John Parkinson - Ethics and Politics in Big DataHealth Data
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Transcript of John Parkinson - Ethics and Politics in Big DataHealth Data
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Big Data for security and ResilienceChallenges and OpportunitiesJohn Parkinson
Ethics and Politics in Big DataHealth Data
CPRD
Clinical Practice Research Datalink
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MedicinesDevicesCTRegulator
BiologicsStandards& Controls
More dimensionsto data
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PHE
NHSEHSCIC
CPRDResearch
Surveillance
BI
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Unlocking the potential of NHS Patient Data in Research
Observational & InterventionalOTHER
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The Power of the 54 million
in the NHS…with25 years of coded data
Big data is high volume, high velocity, and/or high variety information
assets that require new forms of processing to enable enhanced
decision making, insight discovery and process optimization
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Data Mining( hypothesis generation)
Hypothesis Strengthening
Hypothesis Testing
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BIGTruthfulResults
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BIGTruthful, Powerful
Results
EthicsLinkageSecurity
SCIENCERisk based approach
Big Health Data Cycle
TransformData
Instance it
Listen, HearDeliver
N of 1From the BIG
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NHS DatasetsSocialCareData
LocalData
DiseaseReg.
5
NHS Audits40 Granularity
100%
I o Care8500Practices8LRNs %
Very detailedCodedrecord
2 o Care
HES+Rx
100%ICD10OPCS4Drugs
Lab Path Microb.
DeathBirthDemography
100%
National central Data - ONS
Environ.Air Poll.
Club CardData
?
Linkage on NHS#And OrPC, sex, DOB
ApprovedResearchers
ClinicalTrials
BiosamplePROs
Consented
100%PHECancerBINOCAR
Genetic data
Digital path. datafut
ure
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Triple linkage- MI -17,964nBMJ paper May 21st 2013
3188
CPRD1338074.5%
MINAP 9438, 52.5%
HES 11998, 67.9%
3532
5561
1806
12901099
1488
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GPRD- Clinical Record
Liveflag Audit seq Oper. ID sys date sys timeClintype ClinID Patient Id Consulation ID Topic Category Staff ID Event date End dateinpractice Private Medcode Data1 data2 2 4732314 000p 20050404 142154 000s 0?Oe 01aE 3qDi 1 SED002 000m 20050404 Y N 246..00 70 1481 4732337 000p 20050404 143202 000s 0?Oe 01aE 3qDi 1 SED002 000m 20050404 Y N 246..00 70 1481 4732613 000@ 20050404 151722 000s 0?Of 013O 3qEn 1 SED002 000A 20050404 Y N 246..00 105 2001 4732660 000@ 20050404 154024 000s 0?Og 00Zz 3qEv 1 SED002 000A 20050404 Y N 246..00 90 1741 4733221 000@ 20050404 173149 000s 0?Oh 03EG 3qGF 1 SED002 000A 20050404 Y N 246..00 71 1461 4733312 000@ 20050404 181118 000s 0?Oi 00eL 3qGP 1 SED002 000A 20050404 Y N 246..00 95 1461 4734735 000A 20050405 85938 000s 0?Oj 02gL 3qIS 1 SED002 000@ 20050405 Y N 246..00 80 1401 4734759 000@ 20050405 90422 000s 0?Ok 01a@ 3qIP 1 SED002 000A 20050405 Y N 246..00 78 1221 4734762 000m 20050405 90434 000s 0?Ol 00ov 3qIU 1 SED002 000j 20050405 Y N 246..00 85 1551 4734820 000A 20050405 90905 000s 0?Om 02NI 3qIZ 1 SED002 000@ 20050405 Y N 246..00 90 1601 4734829 000N 20050405 90948 000s 0?On 02wM 3qIV 1 SED002 000B 20040730 Y N 246..00 61 1231 4734842 000m 20050405 91143 000s 0?Oo 02XG 3qIb 1 SED002 000j 20050405 Y N 246..00 100 1551 4734844 000m 20050405 91158 000s 0?Op 02XG 3qIb 1 SED002 000j 20050404 Y N 246..00 102 1531 4734849 000m 20050405 91222 000s 0?Oq 02XG 3qIb 1 SED002 000j 20050404 Y N 246..00 108 1562 4734930 000Q 20050405 92235 000s 0?Or 01JH 3qIj 1 SED002 000B 20050405 Y N 246..11 78 1401 4734932 000m 20050405 92313 000s 0?Os 00Uu 3qIi 1 SED002 000j 20050405 Y N 246..00 75 1181 4734955 000N 20050405 92711 000s 0?Ot 01wo 3qIn 1 SED002 000@ 20041013 Y N 246..00 76 1401 4734960 000Q 20050405 92745 000s 0?Or 01JH 3qIj 1 SED002 000B 20050405 Y N 246..11 78 1401 4735043 000h 20050405 94227 000s 0?Ou 01bm 3qIu 1 SED002 000e 20050405 Y N 246..00 70 1201 4735087 000m 20050405 94500 000s 0?Ov 039n 3qJ0 1 SED002 000j 20050405 Y N 246..00 80 1301 4735131 000@ 20050405 95000 000s 0?Ow 001R 3qJ3 1 SED002 000A 20050405 Y N 246..00 81 1241 4735142 000h 20050405 95232 000s 0?Ox 01cH 3qJ7 1 SED002 000e 20050405 Y N 246..00 60 1101 4735224 000N 20050405 101052 000s 0?Oy 00Ny 3qJ9 3 SED002 000B 20050315 Y N 246..00 80 1301 4735297 000m 20050405 101935 000s 0?Oz 01wo 3qJL 1 SED002 000j 20050405 Y N 246..00 85 1601 4735316 000h 20050405 102047 000s 0?P0 01lN 3qJK 1 SED002 000e 20050405 Y N 246..00 70 1101 4735346 000N 20050405 102343 000s 0?P1 005p 3qJM 3 SED002 000A 20050307 Y N 246..00 66 1091 4735352 000N 20050405 102429 000s 0?P2 005p 3qJM 3 SED002 000A 20050307 Y N 246..00 64 1051 4735353 000Q 20050405 102434 000s 0?P3 01SU 3qJR 1 SED002 000A 20050405 Y N 246..11 80 1301 4735357 000A 20050405 102446 000s 0?P4 00Ul 3qJT 1 SED002 000@ 20050405 Y N 246..00 80 1402 4735400 000@ 20050405 102954 000s 0?P5 02kD 3qJU 1 SED002 000A 20050405 Y N 246..00 103 147
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100 million “active years” of data (all England one Billion) 100 billion is total number ever born/lived
Medical codes 107,000Product codes 59,000 3 Terbytes of data *6 at any one time 180 TBs in total for UK would be 2 Petabytes
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Clinical Trials
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Phase 3 to Real World
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N
Practice Filters- Post Code, LRN, CLRN, AHSN Options Modify
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CPRD Trialaviz showing where the patients are by “large population” regions
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CPRD Trialaviz viewer provides for a random series of patients who meet set criteria there record in two views- across a number of years and then magnified to a daily basis. In this case a further magnification of 1o therapy events shows what was prescribed. Any event can be hover over to understand the journey of care.
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Population
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The Power of the 54 million
with real timefast query capabilityauto run capability
algorithmic capability
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Mean Blood Pressure
Mean LDL
Fever/ microbiology
Mumps