OverviewPresenta-on11thFebruary2016

JellyfishCollagenBiomaterialsNextgenera-oncollagenforcellcultureand

med-techproducts

JellagenPtyLtdOverview

•  Jellagenisanextgenera-oncollagenbiomaterialscompany

•  Tobetheleadingproducerintheglobalsupplyofhighqualitymedicalgradejellyfishcollagenproductstothecellculturereagentandmeddevicemarkets

•  Marketlookingforalterna-vetobovine/porcineinsomeapplica-ons

•  Ade-riskedbusinessmodel:CollagenusedinFDA/EUapprovedmed-deviceproducts

•  JPL’sproductsonmarketandgenera-ngearlyrevenuesincellculturemarket

•  Successfullysecuredprivateandpublicsourcesoffinancetoenablecollabora-onswithindustryandacademiatode-riskproductdevelopment.

CollagenANaturalBiomaterialPolymer

•  AkeyproteincomponentoftheExtraCellularMatrix(ECM)

•  Highlyconservedacrossawidevarietyofspecies

•  Triplehelicalscaffold

•  Thetriplehelixmayconferstability(strength&elas-city)

•  Predominantmarketsourcesfrombovine&porcine

•  Usedinawiderangeofmed-device&-ssueengineeringapplica-ons

•  Jellyfishserveasanidealsourceofcollagen

MarketNeedAtrendtowardssaferalternatesources&types

KeyBenefits

•  Nextgenera-oncollagen

•  Nonmammalian&Diseasefree(BSE)

•  Lowimmuneresponse–equivalenttobovinecollagen

•  Materialallowsforefficientnutrientuptakeandoxygensupplytocells

•  Conservedstructuralproteinwithdecadesofprecedenceofmedicaluse

•  Naturallysourcedproduct

Targetjellyfishspeciesrichincollagen–BarrelJellyfish

CompanyOverviewAtaglance

Opera-onalsinceAugust2013–5FTEs

•  Focus: SourcingandprovisionoffuncEonaljellyfishcollagenbiomaterial

•  Products: Cellculture(2D&3D),regenmed/-ssueengineeringandmedicaldevices

•  Markets: Mul--billiondollargrowthmarkets

•  KeyUSPs: NextGenera-on,non-mammalian,nondisease&technicaladvantages

Offersnextgenera-onofcollagen

HeadquarteredinPembrokeshire,Wales

BusinessModel

Harves-ngjellyfishblooms

ProcessingtoGMP/ISOGradecollagen

(9001,10993,22442,13485)

CollagenBulkmaterials

MedicalDevices

R&D/ProductDevelopment

Deriskedmodel

CellCultureProducts

HIGHRISK

LOWRISKProducts

Productdevelopment/salesManufacturing

Harvest

Establish Quality Management systems

ProductPipeline

JellagenProductPipeline R&D Prototype Development OnMarket

CellculturereagentsSoluble&DriedCollagen

3DScaffolds(Hydrogel&Sponges)Bio-mime-cscaffolds

GMPAccreditedproductsGMP/ISOgradecollagen

MedicalDevicesWoundcare(chroniculcer)

HaemostasisCar-lageRepair

CurrentProductsFunc-onalna-vecollagen

ProductSpecificaEon•  ResearchGradeMaterials•  Func-onalna-vejellyfishcollagen

•  Preserva-onoftriplehelicalstructure&func-on•  Suppliedinsolu-onorasdriedcollagen•  BSE&diseasevectorfree•  Solublecollagenavailableas>3mg/ml:•  Suitablefor:

•  2Dand3Dcellculture•  Cosme-cingredient•  Tissueengineering•  Electrospinning•  Regenera-vemedicineresearch

CurrentProductsCellculturereagents

Na-vecollageninsolu-onordried

Collagenspongesfor3Dcellculture

Collagenbiomaterialcoa-ngs

MedicalDeviceProductDevelopmentNano-EngineeredbiomimeEcmedicaldevices

Useofelectrospinningtoproducenano-fibrematsusingjellyfishcollagen

Jellyfishcollagen

ThescaleofthefibresiscommensuratewithnaturalECMsoidealforcellgrowth.

ApplicaEonsCellculture

Collagenmats

Tissueengineering

Biomaterialcoa-ngs

Wounddevice

Bone/dentaldevice

Jellyfishcollagenelectrospunbiomime5cmat-Chrondocyteshownembedded100nm–200nmfibres

IntellectualPropertyWoundcare&diagnos-cs

Inven-on(UKPatent1506236.7)coversanovelmethodtofunc-onalisecollagenforwoundhealingdevelopment

Title Patent or KnowHow

Filedifapplicable

MODIFIEDCOLLAGEN,METHODSOFMANUFACTURETHEREOF

UKPatent1506236.7

FiledApril2015

Collagenextrac-on Know-How PatentApplica-onDueforfilingQ1-2016

Collagen3DCellCulture

Know-how DataunderreviewforpatentsubmissionQ1-2016

Collagenscaffolds Know-How Dataunderreviewforpatentpossibili-es

SummaryWhyJellagen?

•  Productsonmarketandgenera-ngearlyrevenues

•  De-riskedandevolvingbusinessmodelwithglobalreach(US,MiddleEast,EU&Asia)•  Interestfromlargecorporatesprovidingcredibleroutestoglobalmarkets

•  IPcoveringcollagenchemistryandprocessmanufacturing

•  NewIP(andproducts)indevelopment

•  >60yrscombinedmanagementexperienceinsales,manufacturing&commercialexploita-on

•  Opentocollabora-onwithcommercialpartnerstosupportnewproductdevelopment

Acknowledgements

ThankYou

andrew@jellagen.co.uk

www.jellagen.co.uk

+44(0)3333583299