Kim Solez, MD

http://www.youtube.com/user/kimsolez

The technological singularity occurs as artificial intelligences surpass human beings as the smartest and most capable life forms on the Earth. Technological development is taken over by the machines, who can think, act and communicate so quickly that normal humans cannot even comprehend what is going on. The machines enter into a "runaway reaction" of self-improvement cycles, with each new generation of A.I.s appearing faster and faster. From this point onwards, technological advancement is explosive, under the control of the machines, and thus cannot be accurately predicted (hence the term "Singularity"). – Ray Kurzweil

All natural disease may be eliminated, leaving

only man-made diseases. But that may leave

as much for physicians to do as there is today!

Challenging responses to bioterrorism and

stem cell technologies.

Focus of medicine no longer disease but

enhancement, elevating the human condition,

which will extend beyond the physical to the

moral and spiritual.

Social responsibility an important aspect of

medicine and one of the focuses of the course.

“It is the curse of humanity that it learns to tolerate even the most horrible situations by habituation. Physicians are the natural attorneys of the poor, and the social problems should largely be solved by them.”-Rudolf Virchow

“Medicine is a social science, and politics is nothing else than medicine writ large. Medicine as a social science, as the science of human beings, has the obligations to point out problems and to attempt their theoretical solution: the politician, the practical anthropologist, must find the means for their practical solution.”

– Rudolf Virchow

Assume the primacy of global health!

Telemedicine and “doctor in your cell phone” main uses of technology!

http://www.youtube.com/user/kimsolez

We shoot broadcast quality video of each lecture & discussion. http://www.singularitycourse.com

Previous lectures at http://www.youtube.com/user/KimSolez . Students critique one past lecture, and suggest improvements in presentation and hot-linked table of contents (20% of grade).

Students write one 3,000 word paper (40%) and give 20 min. presentation on same subject (30%). Also graded on class participation (10%).

No required reading. Suggested reading list in course outline, readings suggested by Email.

Ten minute introduction

Fifty minute lecture

Twenty minute discussion

In the course we talk about machines replacing many of the functions of human beings. This picture was taken by a machine without human intervention, as were many of the best still images from the course. The video camera is constantly comparing the scene to algorithms and takes still pictures when the requirements of the interesting picture algorithm are satisfied.

First teaching session 2011 Recent teaching session 2014

Hot-linked tables of contents in YouTube video descriptions at

http://www.youtube.com/user/kimsolez allow one

to jump right to content of interest.

Director of Social Media at Kandu Inc.

The technological Singularity. Existential

risks, AI, genomics, and nanotech.

Ways to optimize a positive outcome for

humanity in the co-evolution of humans

and machines . The influence of these

considerations on medicine of the future .

Dean of Science speaking, prominent

people internationally. Most lectures not

very “medical”. Easily understood.

Balanced view provided by incorporating

both tech skeptics and tech advocates .

Medical student elective participation in course.

International peer review of YouTube videos, modifications made. Two Quantum Biology lectures.

Young person old person point counterpoint lecture January 30th, Abdullah Saleh/Earle Waugh Medical Ethics in a World of Robots(What will we allow when everything is possible).

Collaboration with Disruptive Technologies in Medicine course in Budapest, Hungary, the only other course somewhat like this one.

Student feedback extremely positive in Fall 2014, all 5’s!

Flipped classroom sessions with well know people by Skype.

Melbourne, Sydney, Hong Kong, Berkeley, Edmonton,

Houston, Hawaii, Sao Paulo, Thanksgiving Point, Utah,

Brussels, Paris, LA, Palo Alto, Washington, Carlton,

Australia, Wroclaw, Poland

Histologic criteria for the diagnosis of rejection and other

conditions in the transplanted kidney, began 1991, updated

and expanded every two years in consensus meeting.

Banff Transplant

Pathology Meetings

Began in the

Transcanada Pipelines

Pavilion at the Banff

Centre in 1991, Future

Meetings Are Planned

through 2021.

To introduce you to the basic elements of artificial intelligence, machine learning, and data mining.

To introduce you to basic concepts of the influence of artificial intelligence on the exponential future, including the concept of unfriendly AI, and the technological Singularity.

To provide you with concrete examples of AI in everyday life and in medicine.

The Technological

Singularity

There were YouTube videos (now removed) suggesting that stem cell generation of complex organs in humans would be routine by 2020. Problems of clotting, endothelial loss, and cell type selection errors not mentioned.

The dramatic slowdown of new drug approvals (Eroom’sLaw) by the FDA suggests that the FDA is ripe for disruptive innovation. Has happened.

However stem cell therapies may be the last area the FDA will relax regulation in, as unproven bogus stem cell therapies are causing widespread suffering and protection of the general public is needed.

The recellularized organ clots like crazy, impossible to regenerate more than 80% of endothelial surface. Artificial heparized surface not fenestrated. Cell traffic abnormal.

Hard to get right types of cells to right places.

Podocytes seems to be terminally differentiated cells, when attempt to culture they turn into different type of cell.

Kidney progenitor stem cell difficult to identify, kidney work has lagged behind.

Easy to make stem cell generated kidneys that lack loop of Henle. Could produce lethal polyuria. What is “function”?

Many old fashioned questions of physiology about how the stem cell generated organ works, not just true for kidney, true for every organ.

Stem cell generated organs, xenografts, and bioartificialorgans can be combined.

Transplant pathologists will also become tissue engineering pathologists, pathologists who analyse organs grown from stem cells. This is not something beyond us, we can adapt to a work life that includes stem cells. Someone needs to cross the disciplines.

Many of the questions that need to be posed about stem cell generated organs are old fashioned questions, intact nephron hypothesis, cell regeneration, stunned myocardium, contraction band necrosis etc. Use your nostalgia! Stimulate conversations between stem cell researchers and transplant physicians.

At least one will reach the clinic soon. Pathologists will be examining stem cell generated organs, xenografts, and bioreactor cells of bioartificial organs. Transplant pathology will transition to tissue engineering pathology. The field will be richer than transplant pathology is today!

We examine the portrayal of translational stem cell research in major daily newspapers in Canada, the United States, and the United Kingdom between 2010 and 2013, focusing on how timelines for stem cell therapies were represented before and after Geron terminated its pioneering stem cell program. The findings raise questions about the degree to which the media’s overly optimistic slant fosters unrealistic expectations regarding the speed of clinical translation and highlight the ethical responsibility of stem cell researchers as public communicators.

Fig. 1. Forecasting the future.

Kalina Kamenova and Timothy Caulfield Sci Transl Med

2015;7:278ps4

Published by AAAS

Asserts a fundamental limit to the precision with which certain pairs of physical properties of a particle known as complementary variables, such as position x and momentum p, can be known simultaneously. Introduced first in 1927 it states that the more precisely the position of some particle is determined, the less precisely its momentum can be known, and vice versa.

Most presentations that purport to be about the future are really about the present, provide experiences, not data. Lack rigor.

Once you have determined that an event described in detail is going to happen in the future it becomes possible to predict when it will happen.

Can run simulations of various future scenarios given various assumptions.

Makes future prediction more tangible and meaningful, provides rigor.

Nova program on PBS Television (7 million viewers)

Big Bang Theory (the TV show; 20 million viewers)

Singularity Summit/Singularity 1on1 (9,000 views per video)

Kim Solez – Technology and Future of Medicine Course LABMP 590 (3,100 views per video)

We need the mainstream public to regard the Singularity as fact, not fiction.

We need to promote organized thinking about the future in Universities and beyond.

We need to make efforts to make Singularitianismaccessible and inclusive, with low barrier to entry, incorporating young people, and balanced views/diversity. “The Singularity for Dummies!” Assume global health is primary link with the Singularity.

UP UNTIL SHORTLY BEFORE HIS DEATH AT 72, ISAAC ASIMOV REFERRED TO HIMSELF AS BEING “IN MY LATE YOUTH”.

A SIMILAR SITUATION FACES ALL OF US BUT THE “YOUTH” WILL CONTINUE WELL BEYOND AGE 72 AND ENHANCED COMMUNICATIONS BROUGHT ABOUT BY TECHNOLOGY WILL BE AN IMPORTANT PART OF WHAT SUSTAINS IT!

In many areas of importance in the future, the boundaries, the limits you may be thinking of may not exist.