Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P....

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Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14, Issue 1, Pages 76-85 (January 2008) DOI: 10.1016/j.devcel.2007.12.002 Copyright © 2008 Elsevier Inc. Terms and Conditions

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Figure 2 Developmental Cell , 76-85DOI: ( /j.devcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions Terms and Conditions

Transcript of Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P....

Page 1: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila 

Gerasimos P. Sykiotis, Dirk Bohmann 

Developmental Cell Volume 14, Issue 1, Pages 76-85 (January 2008)

DOI: 10.1016/j.devcel.2007.12.002

Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 1

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 2

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 3

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 4

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 5

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

Figure 6

Developmental Cell 2008 14, 76-85DOI: (10.1016/j.devcel.2007.12.002) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Functional Characterization of KEAP1 TCGA … KEAP1 mutants cluster into four classes IVR 180-314 KELCH 315-359 KELCH 361-410 KELCH 412-457 KELCH 459-504 KELCH 506-551 KELCH 553-598

Functional Characterization of KEAP1 TCGA … KEAP1 mutants cluster into four classes IVR 180-314 KELCH 315-359 KELCH 361-410 KELCH 412-457 KELCH 459-504 KELCH 506-551 KELCH 553-598

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MECHANISTIC STUDIES OF THE NRF2-KEAP1 SIGNALING PATHWAYzhangd/Donna's paper/15.pdf · MECHANISTIC STUDIES OF THE NRF2-KEAP1 SIGNALING PATHWAY Donna D. Zhang Department of Pharmacology

KEAP1 Genetic Polymorphisms Associate with Breast Cancer ...clincancerres.aacrjournals.org/content/clincanres/21/7/1591.full.pdf · Breast Cancer Risk and Survival Outcomes ... 4Laboratory

KEAP1 Genetic Polymorphisms Associate with Breast Cancer ...clincancerres.aacrjournals.org/content/clincanres/21/7/1591.full.pdf · Breast Cancer Risk and Survival Outcomes ... 4Laboratory

Antioxidant axis Nrf2-keap1-ARE in inhibition of …...translocation of nuclear factor-related factor (Nrf)2 and increased activity of the antioxidant axis Nrf2-keap1-ARE. We aimed

Antioxidant axis Nrf2-keap1-ARE in inhibition of …...translocation of nuclear factor-related factor (Nrf)2 and increased activity of the antioxidant axis Nrf2-keap1-ARE. We aimed

Dual roles and therapeutic potential of Keap1-Nrf2 pathway ...

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A PGAM5–KEAP1–Nrf2 complex is required for …...RESEARCH ARTICLE A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking Gary B. O’Mealey1,2,

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COMPUTATIONAL TOOLS FOR TOPOLOGICAL COHOCHSCHILD HOMOLOGY · COMPUTATIONAL TOOLS FOR TOPOLOGICAL COHOCHSCHILD HOMOLOGY ANNA MARIE BOHMANN, TEENA GERHARDT, AMALIE H˜GENHAVEN, BROOKE

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STK11 and KEAP1 mutations as prognostic biomarkers in an … · Papillon-Cavanaghs etal MO Open 225e6 doi11136esmoopen-22-6 1 Open access STK11 and KEAP1 mutations as prognostic biomarkers

STK11 and KEAP1 mutations as prognostic biomarkers in an … · Papillon-Cavanaghs etal MO Open 225e6 doi11136esmoopen-22-6 1 Open access STK11 and KEAP1 mutations as prognostic biomarkers

TARGETING THE NRF2/KEAP1 INTERACTION · 2014. 6. 12. · 4 Abstract The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory

TARGETING THE NRF2/KEAP1 INTERACTION · 2014. 6. 12. · 4 Abstract The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory

KEAP1 Is a Redox Sensitive Target That Arbitrates the ......2013/07/05  · Therapeutics, Targets, and Chemical Biology KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing

KEAP1 Is a Redox Sensitive Target That Arbitrates the ......2013/07/05  · Therapeutics, Targets, and Chemical Biology KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing

Review Article The Role of the Keap1/Nrf2 Pathway in the ...downloads.hindawi.com/journals/omcl/2013/848279.pdf · The Role of the Keap1/Nrf2 Pathway in the Cellular ... SDH Not de

Review Article The Role of the Keap1/Nrf2 Pathway in the ...downloads.hindawi.com/journals/omcl/2013/848279.pdf · The Role of the Keap1/Nrf2 Pathway in the Cellular ... SDH Not de

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via …mcb.berkeley.edu/labs/zhong/Autophagy Jul 22 2010.pdf · 2010-11-29 · 616 Autophagy Volume 6 issue 5 In Keap1

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via …mcb.berkeley.edu/labs/zhong/Autophagy Jul 22 2010.pdf · 2010-11-29 · 616 Autophagy Volume 6 issue 5 In Keap1

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear ...cabm-ms.cabm.rutgers.edu/PALB2 interacts with KEAP1... · Huo, Allen Alcivar, Monal Mehta, Ka Lung Cheung, Shridar Jianglin Ma,

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear ...cabm-ms.cabm.rutgers.edu/PALB2 interacts with KEAP1... · Huo, Allen Alcivar, Monal Mehta, Ka Lung Cheung, Shridar Jianglin Ma,

Lecture Notes EEE 360 - Michigan Technological … Circuit Calculations, Unsymmetrical Faults Leonard Bohmann, Michigan State University Elham Makram, Clemson University. 2 ... Lecture

Lecture Notes EEE 360 - Michigan Technological … Circuit Calculations, Unsymmetrical Faults Leonard Bohmann, Michigan State University Elham Makram, Clemson University. 2 ... Lecture

KEAP1-modifying small molecule reveals muted NRF2 ... · KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients

KEAP1-modifying small molecule reveals muted NRF2 ... · KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients

On uniform conjugators in torsion-free hyperbolic groupsreh.math.uni-duesseldorf.de/~bogopolski/Artikel/2008_hyp... · 2010. 1. 31. · V. Metaftsis and M. Sykiotis [11, 12] proved

On uniform conjugators in torsion-free hyperbolic groupsreh.math.uni-duesseldorf.de/~bogopolski/Artikel/2008_hyp... · 2010. 1. 31. · V. Metaftsis and M. Sykiotis [11, 12] proved

TITLE: Development of Keap1-interactive small molecules that … · 2016-12-07 · TITLE: Development of Keap1-interactive small molecules that regulate Nrf2 transcriptional activity

TITLE: Development of Keap1-interactive small molecules that … · 2016-12-07 · TITLE: Development of Keap1-interactive small molecules that regulate Nrf2 transcriptional activity

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

Lecture Notes EEE 360 - Michigan Technological … Makram, Clemson University 2 Short Circuit Calculations Leonard Bohmann Michigan State University 3 Line to Ground Short 2003 IEEE

Lecture Notes EEE 360 - Michigan Technological … Makram, Clemson University 2 Short Circuit Calculations Leonard Bohmann Michigan State University 3 Line to Ground Short 2003 IEEE