ISOT NEWSLETTER 2nd issue 2015.cdr

Issue No. 2 May – August, 2015

Dear colleagues and friends

Greetings from Lucknow. Hope you had received the first issue of ISOT Newsletter in time and liked its content and the production standards. Shall

look forward to your sugges t ions and ideas as to how we can make it more worthy, content and communication wise. I am thankful to all of you in making this

effort of mine, a grand success.

The second issue of ISOT Newsletter is now in your hands covering some important scientific articles and happenings and news of Indian transplant world, in its own humble way.

On page 2 onwards you will find thScientific Program of 26 Annual

Conference of Indian Society of Organ Transplantation, to be held on 2 - 4 October 2015 at Chennai. The details

of Nominations / Applications for ISOT Orat ion Awards and Fellowship, are also given on ..... page. You are requested to submit your applications for the same by 25th August 2015.

Your feedback is important in addressing the various issues

faced by the transplant community at large and the Indian Society of Organ Transplantation in particular.

Sincerely yours,Narayan Prasad

ISOTNewsletterAn official Quaternary Print Communication of Indian Society of Organ Transplantation for its members only

Editor’s Note

Designed and printed by Alpana Productions, Lucknow on behalf of its Editor, Prof Narayan Prasad, Secretary, Indian Society of Organ Transplantation (ISOT), Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, 226 014 UP, INDIA.

Send inYour News,Views & Reviews

Gujarat University Of Transplantation Sciences (GUTS)

Ahmedabad Gets The First Transplant Varsity Of WorldThe long cherished dream of Prof. H.L. Trivedi, was at last realized in May, 2015 with the creation of a University of Transplantation Sciences at Ahmedabad which happens to be the World’s first.

The Notification to the effect was issued by Department of Health and Family Welfare, Government of Gujarat, on 29th April, 2015 and “Gujarat University Of Transplantation Sciences” (GUTS) started functioning from 1st May, '15 with Prof. H. L. Trivedi the founder – Director of IKDRC-ITS, as its first Pro-Chancellor and Prof. Veena R. Shah, the Deputy Director and HOD Anesthesia and Critical Care of IKDRC-ITS, as its first Vice Chancellor.

Prof. Kamal V. Kanodia, Prof. of Dept. of Pathology, Lab Medicine, Transfusion Services and Immunohematology of IKDRC-ITS, was appointed its first Registrar.

GUTS would be a non-affi l iating University and will have its constituent, recognized or approved colleges or schools in future.

The mission of the University is to serve as an academic and research nucleus to these specialties to improve the clinical, scientific, and social aspects of Transplantation m a k i n g i t a c c e s s i b l e a n d

affordable to population at large giving them healthy and productive lives. Different specialty, super-specialty and paramedical courses will begin from this academic year.

The website www.guts.education has also been launched. g

2ON PAG

E Scientific Program : th 26 Annual Conference

of Indian Society of Organ Transplantation,

, Chennai2 - 4 October 2015

ISOT Newsletter 3May to August 20152 ISOT Newsletter May to August 2015

Plenary & Renal Scientific Programme

nd2 October 2015

08:30-11:00

Time Topic

Histo-Compatiblity Testing for the clinician - 20 mins

JM Patel Oration - 30 mins

Antibody mediated allo-immune responses - 30 mins

Surrogacy in immune surveillance - 20 mins

08:00-09:00 Registration

11:00-11:20 Tea / Coffee Break

13:00-13:45 Lunch Break

16:00-16:15 Transplantation in abnormal bladder - 15 mins

PLENARY EVENING

13:45-15:00

UTI in diabetic renal transplant - 15 mins

BKV - 15 mins

Genomics - 15 mins

Isurgical cause of UTI - 15 mins

Resistant MDR bugs - 15 mins

Symposium - 75 minsUrinary Tract Infections Post Transplant

16:15-18:00

Making Renal Transplantation Affordable - 20 mins

18:30 Inuguration Hall A - Cultural Program

RVS Yadav Oration - 25 mins

Donation after cardiac death - 20 mins

Are we ready to come in from the cold? - 20 mins

Organ Preservation and Perfusion :In the cold light of day ice is king - 20 mins

15:00-16:00Difficult Case scenarios- Nephro - Uro Related to Transplant - 30 mins (6 cases each 10 mins)

11:20-12:15

Immunology perspectives - 15 mins

Pathological perspectives - 15 mins

Nephrology perspectives - 15 mins

Discussion - 10 mins

12:15-13:00

Desensitization Coming of Age - 20 mins

Handling patients with positive cross-match in Indian context

Discussion - 5 mins

Symposium on ABO incompatible Transplantation - 50 mins

l Basic Science - 11 mins

l Heart and lung – 13 mins

l Liver – 13 mins

l Kidney – 13 mins

Concurrent session LIVER, HAND, PATHO and TID

Late Kidney Allograft failure (55 mins)

Proposed Pre Conference Workshop

Time Topic

14:00-15:00

Pediatric Transplantation - 15 mins each

l The Future of Immunosuppressive Therapy in

Children after SOT

l Pediatric organ donation

l Surgical challenges in Pediatric Transplantation

l Application of novel biomarkers in pediatric transplant

16:15-17:15

Post transplant problems orientation - 15 mins each

l Post transplant diarrhoea

l Vaccination in solid organ transplant recipient

l Post transplant metabolic syndrome

l Post-transplant HUS

15:00-16:00

Immunology Perspectives - 15 mins each

l Influence of Ischemia Reperfusion Injury on immune

system:

l Non-complement Fixing and Non-HLA Antibodies in

kidney transplantation

l Immunologic Issues in Deceased Donor

Transplantation

l Evolution of the Clinical Application of Stem Cells


Cases Discussion (3 Nephrology and 3 Urology cases)

Role of registry in transplantation: Noble Gracious, Trivandrum

17:15-18:15

18:15-18:30

st1 October 2015

Dear Delegates,

Greetings from the Organizing Committee of the 26th Annual Conference of Indian Society of Organ Transplantation. It is our proud privilege to make the first announcement of this Conference and welcome you to Chennai.

The venue and dates for the conference have been finalized. Chennai is hosting this conference after 17 years and many, who attended the last conference, will remember it with some fond memories. Do check out the website to see images from the 1997 conference and take a walk down memory lane.

The current organizing committee will try and match the hospitality of the 1997 conference and ensure that the scientific content of the meeting is of the highest quality. The committee will do its very best to bring together leading national and international faculty for the conference. Our endeavor will be to ensure that the delegates get the best value of their time and money. Making this conference a memorable experience is one of the highest priorities of the organizing committee.

Chennai is the gateway for exploring 'South India' and there are many interesting and historical places to visit. Please plan your visit well in advance to enjoy your stay in this part of the world.

Please remember that 'Early Bird' enjoy discounted registration.

Yours truly,

Dr. Sunil Shroff Dr. Georgi AbrahamOrganizing Secretary Organizing Chairman

Chennai 2nd to 4th October 2015

26TH ANNUAL CONFERENCE OF INDIAN SOCIETY OF ORGAN TRANSPLANTATION

Dr. Georgi Abraham Dr. Sunil Shroff

Who Should Attend

The congress will have sessions related to kidneys, liver, heart, lungs, hand, skin donation and transplantation. It aims to brings together - Transplant Physicians, Transplant Surgeons, Transplant Scientists, Transplant Pathologists, Transplant Immunologists, Transplant Coordinators & Nurses and Other transplant professionals

Workshops On

Interventional Nephrology

Transplant Coordinators

Transplant Immunology

Transplant Pathology

Abstract Online: http://www.isot2015.com/abstract.asp

Registration Online: http://www.isot2015.com/register.asp

Registered delegates will enjoy all the benefits of the conference, however this cannot be guaranteed for spot registration. Delegates will receive a comprehensive 'Conference Kit' along with other benefits such as lunch, dinner and beverages.

Registrations also get a free entry to the 'Trade Fair' organized to display the latest products from the Pharma Companies.

Secretariat for ISOT 2015 Conference

MOHAN Foundation, 3rd Floor, 267 Kilpauk Garden Road, Chennai 600010, India Tel +91-44-26447000/+919444607000

Email: [email protected]/[email protected]

Overview of Scientific Program

11:15-16:0045 minutes

Lunch Breakwithin

session

16:15-17:45

16:30-18:30

18:30

Day 1nd2 October 2015

Registration

Coffee Break

Coffee Break

Plenary Session

Plenary Session

Inauguration Entertainment &Inaugural Dinner at Venue

Concurrent Sessions

l Kidney

l Liver, Pancreas and small bowel

l Heart and Lung

l Infections In Transplant

l Immunology and pathology

Day 2rd3 October 2015

Instruction Course

Registration

Coffee Break

Coffee Break

Plenary Session

Plenary Session

Banquet / Gala Entertainment on the beach

Concurrent Sessions

l Kidney

l Liver, Pancreas and small bowel

l Heart and Lung

l Infections In Transplant

l Transplant Coordination

l Reconstructive Transplant

Day 3th4 October 2015

Coffee Break

Coffee Break

Plenary Session

Public Event on Organ Donation

End of Conference

Registration

Instruction Course

Concurrent Sessions

l · Kidney

l Critical care and anaesthesia

l Paper Presentations

l Transplant Coordination

Time

07:00

08:00

08:30-11:00

ISOT Newsletter 5May to August 20154 ISOT Newsletter May to August 2015

Plenary & Renal Scientific Programme


rd3 October 2015 - Day Two

Time Topic

Session 1 : Intestinal failure & bridge to Transplantation - 25 Mins each

l Marginal Donor & Recipient – How Do We Balance

l Is it Renal failure, AKI or HRS?

l ??????

11:15-12:30

Session 2 -

l Nutrition in liver failure patients - 25 Mins

l Setting Up A Liver Transplant Program -

Lessons for Young Surgeons - 15 Mins

l Free Paper Presentation - 1 hour 20 Mins

14:00-16:00

Session 3 - 15 mins each

l Who Needs It?

l Preoperative OptimizationSurgical

l Challenges in Paediatric Liver Transplantation

l Nuances in Postoperative Care of Paediatric Liver

Transplantation

16:15-17:15

07:30-08:15

12:30-13:15

13:15-14:00

Pump Workshop

General Body Meeting

Lunch Break

INSTRUCTION COURSE: Setting up a basic science research lab - 15 mins each

l Legal considerations

l Scope of basic science research

l Applying for grant

nd2 October 2015 - Day One

Time Topic

07:30-08:15

SESSION: 1 - Acute Liver Failure Session - 30 mins each

l Various faces of ALF

l Acute Liver drug toxicity

l Hepatocyte transplant in ALF

l Auxillary Liver Transplantation

11:15-13:15

SESSION: 2 - 15 mins each

l Tricks of trade in LDLT

l Posterior Sector LDLT

l Live donor liver tx Robotics

l Minimal Invasive Donor hepatectomy

14:00-15:00

SESSION: 3 - 30 mins each

l HCC with vascular invasion – Down staging &

Impact on Transplant - Transplant or no Transplant

l Liver Transplant In Acute Alcoholic Hepatitis:

To do or Not To do

15:00-16:00


Concurrent Session Liver

SESSION: 1 - Immunology/Basics of Heart Transplantation

l Immunology of antibody mediated rejection

- 20 mins

l Non biopsy markers of rejection - 20 mins

l Inducing Immunological Tolerence and Accomodation

in Heart Lung Transplants - 30 mins

11:15-12:25

SESSION: 2 - Lung Transplant

l Current outcomes in lung transplants in Australia

- 20 mins

l Lung Transplant - Our experience - 20 mins

l Outcomes of VV ECHMO - 25 mins

12:25-13:30

SESSION: 3 - PRO versus CON Debates

l LVAD vs Heart Transplant - 20 mins

l ECMO followed by Heart Transplants - 20 mins

l CNI free immunosuppression protocols - 20 mins

SESSION: 4 - Symposium on Interesting Cases

l 6 Cases

14:00-15:00

15:00-16:00


Time Topic


Concurrent Session Heart & Lung

SESSION: 3 - Technical issues in Heart Transplant

l Operative challenges in heart transplant - 20 mins

l CABO incompatible heart transplants - 20 mins

l Challenges of perioperative management and

intensive care - 20 mins

SESSION: 2 - Recipient and Donor issues in Heart Transplant

l The Canadian National Transplant program – learning

experience - 20 mins

l Challenges of transport of sick patients for heart

transplant - 15 mins

l Donation after Clinical death - 25 mins

14:00-15:00

15:00-16:00

SESSION: 1 - Clinical Assessment

l Pre Transplant Preparation - Workup and clinical

approach to Heart Failure/Heart Transplant patients- 20 mins

l Pediatric Heart Failure - Indications and clinical

workup prior to tx - 30 mins

l Mechanical assist as a bridge to Heart Transplant

- 30 mins

l Use of organ care system in Tranporting donor heart

and lung - 20 mins

11:45-13:25


Time

11:15-11:30

11:30-11:45

Topic

Overview and challenges facing Heart Transplantation in India

Organ Donation Scenario in India with special reference to Tamil Nadu


nd th2 to 4 October 2015, Chennai, India

CONTACT: Tel: +91 44 26447000 / +91 9444607000Email: [email protected] / [email protected]

www.isot2015.com


12:15-13:15

13:15-14:15

FREE PAPER PRESENTATION

15:25-16:25 6 interesting cases from nephrology side

16:25-17:00 Debate : To deplete vs Not to deplete

17:00 Valedictory and Public functions

11:15-11:45

11:45-12:15

Paired kidney exchanges:-an idea whose time has come? Indian perspective - 15 mins International Perspective - 15 mins

Debate : Minimization versus Avoidance Avoid CNIs - 15 minsMinimize CNIs - 15 mins

14:15-15:25

Lunch Break - Symposia

Well begun is half done - The rationale for induction therapy - 20 minsSteroid avoidance in Renal Transplantation - 20 mins Renal transplant in Diabetics - 15 mins Renal transplant in elderly - 15 mins

th4 October 2015

Time Topic

08:30-11:00

Still the enemy within - Post transplant lympho proliferative disease - 20 mins

Long term survival of renal allografts - 20 mins

Role of transplant ID physicians - 20 mins

Timeline of infections In SOT recipients - 20 mins

Dr. K N Udupa Memorial Lecture - 20 mins

Vidya Acharya Memorial Oration - Anti body mediated rejection - 30 mins

Tolerance from the lab to bedside - Birgit Sawitzki, Berlin- 20 mins

Time Topic

08:30-11:00

Logistics challenges and “Jugaad” in deceased organ donation and transplantation in India - 3 cases - 20 min

Improving the deceased Donation rate in Pennsylvania/Philadelphia - Gift of Life Model - 20 min

ITHO Act - 2011 - What is Good & What is bad what the clinicians should know? - 20 min

All hands on Deck – First Dual hand Transplantin India - 20 mins

Pancreas transplantation in India - Coming of Age - 20 mins

PLENARY EVENING



12:45-13:45 General Body Meeting

13:45-14:30

Lunch Break - Symposia

19:30 Cultural Evening

12:15-12:45Debate - 30 minsOpen - 15 mins Robotic Transplant -15 mins

Mtor inhibitors- where to place as immunosupression -15 mins Post transplant fungal infection - 15 mins Discussion - 15 mins

11:15-12:15FREE PAPER PRESENTATIONConcurrent session in other Halls

17:00-17:20Hepatitis C - New kids on the block making a difference - 20 mins

14:30-15:50

Complications in transplantations - Symposium - 80 mins

l Post-transplant anemia - 15 mins

l Recurrence of Ds post transplants - 15 mins

l New onset diabetes after Transplantation - 15 mins

l Malignancies Post transplantation - 20 mins

l Challenges posed by repeat KTR - 15 mins

17:20-18:20

Deceased Organ Donor - Symposium - 60 mins

l ECD in Deceased Donor Transplantation

l Perfusion, Packing the Organ for Transportation & Documentation

l Creatinine high on donor Kidney - to take or not to take:

l Multivisceral Transplantation for Slow Growing Abdominal Tumours: Sepsis in deceased donation

16:00-17:00

Kidney transplants - Surgical Case Discussions - 60 mins

l Graft Kidney with injuries & lesions - to take or not

l Perfusion & Bench Dissection for Donor -

How much to do & How to do.

l Making Right kidney transplantation easier -

What to do: Philips Thomas

l en bloc kidney transplantation:

l Drop in urine output post transplant - on table, after

closure after 3 hrs, after 24 to 48 hrs, after 5th day

rd3 October 2015

Presidential Talk - 30 min

4 ISOT Newsletter ISOT Newsletter 5May to August 2015May to August 2015

Concurrent Session Infections in Transplantation

11:15-12:15

Panel Discussion l Spectrum and epidemiology of Invasive fungal

infections in Indial Risk Stratification / Prophylaxis

l Diagnosis

l Management strategies

14:30-16:00

Panel Discussion - Tuberculosisl Pretransplant screening and Prophylaxis

l Treatment of acute tuberculosis on Immuno-

suppression with special reference to OLT recipientsl Considerations in the era of MDR and XDR TB


Time Topic


11:15-11:45 Pre transplant screening and vaccination

08:00-08:30Management of febrile neutropenia in the era of multiresistant bacteria

08:30-09:15Types of stem cell transplants and implications for infection

09:15-09:45 Infections in HSCT recipients- Indian data

09:45-11:00 Panel Discussion-Cases in Hem-Onc or HSCT recipients

11:45-13:15

Panel Discussionl Advances in Microbiology to help the transplant

physicianl Role of gene sequencing

l PCR based platforms for respiratory viruses and

bacteria

16:45-18:15

Panel Discussion - Approach to CMV viruses l Serological testing

l CMV Prophylaxis in India

l CMV Treatment and resistance

l Management of blips: when to start and stop

l Immune monitoring



14:00-14:30 Infection control in transplant

14:30-15:15 Antimicrobial prophylaxis in solid organ transplantation

15:15-16:00 Clostridium difficile-epidemiology & management options

16:15-16:45 Safe living after transplantation



16:15-18:00 Panel Discussion - Cases in SOT recipients


Time Topic

07:30-08:30

10:00-11:00

MDR Gram negatives - microbiology and management perspectives

Plenary 1: Role of an ID physicians in the transplant teamPlenary 2: Timeline of infections in SOT

12:15-13:15

13:15-14:00

14:00-14:30

General Body Meeting

Lunch Break

Influenza in transplant recipients

Concurrent Session Reconstructive & Hand Transplantation

11:15-12:15

Panel Discussion - Basic issues in Reconstructive Transplant

l Donor and recipient selection criteria

l Ethical , legal and psychological issues

l Pre op Preparation , counseling and informed

consents

14:00-14:40

14:40-15:40

15:40-16:00

Logistics

l Setting up a skin bank

l Setting up hand and face transplant program

16:30-17:30General Body Meeting

ISRT (Indian Society for Reconstructive Transplant)

Debates

l Cost effectiveness of reconstructive transplant

l Present and Future and beyond hand and face

l Outcome and life after reconstructive transplant

l Role of nurses in reconstructive transplantation

surgery

l Role of Transplant co ordinators and grief counselors

in reconstructive transplant

12:15-13:15

Symposium

l Donor Organ procurement and preparation of hand

l Surgical techniques of hand transplant

l Surgical techniques of face transplant

l Immunosuppression and regulation of drugs

l Post transplant monitoring and protocol/guidelines

l Rehabilitation after transplant surgery


rd3 October 2015

Time Topic


Concurrent Session Critical Care & Anaesthesia in Transplantation


14:00-16:00 Session IV : Critical Care

SESSION: 1 - Heart & Lung Transplant - 20 mins each

l Pre operative workup of Heart Transplant patients

l Anaesthetic Challenges of heart Lung block

Transplant

l Anaesthetic Challenges in VAD placement and Role of

TEE

l Heart Transplant from DCD donor.

09:00-10:20

SESSION: 2 - Liver Transplant - 20 mins each

l Recent updates on Coagulation monitoring and How

to optimize coagulation to minimize transfusion (Role of Anti-fibrinolytics, Factor VIIa, PCC etc)

l Marginal livers: The challenges for the anaesthetist!

l Management of patients with Pulmonary

Hypertension

l Choice of intra operative IV Fluids in the Cirrhotic

patients.

10:40-12:00

SESSION: 3 - Kidney/ Multi visceral/ Bowel Transplant - 20 mins each

l Recent advances in anaesthesia for Kidney

Transplantation.

l Challenges for the anaesthetist in Multi Visceral

Transplant

l Reperfusion Syndrome: Preparation and the

Challenges!

13:00-14:00

14:20-15:00

Panel Discussion

l What is stopping intensive care to certify somebody

brain dead and introduce organ donation?

l Systemic hinderances

l Medicolegal issues

14:00-14:20Management of Brain stem dead donor.: Challenges in family counselling and Role of protocols in the Intensive Care Unit for optimization of Organs.

15:00-15:20

15:20-15:40

15:40-16:00

Debate - Fast Tracking extubation in Liver transplant Recipients: PROS/CONS

Sepsis & Rejection in the early Postoperative period- Challenges in the diagnosis and treatment

Role of TEE for pre-operative assessment, intra operative and postoperative uses

th4 October 2015

Time Topic

Concurrent Session Transplant Pathology & Immunology



Time Topic

SESSION: 1 - Liver & Heart Transplant Pathologyl Approach to liver allograft dysfunction - 20 mins

l Recurrent diseases in liver allograft - 20 mins

09:00-11:00

SESSION: 2 - Transplant Pathology l Nephrologists' perspective: Renal biopsy in graft

dysfunction - 20 minsl Diagnosis of border line and acute T cell mediated

rejection with Banff schema- 20 mins l Acute antibody mediated rejection- 20 mins

l Diagnosis of Chronic active antibody mediated

rejection and Transplant glomerulopathy - 20 minsl Drug induced changes in renal allograft biopsy

- 20 minsDiscussion - 10 mins

11:15-13:0511:15-13:05

14:00-15:00

SESSION: 5 - Transplant Immunologyl Role of HLA in Allograft Monitoring - kidney, liver,

heart - 15 minsl Overview on DSA testing modalities and its clinical

significance in renal transplantation - 15 mins l Transplantation tolerance - 15 mins

l Urinary and plasma biomarkers in renal allograft

rejection - 15 mins

16:15-17:15

SESSION: 4 Case Discussions-Renal allograft biopsiesCase – 1 Ac T Cell Rej Case – 2 ABMRCase – 3 TGCase – 4 CNI TxCase – 5 Rec GNCase – 6 Post Tx infection (8min case +2 Min discussion)

15:00-16:15


Case DiscussionsCase based approach to 1 Acute liver allograft dysfunction - 2 cases 2 Chronic liver allograft dysfunction - 2 cases

Discussion

SESSION: 3l Recurrent diseases in renal allograft - 20 mins

l The role of electron microscopy in renal graft

dysfunction - 20 minsl Histological diagnosis of infections after renal

transplant - 20 mins

1. Ramkrishna Math, Chennai2. Valluvar Kottam, Chennai

1 2

3. MGR Memorial, Chennai4. Vivekanad Rock Memorial, Kanyakumari5. Velankanni Church, Chennai6. Meenakshi Temple, Madurai

3

4

5 6


Prof Manikkam Suthanthiran The NewYork-Presbyterian-Weill Cornell Medical Center (NYP-WCMC)

Dr Ira J Fox MD McGowan Institute for Regenerative Medicine

Mr Howard M Nathan Gift of Life Donor Program Philadelphia, PA

Dr Manjula Balasubramanian Einstein Medical Center Philadelphia, PA

Dr Victor Navarro Jefferson Medical College Philadelphia, PA

Prof Gurch Randhawa Professor of Diversity in Public Health and Director, Institute for Health Research, University of Bedfordshire

Prof Hariharan Iyer Schulich School of Medicine & Dentistry, London Health Sciences Center, Western University, London, Ontario, Canada

Prof Birgit Sawitzki Institute of Medical Immunology at the Charité University Hospital in Berlin

Prof Chandrasekar P H Karmanos Cancer Institute Detroit

Prof Ajit P. Limaye University of Washington, Seattle, USA

Prof George Alangaden Wayne State University Infectious Diseases, CFP-316

Dr Mayur S Ramesh Henry Ford Hospital 2799 West Grand Blvd

Prof Amitabh Gautam Boston Medical Center

Dr Nithya Krishnan University Hospitals Coventry and Warwickshire NHS Trust, U.K

Dr Anirban Bose Associate Professor of Medicine and Nephrology at the University of Rochester, NY

Dr George T John Senior Consultant in Renal Medicine at the Royal Brisbane and Women's Hospital, Australia

Dr Chandraker A Medical Director of Kidney and Pancreas Transplantation and Director of the Transplant Research Center at Brigham and Women's Hospital/Harvard Medical School

Dr Rodrigo Vianna University of Miami/Jackson Memorial Hospital, Miami, US

International Faculties ISOT 2015

A Huligol Bangalore

A K Barman Guwahati

A K Bhalla New Delhi

A K Vaidya Ranchi

A Khakhar Chennai

A Majumdar Kolkatta

A Murali Chennai

A Murthy Hyderabad

A S Soin Gurgaon

Abha Nagral Mumbai

Abhay Mahajan Aurangabad

Abraham Kurian Chennai

Aditya Pradhan Chennai

Ajay Chennai

Alan Almeida Mumbai

Alok Kumar Dehradun

Amalopavanathan J Chennai

Amit Gupta Lucknow

Amresh Mumbai

Anand Khakar Chennai

Anand Ramamurthy Chennai

Anant Kumar Delhi

Aneesh Srivastav Luchnow

Anil Vaidya Chennai

Anila Abraham Chennai

Anita Cherian Thiruvananthapuram

Anita Dinda Chennai

Anupam Saha New Delhi

Anupam Sibal New Delhi

Anusha Rohit Chennai

Archana Rastogi Delhi

Aroghya Majumdar Kolkata

Arpita Roy Chaudhary Kolkata

Arti Vij Delhi

Aruna Vanikar Ahmedabad

Arvind Bagga New Delhi

ASatish LaL Madurai

Ashok Kirpalani Mumbai

Balajee Chennai

Balaraman Chennai

Bhanumati Vellore

Bharat Shah Mumbai

Bhattacharya Chennai

Biju George Vellore

Biju Pottakat Pondicherry

C E Eapen Vellore

C M Thiagarajan Chennai

C R Kar Bhubaneshwar

Chandrasekhar Chennai

Chitra Madiwale Mumbai

Col Gopi Delhi

D K Pahari Kolkata

D Ramesh Bangalore

D S Bhadauria Lucknow

D S Rana New Delhi

Daphnee Chennai

Deepak Dubey Bangalore

Dharmesh Kapoor Hyderabad

Dilip Dhanapal Bangalore

Dinesh Babu Chennai

Dinesh Jothimani Chennai

Dinesh Khullar New Delhi

Dipankar Bhowmik New Delhi

Diwakar Chennai

Dolly Daniel Vellore

Edwin Fernando Chennai

Firoz Sonawala Mumbai

G H Mallik Srinagar

G Karthikeyan Chennai

Ganapathy Chennai

Ganesh Gopalakrishnan Coimbatore

Gangadhar Reddy Hyderabad

Geeta Billa Mumbai

Geetha Kalpana Chennai

George Chandy Chennai

George Kurian Pondicherry

George M Varghese Vellore

Georgi Abraham Chennai

Gokulnath Bangalore

Gomathy Narasimhan Chennai

Gourdas Choudhuri Gurgaon

H S Kohli Chandigarh

Harsh Jauhari New Delhi

Hemal Kaninde Chennai

Hemant Kumar Patna

Himanshu Mahapatra New Delhi

Ilamparuthi Chennai

Ilannkumaran Chennai

Imtiyaz Ahmed Srinagar

J P Ojha Varanasi

J P Tiwari Goa

J Thanka Chennai

Jacob George Trivandrum

Jai Kumar Chennai

Jai Ram New Delhi

Jamal Rizvi Mumbai

Jayakumar Chennai

Jayant Thomas Mathew Thrissur

Jayaraman Chennai

Jerry Paul Chennai

Jimmy Cochin

Jitendra Kumar Faridabad

Jitin Kothari Mumbai

Jose Chako Pariappan Cochin

Joseph John Ludhiana

Joy Michael Vellore

Joy Varghese Chennai

K C Prakash Chennai

K L Gupta Chandigarh

K M Cherian Chennai

K M Sahu Ranchi

K R Balakrishnan Chennai

K R Palaniswamy Chennai

K S Nayak Hyaderabad

K Sampath Kumar Madurai

K Sridhar Chennai

K V Dakshinamurty Bangalore

Kaiser Raja Bangalore

Kamal Kanodia Ahmedabad

Kesava Kumar Chennai

Kishore Cochin

Krishnamurthy Chennai

Lakshmi Kumar Trivandrum

Lalitha Raghuraman Hyderabad

Luis Bakero Chennai

M G Rajamanickam Chennai

National faculties ISOT 2015

M Salim Nazar Srinagar

M Subba Rao Chennai

M Vijaykumar Chennai

Madhu Shankar Chennai

Mahesh Gopashetty Chennai

Mahesha V Bangalore

Mammen Chandy Vellore

Manav Wadhawan New Delhi

Manav Wadhwan Delhi

Manish Rathi Chandigarh

Manish Varma Hyderabad

Manisha Sahay Hyderabad

Manoj Jain Lucknow

Matthew Jacob Bangalore

Matthew Cochin

Maya Menon Chennai

MG Rajamanickam Chennai

Mohammed Rela Chennai

Mohan Rajapurkar Nadiad

Mohit Sharma Cochin

MS Ansari Lucknow

Mukul Vij Chennai

Murali Venkatraman Chennai

Murli Chennai

Muthu Jayaraman Chennai

Muthu Ramaswamy Chennai

Muthusethupathy Chennai

N Gopalakrishnan Chennai

N Jayram Bangalore

N Murugan Chennai

N Sharad Kumar Manipal

Naimish Mehta Delhi

Narayan Prasad Lucknow

Neeraj Saraf Gurgaon

Neerav Goyal New Delhi

Nitin Kekre Vellore

Nitya Krishnan Chennai

NK Mohanty Bhubaneshwar

Noble Gracious Trivandrum

Om Kumar Patna

P P Varma New Delhi

P Soundararajan Chennai

P V L N Murthy Hyderbad

Pallav Gupta Delhi

Pari Chennai

Paul Dinakaran Chennai

Paul Ramesh Chennai

Philip Thomas Cochin

Pitchai Chennai

Poovizhi Chennai

Prabha Senguttuvan Chennai

Prahlad N Chennai

Pranjal Modi Ahmedabad

Prashant Ghosh Delhi

Pratik Das Kolkatta

Praveen Varma Chennai

R G Singh Varanasi

R K Dhiman Chandigarh

R K Sharma Lucknow

R Krishnammoorthy Chennai

R N Sahoo

R Raghevendran Chennai

R Raghuveer Hyderabad

R Ravikumar Chennai

R Vijaykumar Chennai

Rahul Kakodkar Mumbai

Rajan Duggal Delhi

Rajan Ravichandran Chennai

Rajasekar Perumala Chennai

Rajeev Annigeri Bangaluru

Rajendiran Chennai

Rajendra Pandey Kolkatta

Rajendran Chennai

Rajesh NG Pondicherry

Rajesh Prabhu Madurai

Rajiv Karthik Vellore

Rajiv Soman Mumbai

Ram Gopal Krishnan Chennai

Ram Subramanian Chennai

Rama Mani Chennai

Ramachandran Menon Kochi

Ramalingam Chennai

Ramasubramaniam Chennai

Ramdas Pischarody Trivandrum

Ramesh D Bangalore

Ranganathan Iyer Hyderabad

Ranjan Mohapatra Chennai

Ratan Jha Hyderabad

Ravi Mahajan Haryana

Ravi Mohanka Mumbai

Ravi Raya Hyderabad

Ravi Shankar Haryana

Ritambhara Nada Chandigarh

Ronica Baruah Guwahati

S Asthana Bangalore

S C Das Bhubaneshwar

S Jasuja New Delhi

S K Agarwal Lucknow

S K Agarwal New Delhi

S K Sarin Noida

S Padmanabhan Bangalore

S R Balakrishnan Chennai

S Ramalakshmi Chennai

S Sahariya Hyderabad

S Subramanian Iyer Cochin

S Subramanian Chennai

S Sunder Bangalore

S. Saravanan Chennai

Sampath Kumar Madurai

Sandeep Agawal New Delhi

Sandeep Guleria New Delhi

Sandeep Mahajan New Delhi

Sandeep Saxena Indore

Sandeep Kerala

Sandhya Srinivasan Chennai

Sanjeev Gulati New Delhi

Sanjeev Kanoria Mumbai

Sanjeev Nair Chennai

Santosh Kumar Chennai

Santhosh Varghese Vellore

Sarah Kuruvilla Chennai

Satish Balan Cochin

Satish Chennai

Saubhik Sural Kolkatta

Seethalekshmy NV Kochi

Shailesh Raina Mumbai

Shalimar New Delhi

Sheetal Dhadphale Pune

Sheo Kumar Tirupati

Shishir Gang Nadiad

Shrirang Bichu Mumbai

Shruti Tapiawala Mumbai

Sidhe Pune

Sivaraman Chennai

SL Tulani Jaipur

SN Mehta Delhi

Sonal Asthana Bangalore

Sorabh Kapoor Mumbai

Soumitra Bagchi Delhi

Sreebhushan Raju Hyderabad

Sreejith Parameswaran Pondicherry

Sreelatha M Calicut

Sridhar N Chennai

Subhash Gupta New Delhi

Subramaniam Iyer Cochin

S Swaminathan Chennai

Suceena Alexander Vellore

Sudarshan Ballal Bangalore

Sudhindran Cochin

Sudipta Roy Kolkata

Suhas Salpekar Nagpur

Sujata Patwardhan Mumbai

Sujoy Pal New Delhi

Sumana Navin Chennai

Sundeep Vijayaraghvan Kerala

Suneetha Narreddy Hyderabad

Sunil Prakash New Delhi

Sunil Shroff Chennai

Surendran Chennai

Suresh Rao Chennai

Swarnalatha G Hyderabad

T Sunder Chennai

T Ravi Raju Hyderabad

T T Paul Thrissur

Tarun Jeloka Pune

Thangam Menon Chennai

Thiagrajan K Chennai

Tomar Jaipur

Uday Ghoshal Lucknow

Umesh Lingarajan Bangalore

Umesh Oza Mumbai

Urmila Anand Mumbai

V Balaji Vellore

V G Mohan Coimbatore

V Mahesha Bangalore

V N Unni Kochi

V S Mehta New Delhi

V S Saraswat Lucknow

V Tamilarasi Vellore

Wani Mohd Saleem Srinagar

Vasantha Roopan Chennai

Vasudevan Trivandrum

Veena Chennai

Venugopalan G Trivandrum

Vijay Kher New Delhi

Vijay Vohra Delhi

Vijayanand P Coimbatore

Vijaykumar Chennai

Vinay Kumaran Mumbai

Vinay Malhotra Jaipur

Vinay Pathak Tamiladu

Vinita Agarwal Lucknow

Vinod Rai Hyderabad

Vivek Kute Ahmedabad

Vivek Pathak Coimbatore

Vivekanada Jha Chandigarh

Vivekanandan Bangalore

Yogesh K Chawla Chanidgarh

Zacharia Paul Kochi

NOMINATIONS / APPLICATIONS INVITED FOR ISOT ORATION AWARDS AND FELLOWSHIP

Dr. J. M. Patel Oration

This award is intended to recognize outstanding contribution by the member of ISOT in the field of Organ Transplantation that significantly advances the field of organ transplantation in India. Any member can apply for this Award. The application along with six copies of CV, topic of Oration and the original work of the member done in India in relation to the topic of the Oration should reach the Secretariat before 25th August 2015. The Scientific Committee of the ISOT is the evaluating authority for this Award.

Award: Plaque and Shawl

Dr. R. V. S. Yadav Oration

Applicant should be member or has to apply for ISOT membership to be eligible for this award. This Oration is awarded to a senior Transplantation Surgeon who has contributed significantly to the practice and teaching of Organ Transplantation in India. The awardee will be selected by the Scientific Committee of the ISOT. The application must reach to the Secretariat before 25th August 2015


Dr. K. N. Udupa Memorial Lecture

This award is reserved for outstanding research work done by ISOT members below the age of 40. The application along with six copies of CV, topic of lecture and the original work of the member done in India in relation to the topic of the lecture should reach the Secretariat before 25th August 2015. The Scientific Committee is the evaluating authority for this Award.

Award: Certificate and Medallion

Novartis Transplant Fellowship

Applicant should be a member or has to apply for ISOT membership to be eligible for this award. Trainee has to be post MD or post MS (Medicine, Surgery or Pathology or Basic science relevant to transplantation). Head of the Department of their Institute should certify that he/she is interested to work in Transplantation and will be given necessary leave if selected for the grant. The fellow selected will spend minimum 2weeks at the selected centre. He will have to submit his report to the Secretary of ISOT. The last date for application submission 25th August 2015

Award: The award will be Rs. 40,000/- (at the next conference)

Dr Vidya Acharya Oration of ISOT

This award is intended to recognize outstanding research work done by any International Faculty (preferably of Indian Origin) that significantly advances the

field of organ transplantation in India or, overseas. Any ISOT member can also apply for this Award whose research

work has been exceptionally recognised. The application along with CV, a write up on the proposed Oration based on original work in relation to the topic of the Oration should reach the Secretariat before 25th Aug 2015. The Scientific Committee and ISOT councils are the evaluating authority for this Award.


th Last Date : Tuesday 25 August 2015

INTRODUCING

Email: [email protected]

Please send your nomination / applications

to the Secretariat :

Dr. Narayan Prasad, Secretary ISOT

Department of NephrologySanjay Gandhi Postgraduate Institute of Medical Sciences,

Lucknow, India-226014

26th Annual Conference of ISOT, 2 - 4 October 2015, Chennai


e c e a s e d d o n a t i o n

Dtransplantation in India is now gradually moving forward. In the

last two years we have seen the doubling of the deceased donation rate from 196 donors in 2012 or 0.16 per million population (pmp) to 411 in 2014 or 0.34 pmp. The figures may not look impressive enough, but when you consider that these figures are of only 10 states and union territories (UTs) of India and the donations resulted in 1150 solid organs like kidney, liver, heart, lung, pancreas and intestine and thus it does become significant. Rather than looking at the national average, it may be better to look at the state wise figures and many states have crossed 1 or 2 donations per million population. It also means that deceased donat ion transplantation is now responsible for almost 40% of the liver transplants done in the country and over 15% of kidney transplants.

The few states that have led the way forward include Tamil Nadu, Kerala, Andhra P radesh , Maharash t ra , Karnataka, Gujarat, Uttar Pradesh, P o n d i c h e r r y , D e l h i - N C R a n d Chandigarh

The factors that have been responsible for this increase in the numbers are as follows -

1. Support of the media in promoting the cause

2 . I n c r e a s e i n n u m b e r o f h o s p i t a l s / c e n t r e s d o i n g transplantation especially liver

3. Increase in number of trained transplant coordinators in the programme

4. State Government's proactive role in the programme in some of the states

5. Cooperation between public and private hospitals in the states that have done well

6. Specialist Intensive care doctors who have been supportive of the programme

7. Awareness among the public and t h e i r s u p p o r t t o w a r d s t h e programme

8. Ro le o f NGO's l i ke MOHAN Foundation in helping with capacity building and creating awareness among the public and in hospitals.

Tamil Nadu has continued to contribute substantially to the number of deceased donors and is the only state where the second tier cities like Coimbatore, Madurai, Trichy, Vellore, Salem and Tirunelveli have had deceased donors. This speaks highly not only about the programme, but also the availability of advanced medical facility in the state.

T h e l a s t a d v a n c e d t r a n s p l a n t coordinators conference in Chennai conducted by MOHAN Foundation was attended by many senior coordinators from across the country. When they were qu izzed about where the challenge lay in the deceased donation programme in our country, most said it

Reference and Source – Indian Transplant newsletter - Vol. 14 Issue No.: 44 March 2015 – June 2015Deceased Multi-Organ Donors in India

was in the hospital domain and not among the public. They believed that when with the doctor from ICU spoke to the relatives of the family of a deceased donor along with a trained co-ordinator,

in many instances the initial 'No' for donation was converted to 'Yes'. This fact is important for the hospital authorities to understand, if they wish to take this programme forward.

No. of Deceased Multi-Organ Donors

Deceased donation rate in India doubles in the last two yearsSunil ShroffMOHAN Foundation, 3rd Floor, 267 Kilpauk Garden Road, Chennai 600010, India

Mesenchymal stem cells and transplant tolerance

1 2, 3Aruna V Vanikar , Hargovind L Trivedi Ashutosh Kumar , 4 2Saroj Chooramani Gopal , 5, Vivek B Kute

1. Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology. IKDRC and ITS, Ahmedabad, India.2. Department of Nephrology and Transplantation Medicine,

IKDRC and ITS, Ahmedabad, India.3. Department of Hematology, KGMU Hospital, Lucknow, India.

4. Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

5. Department of Pediatric Surgery, KGMU Hospital, Lucknow, India.

Review Article

Abstract

Different strategies are being tried to induce transplant tolerance in clinical settings; however, none of them are both safe and effective. Mesenchymal stem cells have been found to be potent immunomodulators and immuno-suppressants. We discuss in this review different sources of mesenchymal stem cells and the potent role of adipose tissue-derived mesenchymal stem cells

Figure 1: Ahmedabad protocol for minimization of immunosuppression in living donor renal transplantation using stem cells, (A) Recipient Protocol (B) Donor Protocol

The major advantage using AD-MSC is that patients return to mainstream of life with ≤ 2 immunosuppressants, less rejections and minimum infections. Financial burden on the system is significantly reduced due to lesser requirement of medications and morbidity as compared to controls on standard triple immunosuppression regime.

Future

We have also generated in vitro, regulatory T cells which have further improved our results.

References

1. Trivedi HL, Vanikar AV, Patel HV, Kute VB, Dave SD. Regulatory T-cells support stem cell therapy in safe minimization of immunosuppression in living donor renal transplantation. J Stem Cell Res Ther 2014; 4(10):1-8.

2. Vanikar AV, Trivedi HL.T-Regulatory Cells: The Recently Recognized Players of Immunomodulation. J Stem Cell Res Ther 2014; 4(10):1-6.

3. Trivedi HL, Vanikar AV, Kute VB, et al. The effect of stem cell transplantation on immunosuppression in living donor renal transplantation: A clinical trial. Int J Org Transplant Med 2013; 4 (4): 155-162.

in induction of transplant tolerance including when to use them and how to use them for achieving the Utopian dream of transplant tolerance.

Supplementary

Experience Of Renal Transplantation Using Donor Adipose Tissue Derived Mesenchymal Stem Cells (AD-MSC) And Hematopoietic Stem Cells (HSC) In IKDRC-ITS, Ahmedabad

Figure 2: (A) Kaplan Meier graph

We have developed the technique of in vitro AD-MSC generation without using xenogeneic material. We have then developed our own protocol for living donor renal transplantation using these stem cells. (Figure1)

Figure 2: (A) Kaplan Meier graph depicting patient survival of protocol and control groups. Protocol patients underwent infusion of adipose derived m e s e n c h y m a l s t e m c e l l s a n d hematopoietic stem cells and controls were transplanted without stem cells. Patient as well as combined patient + graft survival was significantly better in protocol group vs. controls.

(B) Kaplan Meier graph depicting death censored renal allograft survival of protocol and control groups. Protocol p a t i e n t s w e r e u n d e r ≤ 2 immunosuppressants and controls w e r e u n d e r s t a n d a r d t r i p l e immunosuppress ion. Stat is t ica l significance was not seen (p=0.02).

© Graph depicting graft survival as noted in UNOS data, CTSE data and IKDRC-ITS, Ahmedabad data * (D) Kaplan Meier graph depicting patient + renal allograft survival of protocol and control groups.

*Gondos A, Dohler B, Brenner H, Opelz G.Kidney graft survival in Europe and the United States: strikingly different long-term outcomes. Transplantation 2013 Jan 27; 95(2):267-74.

Table 1: Experience using AD-MSC in living donor renal transplantation

Delhi Chennai

Odisha Kolkata

India Observes on World Kidney Day 12 March 2015Delhi: The department of Nephrology PGIMER, Dr R M L Hospital and AIIMS jointly organised a conference on World Kidney Day at the institute’s auditorium.

Chennai: TANKER FOUNDATION, Distributed leaflets and water bottles to the general public on the World Kidney Day 2015.

Odisha: Students of Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar participate in a rally to create awareness on World Kidney Day 2015.

Kolkata: Paediatric Nephrology unit of Fortis Hospital, Kolkata celebrated World Kidney Day where an interactive session was organized between parents and children who have undergone transplant.


Randy’s

Laughing Corner

The 26th Annual Conference of Indian Society of Organ Transplantation is scheduled from 2nd to 4th October 2015 at Chennai. For further details contact: Secretariat for ISOT 2015 Conference, MOHAN Foundation,3rd Floor, 267 Kilpauk Garden Road, Chennai -600010, India; Tel:-91 44 26447000 / 91 9444607000;E - m a i l : i n f o @ i s o t 2 0 1 5 . c o m o r [email protected]

TTS 2015 14th Transplantation Science Symposia scheduled from November 11-13, 2015 at Lorne, Australia. For further details contact: tts2015.org.

ILTS 22nd ILTS Annual International Congress will be held at Seoul, South Korea from May 4-7, 2016. For further details contact: http://www.ilts.org

52nd ERA-EDTA Congress is scheduled from May 21-24 at Viana, Australia. For f u r t h e r d e t a i l s c o n t a c t : w w w. e r a -edta2016.org

American Transplant Congress 2016 will be held at John B. Hynes Convention Center, Boston, MA from June 11-15, 2016. Abstract Submission Deadline: December 4, 2015.For further detai ls contact; http://2016.atcmeeting.org/

6th International Congress of The Transplantation Society will be held in Hong Kong from the 18th to the 23rd August 2016. F o r f u r t h e r d e t a i l s c o n t a c t : http://www.tts2016.org/

FORTHCOMING EVENTS

NEWS SPOTTED

he first man set to undergo a head

Ttransplant has been revealed, saying that he finds the controversial surgery

“very scary, but also very interesting”.

Valery Spiridinov is set to be the first person to undergo the operation. It will be carried out by controversial Italian doctor Sergio Canavero, whose optimistic plans have mostly been met with scepticism.

But Spiridonov — who has the rare genetic Werdnig-Hoffman disease, which gradually wastes away muscles — says that he is willing to undergo the risky procedure to give himself a chance at living in a healthy body.

“Am I afraid? Yes, of course I am. But it is not just very scary, but also very interesting,” Spiridonov, speaking from his house in the Russian town of Vladimir about 120 miles from Moscow, told MailOnline.

“But you have to understand that I don't really have many choices,” he said. “If I don't try this chance my fate will be very sad. With every year my state is getting worse.”

Spiridinov said that he has spoken with Dr Canavaro over Skype but they are yet to meet. The Russian man was chosen from a number of people that emailed and wrote to Canavaro to ask to undergo the procedure, he said.

Canavaro raised scepticism earlier this year when he said that he would be able to carry out the procedure within two years. Other

medical experts called the procedure unlikely, and rare, as well as highlighting the fact that it would never be used for those that simply want to replace an ailing body. Some have even compared Canavaro to Frankenstein.

The head transplant is set to work by taking the head off a person suffering from a wasting or degenerative disease, and transplanting it onto the body of someone who is braindead but still has a functioning body. It would be akin to the process of moving organs into a body — but would rely on the donor's family giving away the entire body, rather than just parts of it.

The procedure was carried out on a monkey in 1970. But surgeons didn't transplant the spinal cord, so the monkey could not move, and it lived for only nine days and died when the head was rejected by the body's immune system.

It has never been done on a human, but Canavaro claims that all the necessary science and technology is now in place. “I think we are now at a point when the technical aspects are all feasible,” Canavaro has said.

g

Head transplant: Russian man to become first to undergo pioneering and controversial surgery

“Good News — they found you a donor for a smile transplant!”

ISOT Council Members

Post Name Email ID

President Dr. Umesh Oza [email protected]

Vice-Presidents Dr. Aruna Vanikar [email protected]

Dr. Sanjeev Gulati [email protected]

Dr. Aneesh Srivastava [email protected]

Secretary Dr. Narayan Prasad [email protected]

Joint Secretary Dr. Sudhir Kulkarni [email protected]

Treasurer Dr. Alan F Almeida [email protected]

Council Dr. Sanjay K Agarwal [email protected]

Dr. Sunil Shroff [email protected]

Dr. Gopal Basu [email protected]

Dr. Manish Rathi [email protected]

Dr. Sandip Saxena [email protected]

Dr. LK Tripathi [email protected]

Dr. Manisha Sahay [email protected]

Dr. Dhanajai Agarwal [email protected]

Immediate Past President Dr. Ashok L. Kirpalani [email protected]

Editor, IJT Dr. Raj Kumar Sharma [email protected]

Correspondence: Dr. Narayan Prasad, Secretary, Indian Society of Organ Transplantation, Additional Professor, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow-226014, INDIA c Email: [email protected] Mobile: +91-9415403140 c Ph.: +91-522-2495187 (O), 2495188 (R)

Maryland 8-year-old is youngest to receive double hand transplant

maryland boy who lost both his hands

Ato an infection while a toddler became the youngest patient to receive a

successful double hand transplant, surgeons announced Tuesday.

Surgeons at The Children's Hospital of Philadelphia told a news conference they operated on Zion Harvey for nearly 11 hours earlier this month. A 40-person team used steel plates and screws to attach the old and new bones. Surgeons then painstakingly reconnected Zion's arteries, veins, muscles, tendons and nerves.

Zion appeared at the hospital's news conference with his forearms bandaged, but his hands visible. He demonstrated his still-delicate grip and described waking up with new hands as "weird at first, but then good."

"He woke up smiling," said Dr. L. Scott Levin, who heads the hand transplant program. "There hasn't been one whimper, one tear, one complaint."

Zion, of Owings Mil ls, Md., outside Baltimore, contracted sepsis at age 2. The resulting multiple organ failure forced the amputation of his hands and feet; by age 4, he needed a kidney transplant, receiving the organ from his mother.

Leg prosthetics have allowed Zion to be very active, including walking, running and jumping. He learned to use his forearms to write, eat and play video games and has been attending school. Physicians hope he'll now be able to achieve more milestones, including his goals of throwing a football and playing on the monkey bars. "It was no more of a risk than a kidney transplant," his mother, Pattie Ray, said. "So I felt like I was willing to take that risk for him, if he wanted it — to be able to play monkey bars and football.”

The donor's family chose to remain anonymous. g

Zion, (8) the receipient of a successful double hand transplant, at a press conference

14 ISOT Newsletter ISOT Newsletter 15May to August 2015 May to August 2015

ANNOUNCEMENT OFISOT ELECTIONSPresident (Physicians) - 1President Elect (Surgeon) - 1

Last date of Nomination Sumbmission - 31st August 2015

Download Nomination Froms from www.isot.co.in

ISOT NEWSLETTER 2nd issue 2015.cdr

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