Chang Gung University, Waters Metabolomics Meeting, Taiwan, November 2014 ASN, Symposium on Diabetic Nephropathy, Philadelphia, PA, November 2014 US-Mexico Collaboration on Diabetic Kidney Disease, Mexico City, Feb 2015 UCSD-Kyoto University Collaboration Symposium, Kyoto, Japan, March 2015 Rachmiel Levine Symposium on Diabetes, San Diego, March 2015 EB 2015, AMPK in Diabetic Kidney Disease, Boston, MA, April 2015 ADA, Symposium for Annual Meeting, Boston, MA, June 2015 ADA-JDRF Joint Symposium for New Directions in Diabetes, Miami, October 2015 ASN, Systems Biology and Diabetic Kidney Disease, San Diego, November 2015 University of Texas Health Sciences Center, San Antonio Renal Grand Rounds, Dec 2015 Joslin Diabetes Center, Longwood Metabolic Seminar, February 2016 Northwestern University Pathology Grand Rounds, April 2016 NIH Workshop on Mitochondria and NIDDK Related Diseases, May 2016 American Society of Nephrology Annual Meeting, Chicago, IL, November 2016 (3 invited talks)

Memberships in Professional and Scientific Societies: American Heart Association American Society of Nephrology American Association for the Advancement of Science American Diabetes Association-Member of local ADA Board 1999-2001 International Society of Nephrology, Chair of ISN Nexus (Translational Research) Symposia Series (2010-present) Juvenile Diabetes Research Foundation-International, Strategic Research Advisory Group 2009-2012 Inaugural Fellow of the American Heart Association, FAHA President of the Community Board of the American Diabetes Association, San Diego, 2009, 2010 Member of Research Council, American Diabetes Association, 2009- Member of Research Advocacy Committee, American Society of Nephrology, 2012-

Bibliography: (Google Scholar: 13,107 citations) Original Publications and Peer-Reviewed Invited Reviews 1. Livneh, A., K. Sharma, K.L. Sewell, H. D. Keiser. Multisystem disease in post-

streptococcal arthritis. Annals of Rheumatic Diseases, 50: 328-329, 1991. 2. Wolf, G., K. Sharma, Y. Chen, M. Ericksen, F.N. Ziyadeh: High glucose-induced

proliferation in mesangial cells is reversed by autocrine TGF-b. Kidney International,

Kumar Sharma, M.D. April, 2016

Page13

42: 647-656, 1992. 3. Ziyadeh, F.N., K. Sharma, M. Ericksen, G. Wolf. Stimulation of collagen gene

expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-b. Journal of Clinical Investigation, 93: 536-542, 1994.

4. Sharma K., F.N. Ziyadeh: Renal hypertrophy is associated with upregulation of TGF-

b1 gene expression in diabetic BB rat and NOD mouse. American Journal of Physiology, Renal Fluid and Electrolyte, 267: F1094-1101, 1994

5. Sharma K, Ziyadeh FN. The transforming growth factor-b system and the

kidney. Seminars in Nephrology, 13: 116-128, 1993. 6. Sharma K, Ziyadeh FN. The emerging role of transforming growth factor-b in

kidney disease (Editorial Review). American Journal of Physiology, Renal Fluid and Electrolyte Physiology, 266: F829-842, 1994.

7. Sharma K., Ziyadeh FN. Hyperglycemia and diabetic kidney disease: The case

for transforming growth factor-b as a key mediator (Perspectives in Diabetes). Diabetes, 44: 1139-1146, 1995.

8. Ziyadeh, F.N., Sharma K.: Role of Transforming growth Factor-beta in diabetic

glomerulosclerosis and renal hypertrophy. Kidney International 48:S34-S36, 1995. 9. Sharma K., T.M. Danoff, A. DePiero, F.N. Ziyadeh: Enhanced expression of inducible

nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: possible mediation via protein kinase C. Biochemical and Biophysical Research Communication, 207: 80-88, 1995

10. Cohen, M., K. Sharma, Y. Jin, E. Hud, V-Y. Wu, J. Tomaszewski, F.N. Ziyadeh.

Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists: a novel treatment strategy. Journal of Clinical Investigation: 95: 2338-2345, 1995.

11. Baffy, G., K. Sharma, W. Shi, F.N. Ziyadeh F.N., Williamson J.R. Growth arrest of a

murine mesangial cell line by transforming growth factor b1 is associated with inhibition of mitogen-induced Ca2+ mobilization. Biochemical and Biophysical Research Communication, 210: 378-383, 1995

12. Sharma K., J. Guo, Y. Jin, F.N. Ziyadeh. Neutralization of TGF-beta by anti-TGF-beta

antibody attenuates kidney hypertrophy and enhanced extracellular matrix gene expression in streptozotocin-diabetic mice Diabetes 45: 522-530, 1996

13. Ziyadeh, F.N., K. Sharma: The use of neutralizing antibodies to demonstrate the role of

Transforming Growth Factor-b or Amadori-glycated albumin as mediators of experimental diabetic kidney disease. Contributions to Nephrology 118: 188-194, 1996.

14. Sharma K., Ziyadeh FN. Biochemical, metabolic, and cellular events linking glucose

metabolism to the development of diabetic nephropathy. Seminars in Nephrology,

Kumar Sharma, M.D. April, 2016

Page14

17:80-92, 1997 15. Sharma K., F.N. Ziyadeh, B. Alzahabi, T. McGowan, B. Kurnik, P.Kurnik, L. Weisberg.

Renal production of TGF-b and endothelin in diabetic patients. Diabetes, 46:854-859, 1997. Selected article in Yearbook of Medicine-1998.

16. Sharma K., R.V. Considine, B. Michael, S. Dunn, L. Weisberg, B. Kurnik, P. Kurnik, J.

OConnor , M. Sinha, J.F. Caro. Plasma leptin is cleared by the kidney and is markedly elevated in hemodialysis patients. Kidney International, 51:1980-1985, 1997

17. Sharma K., L. Wang, Y. Zhu, S. Bokkala, and S. Joseph. Transforming growth factor-b1

inhibits type I inositol 1,4,5-trisphosphate receptor expression and enhances its phosphorylation in mesangial cells. Journal of Biological Chemistry, 272:14617-14623, 1997

18. Hoffman B.B., Sharma K., F.N. Ziyadeh: The potential role of transforming growth

factor-b in diabetic nephropathy. Mineral Electrolyte Metabolism. 24:190-6, 1998. 19. Wang, L., Y. Zhu, K. Sharma. Transforming growth factor-b1 stimulates protein kinase

A in mesangial cells. Journal of Biological Chemistry. 273:8522-8527, 1998. 20. Hoffman, BB., K. Sharma, Y. Zhu, FN Ziyadeh. Transciptional activation of

transforming growth factor-1 in mesangial cell culture by high glucose concentration. Kidney International 54:1107-1116, 1998.

21. Cohen, M., K. Sharma, B.O. Eltayeb, J. Guo, F.N. Ziyadeh. TGF- b1, Type II receptor,

and decorin in the db/db mouse model of diabetic nephropathy. Experimental Nephrology 6:226-33,1998.

22. Sharma, K., L. Wang, Y. Zhu, A. DeGuzman, G-Y. Cao, R. Lynn, S.K. Joseph.

Decreased type I inositol 1,4,5-trisphosphate receptor expression in kidneys from diabetic rodents. American Journal of Physiology, Renal Fluid and Electrolyte , 276: F54-F61, 1999.

23. Sharma, K., B. Eltayeb, T. McGowan, S. Dunn, B. Alzahabi, R. Rohde, F. Ziyadeh, E.

Lewis. Captopril induced reduction of serum levels of transforming growth factor-b1 predicts long-term reno-protection in insulin-dependent diabetic patients. American Journal of Kidney Diseases. 34:818-823, 1999.

24. Gaughn, W., Hassan, M., McCue, P., Burke, J., Sharma, K. Association of IgA

nephropathy with Clostridium difficile colitis. American Journal of Kidney Diseases. 34:e16, 1999.

25. Mogyorsi A., A. Kapoor, M. Isono, S. Kapoor, K. Sharma, F.N. Ziyadeh: Utility of

serum and urinary transforming growth factor-beta levels as markers of diabetic nephropathy. Nephron 86:234-5, 2000.

26. Sharma, K, McGowan, T., Wang, L., Kaspar, V., Szalai, G., Thomas, A.P., Hajnoczky,

G. Down-regulation of types I, and III 1,4,5-triphosphate (IP3) receptors by transforming growth factor- is associated with impaired IP3-mediated calcium release in

Kumar Sharma, M.D. April, 2016

Page15

permeabilized mesangial cells. American Journal of Physiology, Renal Fluid and Electrolyte 278:F1022-F1029, 2000.

27. Ziyadeh FN., Hoffman BB., Han DC., Iglesias-De La Cruz MC., Hong SW., Isono M.,

Chen S., McGowan TA., Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti-transforming growth factor-beta antibody in db/db diabetic mice. Proceedings of the National Academy of Sciences-USA. 97:8015-8020, 2000. Press release.

28. Sharma, K., McGowan, TA. TGF- in Diabetic Kidney Disease: Role of Novel Signaling

Pathways. Cytokine and Growth Factor Reviews, 11:115-123. 2000. 29. Islam, M., Wang.L., Dunn, S., McCue, P., Burke, J., Sharma, K. Anti-TGF-b antibody

attenuates cyclosporine-induced nephrotoxicity in rats. Kidney International. 59:498-505, 2001

30. Viswanathan, V., Zhu, Y., Bala, K., Dunn, S., Sharma, K. Association of ACE

polymorphism with diabetic nephropathy in a South Asian Indian population. Journal of Pancreatology, 2:83-7 (2001).

31. McGowan, T., Madesh, M., Wang, L., Zhu, Y., Russo, M., Deelman, L., Henning, R.,

Joseph, S., Hajnoczky, G., Sharma, K. TGF-b-induced calcium influx is mediated by type III inositol 1,4,5-trisphosphate receptor and regulates the actin cytoskeleton. American Journal of Physiology, Renal Fluid and Electrolyte 282:F910-F920 (2002).

32. Tsuchida, K., Cronin, B., Sharma, K. Novel Aspects of the role of TGF-b in Diabetic

Kidney Disease. Invited review. Nephron, ed. Sadayoshi Ito 2002. 33. Agarwal, R., Siva, S., Dunn, S., Sharma, K. Effect of add-on angiotensin II receptor

blockade on urinary transforming growth factor-beta levels. American Journal of Kidney Diseases 39:486-492 (2002).

34. Tsuchida, K., Zhu, Y., Siva, S., Dunn, S.R., Sharma, K. Role of Smad4 on TGF-b-

induced extracellular matrix stimulation in mesangial cells. Kidney International 63:2000-2009, 2003.

35. Sharma, K., Deelman, L., Madesh, M. Kurz, B., Ciccone, E., Siva, S., Hu, T., Zhu, Y.,

Wang, L., Henning, R., Ma, X., Hajnoczky, G. Involvement of Transforming Growth Factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. American Journal of Physiology, Renal Fluid and Electrolyte, 285:F1258-F1270, 2003

36. Susztak, K., Bottinger, E., Sharma, K. Genomic approach to diabetic nephropathy.

Journal of the American Society of Nephrology, supplement, 2003. 37. Sharma, K. McCue, P., Dunn, S. Diabetic Kidney Disease in db/db Mice. Invited review.

American Journal of Physiology: Renal Physiology (2003). 38. Dunn, S., Qi, Z., Bottinger, E.P., Breyer, M.D., Sharma, K. Utility of endogenous

Kumar Sharma, M.D. April, 2016

Page16

creatinine clearance as a measure of renal function in mice. Kidney International, 65:1959-1967, 2004.

39. Susztak, K., Bottinger, E.P, Novetsky, A., Liang, D., Zhu, Y, Ciccone, E., Wu, D., Dunn,

S., McCue, P., Sharma, K. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes, 53:784-794 2004.

40. Lee, S., Lee, S., Sharma, K. Renal fibrosis in scleroderma kidney disease. Invited

review for Current Reports in Rheumatology, 2004. 41. McGowan, T.A., Zhu, Y., Sharma, K. Transforming Growth Factor--b: A clinical target

for the treatment of diabetic nephropathy. Current Reports in Diabetes. 4(6):447-54, 2004.

42. Yuen, P., Dunn, S., Miyaji, T., Yasuda, H., Sharma, K., Star, R. A simplified method for

HPLC determination of creatinine in mouse serum. American Journal of Physiology, Renal Fluid and Electrolyte, 286:F1116-F1119, 2004

43. Kim, Y, Xu, G, Lanting, L, Reddy, M, Sharma, K, Adler, S.G., Natarajan, R. Novel

interactions between Transforming Growth Factor-b1 and the 12/15-Lipoxygenase pathway in Mesangial Cells. Journal of the American Society of Nephrology, 16(2):352-62, 2005.

44. Breyer, M., Bottinger, E.B., Brosiun, F., Coffman, T., Harris, R., Heilig, C., Sharma, K.

Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology, 16(1):27-45, 2005.

45. Sharma, K., Cook, A., Smith, M. Inscho, E. Transforming growth factor-beta impairs

renal autoregulation by generating reactive oxygen species. American Journal of Physiology, Renal Fluid and Electrolyte, 288(5):F1069-77, 2005.

46. Susztak, K, Ciccone, E, McCue, P., Sharma, K, Bttinger, E. Multiple Metabolic Hits

Converge on CD36 Scavenger Receptor as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy. Public Library of Science, 2:0152-0161, e45, 2005. Press release.

47. Hu, T, Siva, S, Valancius, C, Rao, S, Kalyan, M, Toh, I, Goldstein, B, Woolkalis, M,

Sharma, K. Reactive oxygen species production via Nox4 mediates TGF- induced cytoskeletal alterations in endothelial cells. American Journal of Physiology, Renal Fluid and Electrolyte 289: F816 - F825, 2005.

48. Williams, KJ, Liu, M-L, Zhu, Y, Xu, X, Davidson, W, McCue, P, Sharma, K. Loss of

heparan N-sulfotransferase in diabetic liver: role of angiotensin II. Diabetes 54(4):1116-22, 2005.

49. Sharma, K, Lee, S-H, Han, S, Lee, S, Francos, B, McCue, P, Shaw, M.A.,

RamachandraRao, S, Two dimensional fluorescence difference gel electrophoresis (DIGE) analysis of the urine proteome in human diabetic nephropathy. Proteomics 5:2648 2655, 2005.

Kumar Sharma, M.D. April, 2016

Page17

50. Zhu, Y., Casado, M., Vaulont, S., Sharma, K. Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-b1. Diabetes 54: 1976-1984, 2005.

51. Heeg, M., Koziolek, M., Vasko, R., Schaefer, L., Sharma, K., Muller, G., Strutz,

F. The anti-fibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney International, 289(4):F816-25, 2005.

52. Ewen, K., Ziyadeh, F, Sharma, K., Spielman, R. Candidate SNP analysis in

Diabetic Nephropathy. Diabetes, 54: 3305-3318, 2005. 53. Breyer MD. Bottinger E. Brosius FC. Coffman TM. Fogo A. Harris RC. Heilig CW.

Sharma K. Diabetic nephropathy: of mice and men. [Review] [222 refs] Advances in Chronic Kidney Disease. 12(2):128-45, 2005

54. Madesh, M., Hawkins, B., Milovanova, T., Bhanumathy, C., Joseph, S.,

RamachandraRao, S., Sharma, K., Kurosaki, T., Fisher, A. Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. Journal of Cell Biology, 170:1079, 2005

55. Cai, Q., Keck, M., McReynolds, M., Klein, J., Greer, K., Sharma, K., Hoying, J., Sands,

J., Brooks, H. Effects of water restriction on gene expression in mouse renal medulla: Identification of 3[beta]HSD4 as a collecting duct protein. American Journal of Physiology, Renal Fluid and Electrolyte 291: F218 - F224, 2006

56. McGowan, T., Dunn, SR., Falkner, B., Sharma, K. Stimulation of Urinary TGF- and

Isoprostanes in Response to Hyperglycemia in Humans. Clinical-Journal of the American Society of Nephrology, 1:263-268, 2006.

57. Ling Tao, Erhe Gao, Satish P. RamachandraRao, Aihua Hu, Yan Qu, Hui-Rong

Liu, Theodore A. Christopher, Bernard L. Lopez, Kumar Sharma, Walter J Koch, Xin L. Ma. Nitrative Inactivation of Thioredoxin Reductase in Ischemic / Reperfused Heart and Its Role in Post-ischemic Myocardial Apoptosis. Circulation, 114: 1395 - 1402, 2006.

58. Tchekneva, E., Rinchik, E., Polosukhina, D., Kadkina, V., Dunn, S., Sharma, K.,

Qi, Z., Fogo, A., Breyer, M. Generation of dominant ENU-induced mutations that predispose mice to diabetic nephropathy. Journal of the American Society of Nephrology, 18:103-12, 2007

59. Saltzman HE, Sharma K, Mather PJ, Rubin S, Adams S, Whellan DJ. Renal

dysfunction in heart failure patients: what is the evidence? Heart Fail Rev. 2007 Mar;12(1):37-47. Epub 2007 Mar 29

60. Zhu, Y., Usui, H., Sharma. K. Regulation of Transforming Growth Factor--beta in

Diabetic Nephropathy: Implications for Treatment in Diabetic Nephropathy. Seminars in Nephrology, invited review Mar;27(2):153-60, 2007

Kumar Sharma, M.D. April, 2016

Page18

61. Sharma, K. and Ziyadeh, F. The Prospects for Anti-Transforming Growth Factor- Approaches to Treat Diabetic Nephropathy. Diabetes, in press, 2007

62. RamachandraRao, S., Wassell, R., Shaw, A., Sharma, K. Protein Expression

Profiling of Human Mesangial Cell Sub-Proteomes Reveals a Role for Calmodulin in Glucose Uptake In press, American Journal of Physiology, Renal Fluid and Electrolyte, Apr;292(4):F1182-9. Epub 2007 Jan 2. 2007

63. Kalantar-Zadeh, K.; Regidor, D., Kilpatrick, R.; Aronovitz, J.; McAllister, C., Whellan, D.,

Sharma, K. Hemoglobin A1c and Survival in Hemodialysis Patients. Diabetes Care, 2007 May;30(5):1049-55. Epub 2007 Mar 2.

64. Scalia R, Gong Y, Berzins B, Zhao LJ, Sharma K. Hyperglycemia Is a Major

Determinant of Albumin Permeability In The Diabetic Microcirculation: The Role of {micro}-Calpain. Diabetes, 2007 Jul;56(7):1842-9.

65. Williams, K., Qiu, G., Zhu, Y., Dunn, S., McCue, P., Bottinger, E., Iozzo, R.,

Sharma, K. Decorin deficiency causes an advanced and lethal nephropathy in diabetic mice. American Journal of Pathology, 2007, 171(5):1441-50

66. Sharma, K. RamachandraRao, S., Qiu, G., Kataoka Usui, H, Zhu, Y., Dunn,

S.R., Ouedraogo, R., Hough. K., McCue, P., Chan, L., Falkner, B., Goldstein, B. Adipokines and Albuminuria: A Direct Communication between Adiponectin and Podocytes. Journal of Clinical Investigation, 118(5): 1645-1656 (2008). doi:10.1172/JCI32691. The article received an Editorial comment .

67. Kovesdy, C., Sharma, K., Kalantar-Zadeh, K. Glycemic Control in Diabetic CKD

Patients: Where do we Stand? Am J Kidney Dis. 2008 Oct;52(4):766-77. 68. Pacher, P., Sharma, K., Csordas G., Zhu, Y., Hajnoczky, G. Uncoupling of ER-

Mitochondrial Calcium Communication by Transforming Growth factor-{beta}. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1303-12. The article received an Editorial comment .

69. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR,

Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metab. 2008 Jul 2. [Epub ahead of print].

70. Meijering, B. Els A. van der Wouden, Vincent Pelgrm, Robert H. Henning,

Kumar Sharma, and Leo E. Deelman. TGF- inhibits Ang II-induced MAPK signaling in vascular smooth muscle cells through downregulation of Ang II type 1 receptors. Journal of Vascular Research, 10:459-468, 2009

71. Burnt-out diabetes: impact of chronic kidney disease progression on the natural

course of diabetes mellitus. Kalantar-Zadeh K, Derose SF, Nicholas S, Benner D, Sharma K, Kovesdy CP. J Ren Nutr. 2009 Jan;19(1):33-7

Kumar Sharma, M.D. April, 2016

Page19

72. Mechanisms of kidney fibrosis and the role of antifibrotic therapies. Deelman L,

Sharma K. Curr Opin Nephrol Hypertens. 2009 Jan;18(1):85-90. 73. Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport:

role in diabetes mellitus and potential clinical implications. Kidney Int. 2009 Jun;75(12):1272-7.

74. Sanjoy Ghosh, Majid Khazaei, Farzad Moien Afshari, Lisa S. Ang, David J.

Granville, Bruce Verchere, Stephen R. Dunn, Peter McCue, Andrew Mizisin, Kumar Sharma, and Ismail Laher. Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice Am J Physiol Renal Physiol 2009 Apr;296(4):F700-8.

75. Sanchez AP, Sharma K. Transcription factors in the pathogenesis of diabetic

nephropathy. Expert Rev Mol Med. 2009 Apr 28;11:e13. 76. Sharma K. The Link between Obesity and Albuminuria: Adiponectin and

Podocyte Dysfunction. Kidney Int. 2009 Jul;76(2):145-8. Epub 2009 Apr 29. 77. Ramachandrarao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S,

Shaw MA, Sharma K. Pirfenidone Is Renoprotective in Diabetic Kidney Disease. J Am Soc Nephrol. 2009 Aug;20(8):1765-75. Epub 2009 Jul 2

78. Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB,

Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium. Mouse Models of Diabetic Nephropathy. J Am Soc Nephrol 2009 Dec;20(12):2503-12.

79. Ix JH, Sharma K. Mechanisms Linking Obesity, Chronic Kidney Disease, and

Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK. J Am Soc Nephrol 2010 Mar;21(3):406-12. Epub 2010 Feb 11.

80. Rossini M, Naito T, Yang H, Freeman M, Donnert E, Ma LJ, Dunn SR, Sharma K,

Fogo AB. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol Dial Transplant. 2010 Jun;25(6):1803-10. Epub 2010 Jan 7.

81. Huan Y, DeLoach S, Daskalakis C, Dunn SR, Sharma K, Falkner B.Regulation

of transforming growth factor-beta1 by insulin in prediabetic African Americans. Kidney Int. 2010 Aug;78(3):318-24. Epub 2010 Apr 14.

82. Morse E, Schroth J, You YH, Pizzo DP, Okada S, Ramachandrarao SP, Vallon V, Sharma K, Cunard R.TRB3 is stimulated in diabetic kidneys, regulated by the ER Stress marker CHOP and is a suppressor of podocyte MCP-1.Am J Physiol Renal Physiol. 2010 Jul 21. [Epub ahead of print]

Kumar Sharma, M.D. April, 2016

Page20

83. Calhoun DA, Sharma K. The role of aldosteronism in causing obesity-related cardiovascular risk. Cardiol Clin. 2010 Aug;28(3):517-27.

84. Vallon V, Sharma K. Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Curr Opin Nephrol Hypertens. 2010 Sep;19(5):425-31.

85. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, Thomson SC. Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol. 2010 Aug;299(2):C374-80. Epub 2010 May 26.

86. Declves AE, Sharma K. New pharmacological treatments for improving renal outcomes in diabetes. Nat Rev Nephrol. 2010 Jun;6(6):371-80. Epub 2010 May 4.

87. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet. 2010 Oct 1;3(5):414-25. Epub 2010 Aug 20.

88. Deelman LE, Declves AE, Rychak JJ, Sharma K. Targeted renal therapies through microbubbles and ultrasound. Adv Drug Deliv Rev. 2010 Nov 30;62(14):1369-77. Epub 2010 Oct 11.

89. Mathew AV, Okada S, Sharma K. Obesity related kidney disease. Curr Diabetes Rev. 2011 Jan 1;7(1):41-9.

90. Sharma, K, Ix, J.H., Mathew, A.V., Cho, M, Pflueger, A., Dunn, S.R., Francos, B., Sharma, S, Falkner, B., McGowan, T., Donohue, M., RamachandraRao, S., Xu, R., Fervenza, F., Kopp, J.B. Pirfenidone for Diabetic Nephropathy: A Randomized Placebo Controlled Clinical Study. Journal of the American Society of Nephrology 22:1144-1151, 2011

91. Maher P, Dargusch R, Ehren JL, Okada S, Sharma K, Schubert D. Fisetin

lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One. 2011;6(6):e21226. Epub 2011 Jun 27.

92. Mathew A, Cunard R, Sharma K. Antifibrotic treatment and other new strategies

for improving renal outcomes. Contrib Nephrol. 2011;170:217-27. Epub 2011 Jun 9.

93. Sanchez AP, Zhao J, You YH, Diamond-Stanic M, Sharma K. Role of the USF1

Transcription Factor in Diabetic Kidney Disease. Am J Physiol Renal Physiol. 2011 Aug;301(2):F271-9. Epub 2011 May 4.

94. Cunard R, Sharma K. The endoplasmic reticulum stress response and diabetic

kidney disease. Am J Physiol Renal Physiol. 2011 May;300(5):F1054-61. Epub 2011 Feb 23.

95. Anderson CR, Hu X, Zhang H, Tlaxca J, Declves AE, Houghtaling R, Sharma K, Lawrence M, Ferrara KW, Rychak JJ. Ultrasound molecular imaging of tumor

Kumar Sharma, M.D. April, 2016

Page21

angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011 Apr;46(4):215-24.

96. Decleves, A-E., Mathew, A.V., Cunard, R., Sharma, K. AMPK Mediates the Initiation of High Fat Induced Kidney Disease. Journal of the American Society of Nephrology 2011 Oct;22(10):1846-55.

97. Jakob Appel stergaard, Mette Bjerre, Satish Rao, Kumar Sharma, J. R.

Nyengaard, T. Hansen, Steffen Thiel and A. Flyvbjerg. Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model, Experimental Diabetes Research, 2012;2012:678381. doi: 10.1155/2012/678381. Epub 2012 May 8.

98. Vallon V, Eraly SA, Ramachandra Rao S, Gerasimova M, Rose M, Nagle M,

Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May 15;302(10):F1293-9.

99. Diamond-Stanic, M., You YH, Sharma, K. Sugar, sex and TGF-b in diabetic

nephropathy. Semin Nephrol. 2012 May;32(3):261-8 100. Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K,

Yu W, Chen S. Visualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun. 2012 Sep 26. pii: S0006-291X(12)01836-0. doi: 10.1016/j.bbrc.2012.09.089. [Epub ahead of print]

101. National Kidney Foundation. KDOQI Clinical Practice Guideline for Diabetes and CKD. 2012 Update. Am J Kidney Dis. 2012 Nov;60(5):850-86. doi: 10.1053/j.ajkd.2012.07.005. Erratum in: Am J Kidney Dis. 2013 Jun;61(6):1049. PMID:23067652

102. Vallon, V., Rose, M, Gerasimova, M., Satriano, J., Platt, K., Whaley, J., Koepsell,

H., Cunard, R., Sharma, K., Thomson, S., Rieg, T. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013 Jan;304(2):F156-67. doi: 10.1152/ajprenal.00409.2012. Epub 2012 Nov 14. PMID: 23152292

103. Borgeson, E., and Sharma, K. Obesity, immunomodulation Inflammation, and

chronic kidney disease, Current Opinion in Pharmacology, 2013 Aug;13(4):618-24. doi: 10.1016/j.coph.2013.05.011. Epub 2013 Jun 7. PMID 23751262

104. Miyamoto, S. and Sharma, K. Adipokines protecting chronic kidney disease,

Nephrology, Dialysis and Transplantation, 2013 Nov;28 Suppl 4:iv15-22. doi: 10.1093/ndt/gft261. PMID: 24179009

105. You YH, Okada S, Ly S, Jandeleit-Dahm KA, Barit D, Namikoshi T, Sharma K.

Role of Nox2 in Diabetic Kidney Disease. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F840-8. doi: 10.1152/ajprenal.00511.2012. Epub 2013 Feb 6. PMID: 23389458

Kumar Sharma, M.D. April, 2016

Page22

106. Satriano, J, and Sharma, K. Autophagy and metabolic changes in obesity-

related CKD, Nephrology, Dialysis and Transplantation, 2013 Nov;28 Suppl 4:iv29-36. doi: 10.1093/ndt/gft229. Epub 2013 Jul 30. PMID: 23901047

107. Hu, X., Caskey, C., Mahakian, L., Kruse, D., Beegle, J., Declves, A-E., Rychak,

J., Sutcliffe, P., Sharma, K., Ferrara, K. In vivo validation and 3D visualization of broadband ultrasound molecular imaging. American Journal of Nuclear Medicine and Molecular Imaging. 3(4):336-49, 2013.

108. Satriano, J., Sharma, K., Blantz, R.C., Deng A. Induction of AMPK activity

corrects early pathophysiologic alterations in the subtotal nephrectomy model of chronic kidney disease. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F727-33. doi: 10.1152/ajprenal.00293.2013. Epub 2013 Jul 3. PMID: 23825068.

109. Declves, A.E., Rychak, J., Smith, D., and Sharma, K. Effects of high fat diet

and losartan on renal cortical blood flow using contrast ultrasound imaging. Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1343-51. doi: 10.1152/ajprenal.00326.2013. Epub 2013 Sep 18. PMID: 24049144

110. Declves, A.E., Zolkipli, Z., Satriano, J., Wang, L., Nakayama, T., Rogac, M., Le,

T., Nortier, J., Farquhar, M., Naviaux, R., and Sharma, K. Regulation of lipid accumulation by AMPK in High-Fat Diet-Induced Kidney. Kidney International, 2013 Dec 4. doi: 10.1038/ki.2013.462, [Epub ahead of print], PMID: 24304883.

111. Sharma, K., Karl, B., Mathew, A., Gangoiti, J., Wassel, C., Saito, R., Pu, M.,

Sharma, S., You, Y., Wang, L., Diamond-Stanic, M., Lindenmeyer, M.T., Forsblom, C., Wu, W., Ix, J. Ideker, T., Kopp, J.B., Nigam, S., Cohen, C., Groop, P-H., Barshop, B., Natarajan, L., Nyhan, W.L., Naviaux, R. Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease. Journal of the American Society of Nephrology 2013 Nov;24(11):1901-12. doi: 10.1681/ASN.2013020126. Epub 2013 Oct 10. PMID: 23949796.

112. Dugan, L., You, Y-H., Ali, S., Diamond-Stanic, M., Miyamoto, S., DeCleves, A.E.,

Andreyev, A. Quach, T., Ly, S., Shekhtman, G., Nguyen, W., Chepetan, A., Le, T.P., Wang, L., Xu, M., Paik, K.P., Fogo, A., Viollet, B., Murphy, A., Brosius, F., Naviaux, R.K., Sharma, K. Reduced Superoxide and Mitochondrial Function in Diabetes is AMPK Dependent. Journal of Clinical Investigation, 2013 Nov 1;123(11):4888-99. doi: 10.1172/JCI66218. Epub 2013 Oct 25. PMID: 24135141

113. Borsting, E., Patel, S., Decleves, A-E., Rahman, Q., Satriano, J., Sharma, K.,

Vallon, V., Cunard, R. TRB3, an Endoplasmic Reticulum Stress-associated protein, is upregulated in the diabetic kidney and binds to Rictor to attenuate mammalian target of rapamycin complex-2 signaling and inflammatory cytokines and chemokines. Journal of the American Society of Nephrology, 2014 Sep;25(9):2067-78. PMID:24676635

114. Sweiss N, Sharma K. Adiponectin effects on the kidney. Best Pract Res Clin

Endocrinol Metab. 2014 Jan;28(1):71-9. PMID:24417947

Kumar Sharma, M.D. April, 2016

Page23

115. Bansaghi, S., Golenar, T., Madesh, M., Csordas, G., Ramachandrarao, S., Sharma, K., Yule, D., Joseph, S., Hajnoczky, G. Isoform and species specific control of IP3 receptors by reactive oxygen species. Journal of Biological Chemistry, J Biol Chem. 2014 Mar 21;289(12):8170-81. PMID:24469450

116. Decleves, A-E., Sharma, K. Novel targets of anti-fibrotic and anti-inflammatory

treatment in CKD. Nat Rev Nephrol. 2014 May;10(5):257-67. PMID:24662433 117. Sharma K. Obesity, oxidative stress and fibrosis in chronic kidney disease.

Kidney Int Suppl (2011). 2014 Nov;4(1):113-117. Review. PMID:25401040 118. Declves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP,

Nortier JL, Farquhar MG, Naviaux RK, Sharma K. Regulation of lipid accumulation in high fat diet-induced kidney injury. Kidney International, 2014, 85:611-623. PMID:24304883

119. Guan X, Nie L, He T, Yang K, Xiao T, Wang S, Huang Y, Zhang J, Wang J,

Sharma K, Liu Y, Zhao J. Klotho suppresses renal tubule-interstitial fibrosis by controlling basic fibroblast growth factor2 signaling. Journal of Pathology 2014 Aug 11. doi: 10.1002/path.4420. [Epub ahead of print]. PMID:25130652

120. Sharma K. Telltale signs of perturbed podocytes. Journal of the American

Society of Nephrology 2014 Jul;25(7):1367-9. doi: 10.1681/ASN.2014020200. Epub 2014 Mar 27. PMID:24676633

121. Sharma K and Natarajan, L. Statins for microvascular complications-all but the

kidney. Nature Reviews/Nephrology, 2014 Dec;10(12):680-1. PMID:25366041 122. Declves AE, Sharma K. Obesity and kidney disease: differential effects of

obesity on adipose tissue and kidney inflammation and fibrosis. Curr Opin Nephrol Hypertens. 2015 Jan;24(1):28-36. PMID:25470014

123. Kang, H., Ahn, S., Choi, P., Ko, Y-A., Han, S., Chinga, F., Park, A., Tao, J.,

Sharma, K., Pullman, J., Bottinger, E., Goldberg, I., Susztak, K. Defective fatty acid oxidation in renal tubular epithelial cells plays a key role in kidney fibrosis development. Nature Medicine, 2015 Jan;21(1):37-46.

124. Sharma, K. Mitochondrial Hormesis and Diabetic Complications, Perspectives in

Diabetes. Diabetes, 2015 Mar;64(3):663-72. PMID:25713188 125. Zhao, J., Miyamoto, S., You, Y., Sharma, K. AMP-activated protein kinase

(AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys. Am J Physiol Renal Physiol. 2015 May 15;308(10):F1167-77. PMID:25428125

126. Groop, P-H., Cooper, M., Perkovic, V., Sharma, K., Schernthaner, G., Haneda,

M., Hocher, B., Gordat, M., Cescutti, J., Woerle, H-J., Eynatten, M. Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINAT2D trial. Diabetes and Vascular Disease

Kumar Sharma, M.D. April, 2016

Page24

Research, Diab Vasc Dis Res. 2015 Jul 28. pii: 1479164115579002. PMID:26224765

127. Mather KJ, Pan Q, Knowler WC, Funahashi T, Bray GA, Arakaki R, Falkner

B, Sharma K, Goldstein BJ; DPP Research Group. Treatment-induced changes in plasma adiponectin do not reduce urinary albumin excretion in the Diabetes Prevention Program cohort. PLoS One. 2015 Aug 27;10(8):e0136853. PMID:26312480

128. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows

KR, Singh P. Interactions between HIF1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F414-28. PMID:26136559

129. Brgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli

J, Colas RA, Serhan CN, Sharma K, Godson C. Lipoxin A4 attenuates obesity-induced adipose inflammation and asscoaited liver and kidney disease. Cell Metabolism. 2015 Jul 7;22(1):125-37. PMID:26052006

130. Abuyassin B, Sharma K, Ayas NT, Laher I. Obstructive sleep apnea and kidney

disease: A potential bidirectional relationship. J Clin Sleep Med. 2015 Aug 15;11(8):915-24. PMID:25845900

131. Zhu K, Kakehi T, Matsumoto M, Iwata K, Ibi M, Ohshima Y, Zhang J, Liu J, Wen

X, Taye A, Fan C, Katsuyama M, Sharma K, Yabe-Nishimura C. NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. Free Radic Biol Med. 2015 Jun;83:21-30. PMID:25701431

132. Takaori K, Nakamura J, Yamamoto S, Nakata H, Sato Y, Takase M, Nameta M,

Yamamoto T, Economides AN, Kohno K, Haga H, Sharma K, Yanagita M. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis. J Am Soc Nephrol. 2015 Dec 23. [Epub ahead of print] PubMed PMID: 26701981.

133. You YH, Quach T, Saito R, Pham J, Sharma K. Metabolomics reveals a key role

for fumarate in mediating the effects of NADPH Oxidase 4 in diabetic kidney disease. Journal of the American Society of Nephrology. 2016 Feb;27(2):466-8. PMID:26203118

134. Darshi, M., van Espen, B., Sharma, K. Metabolomics in diabetic kidney disease:

Unraveling the biochemistry of a silent killer. Am J Nephrology, in press, 2016 135. Coughlan, M., Sharma, K. Challenging the dogma of mitochondrial reactive

oxygen species overproduction in diabetic kidney disease. Kidney International, in press, 2016

136. Sharma, K. Obesity and diabetic Kidney Disease: Role of Oxidant Stress and

Redox Balance. Antioxid Redox Signal, in press 2016. PMID: 26983586 137. Miyamoto, S., C-C, Hsu, Hamm, G., Darshi, M., Diamond-Stanic, M., Decleves,

Kumar Sharma, M.D. April, 2016

Page25

A-E., Slater, L., Pannathur, S., Stauber, J., Dorrestein, P., Sharma, K. Mass spectrometry imaging reveals elevated glomerular ATP/AMP in diabetes/obesity and identifies sphingomyelin as a possible mediator. EBioMedicine, in press, 2016.

Book Chapters: 1. Sharma, K., Cox, M. Potassium Homeostasis. In: Workshops in Fluid and Electrolyte

Disorders, H.Szerlip and S. Goldfarb (eds) Churchill-Livingstone, 1993 2. Sharma K, Goldfarb S. Diabetic nephropathy. In Current Practice of Medicine,

edited by R C Bone, 1995. 3. Golfarb, S., K. Sharma. Acid-base disturbances. In Fishmans Pulmonary Diseases

and Disorders, Third Edition, McGraw-Hill, 1998. 4. Sharma K., D.C. Han, A. Mogyorosi, F.N. Ziyadeh: Structural and functional

consequences of streptozotocin-induced diabetes on the kidney. In: Experimental Models of Diabetes. J. H. McNeill (ed.) CRC Press Boca Raton 1998.

5. Fuchs, B., Sharma, K., Sherman, M. Acute Renal Failure chapter in The Pocket

Doctor. M. Sherman and E. Schulman (eds). Educational Communications, 1999. 6. Sharma, K., Ziyadeh, F. The role of the TGF-b superfamily in kidney disease. Chapter

in Textbook of Nephrology, S. Massry and R. Glassock (eds) 3rd ed. Lippincott Williams and Wilkins, 2000.

7. McGowan, TA, McCue, P., Sharma, K. Diabetic Nephropathy. Clinics in Laboratory

Medicine, eds. B Goldstein and F Gorstein 21:111-46, 2001. 8. Ziyadeh, F.N., Sharma, K. Combating Diabetic Nephropathy. Invited guest editor for

Frontiers in Nephrology series, Journal of the American Society of Nephrology 14:1355-1357, 2003

9. Golfarb, S., K. Sharma. Acid-base disturbances. In Fishmans Pulmonary Diseases

and Disorders, Fourth Edition, McGraw-Hill, 2006. 10. Wolf, G., Sharma, K., Ziyadeh, FN. Pathogenesis of Diabetic Nephropathy. Chapter in

textbook of Nephrology, 2006. 11. Susztak, K., Bottinger, E., Sharma, K. Gene expression profiling in the investigation of

diabetic nephropathy. Chapter in textbook of The Diabetic Kidney, edited by Pedro Cortes and Carl Erik Mogensen, 2006.

12. Katoako, H., Sharma, K. Renal Handling of Adipokines. Chapter in textbook of Obesity

Related Kidney Disease, edited by G. Wolf, Karger Publishing, Contrib Nephrol. 2006;151:91-105.

13. Garg, N., Sharma, K. Renal Insufficiency. Chapter in Pharmacology and

Therapeutics: Principles to Practice Scott Waldman and Andre Terzic ed. 2008

Kumar Sharma, M.D. April, 2016

Page26

14. RamachandraRao, S.P., Shaw, M.A., Sharma, K., 2D-Difference Gel Electrophoresis (DIGE) in Urinary Proteomics, an invited chapter for Renal and Urinary Proteomics: Methods and Protocols Wiley-VCH, publisher, V. Thongboonkerd, editor, in preparation, 2007

15. A. Mathew, R. Cunard and K. Sharma. Antifibrotic Treatment and Other New

Strategies for Improving Renal Outcomes. K.N. Lai, editor, 2011 16. Karl, B., Sharma, K. Natural history of Diabetic Kidney Disease. Book Chapter for

Diabetes and Kidney Disease. Editor Gunter Wolf, 2012. 17. Sharma, K. Thomson, S. Goldfarb, S. Diabetic Kidney Disease. NephSAP series,

American Society of Nephrology, Stanley Goldfarb, editor, (August 2012) 18. KDOQI Clinical Proactive Guideline for Diabetes and CKD: 2012 Update. National

Kidney Foundation. Am J Kidney Dis. 2012 Nov;60(5):850-86. doi: 10.1053/j.ajkd.2012.07.005. PMID: 23067652

19. You, Y., and Sharma, K., Reactive oxygen species and chronic kidney disease,

Systems Biology of Oxidative Stress, I. Laher, Editor, in press 2013. 20. Wolf, G., and Sharma, K. Pathogenesis, Clinical Manifestations, and Natural

History of Diabetic Nephropathy. Chapter in Comprehensive Clinical Nephrology, 5th edition, edited by Richard Johnson, John Feehally and Jurgen Floege, 2014

21. Thomas, M., Brownlee, M., Susztak, K., Sharma, K., Jandeleit-Dahm, K.,

Zoungas, S., Rossing, P., Per-Henrik Groop, P-H, Cooper, M. Diabetic kidney disease. Nature Reviews Disease Primers, 2015 in press