KLP 4. Breast Cancer
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Transcript of KLP 4. Breast Cancer
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Breast Cancer
Lycopene
Resveratrol
Coenzim Q10
Isoflavon Soy
Melatonin
Epigallocatechin
gallate
Vitamin D
PUFA
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Sel kelenjar, saluran kelenjar dan
jaringan penunjang payudara yang
tumbuh tidak normal/terus menerus dantidak terkendali, dapat bersifat ganas
dan merusak jaringan sekitarnya serta
dapat bermetastasis (Depkes RI, 2009)
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Mekanisme
aksi
Menghambat progresivitas b.c pada estrogen-
positive (MCF-7) dan estrogen-negative (MDA-
MB-231)
Dosis 250mg / hari
Kombinasi 15 μg/ml resveratrol 24 jam sebelum doxorubicin
Resveratrol + tamoxifen b.c tamoxifen resisten
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Mekanisme aksi Menghambat proliferasi sel kanker
Dosis 3 kali sehari 700mg
Kombinasi Green tea + tamoxifen
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Lockwood, 2007
Mekanisme aksi Sebagai antioksidan meredam O2 reaktif
dan meningkatkan potensi antioksidan
sehingga mengurangi kerusakan oksidatifprotein dan DNA
Dosis 60mg/hari
Profl
Farmakokinetik
Cmax 0,04 g/mL
Tmax 16,6 jamT1/2 max 28 jam
AUC 27,4 g.jam/Ml
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Lycopene memiliki aktivitas anti proliferatif melawan ER/R ositive MCF-7, HER2-positive SK-BR-3, dan triple-negative MDA-MB-468. Aktivitas dominan Lycopenesebagai antikanker yang ditemukan pada sel MDA-MB-468 menunjukkan bahwalycopene memiliki peran yang potensial dalam mencegah kanker payudara
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Lycopene: Food Sources, Properties, and Health
The relationship between breast cancer risk and plasma
carotenoids was assessed using a nested case-referent design.84Plasma samples from 201 cases and 290 referents were obtained
at study enrollment, and breast cancer incidence was identified
via cancer registries. None of the carotenoids measured were
related to the risk of developing breast cancer. However, amongpremenopausal women only, there was a significant inverse
relationship between breast cancer and plasma lycopene.
Therefore, it seems possible that lycopene may reduce the risk
of breast cancer among young, premenopausal women.
(Handbook of nutraceuticals and functional foods / edited by Robert E.C.Wildman. -- 2nd ed. p. cm.)
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Mekanisme
aksi
Menghambat proliferasi sel pada estrogen
receptor-positive (MCF-7) dan estrogen
receptor-negative (MDA-MB-231) (Shon et al ,
2006).Dosis 2-3 kali 1 tablet/hari (30-50mg/minum) atau
berdasarkan resep dokter
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Lockwood, 2007
Fungsi Digunakan sebagai tambahan untuk
kemoterapi konvensional dan dapat
meningkatkan efikasi kemoterapi dan
mengurangi efek samping beracun yangdialami oleh pasien kanker
Dosis 0,3 – 25 mg/hari (tablet, patch dan liquid)
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Sifat antioksidan kuat dari melatonin dapatmeningkatkan sitotoksisitas agen kemoterapi.
Melatonin mengurangi kejadian trombositopenia,
cardiotoxicity, neurotoksisitas dan efek samping lainnya
diinduksi oleh kemoterapi.
Melatonin dengan cepat dimetabolisme oleh hati,
dengan lebih dari 85% diekskresikan menjadi 6
sulfatoxymelatonin (6-SMT) dalam urin.
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Lockwood, 200722
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Lockwood, 2007
Mekanisme aksi mengurangi resiko kanker ductal, tetapi tidak
pada lobular pada kanker payudara
Dosis 1000 mg gabungan antara EPA dan DHA per
hari, pemakaian maksimal kurang dari 3 gram
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Coenzim Q10Mekanisme aksi Sebagai antioksidan melindungi stabilitas
membran sel, melindungi DNA dari radikal
bebas, meregenerasi antioksidan yang lain
Dosis 100 mg-3000mg/hari
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Lockwood, 2007
National Institute of Health, 2014
Lockwood, 2007
Barekova, 2008
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Mekanisme aksi berperan sebagai faktor transkripsi nuklear
yang mengatur pertumbuhan sel,
diferensiasi, apoptosis dan berbagai
mekanisme seluler pusat perkembangan
kanker.
Sumber Vitamin D bisa didapatkan dari susu, sereal,
telur dan fatty fish.
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Garland., et al., 2006
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Aggarwal, B.B., Bhardwaj, A., Aggarwal, R.S., Seeram, N.P., Shishodia, S., Takada, Y.,
2004, Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and
Clinical Studies, Anticancer Research, 24, 2783-2840
Depkes RI., 2009., Buku Saku Pencegahan Kanker Leher Rahim dan Kanker Payudara,
Depkes RI, Jakarta
Garland., C.F., et al., 2006, Vitamin D and prevention of breast cancer: pooled analysis,
ELSEVIER, 1-4, 2747,.
Lockwood, B.,2007,Nutraceuticals, 2nd ed., Pharmaceutical Press, London.
M., Takeshima, Ono, M., Higuchi, T., Chen, C., Hara, T., Nakono S., 2014,
Antiproliferative an apoptosis inducing activity of lycopene against three subtypesof human breast cancer cell ilnes, Cancer Sci ., 105 (3):2527
Osman, A.M.M., Bayoumi, H.M., Al-Harthi, S.E., Damanhouri, Z.A., ElShal, M.F., 2012,
Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell
line, Cancer Cell International, 12(47), 1-8
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Sartippour, M.R., Pietras, R., Garban, D.C.M., Chen, H.W., Heber, D., Henning, S.M., et
al., 2006, The combination of green tea and tamoxifen is effective against breast
cancer, Carcinogenesis, 27 (12), 2424 –2433
Shi, X.P., Miao, S., Wu, Y., Zhang, W., Zhang, X.F., Ma, H.Z., et al., 2013, ResveratrolSensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-
Mesenchymal Transition Features, International Journal of Molecular Sciences, 14,
15655-15668
Udenigwe, C.C., Ramprasath, V.R., Aluko, R.E., Jones, P.J.H., 2008, Potential of
Resveratrol in anticancer and anti-inflamatory therapy, Nutrition Reviews, 66(8),
445-454 Shon, Y. H., Park, S. D., & Nam, K. S., 2006, Effective Chemopreventive
Activity of Genistein against Human Breast Cancer Cells , Journal of Biochemistry
and Molecular Biology , Vol. 39, 448-451.
Wildman, Robert. C., 2007., Handbook of Nutraceuticals and Functional Foods, Second
Edition, CRC Press, New York.
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