Jeopardy!

Immunology Edition!

By: Brian Jackson, MS I

Instructions

1. Choose the category and dollar amount. The answer will appear on your screen.

2. Once you’ve answered, click anywhere for the correct question.

3. IMPORTANT: Click on the correct question to return to the board!

4. When you’re done with a section, click on the link at the bottom of the board to advance.

“IL”

Wind

Be Sensitive

I’m Cured Less than Ideal

Potpourri Cell it!

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1000 1000 1000 1000 1000 1000Click Here to advance to Double Jeopardy

Click here to return to the board.

Barely Tolerated

Innate Talents

Organs of the Body

Develop Yourself

Signal Received

Diagnosis: Immunity

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800 800 800 800 800 800

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1600 1600 1600 1600 1600 1600

2000 2000 2000 2000 2000 2000Click to advance to Final Jeopardy

Click here to return to the board.

Final Jeopardy!

Category: Immunodeficiency Diseases

Make your wagers now. After you have made your wager, click anywhere to

continue to the Final Jeopardy answer, which you will need to write down on your

own paper.

Final Jeopardy!

Category: Immunodeficiency Diseases

This named syndrome is noted by variable T and B cell populations and is caused by thymic aplasia.

(slide will advance automatically after 30 seconds)

Final Jeopardy

The correct question is...

(click anywhere to see)

What is DiGeorge’s syndrome?

Thanks for playing!

Let me know if you had problems with the program or if any of the questions/answers are wrong!

Comments are always appreciated as well!

E-mail: brianjac@gwu.edu

End Game By Clicking Here

$200 – “IL” Wind

This cytokine is secreted by T cell to self-promote development.

What is IL-2?

$400 – “IL” Wind

This cytokine promotes immunoglobulin switching to IgE.

What is IL-4?

$600 – “IL” Wind

Naïve CD4 T cells developing in the presence of IL-12 and IFN-gamma become this type of cell.

What is Th-1?

$800 – “IL” Wind

These two cytokines are responsible for the acute phase inflammation response.

What are IL-1 and IL-6?

$1000 – “IL” Wind

This molecule is expressed on stromal cells in the thymus and is required for proper T-

Cell development.

What is IL-7?

$200 – Be Sensitive

This type of hypersensitivity reaction is mediated by histamine, serotonin,

prostaglandins, and chemotactic factors.

What is a Type I ?

$400 – Be Sensitive

The hypersensitivity reaction most associated with a delay of 24 to 72 hours.

What is a Type IV reaction?

$600 – Be Sensitive

Allergens which directly enter the blood stream are most likely to cause this disease event?

What is anaphylactic shock?

$800 – Be Sensitive

Along with prostaglandins, this mediator is most prominent in the late-phase allergic response.

What is leukotrienes?

$1000 – Be Sensitive

Contact hypersensitivities destructive effects are mediated by activation of this immune

system cell type.

What is macrophage?

$200 – I’m Cured

NSAIDs block this enzyme.

What is cyclo-oxygenase?

$400 – I’m Cured

This powerful cortisol analog is a strong anti-inflammatory, but beware of side effects.

What is Prednisone?

$600 – I’m Cured

Anti-leukotriene drugs can help minimize the effects of this type of disease state.

What are allergies?

$800 – I’m Cured

Cyclosporine is this type of immunosuppressant.

What is a calcineurin inhibitor?

$1000 – I’m Cured

Monoclonal antibodies against this substance are showing remarkable ability to cause remission of rheumatoid arthritis.

What is TNF-alpha?

$200 – Less Than Ideal

The “boy in the bubble” had this type of immune deficiency.

What is SCID (Severe Combined Immune Deficiency)?

$400 – Less Than Ideal

This is an isotype switch defect with an increased amount of IgM and a decreased

amount of other Ig’s.

What is X-Linked Hyper-IgM Syndrome?

$600 – Less Than Ideal

Chediak-Higashi syndrome involves impairment within this cell type.

What are macrophages?

$800 – Less Than Ideal

This term describes the gene expression events that allow many eukaryotic

pathogens to avoid the immune response.

What is programmed gene rearrangement?

$1000 – Less Than Ideal

Influenza viruses which cause major epidemics have had this genetic event

occur.

What is antigenic shift?

$200 – Potpourri

The HIV gene which encodes the viral capsid proteins.

What is gag?

$400 – Potpourri

The absence of this molecule on antigen-presenting APCs cause T cells to become

anergic.

What is B7?

$600 – Potpourri

The BCR signaling complex is composed of an antibody and these additional trans-

membrane proteins.

What are Ig alpha and Ig beta?

$800 – Potpourri

The HIV glycoprotein necessary for viral integration.

What is gp41?

$1000 – Potpourri

Interaction of Fas with Fas ligand initiates this cellular process.

What is apoptosis?

$200 – Cell it!

This immunological cell can help eliminate cancerous cells by innate responses.

What is a Natural Killer?

$400 – Cell it!

These cells are responsible for transporting pathogens across the intestinal epithelia

layers.

What are M cells?

$600 – Cell it!

Cell responsible for the immediate allergic response.

What is Mast Cell?

$800 – Cell it!

This interaction provides the primary signal needed by mature B cells for activation.

What is Ab : Ag?

$1000 – Cell it!

One of two co-receptors HIV uses to adhere to CD4-containing host cells.

What are CXCR4 or CCR5?

$400 – Barely Tolerated

The name for sites where antigens are kept separate from most lymphocytes to

prevent an immune response.

What are immunologically privileged sites?

$800 – Barely Tolerated

This is the most important genetic factor involved in autoimmune disease

pathogenesis.

What is MHC type?

$1200 – Barely Tolerated

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy

involves a genetic defect in this gene.

What is the AIRE gene?

$1600 – Barely Tolerated

This molecule negatively regulates T cell activation, and mice without this molecule

have a lethal autoimmune lymphoproliferative syndrome.

What is CTLA-4?

$2000 – Barely Tolerated

Lymphocytes that persistently receive a primary stimulatory signal without a co-stimulatory signal are likely to end up in

this inactive state.

What is anergy?

$400 – Innate Talents

These two complement molecules are chemoattractants for additional

lymphocytic infiltration.

What are C3a and C5a?

$800 – Innate Talents

CD8+CD4- T-cells are associated with this type of MHC Complex.

What is MHC Class 1?

$1200 – Innate Talents

Toll like receptors are an example of receptors that bind these molecules.

What are PAMPs (pathogen associated molecular patterns)?

$1600 – Innate Talents

C3b is this type of molecule that enhances phagocytosis.

What is an opsin?

$2000 – Innate Talents

This enzyme is primarily responsible for the oxidative burst in macrophages.

What is NADPH oxidase?

$400 – Organs of the Body

This immune system organ is made up of red pulp and white pulp.

What is the spleen?

$800 – Organs of the Body

The two immune organs designated as “primary.”

What are the bone marrow and the thymus?

$1200 – Organs of the Body

The T-Cell zone within the spleen that surrounds certain blood vessels.

What is the periarteriole lymphoid sheath?

$1600 – Organs of the Body

This lymphatic vessel empties into the left subclavian vein or the left jugular vein.

What is the thoracic duct?

$2000 – Organs of the Body

Areas of enhanced lymphocytic activity in the submucosa of the small intestine are

called these.

What are Peyer’s patches?

$400 – Develop Yourself

B cell development is completed in this organ.

What is the bone marrow?

$800 – Develop Yourself

Most T-cell receptors are made up of these two chains.

What are alpha and beta?

$1200 – Develop Yourself

Receptor editing (additional chain rearrangements) occurs in this type of cell

only.

What are B cells?

$1600 – Develop Yourself

Immediately prior to lineage commitment as CD4 or CD8 cells, T-cells are called this.

What are double positive T cells?

$2000 – Develop Yourself

The principle that there is only one type of receptor per one lymphocyte is called this.

What is allelic exclusion?

$400 – Signal Received

Found in pentamer form, this is the first type of immungloublin produced by B cells.

What is IgM?

$800 – Signal Received

Cytotoxic T-cells use this three-lettered receptor and its ligand to kill infected cells.

What is fas?

$1200 – Signal Received

The process of changing from producing IgM to producing other immunoglobulins is

called this.

What is isotype switching?

$1600 – Signal Received

Interferon gamma is most associated with this type of T cell.

What is a Th1 cell?

$2000 – Signal Received

Cells with these two CD numbers regulate T cells by secreting IL-10 and TGF-beta.

What are CD4/CD25?

$400 – Diagnosis: Immunity

This ABO blood type is the universal donor?

What is O?

$800 – Diagnosis: Immunity

ThoGAM is this type of antibody against Rh antigen.

What is IgG?

$1200 – Diagnosis: Immunity

A direct Coombs test detects antibodies bound to this type of cell.

What is a red blood cell/erythrocyte?

$1600 – Diagnosis: Immunity

A type IV delayed hypersensitivity reaction is used in a skin test for this disease.

What is Tuberculosis?

$2000 – Diagnosis: Immunity

A vaccine for HPV may help to prevent this type of cancer.

What is cervical cancer?

The End!