JUVENILE IDIOPATHIC ARTHRITIS(JIA) · JUVENILE IDIOPATHIC ... –Axial skeleton involvement unusual...
Transcript of JUVENILE IDIOPATHIC ARTHRITIS(JIA) · JUVENILE IDIOPATHIC ... –Axial skeleton involvement unusual...
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IAP UG Teaching slides 2015-16
JUVENILE IDIOPATHIC ARTHRITIS(JIA)
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Outline of Lecture
•What is JIA : Definition : ILAR classification•Clinical Approach•Investigations•Management Principles
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IAP UG Teaching slides 2015-16
DEFINITION
• Arthritis which begins before the 16th birthday
• Has no known cause identifiable
• Lasts for > 6 weeks
• Diagnosis of exclusion
• Incidence of JIA is 10 per 100000
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ILAR* Classification of JIA
•Systemic arthritis•Polyarthritis : Rheumatoid factor: negative, : positive•Oligoarthritis : persistent : extended•Enthesitis related arthritis•Psoriatic arthritis•Undifferentiated: fits no category : fits more than one category
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IAP UG Teaching slides 2015-16
The ethos behind ILAR……
• Homogeneity: define homogenous groups on the basis of patterns of clinical features commonly seen in children with arthritis
• Exclusivity: Each group is mutually exclusive i.e. a patient cannot be included in more than one group
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Parameters used to classify the child with JIA:
1 Presence of objective arthritis
2 Site of inflammation: large, small, peripheral, axial, enthesitis
3 Duration of objective arthritis
4 Number of joints involved5 Systemic disease6 Lab findings: ANA, RF, HLA
B27
7 Onset age 8 Gender9 Progression of joint
involvement: limited or extended oligoarthritis
10 Other system involvement
11 Family history of certain diseases: spondyloarthopathy, psoriasis
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Oligoarthritis
• OJIA is 40 to 50% of all JIA–(Western data)
• Young girls
• Large joint involvement
• Predominantly lower limb (limp)
• Frequent chronic anterior uveitis • ‘The eye and joint disease evolve independently
• ANA antibodies in 40 to 75%
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IAP UG Teaching slides 2015-16
Systemic onset JIA
SOJIA accounts for 10‐20% of all JIA patients
Almost equal sex incidence
Mean age 4‐6 years
HLA:DR 5/DR8/DR4
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SOJIA….Clinical features
• Fever pattern: Quotodian Goes below, baseline
Child well in between spikes
RE involvement, Serositis
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• Arthritis: Most develop it in the first 3 months , 50% develop chronic erosive arthritis• Rash: Evanescent,Salmon pink Can be urticarial/pruritic
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Polyarticular JIA: Rf negative
• Girls: Age 3+
• Symmetric large and small joints
• Hip, TMJ and cervical spine may be investigated
• Extra articular‐low grade fevers
• ANA –40%
• ESR, WBC‐ moderate elevation
• Genetics‐HLA DRB1
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Polyarticular JIA Rf positive
• Females predominate• 10 year +, however may begin at an early age
• Symmetric small joint hand and foot disease ; large joints
• Rarely skin vasculitis, nodules, or pulmonary • disease as described in adults
• Progressive, aggressive and erosive disease
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Enthesitis related arthritis
• Arthritis + EnthesitisOr
• Arthritis or Enthesitis + two
–SI joint tenderness and or Inflammatory spinal pain
–HLA B 27
–Family history of HLA B 27 assoc disease
–Acute anterior uveitis–Onset of arthritis in a boy > 8 years
–Axial skeleton involvement unusual in children !
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Psoriatic Arthritis
• Arthritis and psoriasis• Or arthritis + family history of psoriasis with at least one of the following– Dactylitis– Nail abnormalities
• No HLA B27 association• Spinal inflammatory disease is rare
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IAP UG Teaching slides 2015-16
Red color,font28,
• Black color,28 font. Calibri.• 8‐10 lines only
– If there is sub line like here...font can be 24
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Thank You
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