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1284

INDEX

Volume 262, July-September, 1992

A-63162, vascular permeability changes,

regulation by mast cells, Arthus re-

action (mice), 559

A-68930, SKF-38393 and, comparison, 855

Abboa-Offei, B. E., see Seymour, A. A., 60Abdel-Rahman, A. A., see El-Mas, M. M.,

157 /

Abe, S., see Nagakawa, J.-I., 145/Abels, B. C., CalliS, J. T., Branch, R. A. and

Sabra, R.: Influence of the adenosinereceptor antagonist, CGS 15943A, onrenal function after reconstruciton ofchronic renal artery stenoSis in the

dog, 166Ableitner, A. and Schultz, R.: Neuroana-

tomical sites mediating the central

actions of fl-endorphin as mapped bychanges in glucose utilization: In-volvement of Mu opioid receptors,415

Accumbens, dopaminergic response to stim-ulants (rats), 1085

ACE inhibitors, perindopril effects, myocar-

dial inotropy/lusitropy/economy,

diaphragmatic contractility (ham-

sters), 516

Acetaminophen, -induced hyphophagia, de-velopment of tolerance, prior sensi-tization of stereotypy (rats), 1232

Acetylcholine, influence of epithelium, re-

activity of trachea, bronchoactivedrugs (guinea pigs), 741

Acetylcholinesterase, cimetidine-carbaryl

interaction (humans), 1057

a,-Acid glycoprotein, identification as a ma-jor vanilloid binding protein, serum

(rats), 883

Acquired immunodeficiency syndrome, ef-fects of dideoxyinosine, exocrine pan-

creas (rats), 445Adenosine, chronic renal artery stenosis, in-

fluence of CGS i5943A (dogs), 166

Adenosine 5’-(2-fluorodiphosphate), selec-

tivity, jugular vein (rabbits), 566Adenosine triphosphate

Mg�-complex, binding properties, sulfo-nylurea receptor, 495

purinergic vasoconstrictor component,

moderate cooling, mesenteric vascu-lature (rats), 1133

-sensitive K� channels, inhibition by sul-phonylurea drugs and effects of pH,cardiac muscle (guinea pigs), 71

toxicity of i-methyl-4-phenyl-2,3-dihy-dropyridinium, primary cultures, as-

trocytes (mice), 225

Adenylate cyclasedihydrexidine, D1 receptor agonist (rats),

383serum-induced sensitization, cyclic AMP

accumulation, C62B glioma cells(rats), 471

short-term treatment with gastrin, gas-

trointestinal histamine H2-receptors

(guinea pigs), 624

Adipocytes, l-isoproterenol-induced lipo-lytic response, multiple beta adrener-

gic receptor subclasses (rats), 552Adrenal medulla, bradykinin-induced

plasma extravasation, sympathoad-renal contribution, knee joint (rats),889

Adrenergic nervous system, neural modula-tion of neuroblastoma growth, 6-hy-

droxydopamine (mice), 1070

Adrenoceptorsa�pha

effects of xylamine, vascular neuroef-fector transmission (rabbits), 231

toxicity of norepinephrine, brain stem(rats), 1274

alpha-i, arterial blood pressure and heartrate, chlorethylclonidine (rats), 901

a�pha-2antagonist and agonist binding, phorbol

ester and staurosporine modulation(calves), 775

blunted growth hormone responses,clonidine (rats), 1038

opioid agonists, spinal interactions

(mice), 365

beta

l-isoproterenol-induced lipolytic re-sponse, adipocytes (rats), 552

pharmacological characterization, pri-mary cultures of myocardial cells(chicks, frogs), 217

positive inotropic effects, right atrium

(humans), 532pathophysiological and pharmacological

mechanisms, acute cocaine toxicity(rats), 936

Afferents, glutamatergic, epileptogenesis,

presynpatic r-aminobutyric acidB re-

ceptors (rats), 1011Aging, enhancement of diquat-induced lipid

peroxidation, cytotoxicity, hepato-

cytes (rats), 271

Ahlenius, S., see Lundstr#{246}m, J., 41

AHN 683, fluorescent ligand, peripheral-

type benzodiazepine receptors (rats),734

Airway, constriction and edema induced byneurokinins, sensory nerve stimula-tion, FK224 (guinea pigs), 403

Aldosterone, in vitro pharmacology of L-158,809 (rabbits, rats, monkeys), 133

Alfaxalone, potentiation of r-aminobutyricacid-induced depolarizations, single

myenteric neurons, intestine (guineapigs), 677

Alkylating agents, clocinnamox, opioid an-tagonist (mice), 1051

Allergen, cutaneous challenge, H1 receptorblockade, early and late response (hu-mans), 964

Aloyo, V. J.: Identification and characteriza-

tion of delta opioid binding sites inthe bovine pineal, 292

Alprazolain, Ro 19-8022, neuropharmacol-

ogical profile (mice, rats, monkeys),1121

Amiloride

chronic furosemide administration, ef-fects of renal denervation, sodium

balance (rats), 1103ouabain-evoked catecholamine secretion,

inhibition, adrenal chromaffin cells(cattle), 1209

Amineptine, regional extracellular concen-

trations, dopamine and noradrena-

line, brain (rats), 769Amino acids

excitatoryantagonist/partial agonist, polyamine

recognition site (rats), 539NMDA receptors, peptide synthesis

(rats), 823indole- and quinoline-containing NMDA

antagonists, strychnine-insensitive

glycine binding site (rats), 947-y-Aminobutyric acid

agonists and reduction in potency,chronic flurazepam treatment, hip-pocampus (rats), 204

decrease in function, pentylenetetrazolkindling, antagonism by MK-801(rats), 792

Aminoglycoside, -mediated calciuresis(rats), 151

DL-a-Amino-3-hydroxy-5-methyl-4-isoxal-

one propionic acid, N-methyl-D-as-partate and, receptors expressed in

Xenopus oocytes, ethanol sensitivity,487

Amiodarone, -induced lung fibrosis andphospholipidosis, attenuation by tau-rine and/or niacin (hamsters), 127

Amphetamine

opioid antagonists and, mediation, centraldelta opioid receptors (rats), 638

uptake blockers, caudate and accumbensdialysate dopamine and 3-methoxy-tyramine (rats), 1085

D-Amphetamine, serotonin-stimulated re-lease of dopamine, reversal, dopa-mine transporter (rats), 356

Amygdala, epileptogenesis, presynaptic r-

aminobutyric acidB receptors (rats),

1011Analgesia

clocinnamox, opioid antagonist (mice),1051

development of tolerance to analgesic ac-tivity, mu agonists, infusion of mor-phine/meperidine/fentanyl (rats), 1

morphine-6fl-glucuronide, more potent

opioid agonist, morphine (rabbits,guinea pigs, mice), 25

nalbuphine, mixed kappa1 and kappa3 an-algesic (mice), 1044

Andazola, J. J., see Chiono, M., 1248Anders, M. W., see Simmons, T. W., 1182Anesthetics, regional variation in steroid

anesthetic modulation, TBPS bind-

1992 Index 1285

ing to GABAA �Cept0m, brain (rats),801

Angiotensin II-induced vasoconstriction, norepineph-

rine, femoral artery (rabbits), 198monocrotaline-induced pulmonary hyper-

tension, losartan effect (rats), 1168receptor antagonism, antihypertensive ef-

feet, DuP 753 (rats), 595renal hemodynamic and excretory re-

sponses, PD 123319 and losartan

(dogs), 1154

Angkachatchai, V., see Ramos, B. F., 559Antiarrhythmic agents

clofilium andlidocaine, electrophysiologic

actions, ischemically injured epicar-cHum (dogs), 375

differential effects of glyburide, prema-ture beats and ventricular tachy-cardia, tissue model of ischemia andreperfusion (guinea pigs), 1076

dofetilide, delayed K� current, cardiac

myocytes (guinea pigs), 809slow inward Na� current, ibutilide, yen-

tricular cells (guinea pigs), 99

Anticonvulsanta2-aryl-3-indoleacetamides, mitochondrial

DBI receptor (rats), 971indole- and quinoline-containing NMDA

antagonists, strychnine-insensitiveglycine binding site (rats), 947

Antigen, -induced enhancement, noncholi-nergic contractile responses to vagus

nerve, trachea (guinea pigs), 646Antihistamines, effect of H1 receptor block-

ade, early and late response, cuta-neous allergen challenge (humans),964

Antihypertensives, in vivo pharamcology of

L-158,809 (rats, monkeys), 139Antinociception

endogenous opioids, intratheceally ad-ministered calcium (mice), 995

intrathecally administered cannabinoids,

morphine (mice), 10

properties of two alkylating derivatives,morphinone (mice), 526

swim-stress, mediation by opioid delta�

receptors (mice), 190Antipsychotic agents

behavorial pharmacology of olanzapine(rats, mice), 545

haloperidol and BMY 14802, modulation,regional brain neurotensin (rats), 348

Anxietycomparison of E-4424, diazepam/buspi-

rone/ipsapirone, models (rats, mice,marmosets), 90

proconflict effects, corticotropin-releas-ing factor (rats), 335

Ro 19-8022, neuropharmacological profile(mice, rats, monkeys), 1121

Aorta

baroreceptors, ethanol.induced impair-

ment of baroreflex control, heart rate(rats), 157

vascular neuroeffector transmission, ef-fects of xylamine (rabbits), 231

Apoptosis, thymocyte injury, in vitro chem-ical exposure (rats, mice), 1267

Arachidonic acid

biochemical studies of fuscoside, neutro-phils (humans), 874

P-450-dependent metabolism, olfactory

microsomes (rabbits), 433

Archer, S., see Jiang, Q., 526

Arneson-Rotert, L. J., see Toews, M. L., 471Artery

blood pressure and heart rate, effect of

chlorethylclonidine (rats), 901coronary, endothelial cell reseeding for

recovery (pigs), 841femoral, angiotensin Il-induced vasocon-

striction, norepinephrine (rabbits),198

renal, chronic stenosis, influence of CGS15943A (dogs), 166

Arthritisbiochemical studies of fuscoside, neutro-

phils (humans), 874

bradykinin-induced plasma extravasa-

tion, sympathoadrenal contribution,

knee joint (rats), 889Arthus reaction, vascular permeability

changes, regulation by mast cells(mice), 559

Arylacylamidase, cytosolic, thiacetazonemetabolism (rats), 1225

2-Aryl-3-indoleacetamides, ligands for mi-

tochondrial DBI receptor (rats), 971

Asaad, M. M., see Seymour, A. A., 60Aspartate, conserved residues, allosteric in-

teraction of gallamine, ml musca-rinic receptor, 312

Asprodini, E. K., Rainnie, D. G. and Shin-nick-Gallagher, P.: Epileptogenesisreduces the sensitivity of presynaptic

‘y-aminobutyric acidB receptors onglutamatergic afferents in the amyg-dala, 1011

Astrocytes, primary cultures, toxicity, 1-methyl-4-phenyl-2,3-dihydropyridi-nium (mice), 225

Atrial natriuretic peptides

brain natriuretic peptides, potentiation bySQ 28,603 (monkeys, rats), 60

increased, reduced cisplatin nephrotoxic-ity (rats), 246

Atropine, chronic administration, differen-

tial regulation in forebrain, ml to m5

muscarinic receptor subtypes (rats),

584

Aulakh, C. S., Hill, J. L., Lesch, K. P. andMurphy, D. L.: Functional subsensi-tivity of5-hydroxytryptamine1c or at-

pha-2 adrenergic heteroreceptors me-diating clonidine-induced growthhormone release in the Fawn-Hoodedrat strain relative to the Wistar ratstrain, 1038

Auta, J., see Romeo, E., 971

Autoradiography, localization of leukotrieneC4 receptors, lung (bullfrogs), 1248

Axelson, J. E., see van der Weyde, M. P., 48Axelson, J. E., see Yeleswaram, K., 683Axon, peripheral and central adrenergic,

neural modulation of neuroblastomagrowth, 6-hydroxydopamine (mice),1070

Axton, M. S., see Moore, N. A., 545Azidothymidine analog, dideoxyinosine, ef-

fects on exocrine pancreas (rats), 445

Azoulay-Dupuis, E., see Vall#{233}e,E., 1203

Azuma, M., see Morita, K., 1209

Ballatori, N., see Dutczak, W. J., 619Ballatori, N., see Simmons, T. W., 1182Bals, S., see Deighton, N. M., 532Balster, R. L., see Gold, L. H., 479Bandettini, P. A., see Eells, J. T., 1173

Barbiturates, GABAA responses, single

myenteric neurons, intestine (guinea

pigs), 677

Barker, L. A., see Petropoulos, A. C., 624Baron, B. M., Harrison, B. L., McDonald, I.

A., Meldrum, B. S., Paifreyman, M.G., Salituro, F. G., Siegel, B. W.,Slone, A. L., Turner, J. P. and White,H. S.: Potent indole- and quinoline-containing N-methyl-D-aspartate an-tagonists acting at the strychnine-insensitive glycine binding site, 947

Baroreceptors

aortic, ethanol-induced impairment ofbaroreflex control, heart rate (rats),157

transient vagal cold blockade, reflex ac-tions, polar and nonpolar cardiac gly-cosides (dogs), 1022

Barrett, R. L., see Gold, L. H., 479

Barry, W. H., see Port, J. D., 217

Basbaum, A. I., see Miao, F. J.-P., 889Basinger, M. A., see Ormond, P. M., 246Bauchet, J., see Vall#{233}e,E., 1203Baudy�,ov#{225}, M., see Mare�, V., 818B-cells, Mg�-complex of ATP, binding

properties, sulfonylurea receptor, 495Beckstead, R. M., see Somers, D. L., 823Behavior

abuse liability, diphenhydramine, braze-pam and methocarbamol (humans),707

cocaine, D2-selective dopamine antago-nists (monkeys), 907

differential adaptation of serotonergicsystem, 1-(2,5-dimethoxy-4-iodo-phenyl)-2-aminopropane, ketanserin(mice), 692

pharmacology of olanzapine (rats, mice),545

proconflict effects, corticotropin-releas-

ing factor (rats), 335Behrends, S., see Schwanstecher, M., 495Benowitz, N. L., see Miao, F. J.-P., 889Benzodiazepines

chronic flurazepam treatment, reduction

in potency, GABAA agonists (rats),204

inverse agonist, corticotropin-releasingfactor, proconflict effects (rats), 335

tolerance, cross-tolerance and with-drawal, dependence on diazepam(rats), 751

Bertrand, P. P. and Galligan, J. J.: Alfaxal-one, pentobarbital an diazepam po-tentiate r-aminobutyric acid-induceddepolarizations in single myenteric

neurons of guinea pig intestine, 677Bervoets, K., see Millan, M. J., 451Bicuculline, decrease in GABAergic func-

tion, pentylenetetrazol kindling, an-

tagonism by MK-801 (rats), 792Bidlack, J. M., see Jiang, Q., 526Bigelow, G. E., see Preston, K. L., 279Bile

L-cysteine and S-(1,2-dichborovinyl)-L-

cysteine transport, liver canalicular

membrane vesicles (rats), 1182

mixed disulfide of glutathione and cystei-nylglycine, -y-glutamyl transferase,oxidative stress (mice, hamsters, rats,guinea pigs, rabbits), 896

Billah, M., see Smith, S. R., 721Bjork, F. A., see Keiser, J. A., 1154Blaybock, B. L., see Comment, C. E., 1267

1286 Index Vol. 262

Blood flow, regional cerebral, selective ef-fects, cocaine (rats), 327

Blood pressure

arterial, heart rate and, chlorethylcboni-dine effect (rats), 901

central effects of quinpirole, sponta-neously hypertensive rats, 303

endothelium- 1 release, ischemia-hypoxia,

phosphoramidon (guinea pigs), 1062

ethanol-induced impairment of baroreflexcontrol, role of aortic baroreceptors,heart rate (rats), 157

regulation, central nervous system action,

nitric oxide (rats), 343Bloom, J. W., see Lai, J., 173Blumberg, P. M., see Szallasi, A., 883

BMY 14802, modulation of regional brainneurotensin (rats), 348

Bobbit, J. L., see Snyder, D. W., 1147Bonanno, G. and Raiteri, M.: Functional

evidence for multiple ‘y-aminobutyric

acidB receptor subtypes in the rat cer-

ebral cortex, 114

Bonetti, E. P., see Jenck, F., 1121Bonini, I., see Invernizzi, R., 769Boone, M. S., see Pugh, S. L., 751Boron-lO, accumulation in cell cultures, ex-

posure to mercaptododecaborate,

brain tumors (mice), 818

Bowden, C. R., Voina, S. J., Woestenborghs,

R., De Coster, R. and Heykants, J.:Stimulation by risperidone ofrat pro-

lactin secretion in vivo and in cul-tured pituitary cells in vitro, 699

Bowen, W. D., see Vanderah, T. W., 190

Bowen, W. D., Walker, J. M., de Costa, B.R., Wu, R., Tolentino, P. J., Finn, D.,Rothman, R. B. and Rice, K. C.:Characterization of the enantiomersof cis-N-[2-(3,4-dichloro-

phenyl)ethyl]-N-methyl-2-(1-pyrrol-

idinyl) - cycbohexylamine (BD737and BD738): Novel compounds with

high affinity, selectivity and biobog-

ical efficacy at sigma receptors, 32

Braat, M. C. P., Oosterhuis, B., Koopmans,R. P., Meeuwis, J. M. J. M. and VanBoxtel, C. J.: Kinetic-dynamic mod-

eling of lymphocytopenia induced bythe combined action of dexametha-

sone and hydrocortisone in humans,after inhalation and intravenous ad-ministration of dexamethasone, 509

Braat, M. C. P., see Koopmans, R. P., 503Bradykinin

activation of B1 and B2 kinin receptors,

cyclic GMP production, bovine aorticendothelial cells, 729

-induced plasma extravasation, sympa-thoadrenal contribution, knee joint(rats), 889

recovery of endothelium-dependent re-sponses, reseeding endothelial cells,

denuded coronary artery (pigs), 841

Brain

biochemical and pharmacological proper-

ties, SR 46349B (rats), 759

caudate and accumbens dialysate dopa-mine and 3-methoxytyramine, am-

phetamine and dopamine uptake

blockers (rats), 1085

density of nicotine binding sites, dietary

choline supplementation (rats), 1128ethanol sensitivity, excitatory amino

acids, Xenopus oocytes, 487

levels of 3-(3-hydroxyphenyl)-N-n-pro-

pylpiperidine HCL enantiomers, bo-comotor activity (rats), 41

neonatal 6-hydroxydopamine-lesionedrats, comparison, SKF-38393 and A-

68930, 855

neuroanatomical sites, central actions offl-endorphin, glucose utilization

(rats), 415neurotensin concentrations, modulation

by antipsychotic drugs (rats), 348

permeability, other peripheral tissues,

prostaglandins (rats), 1110

potentiation of natriuretic peptides, SQ

28,603 (monkeys, rats), 60quinpirole binding, D2-like dopamine re-

ceptors (rats), 929

regional cerebral blood flow, selective ef-fects, cocaine (rats), 327

regional extracellular concentrations, do-pamine and noradrenaline, aminep-tine effect (rats), 769

striatum and nucleus accumbens, sero-

tonin-stimulated release, dopamine

(rats), 356

tumors, boron-lO accumulation, cell cul-

tures (mice), 818Brain stem, receptor-mediated toxicity, nor-

epinephrine, catecholasninergic neu-rons (rats), 1274

Branch, R. A., see Abels, B. C., 166

Branch, R. A., see May, D. G., 1057Brandt, C., see Schwanstecher, M., 495

Breathing, dynamics, central opioid modu-lation, [D-Pen2,D-Pen5J-enkephalinand naltrindole (sheep), 1004

Breese, G. R., see Johnson, K. B., 855Breliere, J. C., see Rinaldi-Carmona, M., 759Bremazocine, diuresis by kappa opiate re-

ceptor activation, E-2078 (rats), 979Brewster, W. K., see Mottola, D. M., 383Bril, A., see Gout, B., 987Bristow, M. R., see Port, J. D., 217Britt, D. T., see Gold, L. H., 479

Brocco, M., see Millan, M. J., 451

Brodde, O.-E., see Deighton, N. M., 532

14�3-(Bromoacetamido)-7,8-dihydromorphi-none, antinociceptive properties

(mice), 526Bromocriptine, cocaine alone and in com-

bination, cocaine abusers (humans),

279

Bronchoconstriction, constriction of tra-

chea by endothelins, multiple mech-anisms (guinea pigs), 570

Brooks, D. P., see Ohlstein, E. H., 595Brown, H. W., see Comment, C. E., 1267Brune, K. A., see Dub#{233},G. P., 784Bryant, R. W., see Smith, S. R., 721Buckner, C. K., see Renzetti, L. M., 957Burke, T. F., see Comer, S. D., 1051Buspirone

compared to E-4424, models of anxiety

(rats, mice, marmosets), 90

modulation of micturition reflexes, 5-

HT1A receptors (rats), 181

t-Butyl bicyclophosphorothionate, binding

to GABAA receptors, regional varia-tion, steroid anesthetic modulation

(rats), 801Byrd, L. D., see Howell, L. L., 907

Cadmium, -metalbothionein, induction of

nephropathy, dose-effect relation-

ship (rats), 1256

Cai, Y., see Rikans, L. E., 271

Calcium

indole- and quinoline-containing NMDAantagonists, strychnine-insensitive

glycine binding site (rats), 947intrathecally administered, endogenous

opioids, antinociceptive effects(mice), 995

megakaryoblastic differentiation, throm-

bin (humans), 1242

quinacrine and 7,7-dimethyleicosanoicacid, ischemic hearts (rats), 1161

release channel complex, multiple bindingsites, skeletal and cardiac sarco-plasmic reticulum (rabbits), 1028

thymocyte injury, in vitro chemical expo-sure (rats, mice), 1267

Calcium antagonist, receptors, sustained oc-

cupancy, mepirodipine (rats), 589Calcium channel

ryanodine-sensitive, stereoselective mod-ulation, hexachlorocycbohexane 6 iso-mer (rats), 661

single peptide leukotriene receptor, re-

semblance, human conducting airwaysmooth muscle (guinea pigs), 1095

Calcium channel blockers, pathophysiolog-ical and pharmacological mecha-nisms, acute cocaine toxicity (rats),936

Calciuresis, aminoglycoside-mediated

(rats), 151Caldwell, R. W. and Rebagay, W. R.: Effect

of transient vagal cold blockade uponreflex actions of a polar and nonpolarcardiac glycoside, 1022

Callis, J. T., see Abels, B. C., 166Cannabinoids, intrathecally administered,

antinociceptive activity (mice), 10

Canton, H., see Millan, M. J., 451Capsaicin

antigen-induced enhancement, noncholi-nergic contractile responses, vagus

nerve (guinea pigs), 646effects of FK224, airway constriction and

edema, sensory nerve stimulation(guinea pigs), 403

identification of a1-acid glycoprotein, ma-jor vanilloid binding protein, serum

(rats), 883

modulation of micturition reflexes, 5-HT1A receptors (rats), 181

Captopril, antihypertensive effect of DuP753, angiotensin II receptor antago-

nism (rats), 595Carbachol

bradykinin-induced plasma extravasa-tion, sympathoadrenal contribution,

knee joint (rats), 889charybdotoxin-sensitive K� channel, re-

laxation of bovine tracheal smoothmuscle, glyceryl trinitrate and so-dium nitroprusside, 263

highly selective sigma ligands (guineapigs, rats), 32

influence of epithelium, reactivity of tra-

chea, bronchoactive drugs (guineapigs), 741

Carbaryl, -cimetidine interaction (humans),1057

Carcinoma, bladder, culture medium, gran-ulocyte colony-stimulating factor,Escherichw coli, 439

Cardiomyopathy, myocardial inotropy/lusi-

tropy/economy, diaphragmatic con-tractility (hamsters), 516

Index 12871992

Carmeliet, E.: Voltage-and time-dependentblock of the delayed K� current in

cardiac myocytes by dofetilide, 809

Cassis, L. A., Rippetoe, P. E., Soltis, E. E.,Painter, D. J., Fitz, R. and Gillespie,M. N.: Angiotensin II and monocro-taline-induced pulmonary hyperten-

sion: Effect of lasartan (DuP 753), anonpeptide angiotensin type 1 recep-tor antagonist, 8, 116

Catalepsy, behavioral pharmacology ofolanzapine (rats, mice), 545

Catecholaminesconcentration, neural modulation, neuro-

blastoma growth (mice), 1070ouabain-evoked, inhibition by amiboride,

adrenal chromaffin cells (cattle),

1209receptor-mediated toxicity of norepineph-

rine, neurons, brain stem (rats), 1274

Catechol-O-methyltransferase, dopami-

nergic response to stimulants (rats),

1085Cawley, G., see Coutcher, J. B., 1128

Central nervous system, action of nitric ox-

ide, blood pressure regulation (rats),343

Cerebral cortex, multiple -y-aminobutyric

acid8 receptor subtypes (rats), 114Cerven#{225},J., see Marai, V., 818Cetirizine, effect of H1 receptor blockade,

early and late response, cutaneousallergen challenge (humans), 964

CGP 35348, multiple GABAB receptor sub-

types, cerebral cortex (rats), 114

CGS 15943A, renal function after recon-struction, chronic renal artery ste-nosis (dogs), 166

Chakravarty, P. K., see Chang, R. S. L., 133Chakravarty, P. K., see Siegl, P. K. S., 139Chang, K.-J., see Wong, C.-S., 317Chang, R. S. L., see Siegl, P. K. S., 139Chang, R. S. L., Siegl, P. K. S., Clinesch-

midt, B. V., Mantbo, N. B., Chakra-varty, P. K., Greenlee, W. J., Patch-ett, A. A. and Lotti, V. J.: In vitropharmacology of L-158,809, a new

highly potent and selective angioten-sin II receptor antagonist, 133

Chao, C. C., Hu, S., Molitor, T. W., Zhou,Y., Murtaugh, M. P., Tsang, M. andPeterson, P. K.: Morphine poten-tiates transforming growth factor-fl

release from human peripheral bloodmononuclear cell cultures, 19

Charlesworth, E. N., Massey, W. A., Kagey-Sobotka, A., Norman, P. 5. and Lich-tenstein, L. M.: Effect of H1 receptorblockade on the early and late re-sponse to cutaneous allergen chal-lenge, 964

Charybdotoxin, -sensitive K� channel, re-laxation of bovine tracheal smoothmuscle, glyceryl trinitrate and so-dium nitroprusside, 263

Chemla, D., Scalbert, E., Desche, P.,Pourny, J.-C., Lambert, F. and Le-carpentier, Y.: Effects of perindoprilon myocardiab inotropy, lusitropyand economy, and on diaphragmaticcontractility in the cardiomyopathicSyrian hamster, 516

Chen, X., see Gillis, C. N., 212

Cheng, P. Y., Wu, D. L., Decena, J., Cheng,Y., McCabe, S. and Szeto, H. H.:

Central opioid modulation of breath-ing dynamics in the fetal lamb: Ef-

fects of [D-Pen2,D-Pen5J-enkephalin

and partial antagonism by naltrin-dole, 1004

Cheng, Y., see Cheng, P. Y., 1004

Cherian, M. G., see Zalups, R. K., 1256Chiba, K., see Sohn, D.-R., 1195

Chiba, S., see Narita, M., 577Chiono, M., Andazola, J. J., Torres, 0. A.

and Herman, C. A.: Characterizationand localization of beukotriene C4 re-ceptors in bullfrog lung, 1248

Chiu, P. J. S., see Vemulapalli, S., 1062

Chbordiazepoxide, proconflict effects, corti-cotropin-releasing factor (rats), 335

Chlorethylclonidine, arterial blood pressureand heart rate (rats), 901

Chloride channels, regional variation in ste-

roid anesthetic modulation, TBPS

binding to GABAA receptors, brain

(rats), 801Chborpheniramine, effect of H1 receptor

blockade, early and late response, cu-taneous allergen challenge (humans),

964Cho, A. K., see Nedergaard, 0. A., 231CHO cells, modulation of conserved aspar-

tate residues, allosteric interaction of

gablamine, ml muscarinic receptor,312

Choline, dietary supplementation, density

of nicotine binding sites, brain (rats),

1128

Chromaffin cells, adrenal, ouabain-evokedcatecholamine secretion, inhibition

by amiboride (cattle), 1209Chronopharmacobogy, kinetic-dynamic

modeling of lymphocytopenia, dexa-

methasone and hydrocortisone (hu-mans), 509

Ciesla, W., see Wall, S. J., 584

Cimetidine-carbaryl interaction (humans), 1057

vascular permeability changes, regulation

by mast cells, Arthus reaction (mice),

559Cioffi, C. L., Neale, R. F., Jr., Jackson, R.

H. and Sills, M. A.: Characterizationof rat lung endothelin receptor sub-types which are coupled to phosphoi-nositide hydrolysis, 611

Ciprofloxacin, temafloxacin and, kineticdisposition, pneumococcal pneu-

monia (mice), 1203Cisplatin, reduced nephrotoxicity, increased

atrial natriuretic peptide (rats), 246Clarkson, C. W., see Xu, Y.-Q., 670Clineschmidt, B. V., see Chang, R. S. L., 133Cbocinnamox, opioid antagonist (mice),

1051

Cbofilium, lidocaine and, electrophysiobogic

actions, ischemically injured epicar-

dium (dogs), 375

Cbonidine, -induced growth hormone re-

lease, functional subsensitivity, 5-

HT1� or alpha2-adrenergic heterore-ceptors (rats), 1038

Cocaineacute toxicity, pathophysiobogicab and

pharmacological mechanisms (rats),

936alone and in combination, bromocriptine,

cocaine abusers (humans), 279

behavioral effects, D2-selective dopamineantagonists (monkeys), 907

cardiovascular effects (rats), 602dopaminergic response to stimulants

(rats), 1085selective effects on regional cerebral blood

flow (rats), 327sensitization to toxic effects, regulation of

NMDA receptors, cortex (mice), 464Colon, stimulation of contraction and ion

transport, endothelin-1 (rats), 409Colony-stimulating factor, granulocyte,

bladder carcinoma cell line culture

medium, Escherichia coli, 439Comer, S. D., Burke, T. F., Lewis, J. W. and

Woods, J. H.: Clocinnamox: A novel,systemically-active, irreversibleopioid antagonist, 1051

Comment, C. E., Blaylock, B. L., Germolec,D. R., Pollock, P. L., Kouchi, Y.,Brown, H. W., Rosenthal, G. J. and

Luster, M. I.: Thymocyte injury after

in vitro chemical exposure: Potentialmechanisms for thymic atrophy, 1267

Compton, R. P., see Hood, W. F., 654Congy, C., see Rinaldi-Carmona, M., 759

Convulsions, sensitization to toxic effects ofcocaine, NMDA receptor regulation,cortex (mice), 464

Cook, L. L., see Mottoba, D. M., 383Cooling, puringeric vasoconstrictor compo-

nent, mesenteric vasculature (rats),1133

Corda, M. G., Orlandi, M., Lecca, D. andGiorgi, 0.: Decrease in gabaergicfunction induced by pentylenetetra-zol kindling in rats: Antagonism byMK-801, 792

Cordi, A. A., see Hood, W. F., 654Cortex, sensitization to toxic effects of co-

caine, NMDA receptor regulation(mice), 464

Corticosteroneantagonist activity at 5-HT1�,2 receptors,

S 14671 (rats), 451

influence of epithelium, reactivity of tra-chea, bronchoactive drugs (guineapigs), 741

Corticotropin-releasing factor, common

mechanisms underlying proconflict

effects (rats), 335Costa, E., see Romeo, E., 971

Costall, B., Domeney, A. M., Farre, A. J.,Kelly, M. E., Martinez, L. and Nay-br, R. J.: Profile of action of a novel5-hydroxytryptamine1A receptor li-gand E-4424 to inhibit aversive be-havior in the mouse, rat and mar-moset, 90

Coutcher, J. B., Cawley, G. and Wecker, L.:Dietary choline supplementation in-creases the density of nicotine bind-ing sites in rat brain, 1128

Cox, B. M., see Jacocks, H. M., III, 356

CP 55,490, tetrahydrocannabinol and, dis-criminative stimulus properties (rats,

monkeys), 479CP 96,345, tachykinin neurokinin2 recep-

tors, nonadrenergic contractile re-

sponses, hilar bronchus (guinea pigs),

957

Criswell, H. E., see Johnson, K. B., 855

Cros, J., see Frances, B., 25Cyclic AMP

1288 Index Vol. 262

accumulation, serum-induced sensitiza-

tion, C62B glioma cells (rats), 471

production, activation of protein kinaseA, ethanol-induced desensitization,257

selectivity and functional coupling, chi-meric M1/M2 muscarinic receptors,173

Cyclic GMPbioactivation of organic nitrates, media-

tion by cytochrome P.450, 298production, activation of B1 and B2 kinin

receptors, bovine aortic endothelial

cells, 729

Cysteine

bioactivation of organic nitrates, media-tion by cytochrome P-450, 298

-y-glutamyltransferase-dependent biliary-hepatic recycling, methyl mercury

(guinea pigs), 619L-Cysteine, S-(1,2-dichlorovinyl)-L-cysteine

and, transport, liver canalicularmembrane vesicles (rats), 1182

Cytochrome P-450arachidonic acid metabolism, olfactory

microsomes (rabbits), 433mediation of bioactivation, organic ni-

trates, 298Cytokines, constitutive and inducible nitric

oxide synthases, human megakaryob-

lastic cells, 1220Cytosol, arylacylamidase, thiacetazone me-

tabolism (rats), 1225

Dappen, M. S., see Hood, W. F., 654Darmani, N. A., Martin, B. R. and Glennon,

R. A.: Behavioral evidence for differ-ential adaptation of the serotonergicsystem after acute and chronic treat-ment with (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane or ke-tanserin, 692

Davis, M. G., see Dorn, G. W., II, 1242Debellis, C. C., see Port, J. D., 217Dc Boor, S. F., Katz, J. L. and Valentino,

R. J.: Common mechanisms under-lying the proconflict effects of corti-

cotropin-releasing factor, a benzodi-azepine inverse agonist and electricfoot-shock, 335

Decena, J., see Cheng, P. Y., 1004

de Costa, B. R., see Bowen, W. D., 32

De Coster, R., see Bowden, C. R., 699Deighton, N. M., Motomura, S., Bals, S.,

Zerkowski, H.-R. and Brodde, O.-E.:Characterization of the beta adreno-ceptor subtype(s) mediating the pos-itive inotropic effects of epinine, do-

pamine, dobutamine, denopamineand xamoterol in isolated humanright atrium, 532

De Ladonchamps, B. L., see Millan, M. J.,451

del Prado, M., see Vemulapalli, S., 1062

Denopamine, positive inotropic effects, betaadrenoceptor subtype, right atrium(humans), 532

Desche, P., see Chemla, D., 516Deth, R. C., see Jagadeesh, G., 775Dewey, W. L., see Smith, F. L., 995

Dexamethasone

hydrocortisone and, kinetic-dynamic

modeling, lymphocytopenia (hu-mans), 509

time-dependent effects, suppression of

plasma hydrocortisone (humans),503

Diabetes, increased atrial natriuretic pep-tide, reduced cisplatin nephrotoxicity(rats), 246

Diaphragm, contractility, perindopril ef-fects, myocardial inotropy/lusitropy/economy (hamsters), 516

Diazepamcompared to E-4424, models of anxiety

(rats, mice, marmosets), 90

potentiation of r-aminobutyric acid-in-

duced depolarizations, single myen-teric neurons, intestine (guinea pigs),677

tolerance, cross-tolerance and withdrawal(rats), 751

Diazepam binding inhibitor, mitochondrial,receptor, 2-aryl-3-indoleacetamides(rats), 971

Diazoxide, Mg�-complex of ATP, binding

properties, sulfonylurea receptor, 495DiBona, G. F., see Petersen, J. S., 1103cis-N-[2-(3,4-Dichlorophenyl)ethylj-N-

methyl-2-(1-pyrrolidinyl ) cyclohex-ylamine, enantiomers, biological ef-ficacy, sigma receptors (guinea pigs,rats), 32

S-(1,2-Dichlorovinyl)-L-cysteine, L-cysteine

and, transport, liver canalicularmembrane vesicles (rats), 1182

2 ‘ ,3 ‘ -Dideoxyinosine, effects on exocrinepancreas (rats), 445

Diet, choline supplementation, density ofnicotine binding sites, brain (rats),

1128

Diethyldithiocarbamate, disulfiram and,competitive inhibitors, peripheral

benzodiazepine receptor (rats), 394Digoxin

ouabain and, handling by renal tubularcells, 109

transient vagal cold blockade, reflex ac-tions, polar and nonpolar cardiac gly-cosides (dogs), 1022

Dihydrexidine, novel full efficacy D1 dopa-mine receptor agonist (rats), 383

Dildy-Mayfield, J. E. and Harris, R. A.:

comparison of ethanol sensitivity of

rat brain kainate, DL-a-amino-3-hy-droxy-5-methyl-4-isoxabone pro-prionic acid and N-methyl-D-aspar-tate receptors expressed in xerwpus

oocytes, 487Diltiazem, charybdotoxin-sensitive K�

channel, relaxation of bovine tra-cheal smooth muscle, glyceryl trini-

trate and sodium nitroprusside, 2631-(2,5-Dimethoxy-4-iodophenyl)-2-amino-

propane, ketanserin or, behavioralevidence, differential adaptation

(mice), 692(2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-

benzoquinoyl))-2-nonyl-2-p ropenoicacid, protective effects, endotoxin-

mediated hepatitis (mice), 1457,7-Dimethyleicosadienoic acid, quinacrine

and, ischemic hearts (rats), 11617-[1R-2S,3S,5R)-6,6-Dimethyl-3-(4-iodob-

enzenesulfonylami no)bicyclo [3.1.1J

hept-2-yl]-5(Z)-heptenoic acid, high-

affinity radiolabeled antagonist,

platelet thromboxane A2/prostaglan-din H2 receptors (humans), 632

Di Monte, D. A., see Wu, E. Y., 225

Ding, X., see Laethem, R. M., 433Diphenhydramine, lorazepam and metho-

carbamol, subjective and behavioraleffects, abuse liability (humans), 707

Diquat, -induced lipid peroxidation, age-as-sociated enhancement, cytotoxicityin hepatocytes (rats), 271

Discriminative stimulusproperties of tetrahydrocannabinol and

CP 55,940 (rats, monkeys), 479tolerance, cross-tolerance and with-

drawal, dependence on diazepam

(rats), 751Disulfiram, diethyldithiocarbamate and,

competitive inhibitors, peripheralbenzodiazepine receptor (rats), 394

Diuresis, kappa opiate receptor activation,E-2078 (rats), 979

DNA, thymocyte injury, in vitro chemicalexposure (rats, mice), 1267

Dobutamine, positive inotropic effects, betaadrenoceptor subtype, right atrium(humans), 532

Dofetilide, voltage- and time-dependentblock, delayed K� current, cardiacmyocytes (guinea pigs), 809

Domeney, A. M., see Costall, B., 90Dopamine

behavioral pharmacology of olanzapine(rats, mice), 545

brain levels, 3-(3-hydroxyphenyl)-N-n-

propylpiperidine HCL enantiomers,locomotor activity (rats), 41

central effects of quinpirole, blood pres-sure, spontaneously hypertensiverats, 303

D2-selective antagonists, behavioral ef-

fects, cocaine (monkeys), 907noradrenaline and, regional extracellular

brain concentrations, amineptine ef-fect (rats), 769

positive inotropic effects, beta adrenocep-tor subtype, right atrium (humans),532

serotonin-stimulated release, reversal ofdopamine transporter, striatum andnucleus accumbens (rats), 356

uptake blockers, caudate and accumbensdialysate dopamine and 3-methoxy-tyramine (rats), 1085

Dorn, G. W., H and Davis, M. G.: Thrombin,but not thromboxane, stimulates me-

gakaryocytic differentiation in hu-man megakaryoblastic leukemiacells, 1242

Drug abuse, diphenhydramine/lorazepam/

methocarbamol, subjective and be-havioral effects, abuse liability (hu-mans), 707

Drug discrimination, behavioral pharmacol-

ogy of olanzapine (rats, mice), 545Dub#{233},G. P., Mais, D. E., Jakubowski, J. A.,

Brune, K. A., Utterback, B. G., True,T. A., Rinkema, L. E. and Kurtz, W.L.: In vitro characterization of a

novel TXA2/PGH2 receptor ligand(S-145) in platelets and vascular andairway smooth muscle, 784

DuP 753, see aLso Losartan

antihypertensive effect (rats), 595in vivo pharmacology of L-158,809 (rats,

monkeys), 139

Dutczak, W. J. and Ballatori, N.: ‘y-Gluta-myltransferase-dependent biliary-

1992 Index 1289

hepatic recycling of methyl mercuryin the guinea pig, 619

Dynorphin analog, E-2078, diuresis, kappa

opiate receptor activation (rats), 979

Dystonia, novel, highly selective sigma li-

gands (guinea pigs, rats), 32

E-2078, diuresis by kappa opiate receptor

activation (rats), 979

E-3330, protective effects, endotoxin-me-diated hepatitis (mice), 145

E-4424, comparison with diazepam/buspi.rone/ipsapirone, models of anxiety(rats, mice, marmosets), 90

Edelman, A. M., see Rabin, R. A., 257Edema, airway, effects of FK224, sensory

nerve stimulation (guinea pigs), 403Edwards, R. M., see Ohlstein, E. H., 595Eells, J. T., Bandettini, P. A., Holman, P.

A. and Propp, J. M.: Pyrethroid in-secticide-induced alterations inmammalian synaptic membrane po-tential, 1173

Eguchi, N., Kaneko, T., Urade, Y., Hayashi,H. and Hayaishi, 0.: Permeability ofbrain structures and other peripheraltissues to prostaglandins D2, E2 andF2;� in rats, 1110

Eicosanoids, phospholipase A2 inhibitors,block of contractions, lung pleuralstrips (guinea pigs), 1147

Electrical field stimulation, antigen-inducedenhancement, noncholinergic con-tractile responses, vagus nerve(guinea pigs), 646

Electrophysiology, actions of clofilium and

lidocaine, ischemically injured epi-cardium (dogs), 375

fi-Elemenebiochemical studies of fuscoside, neutro-

phils (humans), 874

physiological and biochemical studies,

fuscoside (mice), 866El-Fakahany, E. E., see Lee, N. H., 312

Elliott, W. C. and Patchin, D. S.: Aminogly-coside-mediated calciuresis, 151

Ellis, J. L. and Undem, B. J.: Antigen-in-duced enhancement of noncholi-

nergic contractile responses to vagusnerve and electrical field stimulationin guinea pig isolated trachea, 646

El-Mas, M. M. and Abdel-Rahman, A. A.:Role of aortic baroreceptors inethanol.induced impairment of bar-oreflex control of heart rate in con-

scious rats, 157

Emmett-Oglesby, M. W., see Pugh, S. L.,751

Enalapril, antihypertensive effect of DuP753, angiotensin II receptor antago-nism (rats), 595

fi-Endorphindelta opioid binding sites, bovine pineal,

292mediation of central actions, neuroana-

tomical sites, glucose utilization(rats), 415

Endothelial cellsbovine aortic, cyclic GMP production, B1

and B2 kinin receptors, 729

constriction of trachea by endothelins,multiple mechanisms (guinea pigs),570

Endothelin-1phosphoinositide hydrolysis, positive in-

otropic effect, ventricular myocar-

dium (rabbits), 1189

stimulation of contraction and ion trans-

port, colon (rats), 409Endothelin-3, effects on renal function,

prostanoid release, kidney (rats), 252Endothelins

contriction of trachea, multiple mecha-

nisms (guinea pigs), 570

receptor subtypes in lung, phosphoinosi-

tide hydrolysis (rats), 611

Endothelium-dependent responses, recovery by reseed-

ing endothelial cells, denuded coro-nary artery (pigs), 841

vascular, free radical-induced functionalinjury, lisinopril and ramiprilat (rab-

bits), 212

Endothelium-1, release induced by ische-mia-hypoxia, phosphoramidon, lungs(guinea pigs), 1062

Endotoxin, -mediated hepatitis, protective

effects, E3330 (mice), 145

[D-Pen2,D-Pen5]-Enkephalin, partial antag-onism by naltrindole, central opioid

modulation, breathing dynamics(sheep), 1004

Epicardium, ischemically injured, electro-

physiologic actions, clofilium and li-

docaine (dogs), 375Epileptogenesis, sensitivity of presynaptic

r-aminobutyric acid5 receptors, glu-tamatergic afferents, amygdala(rats), 1011

Epinine, positive inotropic effects, beta

adrenoceptor subtype, right atrium

(humans), 532

Epithelial cells, constriction of trachea by

endothelins, multiple mechanisms

(guinea pigs), 570

Epithelium, influence on reactivity of tra-

chea, bronchoactive drugs (guineapigs), 741

Escherichia coli, bladder carcinoma cell lineculture medium, purification, granu-locyte colony-stimulating factor, 439

Ethanol

-induced desensitization, activation ofprotein kinase A, cyclic AMP produc-tion, 257

-induced impairment of baroreflex con-trol, heart rate, role of aortic barore-ceptors (rats), 157

sensitivity, DL-amino-3-hydroxy-5-methyl-4-isoxabone proprionic acidand NMDA receptors, Xenopus oo-

cytes, 487Exercise, -induced ischemia, comparative

effects, UK-68,798 and UL-FS 49(dogs), 987

Falcone, R. C. and Krell, R. D.: Guinea piggall bladder contains a single peptideleukotriene receptor which resembles

that present in human conducting

airway smooth muscle, 1095

Farre, A. J., see Costall, B., 90

Fedan, J. S. and Frazer, D. G.: Influence ofepithelium on the reactivity of guineapig isolated, perfused trachea tobronchoactive drugs, 741

Fennell, S., see Seymour, A. A., 60Fentanyl

clocinnamox, opioid antagonist (mice),1051

continuous infusion, tolerance to analge-

sic activity, mu agonists (rats), 1

Ferguson, D. C., see Whittem, T., 834

Fernandes, L. B., Fryer, A. D. and Hirsh-man, C. A.: M2 muscarinic receptorsinhibit isoproterenol-induced relaxa-

tion of canine airway smooth muscle,

119

Ferrier, G. R., see Pasnani, J. S., 1076

Fetus

breathing dynamics, [D-Pen2,D-Pen5]-en-

kephalin and naltrindole (sheep),1004

metabolic effects of ritodrine (sheep), 48Fibroblasts, boron-lO accumulation in cell

cultures, exposure to mercaptodode-

caborate, brain tumors (mice), 818

Fibrosis, amiodarone-induced lung, atten-

uation by taurine and/or niacin

(hamsters), 127

Findlay, I.: Effects of pH upon the inhibi-

tion by sulphonylurea drugs of ATP-

sensitive K� channels in cardiac mus-cle, 71

Fink, D. W., Jr., Horn, P. T. and Mirkin, B.L.: Differential effects of 6-hydroxy-dopamine-induced ablation of pe-

ripheral and central adrenergic axonson C-1300 murine neuroblastoma tu-

mor growth and catecholamine con-centration in the A/J mouse, 1, 070

Finn, D., see Bowen, W. D., 32Fitz, R., see Cassis, L. A., 1168

FK224airway constriction and edema, neuroki-

nins, sensory nerve stimulation

(guinea pigs), 403

NK1 and NK2 receptor selectivity (guinea

pigs, rats), 398

FLA 365, calcium release channel complex,multiple binding sites, skeletal and

cardiac sarcoplasmic reticulum (rab-bits), 1028

Flumazenil, Ro 19-8022, neuropharmacol-ogical profile (mice, rats, monkeys),1121

Flunitrazepam, disulfiram and diethyldi-thiocarbamate, competitive inhibi-

tors, peripheral benzodiazepine re-

ceptor (rats), 394Fluorescence, AHN 683, ligand, peripheral-

type benzodiazepine receptors (rats),734

Flurazepam, chronic treatment, reductionin potency, GABAA agonists (rats),

204Folbergrov#{226},J., see Marai, V., 818Forebrain, differential regulation of ml to

m5 muscarinic receptor subtypes,

chronic atropine administration(rats), 584

Forskolin, isoproterenol-induced relaxation,inhibition by M2 muscarinic recep-

tors, airway smooth muscle (dogs),

119

Forssman antiserum, -induced elevation in

airway resistance, lecithinization, su-

peroxide dismutase (guinea pigs),1214

Frances, B., Gout, R., Monsarrat, B., Cros,J. and Zajac, J.-M.: Futher evidencethat Morphine-6fl-glucuronide is a

more potent opioid agonist than Mor-phine, 25

Frazer, D. G., see Fedan, J. S., 741

1290 Index

Free radicals, -induced functional injury,protection, lisinopril and ramiprilat(rabbits), 212

Fryer, A. D., see Fernandes, L. B., 119

Fuchs, B. A., see Pruett, S. B., 923

Fujii, T., see Morimoto, H., 398

Fujii, T., see M#{252}rai,M., 403Fuller, S. A., see Stein, E. A., 327Fung, H.-L., see Kowaluk, E. A., 916Furosemide, chronic administration, effects

of renal denervation, sodium balance(rats), 1103

Furukawa, Y., see Narita, M., 577

Fuscosidebiochemical studies in neutrophils (hu-

mans), 874physiological and biochemical studies, in-

flammatory models (mice), 866

Gaginella, T. S., see Moummi, C., 409Galactosamine, protective effects of E3330,

endotoxin-mediated hepatitis (mice),

145Gallamine, allosteric interaction, modula-

tion of conserved aspartate residues,

ml muscarinic receptor, 312

Gallbladder, single peptide leukotriene re-ceptor, resemblance, human conduct-ing airway smooth muscle (guineapigs), 1095

Galligan, J. J., see Bertrand, P. P., 677Gastric emptying, secretion and, leukotriene

D4 effect (monkeys), 850Gastrin, short-term treatment, gastrointes-

tinal histamine H2-receptors (guineapigs), 624

Gastrointestinal tract, biochemical studiesof fuscoside, neutrophils (humans),874

Gautret, B., see Rinaldi-Carmona, M., 759Gavish, M., see Katz, Y., 394Gelein, R. M., see Zalups, R. K., 1256

Gellai, M., see Ohlstein, E. H., 595Genetics, Oriental population, omeprazole

disposition kinetics, S-mephenytoin

4’-hydroxylase, 1195

Gentamicin.induced cytotoxicity, protection with

poly-L-aspartic acid, LLC.PK1 cells,

834-induced renal lysosomal phospholipi-

dosis, protectants, poly-L-asparticand poly-L-glutamic acids (rats), 424

Gentamycin, aminoglycoside-mediated cal-

ciuresis (rats), 151Germolec, D. R., see Comment, C. E., 1267Gillespie, M. N., see Cassis, L. A., 1168Gillis, C. N., Chen, X. and Merker, M. M.:

Lisinopril and ramiprilat protectionof the vascular endothelium againstfree radical-induced functional in-jury, 212

Giorgi, 0., see Cords, M. G., 792Gin, S. N., see Wang, Q., 127

Giuliani, S., see Lecci, A., 181Glennon, R. A., see Darmani, N. A., 692Glibenclamide

charybdotoxin-sensitive K� channel, re-

laxation of bovine tracheal smoothmuscle, glyceryl trinitrate and so-

dium nitroprusside, 263inhibition of ATP-sensitive K� channels,

sulphonylurea drugs, effects of pH

(guinea pigs), 71Glioblastoma, boron-lO accumulation in cell

cultures, exposure to mercaptodode-

caborate (mice), 818Glioma, serum-induced sensitization, cyclic

AMP accumulation (rats), 471

Glucocorticoids, suppression of primary hu-moral immune responses, morphine,

indirect mechanism (mice), 923Glucose, utilization, central actions of /3-

endorphin, neuroanatomical sites(rats), 415

Glutamate

afferents, epileptogenesis, presynaptic r-

aminobutyric acid8 receptors (rats),1011

multiple GABAB receptor subtypes, cere-bral cortex (rats), 114

recognition site, antagonist/partial ago-nist, NMDA receptor (rats), 539

Glutamic acid, serotonin-stimulated releaseof dopamine, reversal, dopamine

transporter (rats), 356-y-Glutamyltransferase

-dependent biliary-hepatic recycling,methyl mercury (guinea pigs), 619

mixed disulfide of glutathione and cystei-nylglycine, bile (mice, hamsters, rats,guinea pigs, rabbits), 896

GlutathioneL-cysteine and S-(1,2-dichlorovinyl)-L-

cysteine transport, liver canalicularmembrane vesicles (rats), 1182

cysteinylglycine and, mixed disulfide in

bile, oxidative stress (mice, hamsters,rats, guinea pigs, rabbits), 896

‘y-glutamyltransferase-dependent biliary-

hepatic recycling, methyl mercury(guinea pigs), 619

Glutathione S-transferase, bioactivation oforganic nitrates, mediation by cyto-chrome P-450, 298

Glyburide

Mg4�-complex of ATP, binding proper-ties, sulfonylurea receptor, 495

premature beats and ventricular tachy-

cardia, isolated tissue model, ische-mia and reperfusion (guinea pigs),1076

Glyceryl trinitratebioactivation of organic nitrates, media-

tion by cytochrome P-450, 298sodium nitroprusside and, charybdotoxin-

sensitive K� channel, trachealsmooth muscle (cattle), 263

Glycine

recognition site, indole-2-carboxylate de-

rivatives, antagonists of NMDA re-ceptor activity (rats), 654

strychnine-insensitive binding site, in-dole- and quinoline-containingNMDA antagonists (rats), 947

Glycoside, polar and nonpolar cardiac, re-flex actions, transient vagal coldblockade (dogs), 1022

Gobert, A., see Millan, M. J., 451Gold, L. H., Balster, R. L., Barrett, R. L.,

Britt, D. T. and Martin, B. R: A

comparison of the discriminativestimulus properties of �9-tetrahydro-cannabinol and CP 55,940 in rats andrhesus monkeys, 479

Goldberg, S. R., see Tella, S. R., 602, 936Gout, B., Jean, J. and Bril, A.: Comparative

effects of a potassium channel block-

ing drug, UK-68,798, and a specificbradycardic agent, UL-FS 49, on ex-

Vol. 262

ercise-induced ischemia in the dog:Significance of diastolic time on is-

chemic cardiac function, 987Gout, R., see Frances, B., 25

G-proteinsantagonist and agonist binding, leuko-

triene B4 receptor, polymorphonu-clear neutrophils (humans), 80

mechanism of opioid tolerance, spinalmembranes (rats), 317

phorbol ester and staurosporine modula-

tion, antagonist and agonist binding,

alpha-2 adrenoceptors (calves), 775

selectivity and functional coupling, chi-meric M1/M2 muscarmnic receptors,173

Grady, T., Saluja, A. K., Steer, M. L., Lerch,

M. M., Modlin, I. M. and Powers, R.E.: In vivo and in vitro effects of the

azidothymidine analog dideoxyino-sine on the exocrine pancreas of therat, 445

Gray, N. M., see Hood, W. F., 654Greenlee, W. J., see Chang, R. S. L., 133Greenlee, W. J., see Siegl, P. K. S., 139Griffiths, R. R., see Preston, K. L., 707Gross, S. S., see Togashi, H., 343Grover, G. J., see Sargent, C. A., 1161Growth hormone, clonidine-induced release,

functional subsensitivity, 5-HT1c oralpha��-adrenergic heteroreceptors

(rats), 1038Guanethidine, modulation of micturition re-

flexes, 5-HT1A receptors (rats), 181

Guanylate cyclase, bioactivation of organicnitrates, mediation by cytochrome P-450, 298

Guanylylnucleotide, phorbol ester and stau-rosporine modulation, antagonist

and agonist binding, alpha-2 adre-

noceptors (calves), 775Guarino, J. J., see Preston, K. L., 707Guidotti, A., see Romeo, E., 971

Haefely, W. E., see Jenck, F., 1121

Hall, C., see Yeleswaram, K., 683Haloperidol

modulation of regional brain neurotensin(rats), 348

stimulation of prolactin secretion, risper-idone, cultured pituitary cells (rats),699

Halushka, P. V., see Naka, M., 632Halushka, P. V., see Okwu, A. K., 238Hamaguchi, M., Ishibashi, T. and Imai, S.:

Involvement of charybdotoxin-sensi-tive K channel in the relaxation ofbovine tracheal smooth muscle byglyceryl trinitrate and sodium nitro-prusside, 263

Hamanaka, N., see Naka, M., 632Hamano, S., see Morita, K., 1209Han, Y.-C., see Pruett, S. B., 923

Hande, K. R., see Ormond, P. M., 246Harasawa, Y., see Kimura, M., 841

Harper, P. A., see Ito, S., 109Harris, R. A., see Dildy-Mayfield, J. E., 487

Harrison, B. L., see Baron, B. M., 947

Hasegawa, S., see Ninomiya, H., 570

Hayaishi, 0., see Eguchi, N., 1110Hayashi, H., see Eguchi, N., 1110Hayashi, S., see Kimura, M., 841

Heartcardiovascular effects of cocaine (rats),

602exercise-induced ischemia, comparative

1992 Index 1291

effects, UK-68,798 and UL-FS 49(dogs), 987

inhibition of ATP-sensitive K� channels,sulphonylurea drugs, effects of pH(guinea pigs), 71

ischemic, quinacrine and 7,7-dimethylei-cosanoic acid (rats), 1161

ischemically injured epicardium, electro-

physiologic actions, clofilium and li-docaine (dogs), 375

myocardial inotropy/lusitropy/economy,perindopril effects, diaphragmaticcontractility (hamsters), 516

myocytes, developmental changes in li-docaine effects, sodium channels(rats), 670

parasymptholytic effects of vecuronium,mediation, nicotinic and muscarinicreceptors (dogs), 577

polar and nonpolar cardiac glycoside, re-

flex actions, transient vagal cold

blockade (dogs), 1022potentiation of brain natriuretic peptides,

SQ 28,603 (monkeys, rats), 60premature beats and ventricular tachy-

cardia, differential effects of glybur-

ide, tissue model of ischemia and re-perfusion (guinea pigs), 1076

right atrium, positive inotropic effects,

beta adrenoceptor (humans), 532

ventricular myocardium, positive mo-tropic effect, phosphoinositide hy-

drolysis induced by endothelin-1

(rabbits), 1189Heart rate

arterial blood pressure and, effect ofchlorethylclonidine (rats), 901

ethanol-induced impairment of baroreflexcontrol, role of aortic baroreceptors(rats), 157

Hepatitis, endotoxin-mediated, protectiveeffects, E3330 (mice), 145

Hepatocytes, age-associated enhancement,diquat-induced lipid peroxidation,cytoxicity (rats), 271

Herman, C. A., see Chiono, M., 1248Heteroreceptors, 5-HT1� or alpha2-adrener-

gic, functional subsensitivity, cloni-

dine-induced growth hormone release(rats), 1038

Hexachlorocyclohexane, 6 isomer, stereose-

lective modulation, ryanodine-sensi-tive calcium channels (rats), 661

Hey, J. A., see Vemulapalli, S., 1062

Heykants, J., see Bowden, C. R., 699Hilar bronchus, nonadrenergic contractile

responses, activation, tachykininneurokinin2 receptors (guinea pigs),

957

Hill, J. L., see Aulakh, C. S., 1038Hillegaart, V., see Lundstr#{246}m, J., 41Hippocampus, chronic flurazepam treat-

ment, reduction in potency, GABAAagonists (rats), 204

Hirata, F., see Ninomiya, H., 570Hirota, K., see Nagakawa, J.-I., 145Hirshman, C. A., see Fernandes, L. B., 119Hishinuma, I., see Nagakawa, J.-I., 145Histamine

constriction of trachea by endothelins,multiple mechanisms (guinea pigs),570

influence of epithelium, reactivity of tra-chea, bronchoactive drugs (guineapigs), 741

vascular neuroeffector transmission, ef-

fects of xylamine (rabbits), 231

vascular permeability changes, regulationby mast cells, Arthus reaction (mice),

559

Hnatovicz, V., see Maral, V., 818Hodges, J. C., see Keiser, J. A., 1154

Hoffman, J. M., see Toews, M. L., 471Hollinger, M. A., see Wang, Q., 127

Holman, P. A., see Eells, J. T., 1173

Holtzman, S. G., see Jones, D. N. C., 638

Holtzman, S. G., see Paronis, C. A., 1Hood, W. F., Gray, N. M., Dappen, M. S.,

Watson, G. B., Compton, R. P.,

Cordi, A. A., Lanthorn, T. H. andMonahan, J. B.: Characterization ofindole-2-carboxylate derivatives asantagonists of N-methyl-D-aspartate

receptor activity at the associatedglycine recognition site, 654

Horn, P. T., see Fink, D. W., Jr., 1070

Hoshino, J., see Igarashi, R., 1214

Howell, L. L. and Byrd, L. D.: Enhancedsensitivity to the behavioral effects

of cocaine after chronic administra-

tion of D2-selective dopamine antag-onists in the squirrel monkey, 907

Hu, J., see Lee, N. H., 312Hu, S., see Chao, C. C., 19Hydrocortisone

dexamethasone and, kinetic-dynamicmodeling, lymphocytopenia (hu-mans), 509

plasma, suppression, time-dependent ef-fects of dexamethasone (humans),503

6-Hydroxydopamine, neural modulation of

neuroblastoma growth (mice), 1070

3-(3-Hydroxyphenyl)-N-n-propylpiperidine

HCL, enantiomers, brain levels, lo-comotor activity (rats), 41

Hylden, J. K. L., see Roerig, S. C., 365

Hyperglycemia, pharmacokinetics andpharmacodynamics, labetalol(sheep), 683

Hypertension

angiotensin II and monocrotaline-in-duced pulmonary, losartan effect(rats), 1168

antihypertensive effect ofDuP 753, angio-

tensin II receptor antagonism (rats),595

cardiovascular calcium antagonist recep-

tors, sustained occupancy, mepirodi-

pine (rats), 589

chronic renal artery stenosis, influence ofCGS 15943A (dogs), 166

potentiation of brain natriuretic peptides,

SQ 28,603 (monkeys, rats), 60Hypophagia, acetaminophen-induced, de-

velopment of tolerance, prior sensi-tization of stereotypy (rats), 1232

Hypoxia, -ischemia, endothelium- 1 release,


Ibrahim, S., see Kishore, B. K., 424

Ibutilide, potent class III activity, slow in-ward Na’ current, ventricular cells(guinea pigs), 99

Idazoxan, clocinnamox, opioid antagonist(mice), 1051

Igarashi, R., Hoshino, J., Takenaga, M., Ka-wai, S., Morizawa, Y., Yasuda, A.,Otani, M. and Mizushima, Y.: Leci-

thinization of superoxide dismutase

potentiates its protective effect

against Forssman antiserum-induced

elevation in guinea pig airway resist-

ance, 1214Ileum, short-term treatment with gastrin,

gastrointestinal histamine H�-recep-

tors (guinea pigs), 624

Imai, S., see Hamaguchi, M., 263

Immune complex, vascular permeability

changes, regulation by mast cells, Ar-

thus reaction (mice), 559

Immune response, humoral, suppression by

morphine, indirect mechanism

(mice), 923

Inagaki, 0., see Yamada, S., 589Indole, -containing NMDA antagonists,

strychnine-insensitive glycine bind-

ing site(rats), 947

Indole-2-carboxylate, derivatives, antago-

nists of NMDA receptor activity, gly-cine recognition site (rats), 654

Indomethacin, influence of epithelium, re-

activity of trachea, bronchoactive

drugs (guinea pigs), 741

Inflammation

acute responses, actions of Sch 40120(mice), 721

biochemical studies of fuscoside, neutro-

phils (humans), 874


knee joint (rats), 889physiological and biochemical studies,

fuscoside (mice), 866

Inflammatory cells, early and late response

to cutaneous allergen challenge, H,

receptor blockade (humans), 964

Inositol phosphate, in vitro pharmacology of

L-158,809 (rabbits, rats, monkeys),

133Insecticide

cimetidine-carbaryl interaction (hu-mans), 1057

-induced alterations, mammalian synap-

tic membrane potential (rats), 1173

Intestine, GABAA responses, single myen-

teric neurons (guinea pigs), 677

Invernizzi, R., Pozzi, L., Vallebuona, F.,Bonini, I., Sacchetti, G. and Sa-manin, R.: Effect of amineptine on

regional extracellular concentrationsofdopamine and noradrenaline in the

rat brain, 769Ion transport, stimulation of contraction in

colon, endothelin-1 (rats), 409

Ipsapirone, compared to E-4424, models of

anxiety (rats, mice, marmosets), 90Ischemia

cardiac, quinacrine and 7,7-dimethylei-cosanoic acid (rats), 1161

exercise-induced, comparative effects,UK-68,798 and UL-FS 49 (dogs), 987

-hypoxia, endothelium- 1 release, phos-

phoramidon (guinea pigs), 1062

tissue model, differential effects of gly-

buride, premature beats and ventric-

ular tachycardia (guinea pigs), 1076

Ishibashi, T., see Hamaguchi, M., 263Ishizaki, T., see Sohn, D.-R., 1195

Isoproterenol, -induced relaxation of airway

smooth muscle, inhibition by M2muscarinic receptors (dogs), 119

l-Isoproterenol, -induced lipolytic response

in adipocytes, multiple beta adrener-gic receptor subclasses (rats), 552

Ito, S., Koren, G. and Harper, P. A.: Hand-

1292 Index

ling of digoxin and ouabain by renaltubular cells (LLC-PK1), 109

Itzhak, Y. and Stein, I.: Sensitization to thetoxic effects of cocaine in mice isassociated with the regulation of N-methyl-D-aspartate receptors in thecortex, 464

Jackson, R. H., Morrissey, M. M., Sills, M.A. and Jarvis, M. F.: Comparison ofantagonist and agonist binding to theleukotreine B4 receptor on intact hu-man polymorphonucliar neutrophils(PMN), 80

Jackson, R. H., see Cioffi, C. L., 611

Jacobs, R. S., see Jacobson, P. B., 866, 874

Jacobson, P. B. and Jacobs, R. S.: Fuscoside:An anti-inflammatory marine natu-ral product which selectively inhibits5-lipoxygenase. Part II: Biochemicalstudies in the human neutrophil, 874

Jacobson, P. B. and Jacobs, R. S.: Fuscoside:An anti-inflammatory marine natu-ral product which selectively inhibits5-lipoxygenase. Part I: Physiologicaland biochemiscla studies in murineinflammatory models, 866

Jacocks, H. M., III and Cox, B. M.: Sero-tonin-stimulated release of [3HJdo-pamine via reversal of the dopaminetransporter in rat striatum and nu-cleus accumbens: A comparison withrelease elicited by potassium, N-methyl-D-aspartic acid, glutamic acidand D-amphetamine, 356

Jagadeesh, G. and Deth, R. C.: Phorbol esterand staurosporine modulation of an-tagonist and agonist binding to a!-

pha-2 adrenergic receptors: Differ-

ential influence on Na� versus guan-ylylnucleotide regulation, 775

Jakschik, B. A., see Ramos, B. F., 559Jakubowski, J. A., see Dub#{233},G. P., 784Jarvis, M. F., see Jackson, R. H., 80Jean, J., see Gout, B., 987Jenck, F., Moreau, J.-L., Bonetti, E. P.,

Martin, J. R. and Haefely, W. E.: Ro19-8022, a non benzodiazepine par-tial agonist at benzodiazepine recep-tors: Neuropharmacological profile ofa potential anxiolytic, 1121

Jensen, K. F., see Johnson, K. B., 855

Jiang, Q., Seyed-Mozaffari, A., Archer, S.

and Bidlack, J. M.: Antinociceptiveproperties of two alkylating deriva-

tives of morphinone: 14fl-(thioglyco-lamido)-7,8-dihydromorphinone

(TAMO) and 14fl-(bromoacetam-ido)-7,8-dihydromorphinone(H2BAMO), 526

Johnson, K. B., Criswell, H. E., Jensen, K.F., Simson, P. E., Mueller, R. A. andBreese, G. R.: Comparison of the D1-dopamine agonists SKF-38393 and

A-68930 in neonatal 6-hydroxydopa-

mine-lesioned rats: Behavioral ef-fects and induction of c-fos-like im-munoreactivity, 855

Jones, D. N. C. and Holtzman, S. G.: Inter-action between opioid antagonistsand amphetamine: Evidence for me-diation by central delta opioid recep-tors, 638

Jones, M. M., see Ormond, P. M., 246Joy, R. M., see Pessah, I. N., 661Jugus, J., see Ohlstein, E. H., 595

Kachur, J. F., see Moummi, C., 409Kagey-Sobotka, A., see Charlesworth, E. N.,

964Kainate, ethanol sensitivity, NMDA recep-

tors, Xenopus oocytes, 487Kambam, J. R., see May, D. G., 1057Kaneko,T.,seeEguchi,N., 1110

Kaneko, T., see Tanaka, H., 439Katayama, K.-I., see Nagakawa, J.-I., 145Kato, Y., see Yamada, S., 589

Katz, J. L., see De Boer, S. F., 335Katz, Y., Weizman, R., Weizman, A. and

Gavish, M.: Disulfiram and diethyld-

ithiocarbamate are competitive in-hibitors at the peripheral benzodiaze-

pine receptor, 394Kawai, S., see Igarashi, R., 1214Keiser, J. A., Bjork, F. A., Hodges, J. C. and

Taylor, D. G., Jr.: Renal hemody-namic and excretory responses to PD

123319 and losartan, nonpeptide AT1and AT2 subtype-specific angiotensinII ligands, 1154

Kelly, M. E., see Costall, B., 90

Ketanserin, 1-(2,5-dimethoxy-4-iodo-

phenyl)-2-aminopropane or, behav-

ioral evidence, differential adapts-

tion (mice), 692Kidney

aminoglycoside-mediated calciuresis

(rats), 151

diuresis by kappa opiate receptor activa-

tion, E-2078 (rats), 979effects of renal denervation, sodium bal-

ance and renal function, chronic fu-rosemide administration (rats), 1103

endothelin-3 effects, prostanoid release(rats), 252

gentamicin-induced lysosomal phospho-

lipidosis, protectants, poly-L-aspartic

and poly-L-glutamic acids (rats), 424hemodynamic and excretory responses,

PD 123319 and losartan (dogs), 1154induction of nephropathy, cadium-metal-

lothionein, dose-effect relationship(rats), 1256

Kimura, M., Maeda, K., Harasawa, Y.,Ohno, Y., Nakamura, M., Sakurai, I.

and Hayashi, S.: Recovery of endo-thelium-dependent responses by re-

seeding endothelial cells in cultureonto the denuded coronary artery,841

Kimura, R., see Yamada, S., 589

Kinney, G. G., see Wolgin, D. L., 1232Kishore, B. K., Ibrahim, S., Lambricht, P.,

Laurent, G., Maldague, P. and Tulk-ens, P. M.: Comparative assessmentof poly-L-glutamic acids as protec-tants against gentamicin-inducedrenal lysosomal phospholipidosis,phospholipiduria and cell prolifera-tion in rats, 424

Kitabatake, A., see Togashi, H., 343Kitto, K., see Roerig, S. C., 365

Kiyotoh, S., see Morimoto, H., 398Kiyotoh, S., see Murai, M., 403Klein, J., see Port, J. D., 217

Knee, joint, sympathoadrenal contribution,bradykinin-induced plasma extrava-sation (rats), 889

Kobayashi, K., see Sohn, D.-R., 1195Kobayashi, T., see Togashi, H., 343Kokka, N., see Sapp, D. W., 801Koop, D. R., see Laethem, R. M., 433

Vol. 262

Koopmans, R. P., Braat, M. C. P., Ooster-huis, B. and van Boxtel, C. J.: Time.dependent effects of dexamethasoneadministration on the suppression ofplasma hydrocortisone, assessed witha pharmacokinetic model, 503

Koopmans, R. P., see Braat, M. C. P., 509Koren, G., see Ito, S., 109Korupolu, G. R., see Tella, S. R., 936Kouchi, Y., see Comment, C. E., 1267Kowaluk, E. A., Seth, P. and Fung, H.-L.:

Metabolic actiation of sodium nitro-

prusside to nitric oxide in vascularsmooth muscle, 916

Kozikowski, A. P., see Romeo, E., 971Krell, R. D., see Falcone, R. C., 1095

Kuczenski, R. and Segal, D. S.: Differentialeffects of amphetamine and dopa-mine uptake blockers (cocaine, nom-ifensine) on caudate and accumbensdialysate dopamine and 3-methoxy-tyramine, 1085

Kurtz, W. L., see Dub#{233},G. P., 784

Kvitek, J., see Mare�, V., 818

L-158,809in vitro pharmacology (rabbits, rats, mon-

keys), 133

in vivo pharmacology (rats, monkeys), 139Labeeuw, B., see Rinaldi.Carmona, M., 759

Labetalol, pharmacokinetics and pharma-codynamics, pregnancy (sheep), 683

Laethem, C. L., see Laethem, R. M., 433Laethem, R. M., Laethem, C. L., Ding, X.

and Koop, D. R.: P-450-Dependentarachidonic acid metabolism in rab-bit olfactory microsomes, 433

Lai, J., Nunan, L., Waite, S. L., Ma, S.-W.,Bloom, J. W., Roeske, W. R. andYamamura, H. I.: Chimeric M,/M2muscarinic receptors: Correlation of

ligand selectivity and functional cou-

pling with structural modifications,173

Lambert, F., see Chemla, D., 516Lambricht, P., see Kishore, B. K., 424Langston, J. W., see Wu, E. Y., 225Lanthorn, T. H., see Hood, W. F., 654Laubie, M., see Millan, M. J., 451Laurent, G., see Kishore, B. K., 424Lavielle, G., see Millan, M. J., 451

Lazzara, R., see Patterson, E., 375Lecarpentier, Y., see Chemla, D., 516Lecca, D., see Cords, M. G., 792Lecci, A., Giuliani, S., Santicioli, P. and

Maggi, C. A.: Involvement of 5-hydroxytryptaminelA receptors in themodulation of micturition reflexes inthe anesthetized rat, 181

Lecithin, superoxide dismutase, Forsaman

antiserum-induced elevation, airway

resistance (guinea pigs), 1214Lee, K.-H., see Sohn, D.-R., 1195

Lee, K. S.: Ibutilide, a new compound with

potent class III antiarrhythmic activ-ity, activates a slow inward Na� cur-rent in guinea pig ventricular cells,99

Lee, N. H., Hu, J. and El-Fakahany, E. E.:

Modulation by certain conserved as-

partate residues of the allosteric in-teraction ofgallamine at the ml mus-

carinic receptor, 312

Leff, P., see Wood, B. E., 566Le Fur, G., see Rinaldi-Carmona, M., 759Lei, S., see Roerig, S. C., 365

1992

Lejeune, F., see Millan, M. J., 451Lelchuk, R., Radomski, M. W., Martin, J.

F. and Moncada, S.: Constitutive and

inducible nitric oxide synthases in-human megakaryoblastic cells, 1220

Le Marouille-Girardon, S., see Millan, M.J., 451

Lerch, M. M., see Grady, T., 445Lesch, K. P., see Aulakh, C. S., 1038

Leukemia, megakaryoblastic, stimulation of

differentiation, thrombin (humans),

1242Leukotriene C4, receptor localization in lung

(bullfrogs), 1248Leukotriene D4, gastric emptying and secre-

tion (monkeys), 850Leukotrienes

biochemical studies of fuscoside, neutro-phils (humans), 874


by mast cells, Arthus reaction (mice),

559Levant, B. and Nemeroff, C. B.: Further

studies on the modulation of regionalbrain neurotensin concentrations byantipsychotic durgs: Focus on halo-peridol and BMY 14802, 348

Levi, R., see Togashi, H., 343

Levine, J. D., see Miao, F. J.-P., 889Lewin, N. E., see Szallasi, A., 883

Lewis, J. W., see Comer, S. D., 1051Li, M., see Wall, S. J., 584Lichtenstein, L. M., see Charlesworth, E.

N., 964Lidocaine

clofilium and, electrophysiologic actions,ischemically injured epicardium(dogs), 375

developmental changes, sodium channels,

cardiac myocytes (rats), 670Liewer, S. A., see Toews, M. L., 471Ligands

angiotensin II, PD 123319 and losartan,renal hemodynamic and excretory re-sponses (dogs), 1154

selectivity and functional coupling, chi-meric M1/M2 muscarinic receptors,173

Lindane, ryanodine-sensitive calcium chan-

nels, hexachlorocyclohexane #{244}-iso-mer (rats), 601

Lindgren, J. E., see Lundstr#{246}m,J., 41Lipid peroxidation, diquat-induced, age-as-

sociated enhancement, cytotoxicityin hepatocytes (rats), 271

Lipolysis, l-isoproterenol-induced, multiplebeta adrenergic receptor subclasses

(rats), 552Lipopolysaccharide, protective effects of

E3330, endotoxin-mediated hepatitis(mice), 145

5-Lipoxygenase

biochemical studies of fuscoside, neutro-

phils (humans), 874inhibitor Sch 40120, acute inflammatory

responses (mice), 721physiological and biochemical studies,

fuscoside, inflammatory models

(mice), 866Lisinopril, ramiprilat and, protection of vas-

cular endothelium, free radical-in-duced functional injury (rabbits), 212

Lithium, chronic furosemide administra-tion, effects of renal denervation, so-

dium balance (rats), 1103

Livercanalicular membrane vesicles, L-cysteine

and S-(1,2-dichlorovinyl)-L-cysteinetransport (rats), 1182

�y.glutamyltransferasedependent biliary-

hepatic recycling, methyl mercury(guinea pigs), 619

mixed disulfide of glutathione and cystei-nylglycine, bile (mice, hamsters, rats,

guinea pigs, rabbits), 896

LLC-PK1 cellshandling of digoxin and ouabain, 109

protection against gentamicin-induced

cytotoxicity, poly-L-aspartic acid,834

Locomotor activitybrain levels, 3-(3-hydroxyphenyl)-N-n-

propylpiperidine HCL enantiomers(rats), 41

central effects of quinpirole, blood pres-sure, spontaneously hypertensive

rats, 303

Longoni, B., see Sapp, D. W., 801

Lorazepam, diphenhydramine and metho-

carbamol, subjective and behavioral

effects, abuse liability (humans), 707

Losartan, see al.so DuP 753

PD 123319 and, renal hemodynamic andexcretory responses (dogs), 1154

Lotti, V. J., see Chang, R. S. L., 133Lotti, V. J., see Siegl, P. K. S., 139

Louis, J.-C., Magal, E. and Varon, S.: Re-ceptor-mediated toxicity of norepi-

nephrine on cultured catecholamin-ergic neurons of the rat brainstem,1274

Lundst#{246}m, J., Lindgren, J.-E., Ahlenius, S.

and Hillegaart, V.: Relationship be-tween brain levels of 3-(3-hydroxy-phenyl)-N-n-propylpiperidine HCL

enantiomers and effects on locomo-tor activity in rats, 41

Lungamiodarone-induced fibrosis and phos-

pholipidosis, attenuation by taurine

and/or niacin (hamsters), 127endothelin receptor subtypes, phosphoi-

nositide hydrolysis (rats), 611endothelium- 1 release, ischemia-hypoxia,


Forssman antiserum-induced elevation in

airway resistance, lecithinization, su-peroxide dismutase (guinea pigs),1214

free radical-induced functional injury,protection, lisinopril and ramiprilat(rabbits), 212

leukotriene C4 receptor localization (bull-frogs), 1248

pleural strips, block of contractions, phos-pholipase A2 inhibitors (guinea pigs),1147

Luster, M. I., see Comment, C. E., 1267

Lymphocytes, time-dependent effects ofdexamethasone, suppression, plasmahydrocortisone (humans), 503

Lymphocytopenia, kinetic-dynamic model-

ing, dexamethasone and hydrocorti-

sone (humans), 509Lysophospholipids, quinacrine and 7,7-di-

methyleicosanoic acid, ischemichearts (rats), 1161

Lysosomes, gentamicin-induced phospholi-

pidosis, protectants, poly-L-aspartic

and poly-L-glutamic acids (rats), 424

Index 1293

Ma, D., see Romeo, E., 971

Ma, S.-W., see Lai, J., 173Mack, M. M., Zim#{227}nyi, I. and Pessah, I. N.:

Discrimination of multiple binding

sites for antagonists of the calcium

release channel complex of skeletaland cardiac sarcoplasmic reticulum,1028

Macrophagesperitoneal, antagonist activity, RP 59227

and WEB 2086 (guinea pigs), 1139protective effects of E3330, endotoxin-

mediated hepatitis (mice), 145Maeda, K., see Kimura, M., 841Maeda, Y., see Morimoto, H., 398Maeda,Y., see Murai, M., 403Magal, E., see Louis, J.-C., 1274Maggi, C. A., see Lecci, A., 181

Magnesium

continuous intrathecal opioid treatment,

mu opioid receptor binding, spinalmembranes (rats), 317

Mg�-complex of ATP, binding proper-ties, sulfonylurea receptor, 495

Mailman, R. B., see Mottola, D. M., 383Mais, D. E., see Dub#{233},G. P., 784

Mais, D. E., see Naka, M., 632

Maldague, P., see Kishore, B. K., 424Malondialdehyde, diquat-induced lipid per-

oxidation, age-associated enhance-ment, cytotoxicity in hepatocytes,271

Mantlo, N. B., see Chang, R. S. L., 133Mantlo, N. B., see Siegl, P. K. S., 139Maral, V., Baudyi,ov#{225}, M., Kvitek, J., Hna-

tovicz, V., Cerven#{227}, J., VacIk, J. and

Folbergrov#{225},J.: Accumulation of bo-ron-lO (‘#{176}B)in cell cultures exposedto mercaptododecaborate(Na2H,110B,25H) used for the neutroncapture therapy of brain tumors, 818

Marine natural productfuscoside

biochemical studies, neutrophils (hu-

mans), 874

physiological and biochemical studies(mice), 866

Martin, B. R., see Darmani, N. A., 692Martin, B. R., see Gold, L. H., 479Martin, J. F., see Lelchuk, R., 1220Martin, J. R., see Jenck, F., 1121

Martinez, L., see Costall, B., 90Massey, W. A., see Charleswc�th, E. N., 964Mast cells

constriction of trachea by endothelins,

multiple mechanisms (guinea pigs),

570

regulation of vascular permeability

changes, Arthus reaction (mice), 559Matsumoto, H., see Ninomiya, H., 570

Matsuoka, Y., see Yamada, S., 589

May, D. G., Naukam, R. J., Kambam, J. R.and Branch, R. A.: Cimetidine-car-

baryl interaction in humans: Evi-

dence for an active metabolite of car-baryl, 1057

McCabe, R. T., Newman, A. H. and Skol-nick, P.: AHN 683: A flurosecent Ii-

gand for peripheral-type benzodiaze-pine receptors, 734

McCabe, S., see Cheng, P. Y., 1004McCullough, J. R., see Sargent, C. A., 1161

McDonald, I. A., see Baron, B. M., 947McGiff, J. C., see Stier, C. T., Jr., 252

1294 Index

Meeuwis, J. M. J. M., see Braat, M. C. P.,509

Megakaryoblastic cells, human, constitutiveand inducible nitric oxide synthases,1220

Meldrum, B. S., see Baron, B. M., 947Membrane potential, synaptic, pyrethroid

insecticide-induced alterations(rats), 1173

MEN 10,376, tachykinin neurokinin2 recep-

tors, nonadrenergic contractile re-

sponses, hilar bronchus (guinea pigs),

957Meperidine, continuous infusion, tolerance

to analgesic activity, mu agonists

(rats), 1

S-Mephenytoin 4’-hydroxylase, extensiveand poor metabolizers, omeprazoledisposition kinetics, Oriental popu-

lation, 1195

Mepirodipine, sustained occupancy, cardio-vascular calcium antagonist recep-

tors (rats), 589Mercaptododecaborate, accumulation of bo-

ron-lO in cell cultures, neutron cap-ture therapy, brain tumors (mice),

818

Merker, M. M., see Gillis, C. N., 212

Mesentery, vasculature, moderate cooling,

purinergic vasoconstrictor compo-nent (rats), 1133

Mesulergine, blunted growth hormone re-sponses, heteroreceptors (rats), 1038

Metallothionein, cadmium-, induction of

nephropathy, dose-effect relation-ship (rats), 1256

Met5-enkephalin, substance P and, NMDAreceptor antagonism, neurons in

striatum (rats), 823Methacholine, influence of epithelium, re-

activity of trachea, bronchoactivedrugs (guinea pigs), 741

Methocarbamol, diphenhydramine and br-azepam, subjective and behavioral ef-fects, abuse liability (humans), 707

3-Methoxytyramine, dopaminergic responseto stimulants (rats), 1085

N-Methyl-D-aspartate, antagonists, strych-nine-insensitive glycine binding site

(rats), 947N-Methyl-D-aspartic acid, serotonin-stim-

ulated release of dopamine, reversal,dopamine transporter (rats), 356

Methyl mercury, -y-glutamyltransferase-de-pendent biliary-hepatic recycling(guinea pigs), 619

1-Methyb-4-phenyl-2,3-dihydropyridinium,1-methyb-4-phenylpyridinium and,toxicity, primary cultures of astro-cytes (mice), 225

Methysergide, vascular permeabilitychanges, regulation by mast cells, Ar-thus reaction (mice), 559

Mianserin, blunted growth hormone re-sponses, heteroreceptors (rats), 1038

Miao, F. J.-P., Benowitz, N. L., Basbaum,A. I. and Levine, J. D.: Sympathoad-renal contribution to nicotinic andmuscarinic modulation of bradyki-

nm-induced plasma extravasation in

the knee joint of the rat, 889Microsomes, olfactory, P-450-dependent ar-

achidonic acid metabolism (rabbits),433

Micturition, reflexes, modulation, 5-HT1A

receptors (rats), 181Midazolam, tolerance, cross-tolerance and

withdrawal, dependence on diazepam(rats),751

Mihelich, E. D., see Snyder, D. W., 1147Millan, M. J., Rivet, J.-M., Canton, H., Le-

jeune, F., Bervoets, K., Brocco, M.,Gobert, A., de Ladonchamps, B. L.,Le Marouille-Girardon, S., Verriele,L., Laubie, M. and Lavielle, G.: S14671: A Naphtylpiperazine 5-hydroxytryptamine1A agonist of ex-ceptional potency and high efficacypossessing antagonist activity at 5-

hydroxytryptamine1c,2 receptors, 451

Mirkin, B. L., see Fink, D. W., Jr., 1070Mitochondria

DBI receptor, 2-aryl-3-indoleacetamides(rats), 971

toxicity of 1-methyl-4-phenyl-2,3-dihy-dropyridinium, primary cultures, as-trocytes (mice), 225

Miyamoto, K., see Nagakawa, J.-I., 145

Mizushima, Y., see Igarashi, R., 1214MK-801

antagonism, decrease in GABAergic func-

tion, pentybenetetrazol kindling

(rats), 792

antagonist/partial agonist, polyamine

recognition site, NMDA receptor

(rats), 539sensitization to toxic effects of cocaine,

NMDA receptor regulation, cortex(mice), 464

Modlin, I. M., see Grady, T., 445

Mohr, F. C., see Pessah, I. N., 661Molinoff, P. B., see Williams, K., 539

Molitor, T. W., see Chao, C. C., 19Monahan, J. B., see Hood, W. F., 654Moncada, S., see Lelchuk, R., 1220Monoamine, neuronal uptake, cardiovascu-

lar effects, cocaine (rats), 602Monoamine oxidase, toxicity of 1-methyl-4-

phenyl-2,3-dihydropyridinium, pri-

mary cultures, astrocytes (mice), 225Monocrotaline, -induced pulmonary hyper-

tension, angiotensin II, losartan ef-fect (rats), 1168

Mononuclear cells, peripheral blood, trans-forming growth factor-fl release, mor-phine (humans), 19

Monsarrat, B., see Frances, B., 25Montcalm-Mazzilli, E. and Shea-Donohue,

T.: Effect ofleukotriene D4 on gastricemptying and secretion in rhesusmonkeys, 850

Moore, N. A., Tye, N. C., Axton, M. S. andRisius, F. C.: The behavioral phar-macology of olanzapine, a novel“atypical” antipsychotic agent, 545

Moreau, J.-L., see Jenck, F., 1121

Morimoto, H., Murai, M., Maeda, Y., Ya-maoka, M., Nishikawa, M., Kiyotoh,S. and Fujii, T.: FK 224, A novel

cyclopeptide substance P antagonistwith NK, and NK2 receptor selectiv-

ity, 398Morimoto, H., see Murai, M., 403Morinelli, T. A., see Naka, M., 632

Morita, K., Azuma, M., Hamano, S., Oka,M. and Teraoka, K.: Inhibition byamiloride of ouabain-evoked cat-echolamine secretion from cultured

adrenal chromaffin cells: Evidence

Vol. 262

for its blocking action on interactionbetween ouabain and Na�/K�-pump,

1209

Morizawa, Y., see Igarashi, R., 1214

Morphine

antinociceptive activity, intrathecalby ad-ministered cannabinoids (mice), 10

cbocinnamox, opioid antagonist (mice),1051

continuous infusion, tolerance to analge-sic activity, mu agonists (rats), 1

mechanism of opioid tolerance, spinal

membranes (rats), 317opioid and noradrenergic agonists, spinal

interactions (mice), 365suppression of primary humoral immune

responses, indirect mechanism(mice), 923

transforming growth factor-fl release, pe-

ripheral blood mononuclear cell cub-tures (humans), 19

Morphine-6fl-glucuronide, potent opioid ag-onist than morphine (rabbits, guinea

pigs, mice), 25Morphinone, two alkylating derivatives,

antinociceptive properties (mice),526

Morrissey, M. M., see Jackson, R. H., 80Moseberg, H. I., see Vanderah, T. W., 190Motomura, S., see Deighton, N. M., 532Mottola, D. M., Brewster, W. K., Cook, L.

L., Nichols, D. E. and Mailman, R.B.: Dihydrexidine, a novel full effi-cacy D1 dopamine receptor agonist,383

Moummi, C., Xie, Y., Kachur, J. F. andGaginebla, T. S.: Endothelin-1 stim-ulates contraction and ion transportin the rat colon: Different mecha-nisms of action, 409

Mu agonists, development of tolerance toanalgesic activity, continuous infu-sion of morphine, meperidine or fen-

tanyl (rats), 1

Mueller, R. A., see Johnson, K. B., 855Mural, M., Morimoto, H., Maeda, Y., Ki-

yotoh, S., Nishikawa, M. and Fujii,

T.: Effects of FK224, a novel com-pound NK1 and NK2 receptor antag-onist, on airway constriction and air-way edema induced by neurokininsand sensory nerve stimulation inguinea pigs, 403

Murai, M., see Morimoto, H., 398Murakami, M., see Narita, M., 577

Murphy, D. L., see Aulakh, C. S., 1038Murtaugh, M. P., see Chao, C. C., 19

Muscle, skeletal, myocardial inotropy/lusi-tropy/economy, perindopril effects,diaphragmatic contractility (ham-sters), 516

Muscle, smoothairway, isoproterenol-induced relaxation,

inhibition by M2 muscarmnic recep-tors (dogs), 119

angiotensin Il-induced vasoconstriction,norepinephrine, femoral artery (rab-

bits), 198denuded coronary artery, reseeding of

endothelial cells in culture, recovery(pigs), 841

tracheal, charybdotoxin-sensitive K�channel, glyceryl trinitrate and so-

dium nitroprusside (cattle), 263vascular

1992

free radical-induced functional injury,

lisinopril and ramiprilat (rabbits),212

metabolic activation of sodium nitro-prusside, nitric oxide (cattle), 916

vascular and airway, novel receptor bigandS-145 (guinea pigs), 784

Mutagenesis, modulation of conserved as-

partate residues, albosteric interac-tion of gallamine, ml muscarinic re-

ceptor, 312

Myocardium

primary cell cultures, pharmacologicalcharacterization, beta adrenergic re-ceptors (chicks, frogs), 217

ventricular, positive inotropic effect,phosphoinositide hydrolysis inducedby endothelin-1 (rabbits), 1189

Myocytescardiac

delayed K� current, dofetilide (guinea

pigs), 809developmental changes in lidocaine ef-

fects, sodium channels (rats), 670

Na�,K�-ATPase, handling of digoxin and

ouabain, renal tubular cells, 109Nagakawa, J.-I., Hishinuma, I., Miyamoto,

K., Hirota, K., Abe, S., Yamanaka,T., Katayama, K. I. and Yamatsu, I.:Protective effects of (2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoqui-noyl)J-2-nonyl-2-pr openoic acid on

endotoxin-mediated hepatitis inmice, 145

Naka, M., Mais, D. E., Morinelli, T. A.,Hamanaka, N., Oatis, J. E., Jr. andHalushka, P. V.: 7-[(1R,2S,3S,5R)-6,

6-dimethyl.3-(4-iodobenzenesulfon-ylami no)- bicyciol[3.1.ljhept-2-yl]-5(Z).heptenoic acid: A novel high-affinity radiolabeled antagonist for

platelet thromboxane A2/prostaglan-

din h2 receptors, 632Nakamura, M., see Kimura, M., 841Na�/K� pump, ouabain-evoked catecholam-

inc secretion, inhibition by amiloride,adrenal chromaffin cells (cattle),1209

Nalbuphine, mixed kappa1 and kappa3 an-algesic (mice), 1044

Naloxoneclocinnamox, opioid antagonist (mice),

1051

opioid antagonists and amphetamine, me-diation, central delta opioid receptors(rats), 638

Naltrexone

clocinnamox, opioid antagonist (mice),

1051

diuresis by kappa opiate receptor activa-tion, E-2078 (rats), 979

Naltrindoleopioid antagonists and amphetamine, me-

diation, central delta opioid receptors(rats), 638

partial antagonism and [D-Pen2,D-Pen5J-

enkephalin, central opioid modula-tion, breathing dynamics (sheep),

1004Naphtylpiperazine, S 14671, antagonist ac-

tivity, 5-HT1c,2 (rats), 451Narita, M., Furukawa, Y., Murakami, M.,

Takei, M., Ren, L.-M. and Chiba, S.:Parasympatholytic effects of vecu-ronium are mediated by nicotinic and

muscarinic receptors in hearts of an-esthetized dogs, 577

Natriuretic peptides, brain, potentiation,SQ 28,603 (monkeys, rats), 60

Naukam, R. J., see May, D. G., 1057Naylor, R. J., see Costall, B., 90Neale, R. F., Jr., see Cioffi, C. L., 611Nedergaard, 0. A., Cho, A. K. and Wagga-

man, L. A.: Effects of xybamine onvascular neuroeffector trnasmission,231

Neliat, G., see Rinaldi-Carmona, M., 759Nemeroff, C. B., see Levant, B., 348Neomycin, calcium release channel com-

plex, multiple binding sites, skeletal

and cardiac sarcoplasmic reticulum(rabbits), 1028

Neonatedevelopmental changes in bidocaine ef-

fects, sodium channels, cardiac myo-cytes (rats), 670

6-hydroxydopamine-lesioned rats, com-

parison, SKF-38393 and A-68930,855

Nephropathy, induction by cadmium-metal-lothionein, dose-effect relationship(rats), 1256

Nephrotoxicity, cispbatin, increased atrial

natriuretic peptide (rats), 246

Nerve, sensory, effects of FK224, airwayconstriction and edema induced by

neurokinins (guinea pigs), 403Neurobbastoma

boron-lO accumulation in cell cultures,

exposure to mercaptodocecaborate(mice), 818

neural modulation, catechobamine con-centration (mice), 1070

Neuronscatecholaminergic, receptor-mediated

toxicity, norepinephrine (rats), 1274

single myenteric, GABAA responses, in-testine (guinea pigs), 677

striatum, NMDA receptor antagonism,substance P and met5-enkephalin(rats), 823

Neurosteroidogenesis, 2-aryb-3-indoleace-tamides, mitochondrial DBI receptor

(rats), 971

Neurotensin, brain, modulation by antipsy-chotic drugs (rats), 348

Neurotransmitter, synaptic membrane po-tential, pyrethroid insecticide-in-duced alterations (rats), 1173

Neutral endopeptidase 3.4.24.11, SQ 28,603,potentiation, brain natriuretic pep-

tides (monkeys, rats), 60Neutron capture therapy, accumulation of

boron-lO in cell cultures, exposure to

mercaptododecaborate, brain tumors(mice), 818

Neutrophilsbiochemical studies of fuscoside (hu-

mans), 874polymorphonuclear, antagonist and ago-

nist binding, leukotriene B4 receptor(humans), 80

Newman, A. H., see McCabe, R. T., 734Niacin, attenuation of amiodarone-induced

lung fibrosis, phospholipidosis (ham-sters), 127

Nichols, D. E., see Mottola, D. M., 383Nickols, G. A., see Yamamoto, R., 1133Nicotine

Index 1295

binding sites, dietary choline supplemen-tation, brain (rats), 1128


knee joint (rats), 889Ninomiya, H., Uchida, Y., Saotome, M., No-

mura, A., Ohse, H., Matsumoto, H.,Hirata, F. and Hasegawa, S.: Endo-thelins constrict guinea pig tracheasby multiple mechanisms, 570

Nishikawa, M., see Morimoto, H., 398Nishikawa, M., see Murai, M., 403Nitrates, organic, mediation of bioactiva-

tion, cytochrome P.450, 298Nitric oxide

activation of B, and B2 kinin receptors,

cyclic GMP production, bovine aorticendothebial cells, 729

central nervous system action, blood pres-sure regulation (rats), 343

metabolic activation of sodium nitroprus-side, vascular smooth muscle (cattle),

916Nitric oxide synthases, constitutive and in-

ducible, human megakaryoblasticcells, 1220

Nomifensine, dopaminergic response tostimulants (rats), 1085

Nomura, A., see Ninomiya, H., 570Noradrenaline, dopamine and, regional ex-

tracelbular brain concentrations, ami-

neptine effect (rats), 769Norbinaltorphimine, opioid antagonists and

amphetamine, mediation, centraldelta opioid receptors (rats), 638

Norepinephrinecardiovascular effects of cocaine (rats),

602D2-selective dopamine antagonists, be-

havioral effects, cocaine (monkeys),

907purinergic vasoconstrictor component,

moderate cooling, mesenteric vascu-lature (rats), 1 133

receptor-mediated toxicity, catecholamin-ergic neurons, brain stem (rats), 1274

recovery of endothelium-dependent re-

sponses, reseeding endothelial cells,denuded coronary artery (pigs), 841

Norman, P. 5., see Charlesworth, E. N., 964Nunan, L., see Lai, J., 173

Oatis, J. E., Jr., see Naka, M., 632O’Connor, S. E., see Wood, B. E., 566

Ogletree, M. L., see Sargent, C. A., 11618-OH-DPAT, antagonist activity at 5-HT,�,

2 receptors, S 14671 (rats), 451Ohlstein, E. H., Gellai, M., Brooks, D. P.,

Vickery, L., Jugus, J., Sulpizio, A.,Ruffobo, R. R., Jr., Weinstock, J. andEdwards, R. M.: The antihyperten-sive effect ofthe angiotensin H recep-tor antagonist DuP 753 may not bedue solely to angiotensin II receptorantagonism, 595

Ohno, Y., see Kimura, M., 841Ohse, H., see Ninomiya, H., 570Oka, M., see Morita, K., 1209Okwu, A. K., Ubbian, M. E. and Halushka,

P. V.: Homologous desensitization ofhuman platelet thromboxane A2/prostaglandin H2 receptors, 238

Olanzapine, behavioral pharmacology (rats,mice), 545

Olfaction, microsomes, P.450-dependent ar-

1296 Index

achidonic acid metabolism (rabbits),433

Olsen, R. W., see Sapp, D. W., 801Omeprazole, disposition kinetics and me-

tabolism, S-mephenytoin 4’-hydrox-ylation, Oriental population, 1195

Ondeyka, D. L., see Siegl, P. K. S., 139

Oocytes, Xenopus, ethanol sensitivity, excit-atory amino acids, 487

Oosterhuis, B., see Braat, M. C. P., 509Oosterhuis, B., see Koopmans, R. P., 503Opioids

agonist, morphine-6/3-glucuronide (rab-

bits, guinea pigs, mice), 25antagonists and amphetamine, interac-

tion, mediation by central deltaopioid receptors (rats), 638

continuous intrathecal treatment, mech-anism of opioid tolerance, spinalmembranes (rats), 317

endogenous, antinociceptive effects, in-

trathecally administered calcium

(mice), 995suppression of primary humoral immune

responses, morphine, indirect mech-anism (mice), 923

Orlandi, M., see Corda, M. G., 792Ormond, P. M., Basinger, M. A., Jones, M.

M. and Hande, K. R.: Associationbetween increased atrial natriureticpeptide and reduced cisplatin neph-rotoxicity in rats, 246

Otani, M., see Igarashi, R., 1214Ouabain

digoxin and, handling by renal tubularcells, 109

-evoked catecholamine secretion, inhibi-tion by amiloride, adrenal chromaffincells (cattle), 1209

Oxidative stress, mixed disulfide of gluta-thione and cysteinylglycine, bile(mice, hamsters, rats, guinea pigs,rabbits), 896

Oxotremorine-M, novel, highly selective

sigma ligands (guinea pigs, rats), 32Oxygen

consumption, metabolic effects of rito-dine, fetus (sheep), 48

free radical-induced functional injury,protection, lisinopril and ramiprilat(rabbits), 212

Painter, D. J., see Cassis, L. A., 1168Palfreyman, M. G., see Baron, B. M., 947Pancreas, exocrine, effects of dideoxyino-

sine (rats), 445Pancuronium, parasympatholytic effects of

vecuronium, nicotinic and musca-rinic receptors, heart (dogs), 577

Panten, U., see Schwanstecher, M., 495Papadopoulos, V., see Romeo, E., 971

Parasympathetic nervous system, effects ofvecuronium, nicotinic and musca-

rinic receptors, heart (dogs), 577Parkinsonism, toxicity of 1-methyl-4-

phenyl-2,3-dihydropyridinium, pri-

mary cultures, astrocytes (mice), 225Paronis, C. A. and Hobtzman, S. G.: Devel-

opment of tolerance to the analgesic

activity of Mu agonists after contin-uous infusion of Morphine, Meperi-

dine or Fentanyl in rats, 1Pasnani, J. S. and Ferrier, G. R.: Differen-

tial effects of glyburide on prematurebeats and ventricular tachycardia in

an isolated tissue model of ischemiaand reperfusion, 1076

Pasternak, G. W., see Pick, C. G., 1044Patchett, A. A., see Chang, R. S. L., 133

Patchett, A. A., see Siegl, P. K. S., 139Patchin, D. S., see Elliott, W. C., 151Patterson, E., Scherlag, B. J. and Lazzara,

R.: Electrophysiologic actions of clof-ilium and lidocaine in ischemicallyinjured canine epicardium, 375

Paul, D., see Pick, C. G., 1044PD 123319, bosartan and, renal hemody-

namic and excretory responses(dogs), 1154

Peeters, G. A., see Port, J. D., 217Pentobarbital, potentiation of r-aminobu-

tyric acid-induced depolarizations,single myenteric neurons, intestine(guinea pigs), 677

Pentylenetetrazol

kindling, decrease in GABAergic func-tion, antagonism by MK-801 (rats),792

tolerance, cross-tolerance and with-drawal, dependence on diazepam(rats), 751

Peptides, short-term treatment with gas-trin, gastrointestinal histamine H2-receptors (guinea pigs), 624

Perindopril, myocardial inotropy, lusitropy

and economy, diaphragmatic con-tractility (hamsters), 516

Pessah, I. N., Mohr, F. C., Schiedt, M. andJoy, R. M.: Stereoselective modula-tion of ryanodine-sensitive calciumchannels by the 6 isomer of hexach-lorocycbohexane (o-HCH), 661

Pessah, I. N., see Mack, M. M., 1028Petersen, J. S. and DiBona, G. F.: Effects

of renal denervation on sodium bal-ance and renal function duringchronic furosemide administration inrats, 1103

Peterson, P. K., see Chao, C. C., 19Petropoulos, A. C., Winbery, S. L. and Bar-

ker, L. A.: Effect of short-term treat-ment with gastrin and related pep-tides on gastrointestinal histamineH2-receptors, 624

pHinhibition of ATP-sensitive K� channels,

sulphonylurea drugs, cardiac muscle(guinea pigs), 71

megakaryoblastic differentiation, throm-

bin (humans), 1242Phacbofen, multiple GABAB receptor sub-

types, cerebral cortex (rats), 114Phenylephrine

charybdotoxin-sensitive K� channel, re-laxation of bovine tracheal smooth

muscle, glyceryl trinitrate and so-dium nitroprusside, 263

ethanol-induced impairment of baroreflexcontrol, role of aortic baroreceptors,heart rate (rats), 157

Phorbol esterphysiological and biochemical studies,

fuscoside (mice), 866staurosporine modulation and, antagonist

and agonist binding, a!pha-2 adre-noceptors (calves), 775

Phosphatidylcholine, lecithinization of su-

peroxide dismutase, Forssman anti-serum-induced elevation, airway re-

sistance (guinea pigs), 1214

Vol. 262

Phosphodiesterase, serum-induced sensiti-

zation, cyclic AMP accumulation,C62B glioma cells (rats), 471

Phosphoinositide

hydrolysis, lung endothelin receptor sub-types (rats), 611

hydrolysis induced by endothelin-1, posi-

tive inotropic effect, ventricular myo-cardium (rabbits), 1189

novel, highly selective sigma ligands(guinea pigs, rats), 32

Phosphoinositols, single peptide leukotrienereceptor, resemblance, human con-

ducting airway smooth muscle(guinea pigs), 1095

Phospholipase, platelet thromboxane A2!

prostaglandin H2 receptors, homolo-

gous desensitization (humans), 238Phospholipase A2

inhibitors, block of contractions, lungpleural strips (guinea pigs), 1147

inhibitors quinacrine and 7,7-dimethylei-

cosadienoic acid, ischemic hearts(rats), 1161

Phospholipidosisamiodarone-induced lung fibrosis and, at-

tenuation by taurine and/or niacin(hamsters), 127

gentamicin-induced renal, protectants,poly-L-aspartic and poly-L-glutamicacids (rats), 424

Phosphoramidon, endothelium-1 release, is-

chemia-hypoxia, lungs (guinea pigs),

1062Physostigmine, influence of epithelium, re-

activity of trachea, bronchoactive

drugs (guinea pigs), 741

Piascik, M. T., Sparks, M. S. and Pruitt, T.A.: Effect of chborethylcbonidine onarterial blood pressure and heart ratein the conscious rat, 901

Pick, C. G., Paul, D. and Pasternak, G. W.:Nalbuphine, a mixed kappa, andkappa3 analgesic in mice, 1044

Pickoff, A. S., see Xu, Y.-Q., 670Picrotoxin, decrease in GABAergic func-

tion, pentylenetetrazol kindling, an-tagonism by MK-801 (rats), 792

Pineal, delta opioid binding sites (cattle),292

Pirenzipine, differential regulation of ml to

m5 muscarinic receptors, chronic

atropine administration (rats), 584

Pituitary, prolactin secretion, stimulationby risperidone (rats), 699

PK 11195, disulfiram and diethyldithiocar-bamate, competitive inhibitors, pe-ripheral benzodiazepine receptor

(rats), 394Plasma, bradykinin-induced extravasation,

sympathoadrenal contribution, knee

joint (rats), 889

Platelet-activating factor, antagonist activ-

ity of RP 59227 and WEB 2086, per-

itoneal macrophages (guinea pigs),1139

Plateletsnovel receptor ligand S-145 (guinea pigs),

784

thromboxane A2/prostaglandin H2 recep-tors

high-affinity radiolabeled antagonist(humans), 632

homologous desensitization (humans),238

Index 12971992

Platinum, reduced cisplatin nephrotoxicity,

increased atrial natriuretic peptide(rats), 246

Pneumonia, pneumococcal, kinetic disposi-tion, temafloxacin and ciprofloxacin(mice), 1203

Pocidalo, J.-J., see Vall#{233}e,E., 1203Pollock, P. L., see Comment, C. E., 1267

Polyamine, recognition site of NMDA re-ceptor, antagonist/partial agonist,

glutamate recognition site (rats), 539Poly-L.aspartic acid

poly-L-glutamic and, protectants, genta-micin-induced renal lysosomal phos-

pholipidosis (rats), 424protection against gentamicin-induced

cytotoxicity, LLC-PK1 cells, 834

Porreca, F., see Vanderah, T. W., 190

Port, J. D., Debellis, C. C., Klein, J., Peeters,G. A., Barry, W. H. and Bristow, M.R.: Pharmacological characterization

of chick and frog beta adrenergic re-ceptors in primary cultures of myo-cardial cells, 217

Portoghese, P. 5., see Vanderah, T. W., 190Potassium, serotonin-stimulated release of

dopamine, reversal, dopamine trans-

porter (rats), 356

Potassium channelATP.sensitive, inhibition by sulphonylu-

rea drugs and effects of pH, cardiacmuscle (guinea pigs), 71

charybdotoxin-sensitive, relaxation of be-vine tracheal smooth muscle, glyceryltrinitrate and sodium nitroprusside,263

Potassium channel blockers, UK-68,798,comparative effects of UL-FS 49, ex-

ercise-induced ischemia (dogs), 987Potassium current, delayed, voltage- and

time-dependent block by dofetilide,

cardiac myocytes (guinea pigs), 809Pourny, J.-C., see Chemla, D., 516Powel, R. J., see Williams, K., 539Powers, R. E., see Grady, T., 445

Pozzi, L., see Invernizzi, R., 769Pregnancy, pharmacokinetics and pharma-

codynamics, labetalol (sheep), 683Preston, K. L., Sullivan, J. T., Strain, E. C.

and Bigelow, G. E.: Effects of cocainealone and in combination with bro-mocriptine in human cocaine abu-sers, 279

Preston, K. L., Wolf, B., Guarino, J. J. and

Griffiths, R. R.: Subjective and be-

havioral effects of diphenhydramine,

lorazepam and methocarbamol: Eval-uation of abuse liability, 707

Prins, B. A., Weber, M. A. and Purdy, R.E.: Norepinephrine amplifies angio-tensin Il-induced vasoconstriction inrabbit femoral artery, 198

Prolactindihydrexidine, D1 receptor agonist (rats),

383secretion, stimulation by risperidone, cub-

tured pituitary cells (rats), 699Promethazine, effect of H1 receptor block-

ade, early and late response, cuta-neous allergen challenge (humans),964

Propionibacterium acnes, endotoxin-me-diated hepatitis, protective effects ofE3330 (mice), 145

Propp, J. M., see Eells, J. T., 1173

Propranolol, influence of epithelium, reac-

tivity oftrachea, bronchoactive drugs

(guinea pigs), 741

Prostaglandin E2, physiological and bio-chemical studies, fuscoside (mice),866

Prostaglandin H2novel receptor ligand S-145, platelets,

vascular and airway smooth muscle(guinea pigs), 784

platelet thromboxane A2, high-affinity ra-diolabeled antagonist (humans), 632

receptors, thromboxane A2 receptors, ho-mologous desensitization (humans),

238Prostaglandins, permeability of brain struc-

tures, other peripheral tissues (rats),

1110Prostanoid, release, endothelin-3 effects,

kidney (rats), 252Prostanoids, influence of epithelium, reac-

tivity oftrachea, bronchoactive drugs

(guinea pigs), 741Protein kinase A, activation, ethanol-in-

duced desensitization, cyclic AMPproduction, 257

Protein kinase C

phorbol ester and staurosporine modula-tion, antagonist and agonist binding,a4,ha-2 adrenoceptors (calves), 775

serum-induced sensitization, cyclic AMPaccumulation, C62B glioma cells(rats), 471

Proto-oncogenesc-los, SKF-38393 and A-68930, neonatal

6-hydroxydopamine-lesioned rats,

855megakaryoblastic differentiation, throm-

bin (humans), 1242Pruett, S. B., Han, Y.-C. and Fuchs, B. A.:

Morphine suppresses primary hu-

moral immune responses by a pre-dominantly indirect mechanism, 923

Pruitt, T. A., see Piascik, M. T., 901Psoriasis, biochemical studies of fuscoside,

neutrophils (humans), 874Pugh, S. L., Boone, M. S. and Emmett-

Oglesby, M. W.: Tolerance, cross-tol-erance and withdrawal in rats madedependent on diazepam, 751

Puia, G., see Romeo, E., 971Pullan, L. M., see Williams, K., 539

Purdy, R. E., see Prins, B. A., 198Purines, vasoconstrictor component, mes-

enteric vasculature (rats), 1133Purinoceptors, P2y, selectivity of adenosine

5’-(2-fluorodiphosphate), jugularvein (rabbits), 566

Pyrethroid, insecticide-induced alterations,mammalian synaptic membrane po-

tential (rats),1173

Pyrilamine, vascular permeability changes,regulation by mast cells, Arthus re-action (mice), 559

Quilley, C. P., see Stier, C. T., Jr., 252Quinacrine, 7,7-dimethyleicosadienoic acid

and, ischemic hearts (rats), 1161Quinoline, -containing NMDA antagonists,

strychnine-insensitive glycine bind-ing site (rats), 947

Quinolones, temafloxacin and ciprofloxacin,kinetic disposition, pneumococcalpneumonia (mice), 1203

Quinpirole

binding to D2-like dopamine receptors,brain (rats), 929

central effects on blood pressure, sponta-neously hypertensive rats, 303

dihydrexidine, D, receptor agonist (rats),383

Rabin, R. A., Edelman, A. M. and Wagner,J. A.: Activation of protein kinase A

is necessary but not sufficient for

ethanol-induced desensitization ofcyclic AMP production, 257

Radioligandsantagonist and agonist binding, leuko-

triene B4 receptor, polymorphonu-clear neutrophils (humans), 80

platelet thromboxane A2/prostaglandin

H2 receptors, homologous desensiti-zation (humans), 238

Radomski, M. W., see Lelchuk, R., 1220Rainnie, D. G., see Asprodini, E. K., 1011

Raiteri, M., see Bonanno, G., 114Ramiprilat, lisinopril and, protection of vas-

cular endothelium, free radical-in-duced functional injury (rabbits), 212

Ramos, B. F., Zhang, Y., Angkachatchai, V.and Jakschik, B. A.: Mast cell media-tors regulate vascular permeabilitychanges in arthus reaction, 559

Rebagay, W. R., see Caldwell, R. W., 1022

Receptors

angiotensinbosartan effect, monocrotaline-induced

pulmonary hypertension (rats), 1168

PD 123319 and losartan, renal hemo-dynamic and excretory responses(dogs), 1154

angiotensin IIantagonist, in vivo pharmacology of L-

158,809 (rats, monkeys), 139antagonist, pharmacology of L-158,809

(rabbits, rats, monkeys), 133benzodiazepine

competitive inhibitors, disulfiram and

diethydithiocarbamate (rats), 394Ro 19-8022, neuropharmacological pro-

file (mice, rats, monkeys), 1121

benzodiazepine peripheral-type, AHN 683fluorescent ligand (rats), 734

cardiovascular calcium antagonist, sus-tamed occupancy, mepirodipine

(rats), 589

chimeric M,/M2 muscarinic, ligand selec-tivity, functional coupling, 173

dopamine Dl, agonist dihydrexidine(rats), 383

dopamine D2, quinpirole binding, brain(rats), 929

endorphin, antinociceptive properties, al-kylating derivatives of morphinone

(mice), 526

endothelin, phosphoinositide hydrolysis,lung (rats), 611

GABA, pentylenetetrazol kindling, antag-onism by MK-801 (rats), 792

GABAA, steroid anesthetic modulation,

TBPS binding in brain (rats), 801GABAB, functional subtypes, cerebral

cortex (rats), 114

histamine H,, early and late response,cutaneous allergen challenge (hu-mans), 964

histamine H2, short-term treatment, gas-trin (guinea pigs), 624

5-HT,

1298 Index

biochemical and pharmacological prop-erties, SR 46349B (rats), 759

differential adaptation, serotonergicsystem (mice), 692

5-HTA, modulation of micturition reflexes(rats), 181

5-HT,�,2, antagonist activity, S 14671

(rats), 451kinin B, and B2, cyclic GMP production,

bovine aortic endothelial cells, 729leukotriene, single peptide, gallbladder

(guinea pigs), 1095

leukotriene B4, antagonist and agonistbinding, polymorphonuclear neutro-phils (humans), 80

leukotriene C4, localization in lung (bull-frogs), 1248

-mediated toxicity of norepinephrine, cat-echolaminergic neurons, brain stem

(rats), 1274

N-methyl-D-aspartateindole-2-carboxylate derivatives, gly-

cine recognition site (rats), 654substance P and met5-enkephalin bio-

synthesis, neurons in striatum (rats),823

mitochondrial DBI, 2-aryl-3-indoleace-tamides (rats), 971

muscarinic ml, modulation of conservedaspartate residues, allosteric interac-tion of gallamine, 312

muscarinic M2, inhibition of isoproter-enol-induced relaxation, airwaysmooth muscle (dogs), 119

muscarinic ml to m5, differential regula-tion in forebrain, chronic atropineadministration (rats), 584

nicotinic and muscarinic, parasympath-

olytic effects of vecuronium, heart(dogs), 577

NK, and NK2effects of FK224, sensory nerve stimu-

lation (guinea pigs), 403

FK 224, novel cycbopeptide substance Pantagonist (guinea pigs, rats), 398

NMDAethanol sensitivity, Xenopus oocytes,

487

polyamine recognition site, antagonist/partial agonist (rats), 539

sensitization to toxic cocaine effects,

cortex (mice), 464opiate kappa, diuresis, E-2078 (rats), 979opioid

breathing dynamics, [D-Pen2,D-Pen5J-enkephalin and naltrindole (sheep),1004

clocinnamox, antagonist (mice), 1051opioid delta

interaction, opioid antagonists and am-phetamine (rats), 638

noradrenergic agonists and, spinal in-teractions (mice), 365

pineal binding sites (cattle), 292opioid delta2, mediation, swim-stress an-

tinociception (mice), 190opioid kappa, and kappa3, nalbuphine, an-

algesic (mice), 1044opioid mu

mechanism of opioid tolerance, spinalmembranes (rats), 317

neuroanatomical sites, fi-endorphin

central actions (rats), 415platelet thromboxane A2/prostaglandin

H2

high-affinity radiolabeled antagonist(humans), 632

homologous desensitization (humans),238

presynaptic r-aminobutyric acidB, gluts-

matergic afferents, amygdala (rats),1011

puringeric, moderate cooling, mesentericvasculature (rats), 1133

reflex, polar and nonpolar cardiac glyco-side, transient vagal cold blockade

(dogs), 1022sigma, enantiomers of cis-N-[2-(3,4-dich-

lorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl) cycbohexylamine, bio-logical efficacy (guinea pigs, rats), 32

steroid, GABAA responses, single myen-

teric neurons (guinea pigs), 677sulfonylurea, binding properties, Mg�-

complex of ATP, 495tachykinin neurokinin2, nonadrenergic

contractile responses, hilar bronchus(guinea pigs), 957

Reflex, micturition, modulation, 5-HT,A re-ceptors (rats), 181

Ran, L.-M., see Narita, M., 577

Renin, endothelin-3 effects, prostanoid re-lease, kidney (rats), 252

Renzetti, L. M., Shenvi, A. and Buckner, C.K.: Nonadrenergic, noncholinergiccontractile responses of the guineapig hilar bronchus involve the pref-erential #{149}activation of tachykininneurokinin2 receptors, 957

Resiniferatoxin, identification of a,-acid

glycoprotein, major vanilloid bindingprotein, serum (rats), 883

Rice, K. C., see Bowen, W. D., 32Rikans, L. E. and Cai, Y.: Age-associated

enhancement of diquat-induced lipidperoxidation and cytotoxicity in iso-lated rat hepatocytes, 271

Rinaldi-Carmona, M., Congy, C., Santucci,V., Simiand, J., Gautret, B., Neliat,G., Labeeuw, B., Le Fur, G., Soubrie,P. and Breliere, J. C.: Biochemiscland pharmacological porperties ofSR 46349B, a new potent and selec-tive 5-hydroxytryptamine2 receptorantagonist, 759

Rinkema, L. E., see Dub#{233},G. P., 784

Rippetoe, P. E., see Cassis, L. A., 1168Risius, F. C., see Moore, N. A., 545

Risperidone, stimulation by prolactin secre-tion, cultured pituitary cells (rats),699

Ritanserin, blunted growth hormone re-sponses, heteroreceptors (rats), 1038

Ritodrmne, metabolic effects, fetus (sheep),48

Rivelli, M., see Vemulapalli, S., 1062Rivet, J.-M., see Millan, M. J., 451Ro 15-4513, decrease in GABAergic func-

tion, pentylenetetrazol kindling, an-tagonism by MK-801 (rats), 792

Ro 19-8022, neuropharmacological profile,potent anxiolytic (mice, rats, mon-keys), 1121

Roerig, S. C., Lei, S., Kitto, K., Hylden, J.

K. L. and Wilcox, G. L.: Spinal inter-actions between opioid and noradre-nergeic agonists in mice: Multiplica-tivity involves delta and alpha-2 re-ceptors, 365

Roeske, W. R., see Lai, J., 173

Vol. 262

Rogers, W. L., see Seymour, A. A., 60Romano, C., see Williams, K., 539Romeo, E., Auta, J., Kozikowski, A. P., Ma,

D., Papadopoulos, V., Puia, G., Costa,E. and Guidotti, A.: 2-Aryl-3-indole-acetamides (FGIN-i): A new class of

potent and specific ligands for the

mitochondrial DBI receptor (MDR),971

Rosenthal, G. J., see Comment, C. E., 1267Rothman, R. B., see Bowen, W. D., 32Rovnyak, P. L., see Seymour, A. A., 60RP 59227, WEB 2086 and, antagonist activ-

ity, peritoneal macrophages (guineapigs), 1139

Ruffolo, R. R., Jr., see Ohlstein, E. H., 595Rurak, D. W., see van der Weyde, M. P., 48Rurak, D. W., see Yeleswaram, K., 683Ruthenium red, calcium release channel

complex, multiple binding sites, skel-etal and cardiac sarcoplasmic reticu-lum (rabbits), 1028

Ryanodinecalcium release channel complex, multi-

ple binding sites, skeletal and cardiacsarcoplasmic reticulum (rabbits),1028

-sensitive calcium channels, stereoselec-tive modulation, hexachlorocycloh-exane (rats), 661

S-145, characterization in platelets, vascu-lar and airway smooth muscle(guinea pigs), 784

S 14671, antagonist activity, 5-HT1c,2 recep-tors (rats), 451

Sabra, R., see Abels, B. C., 166Sacchetti, G., see Invernizzi, R., 769Saito, H., see Togashi, H., 343Sakuma, I., see Togashi, H., 343Sakurai, I., see Kimura, M., 841Salama, A. I., see Williams, K., 539Salituro, F. G., see Baron, B. M., 947Saluja, A. K., see Grady, T., 445Samanin, R., see Invernizzi, R., 769

Santicioli, P., see Lecci, A., 181Santucci, V., see Rinaldi-Carmona, M., 759Saotome, M., see Ninomiya, H., 570Sapp, D. W., Witte, U., Turner, D. M., Len-

goni, B., Kokka, N. and Olsen, R. W.:Regional variation in steroid anes-thetic modulation of [�S]TBPSbinding to r-aminobutyric acidA re-ceptors in rat brain, 801

Sarafotoxin, lung endothelin receptor sub-ytpes, phosphoinositide hydrolysis(rats), 611

Sarcoplasmic reticulumryanodine-sensitive calcium channels,

hexachlorocyclohexane 6-isomer(rats), 661

skeletal and cardiac, multiple bindingsites, antagonists of calcium releasechannel complex (rabbits), 1028

Sargent, C. A., Vesterqvist, 0., McCullough,J. R., Ogletree, M. L. and Grover, G.J.: Effect of the phospholipase A2 in-hibitors quinacrine and 7,7-dimethy-leicosadienoic acid in isolated glob-ally ischemic rat hearts, 1161

Scalbert, E., see Chemla, D., 516SCH23390

dihydrexidine, D1 receptor agonist (rats),383

modulation of regional brain neurotensin,antipsychotic drugs (rats), 348

Index 12991992

SCH4O12O, actions on acute inflammatoryresponses (mice), 721

Scherlag, B. J., see Patterson, E., 375Schiedt, M., see Pessah, I. N., 661Schindler, C. W., see Tella, S. R., 602, 936Schnellmann, R. G., see Whittem, T., 834

Schroder, H.: Cytochrome P-450 mediatesbioactivation of organic nitrates, 298

Schultz, R., see Ableitner, A., 415Schwanstecher, M., Behrends, S., Brandt,

C. and Panten, U.: The binding prop-erties of the solubilized sulfonylureareceptor from a pancreatic B-cell line

are modulated by the Mg�-complexof ATP, 495

Segal, D. S., see Kuczenski, R., 1085Serotonin

antagonist activity at 5-HT1�,2 receptors,S 14671 (rats), 451

behavioral evidence for differential adap-tation, 1-(2,5-dimethoxy-4-iodo-phenyl)-2-aminopropane or ketan-serin (mice), 692

biochemical and pharmacological proper-

ties, SR 46349B (rats), 759D2-selective dopamine antagonists, be-

havioral effects, cocaine (monkeys),907

models of anxiety, comparison of E-4424,diazepam/buspirone/ipsapirone(rats, mice, marmosets), 90

recovery of endothelium-dependent re-sponses, reseeding endothelial cells,denuded coronary artery (pigs), 841

-stimulated release of dopamine, reversalof dopamine transporter, striatumand nucleus accumbens (rats), 356

vascular neuroeffector transmission, ef-fects of xylamine (rabbits), 231


by mast cells, Arthus reaction (mice),559

Serum, -induced sensitization, cyclic AMPaccumulation, C62B glioma cells(rats), 471

Seth, P., see Kowaluk, E. A., 916Seyed-Mozaffari, A., see Jiang, Q.,526Seymour, A. A., Asaad, M. M., Abboa-Offei,

B. E., Rovnyak, P. L., Fennell, S. andRogers, W. L.: Potentiation of brainnatriuretic peptides by SQ 28,603,and inhibitor of neutral endopepti-dase 3.4.24.11, in monkeys and rats,60

Shea-Donohue, T., see Montcalm-Mazzilli,

E., 850Shenvi, A., see Renzetti, L. M., 957Shin, S.-G., see Sohn, D.-R., 1195Shinnick-Gallagher, P., see Asprodini, E.

K., 1011Siegel, B. W., see Baron, B. M., 947

Siegel, M. I., see Smith, S. R., 721Siegl, P. K. S., Chang, R. S. L., Mantlo, N.

B., Chakravarty, P. K., Ondeyka, D.L., Greenlee, W. J., Patchett, A. A.,Sweet, C. S. and Lotti, V. J.: In vit�’opharmacology of L-158, 809, a new

highly potent and selective nonpep-

tide angiotensin II receptor antago-

nist, 139

Siegl, P. K. S., see Chang, R. S. L., 133Sills, M. A., see Cioffi, C. L., 611Sills, M. A., see Jackson, R. H., 80Simiand, J., see Rinaldi-Carmona, M., 759Simmons, T. W., Anders, M. W. and Bal-

latori, N.: -Cysteine and S-(1,2-dich-

lorovinyl)-L-cysteine transport in ratliver canalicular membrane vesicles:Potential reabsorption mechanisms

for biliary metabolites of glutathioneand S-conjugates, 1182

Simson, P. E., see Johnson, K. B., 855SK&F 38393, A-68930 and, neonatal 6-hy-

droxydopamine-lesioned rats, 855SK&F 108566, antihypertensive effect of

DuP 753, angiotensin II receptor an-tagonism (rats), 595

Skin, physiological and biochemical studies,

fuscoside (mice), 866Skolnick, P., see McCabe, R. T., 734Slone, A. L., see Baron, B. M., 947

Smith, F. L. and Dewey, W. L.: Evidence

that endogenous opioids mediate theantinociceptive effects of intrathe-cally administered calcium in mice,

995Smith, S. R., Watnick, A. W., Bryant, R.

W., Billah, M. and Siegel, M. I.: Ac-tions of a 5-lipoxygenase inhibitor,Sch 40120, on acute inflammatoryresponses, 721

Snyder, D. W., Sommers, C. D., Bobbit, J.L. and Mihelich, E. D.: Evidence thatphospholipase A2 (PLA2) inhibitors

can selectively block PLA2-mediatedcontractions of guinea pig lung

pleural strips, 1147Sodium, balance, effects of renal denerva-

tion, chronic furosemide administra-tion (rats), 1103

Sodium channeldevelopmental changes in lidocaine ef-

fects, cardiac myocytes (rats), 670synaptic membrane potential, pyrethroid

insecticide-induced alterations(rats), 1173

Sodium current, slow inward, ibutilide, yen-tricular cells (guinea pigs), 99

Sodium nitroprussideglyceryl trinitrate and, charybdotoxin-

sensitive K� channel, trachealsmooth muscle (cattle), 263

metabolic activation to nitric oxide, vas-cular smooth muscle (cattle), 916

Sohn, D.-R., Kobayashi, K., Chiba, K., Lee,K.-H., Shin, S.-G. and Ishizaki, T.:Disposition kinetics and metabolismof omeprazole in extensive and poor

metabolizers of S-mephenytoin 4’-hydroxylation recruited from and on-ental population, 1, 195

Soltis, E. E., see Cassis, L. A., 1168

Somers, D. L. and Beckstead, R. M.: N-Methyl-D-aspartate receptor antago-nism alters substance P and Met5-enkephalin biosynthesis in neuronsof the rat striatum, 823

Sommers, C. D., see Snyder, D. W., 1147Soubrie, P., see Rinaldi-Carmona, M., 759Sparks, M. S., see Piascik, M. T., 901Spermine, antagonist/partial agonist, po-

lyamine recognition site, NMDA re-ceptor (rats), 539

Spinal cord, interactions between opioidand noradrenergic agonists (mice),365

Spine, mechanism of opioid tolerance, reg-ulatory effects, magnesium and guan-me nucleotides (rats), 317

Spiperone

blunted growth hormone responses, het-eroreceptors (rats), 1038

quinpirole binding in brain, D2-like do-pamine receptors (rats), 929

SQ 28,603, potentiation of brain natriureticpeptides (monkeys, rats), 60

SQ 29,548, novel receptor ligand S-145,platelets, vascular and airway smoothmuscle (guinea pigs), 784

SR 46349B, biochemical and pharmacolog-ical properties (rats), 759

Staurosporine, phorbol ester modulationand, antagonist and agonist binding,alpha-2 adrenoceptors (calves), 775

Steer, M. L., see Grady, T., 445Stein, E. A. and Fuller, S. A.: Selective

effects of cocaine on regional cerebralblood flow in the rat, 327

Stein, I., see Itzhak, Y., 464Stenosis, renal artery, influence of CGS

15943A (dogs), 166

Stereotypy, prior sensitization, develop-ment of tolerance, acetaminophen-induced hypophagia (rats), 1232

Steroids, anesthetic modulation, TBPSbinding to GABAA receptors, brain

(rats), 801Stevens, D. L., see Welch, S. P., 10

Stier, C. T., Jr., Quilley, C. P. and McGiff,J. C.: Endothelin-3 effects on renalfunction and prostanoid release inthe rat isolated kidney, 252

Strain, E. C., see Preston, K. L., 279Streptococcus pneumoniae, pneumococcal

pneumonia, kinetic disposition, te-

mafloxacin and ciprofloxacin (mice),1203

Striatum

neurons, NMDA receptor antagonism,substance P and met5-enkephalin(rats), 823

quinpirole binding, D2-like dopamine re-

ceptors (rats), 929serotonin-stimulated release of dopamine,

reversal, dopamine transporter

(rats), 356Strychnine, -insensitive glycine binding

site, indole- and quinoline-contain-

ing NMDA antagonists (rats), 947Su, Y.-F., see Wong, C.-S., 317

Substance Peffects of FK224, airway constriction and

edema, sensory nerve stimulation(guinea pigs), 403

met5-enkephalin and, NMDA receptorantagonism, neurons in striatum(rats), 823

spinal interactions, opioid and noradre-

nergic agonists (mice), 365Sulfonylurea

binding properties of receptors, Mg�-complex of ATP, pancreatic B-cellline, 495

inhibition of ATP-sensitive K� channels,effects of pH, cardiac muscle (guineapigs), 71

Sullivan, J. T., see Preston, K. L., 279

Sulpiride, modulation of regional brain neu-rotensin, antipsychotic drugs (rats),

348Sulpizio, A., see Ohlstein, E. H., 595Sultana, M., see Vanderah, T. W., 190Superoxide, antagonist activity of RP 59227

and WEB 2086, penitoneal macro-phages (guinea pigs), 1139

1300 Index VoL 262

Superoxide dismutase, lecithinization,Forssman antiserum-induced eleva-tion, airway resistance (guinea pigs),1214

Sweet, S. C., see Siegl, P. K. S., 139Synaptosomes, multiple GABAB receptor

subtypes, cerebral cortex (rats), 114Szallasi, A., Lewin, N. E. and Blumberg, P.

M.: Identification ofa�pka-1-acid gly-coprotein (orsomucoid) as a majorvanilloid binding protein in serum,

883Szeto, H. H., see Cheng, P. Y., 1004

Tachykininneurokinin2 receptors, nonadrenergic

contractile responses, hilar bronchus(guinea pigs), 957

NK, and NK2 receptor selectivity, FK224, novel cyclopeptide substance Pantagonist (guinea pigs, rats), 398

Tachykinins, antigen-induced enhance-ment, noncholinergic contractile re-sponses, vagus nerve (guinea pigs),646

Takasaki, K., see Yamamoto, R., 1133Takei, M., see Narita, M., 577

Takemoni, A. E., see Vanderah, T. W., 190

Takenaga, M., see Igarashi, R., 1214Tanaka, H. and Kaneko, T.: Pharmacoki-

netic and pharmacodynamic compar-

isons between human granulocyte co-loney-stimulating factor purifiedfrom human bladder carcinoma cell

line 5637 culture medium and recom-binant human granulocyte colony-stimulating factor produced in esch-erichia coli, 439

Taurine, attenuation of amiodarone-in-duced lung fibrosis, phospholipidosis(hamsters), 127

Taylor, D. G., Jr., see Keiser, J. A., 1154Taylor, S. M., see van den Weyde, M. P., 48Tella, S. R., Korupolu, G. R., Schindler, C.

W. and Goldberg, S. R.: Pathophysi-ological and pharmacological mecha-nisms of acute cocaine toxicity inconscious rats, 936

Tella, S. R., Schindler, C. W. and Goldberg,S. R.: Cardiovascular effects of co-

caine in conscious rats: Relative sig-nificance of central sympatheticstimulation an dperipheral neuronalmonoamine uptake and release

mechanisms, 602Temafloxacin, ciprofloxacin and, kinetic

disposition, pneumococcal pneu-

monia (mice), 1203Teraoka, K., see Morita, K., 1209Tetrahydrocannabinol, CP 55,490 and, dis-

criminative stimulus properties (rats,monkeys), 479

Tetraphenylphosphonium, pyrethroid in-secticide-induced alterations, synap-tic membrane potential (rats), 1173

Thiacetazone, metabolism, cytosolic aryla-cylamidase (rats), 1225

14fl-(Thioglycolamido)-7,8-dihydromorphi-

none, antinociceptive properties(mice), 526

Thrombin, stimulation of megakaryocytic

differentiation, human megakaryob-

lastic leukemia cells, 1242

Thromboxane, stimulation of differentia-

tion by thrombin, human megakar-yoblastic leukemia cells, 1242

Thromboxane A2novel receptor ligand S-145, platelets,

vascular and airway smooth muscle(guinea pigs), 784

prostaglandin H2 receptorshigh-affinity radiolabeled antagonist

(humans), 632homologous desensitization (humans),

238Thymocytes, injury after in vitro chemical

exposure, mechanisms, thymic atro-phy (rats, mice), 1267

Tietz, E. I., see Xie, X.-H., 204Tiotidine, short-term treatment with gas-

trin, gastrointestinal histamine H2-receptors (guinea pigs), 624

Tobramycin, aminoglycoside-mediated cal-

ciuresis (rats), 151Toews, M. L., Hoffman, J. M., Liewer, S. A.

and Arneson-Rotert, L. J.: Serum-induced sensitization of cyclic AMPaccumulation in C62B rat gliomacells, 471

Togashi, H., Sakuma, I., Yoshioka, M., Ko-bayashi, T., Yasuda, H., Kitabatake,A., Saito, H., Gross, S. S. and Levi,R.: A central nervous system actionof nitric oxide in blood pressure reg-ulation, 343

Tolbutamide, inhibition of ATP-sensitiveK� channels, sulphonylurea drugs,effects of pH (guinea pigs), 71

Tolentino, P. J., see Bowen, W. D., 32

Torres, 0. A., see Chiono, M., 1248Trachea

antigen-induced enhancement, noncholi-nergic contractile responses, vagusnerve (guinea pigs), 646

constriction by endothelins, multiplemechanisms (guinea pigs), 570

reactivity, influence of epithelium, bron-

choactive drugs (guinea pigs), 741Transforming growth factor-fl, potentiation

of release by morphine, peripheralblood mononuclear cell cultures (hu-mans), 19

True, T. A., see Dub#{233},G. P., 784Tsang, M., see Chao, C. C., 19Tulkens, P. M., see Kishore, B. K., 424Tumor necrosis factor-a, protective effects

of E3330, endotoxin-mediated hepa-titis (mice), 145

Turner, D. M., see Sapp, D. W., 801

Turner, J. P., see Baron, B. M., 947Turner, N. C. and Wood, L. J.: Character-

ization of the antagonist activity ofthe PAF antagonists RP 59227 andWEB 2086 on elicited guinea pig per-itoneal macrophages. Evidence forvariable affinities and kinetics, 1139

Tye, N. C., see Moore, N. A., 545

U-50,488, diuresis by kappa opiate receptoractivation, E-2078 (rats), 979

U-50,488H, nalbuphine, mixed kappa, andkappa3 analgesic (mice), 1044

Uchida, Y., see Ninomiya, H., 570UK-68,798, UL-FS 49 and, exercise-induced

ischemia (dogs), 987Ullian, M. E., see Okwu, A. K., 238Undem, B. J., see Ellis, J. L., 646

Urade, Y., see Eguchi, N., 1110Urinary bladder, modulation of micturition

reflexes, 5-HT,A receptors (rats), 181Utterback, B. G., see Dub#{233},G. P., 784

Vacik, J., see Mare�, V., 818Vagus nerve

noncholinergic contractile responses, an-tigen-induced enhancement, trachea(guinea pigs), 646

transient vagal cold blockade, polar andnonpolar cardiac glycoside, reflex re-ceptors (dogs), 1022

Valentino, R. J., see De Boer, S. F., 335Vallebuona, F., see Invernizzi, R., 769Vall#{233}e,E., Azoulay-Dupuis, E., Bauchet, J.

and Pocidalo, J.-J.: Kinetic disposi-tion of temafloxacin and ciprofloxa-cm in a murine model of pneumococ-cal pneumonia. Relevance for drug

efficacy, 1203Van Boxtel, C. J., see Braat, M. C. P., 509van Boxtel, C. J., see Koopmans, R. P., 503van den Buuse, M.: Central effects of quin-

pirole on blood pressure of sponta-neously hypertensive rats, 303

Vanderah, T. W., Wild, K. D., Takemori, A.E., Sultana, M., Portoghese, P. 5.,Bowen, W. D., Moseberg, H. I. andPorreca, F.: Mediation of swim-stress

antinociception by the opioid delta,receptor in the mouse, 190

van der Weyde, M. P., Wright, M. R., Tay-br, S. M., Axelson, J. E. and Rurak,D. W.: Metabolic effects of ritodrinein the fetal lamb, 48

Vanilloid binding protein, a1-acid glycopro.

tein, serum (rats), 883Van Liefde, I., Van Witzenburg, A. and Vau-

quelin, G.: Multiple beta adrenergicreceptor subclasses mediate the I-is-oproterenol-induced lipolytic re-sponse in rat adipocytes, 552

Van Witzenburg, A., see Van Liefde, I., 552Varon, S., see Louis, J.-C., 1274Vasculature, mesenteric, moderate cooling,

purinergic vasoconstrictor compo-nent (rats), 1133

Vasoconstnictionangiotensin Il-induced, norepineprhine,

femoral artery (rabbits), 198chronic renal artery stenosis, influence of

CGS 15943A (dogs), 166endothelin-3 effects, prostanoid release,

kidney (rats), 252Vauquelin, G., see Van Liefde, I., 552Vecuronium, parasympatholytic effects, me-

diation by nicotinic and muscarinicreceptors, heart (dogs), 577

Vein, jugular, selectivity, adenosine 5’-(2-fluorodiphosphate) (rabbits), 566

Vemulapalli, S., Rivelli, M., Chiu, P. J. S.,del Prado, M. and Hey, J. A.: Phos-phoramidon abolishes the increase inendothelin-1 release induced by is-chemia-hypoxia in isolated perfuseguinea pig lungs, 1062

Ventricular cells, slow inward Na� current,

ibutilide (guinea pigs), 99Verriele, L., see Millan, M. J., 451Vesterqvist, 0., see Sargent, C. A., 1161Vickery, L., see Ohlstein, E. H., 595Voina, S. J., see Bowden, C. R., 699

Waggaman, L. A., see Nedergaard, 0. A.,231

Wagner, J. A., see Rabin, R. A., 257Waite, S. L., see Lai, J., 173Walker, J. M., see Bowen, W. D., 32

Wall, S. J., Yasuda, R. P., Li, M., Ciesla, W.and Wolfe, B. B.: Differential regu-

1992 Index 1301

lation of ml to m5 subtypes of mus-carinic receptors in froebrain bychronic atropine administration, 584

Wang, Q., Hollinger, M. A. and Giri, S. N.:Attenuation of amiodarone-induced

lung fibrosis and phospholipidosis inhamsters by taurine and/or niacintreatment, 127

Watkins, W. D., see Wong, C.-S., 317Watnick, A. W., see Smith, S. R., 721Watson, G. B., see Hood, W. F., 654WEB 2086, RP 59227 and, antagonist activ-

ity, peritoneal macrophages (guineapigs), 1139

Weber, M. A., see Prins, B. A., 198Wecker, L., see Coutcher, J. B., 1128

Weinstock, J., see Ohlstein, E. H., 595Weizman, A., see Katz, Y., 394Weizman, R., see Katz, Y., 394Welch, S. P. and Stevens, D. L.: Antinoci-

ceptive activity of intrathecally ad-ministered cannabinoids alone, andin combination with Morphine, inmice, 10

White, H. S., see Baron, B. M., 947Whittem, T., Schnellmann, R. G. and Fer-

guson, D. C.: Poly-L-aspartic acid

does but triiodothyronine does notprotect against gentamicin-inducedcytotoxicity in the porcine kidney cellline LLC-PK1, 834

Wiemer, G. and Wirth, K.: Production of

cyclic GMP via activationof B, andB2 kinin receptors in cultured bovineendothelial cells, 729

Wilcox, G. L., see Roerig, S. C., 365Wild, K. D., see Vanderah, T. W., 190Williams, K., Pullan, L. M., Romano, C.,

Powel, R. J., Salama, A. I. and Moli-

noff, P. B.: An antagonist/partial ag-onist at the polyasnine recognitionsite of the N-methyl-D-aspartate re-ceptor that alters the properties ofthe glutamate recognition site, 539

Winbery, S. L., see Petropoubos, A. C., 624

Wirth, K., see Wiemer, G., 729Witte, U., see Sapp, D. W., 801Woestenborghs, R., see Bowden, C. R., 699Wolf, B., see Preston, K. L., 707

Wolfe, B. B., see Wall, S. J., 584Wolgin, D. L. and Kinney, G. G.: Effect of

prior sensitization of stereotypy onthe development of tolerance to am-phetamine-induced hypophagia, 1232

Wong, C.-S., Su, Y.-F., Watkins, W. D. andChang, K.-J.: Continuous intrathecalopioid treatment abolishes the regu-latory effects of magnesium andguanine nucleotides on Mu opioid re-ceptor binding in rat spinal mem-branes, 317

Wood, B. E., O’Connor, S. E. and Leff, P.:Adenosine 5’-(2-fluorodiphosphate)

is not a selective P2y purinoceptor

agonist in the rabbitjugular vein, 566Wood,L.J.,seeTurner,N.C., 1139

Woods, J. H., see Comer, S. D., 1051

Wright, M. R., see van der Weyde, M. P.,48

Wright, M. R., see Yeleswaram, K., 683Wu, D. L., see Cheng, P. Y., 1004Wu, E. Y., Langston, J. W. and Di Monte,

D. A.: Toxicity of the 1-methyl-4-phenyl-2,3-dihydropyridinium and 1-methyl-4-phenylpyridinium speciesin primary cultures of mouse astro-cytes, 225

Wu, R., see Bowen, W. D., 32Wy48,252, leukotriene D4 effect, gastric

emptying and secretion (monkeys),850

Xamoterol, positive inotropic effects, betaadrenoceptor subtype, right atrium

(humans), 532Xie, X.-H. and Tietz, E. I.: Reduction on

potency of selective �y-aminobutyric

acidA agonists and diazepam in CAlregion of in vitro hippocampal slices

from chronic flurazepam-treated

rats, 204Xie, Y., see Moummi, C., 409Xu, Y.-Q., Pickoff, A. S. and Clarkson, C.

W.: Developmental changes in theeffects of lidocaine on sodium chan-nels in rat cardiac myocytes, 670

Xylamine, vascular neuroeffector transmis-sion (rabbits), 231

Yamada, S., Matsuoka, Y., Kato, Y., Ki-

mura, R. and Inagaki, 0.: A sustainedoccupancy in vivo of cardiovascularcalcium antagonist receptors by me-pirodipine and its relation to phar-

macodynamic effect in sponta-neously hypertensive rats, 589

Yamamoto, R., Takasaki, K. and Nickols,G. A.: Puninergic vasoconstrictorcomponent revealed by moderatecooling in the isolate mesentenic vas-culature of Sprague-Dawley rats,1133

Yamamura, H. I., see Lai, J., 173Yamanaka, T., see Nagakawa, J.-I., 145Yamaoka, M., see Morimoto, H., 398Yamatsu, I., see Nagakawa, J.-I., 145Yasuda, A., see Igarashi, R., 1214Yasuda, H., see Togashi, H., 343Yasuda, R. P., see Wall, S. J., 584Yeleswaram, K., Rurak, D. W., Hall, C.,

Wright, M. R. and Axelson, J. E.:Phanmacokinetics and pharmacody-namics of labetalol in the pregnantsheep, 683

Yoshioka, M., see Togashi, H., 343

Zajac, J.-M., see Frances, B., 25Zalups, R. K., Gelein, R. M. and Cherian,

M. G.: Shifts in the dose-effect rela-tionship for the nephropathy inducedby cadmium-metallothionein in rats

after a reduction in renal mass, 1256

Zerkowski, H.-R., see Deighton, N. M., 532Zhang, Y., see Ramos, B. F., 559Zhou,Y.,seeChao,C.C., 19Zim#{227}nyi,I., see Mack, M. M., 1028

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