NMDA-Receptor Activation InducesCalpain-Mediated -Catenin Cleavages

for Triggering Gene Expression

Kentaro Abe et al., Cell, (2007)

- REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY

- ACTIVITY-DEPENDENT MODULATION OF LOCAL CYTOSKELETON AND ADHESION MOLECULES

- REGULATION OF DENDRITIC DEVELOPMENT BY ACTIVITY DEPENDENT GENE EXPRESSION

Chen Y et al., J Neurobiol, (2005)

NEURONAL ACTIVITY

Chen Y et al., J Neurobiol, (2005)

LTP ( long-terrm potentiation)

Memory formation

NMDA (N-methyl-D-aspartate) receptor

Cooke SF et al., Brain, (2006)

Calpain (calcium-dependent, non-lysosomal cysteine protease)

Franco SJ et al., J Cell Sci (2005)

Calpain regulates cell migration

Franco SJ et al., J Cell Sci (2005)

Motility-related calpain substrates of Calpain

Franco SJ et al., J Cell Sci (2005)

Activity-Dependent Cleavages of -Catenin by Calpain

AVP : NMDA-R antagonist

CNQX : AMPA-R antagonist

MCPG : mGluR antagonist

MDL28170 : calpain inhibitor

Activity-Dependent Cleavages of -Catenin by Calpain

MDL28170 : calpain inhibitor

Nuclear Translocation of Cleaved -Catenin Fragments

AVP : NMDA-R antagonist CNQX : AMPA-R antagonist

MCPG : mGluR antagonist MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments

AVP : NMDA-R antagonist, MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments

MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments

Calpain-Dependent -Catenin Cleavage and Tcf Activation In Vivo