K award NIH Biosketchhttps://grants.nih.gov/grants/forms/biosketch.htm

KarlaKerlikowske,MDProfessorofMedicineandEpidemiologyandBiostatistics

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What is NIH Biographical Sketch?• Highly formatted component of a

grant proposal that captures and communicates the PI’s accomplishments and activities as clearly and effectively as possible

• A concise “personal narrative” of education, training, experiences, contributions, and leadership in profession/field

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Why is the NIH Biographical Sketch Needed? Allows PIs to:• Highlight education, training, experiences,

and qualifications• Describe magnitude and significance of

scientific contributions (plus publications)• Provide significant contributions, relevant

experiences, and/or qualifications in the context of the proposed project

• Enables reviewers to evaluate experience and qualifications of the PI and scientific team that will execute the grant

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In a Nut Shell: Your Biosketch Tells Your Story• Who you are• What makes you great for this

project• What contributions you have made

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Components

• Limit of 5 pages• A. Personal statement -1/2 pgs.• B. Positions and honors-1/2 pgs.• C. Contributions to Science – 2 pgs.• D. Research support and scholastic

performance -2 pgs.

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NIH biosketch●Name●eRA commons

⁃ RMS Research Services Coordinator

●Position Title●Education

⁃ name and location of the institution⁃ degree received (if applicable)⁃ month and year of end date (or

expected end date) ⁃ field of study

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OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020)

BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FIVE PAGES.

NAME: Kim, Tiffany Y. eRA COMMONS USER NAME (credential, e.g., agency login): tiffany.kim POSITION TITLE: Assistant Professor of Medicine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

INSTITUTION AND LOCATION DEGREE (if applicable)

Completion Date

MM/YYYY FIELD OF STUDY

University of California, Berkeley BA 05/2007 Molecular and Cell Biology

University of Illinois at Chicago MD 05/2011 Medicine

University of California, Los Angeles Residency 06/2014 Internal Medicine

University of California, San Francisco Certificate 06/2016 Advanced Training in Clinical Research

University of California, San Francisco Fellowship 06/2017 Endocrinology

San Francisco VA Health Care System Fellowship 06/2019 Women’s Health A. Personal Statement

I am an endocrinologist, Assistant Professor of Medicine at the University of California, San Francisco

(UCSF) and Staff Physician at the San Francisco VA Health Care System (SFVAHCS). My long-term goal is to become an independent clinical investigator focused on understanding mechanisms of diabetic bone disease and improving the skeletal health of people with type 2 diabetes. I am the Principal Investigator for this K23 proposal, which seeks to examine the role of bone marrow fat in diabetic bone disease.

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Personal statement• 3-paragraph statement with the

following content:• Proposal goal• Relevant experiences on this

specific topic or related topic • Leadership qualifications

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Personal statement tip• Tailor to the grant application• Mention the mechanism of the grant

application (e.g., K01)• Speak directly to the purpose of the

funding mechanism and proposal goal• Ex: My goal for this proposed NCI Career

Development Award (K01, K08) or Transition Award (K22) is to conduct basic, translational, or clinical research to study … while further developing and expanding my (training and) career growth in the field of …(or as a…) or etc.

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Personal statement tip• Sell your role in the proposed research

• Why are you a good fit?• What strengths do you have for the

proposal?• Identify yourself – New Investigator – and

discuss your future research direction if you are a new investigator

• Write in first person and limit your personal statement to 300‒400 words (about half a page)

• If someone is mentoring/collaborating with you, include this in the personal statement

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Personal statement examples• I am a clinician-investigator with a

longstanding interest in …..• I have the expertise, leadership and

training in x to carry out the proposed research

• I have a broad background in x with specific training in ….

• My research has evolved from x experience• As an investigator on x grants, I laid the

groundwork for the proposed research by…• I collaborated with x, an expert in x• The proposed studies began under the

mentorship of x11

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Personal statement●Up to 4 publications/research

products●Directly related to research topic●Articles with co-investigators

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Personal statement●Research products●Audio or video products●Conference proceedings -- meeting

abstracts, posters, presentations ●Patents ●Data and research materials;

databases; educational aids or curricula; instruments or equipment; models; protocols; and software or netware

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A. Personal Statement I am a clinician-investigator with a longstanding interest in improving cancer screening and prevention. My research has evolved from describing the unintended effects of cancer screening to studying novel approaches to screening that are informed by individual risk. My current research focuses on developing risk stratification tools to allow personalization of breast cancer screening and prevention, with a special focus on integrating circulating biomarkers and existing risk prediction models. For instance, I have shown that genetic variants and sex hormones can improve the performance of risk models based on clinical risk factors. As an investigator in the WISDOM Study, an ongoing randomized trial of personalized versus annual breast cancer screening, I am studying how to integrate risk models into clinical decision-making around screening and prevention, and whether this practice improves outcomes. This K08 proposal aims to extend my prior work by developing and validating a risk model that accounts for breast cancer phenotype, enabling screening and prevention to target the aggressive cancers most likely to cause morbidity and mortality.

1. Esserman L, Shieh Y, Thompson I. Rethinking screening for breast cancer and prostate cancer. JAMA. 2009 Oct 21; 302(15):1685-92. PMID: 19843904

2. Shieh Y, Eklund M, Sawaya GF, Black WC, Kramer BS, Esserman LJ. Population-based screening for cancer: hope and hype. Nat Rev Clin Oncol. 2016 Sep; 13(9):550-565. PMID: 27071351

3. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JW, Tice JA, Vachon CM, Cummings SR, Kerlikowske K, Ziv E. Breast cancer risk prediction using a clinical risk model and polygenic risk score. Breast Cancer Res Treat. 2016 Oct; 159(3):513-25. PMID: 27565998. PMCID: PMC5033764

4. Shieh Y, Eklund M, Madlensky L, Sawyer SD, Thompson CK, Stover Fiscalini A, Ziv E, Van't Veer LJ, Esserman LJ, Tice JA. Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial. J Natl Cancer Inst. 2017 Jan; 109(5). PMID: 28130475

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Position and Honors●Positions and Employment●Other Experience and Professional

Memberships●Honors – clarify what for●Scholarship●Traineeship●Fellowship●Research Prize

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Contributions to Science (2 pages)● Describe up to 5 of your most significant

contributions to science –1/2 page, including up to 4 published citations (PMC or NIHMS)●Historical background that frames the

scientific problem●Central finding(s)● Influence of the finding(s) on the

progress of science or the application of those finding(s) to health or technology –So what?

● Your specific role in the described work

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Contributions to Science● Historical background that frames the

scientific problem● Similar to background sentence of

abstract● Central finding(s)●My publication was the first to show ….●My publication has contributed

evidence of ….●We identified a molecular signature

that stratified....●We developed a risk model or

nomogram to predict......17

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Contributions to Science● Influence of the finding(s) on the progress

of science or the application of those finding(s) to health or technology

• My results contributed to a growing body of evidence that ….

• My findings have important implications for clinical care of …

• The risk calculator/nomogram/app that I helped is available on the iPhone and facilitates …..

• My contributions have been cited when establishing xx guidelines

• This work led to two patents and development of a commercial test

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Contributions to Science● Your specific role in the described work ●My first authored paper showed….● I served as the primary investigator or

senior investigator for these studies.●With a team of collaborators we

developed x with my contribution to the project ….

● Complete list of x# published works in MyBibliography:

https://www.ncbi.nlm.nih.gov/books/NBK53595/http://www.ncbi.nlm.nih.gov/pubmed/?term=kerlikowske+k

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C. Contribution to Science1. Genetic variants and other circulating markers in breast cancer risk

assessment. Over 150 genetic variants, or single nucleotide polymorphisms (SNPs), have been associated with breast cancer risk, but their role in informing clinical risk prediction is still being elucidated. I showed that a polygenic risk score (PRS) representing the cumulative effect of 83 SNPs had a strong association with breast cancer that was largely independent of family history and other risk factors. Moreover, incorporating the PRS into an established risk model containing clinical risk factors and breast density resulted in improved discrimination and reclassification. These results contributed to a growing evidence base that PRS may enhance risk stratification. I was also the lead author on the first study on the combined effects of sex hormones, SNPs, and clinical risk factors in breast cancer risk predication. My coauthors and I showed that sex hormones could improve prediction of estrogen-receptor positive breast cancers, results that could potentially be used to better identify high-risk women for chemoprevention.

a. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JW, Tice JA, Vachon CM, Cummings SR, Kerlikowske K, Ziv E. Breast cancer risk prediction using a clinical risk model and polygenic risk score. Breast Cancer Res Treat. 2016 Oct; 159(3):513-25. PMID: 27565998. PMCID: PMC5033764

b. Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JWT, Tice JA, Ziv E, Kerlikowske K, Cummings SR. Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones. Breast Cancer Res Treat. 2017 Aug 08. PMID: 28791495. PMCID: PMC5669824

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Additional information: research support and/or scholastic performance (2 pages)●Ongoing Research Support●Completed Research Support

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D. Research Support

Ongoing Research Support K12HL138046 NHLBI Garcia (PI) 07/01/2018-present

Implementing Depression Screening and Care for Patients with CVD and Language Barriers

Cardiovascular disease (CVD) and comorbid depression lead to increased morbidity and mortality.

Patients with CVD and language barriers face additional challenges to obtaining care for depression

in primary care. This study sought to identify ways to improve care for vulnerable patients with CVD

and language barriers.

Completed/Past Research Support D55HP23202 Margot Kushel (PI) Role: Research Fellow 07/01/14-06/30/17

HRSA

Faculty Development in Primary Care (UCSF)

This grant provided fellowship level support for three years to acquire methodological research skills

in addition to mentored research experience with established investigators at the University of

California, San Francisco.

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Thank you

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