ISBS KOBE 2015 Final Program and Proceedings

6th Regional Stress and Behavior ISBS Conference, Kobe, Japan July 26-27, 2015 1

The International STRESS AND BEHAVIOR Society (ISBS) ZENEREI Institute, USA

Program and Proceedings

6th International Regional (Asia) ISBS Neuroscience Conference

Stress and Behavior

Kobe, Japan July 26-27, 2015


IN PARTNERSHIP WITH: The Japan Society for Neuroscience (Japan) Satellite Symposium of JSN ZENEREI Institute (USA) KOBE UNIVERITY (Japan) KOBE UNIVERITY HOSPITAL (Japan) KANEKA Corporation (Japan)

ISBS COMMITTEES:

Conference Co-Chairs: Prof. Allan V. Kalueff, PhD (New Orleans, USA), ISBS President and Fellow Prof. Shun Nakamura, PhD (Tokyo, Japan), LOC Chair, ISBS Fellow International Program Committee: Prof. Shun Nakamura, PhD (Tokyo, Japan), Co-Chair , ISBS Fellow Prof. Allan V. Kalueff, PhD (New Orleans, USA), Co-Chair, ISBS Fellow Prof. Mitsuhiro Yoshioka, PhD (Hokkaido, Japan) Prof. Mamiko Koshiba, PhD (Tokyo, Japan), ISBS Fellow Prof. Elliot A. Beaton, PhD (New Orleans, USA), ISBS Fellow Prof. Viktor M. Klimenko, PhD, MD (St. Petersburg, Russia), ISBS VP and Fellow Local Organizing Committee: Prof. Shun Nakamura, PhD (Tokyo, Japan), Chair Prof. Mitsuhiro Yoshioka, PhD (Hokkaido, Japan) Prof. Mamiko Koshiba, PhD (Saitama, Japan) Prof. Ichiro Sora, MD, PhD (Kobe, Japan)


CONFERENCE PROGRAM Day 1. Sun, July 26, 2015 Shinryoku-Kaikan (Alumnus Hall), School of Medicine, University of Kobe, Kusunokicho, Chuo-ku, Kobe, Japan 09.00-17.00 REGISTRATION Morning session: Chairs: S Nakamura, M Yoshioka (Japan), AV Kalueff (USA) 09.30-09.45 ISBS OPENING CEREMONY AND WELCOMING ADDRESSES 09.45-10.45 OPENING PLENARY LECTURE: ADVERSE SENSORY INPUT OF THE ABUSE

MODIFIED BY EARLY EXPERIENCE. A Tomoda, Research Center for Child Mental Development, University of Fukui, Fukui, Japan

10.45-11.30 ISBS PRESIDENTIAL LECTURE: MODELING AFFECTIVE DISORDERS IN

ZEBRAFISH. AV Kalueff, ISBS Fellow, S Li, Y Liu, P Chen, L Yang, JJ Wang, A Kaluyeva, AM Stewart, ISBS Fellow, C Song, Guangdong Ocean University, Zhanjiang, China; ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), New Orleans, USA; Institute for Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia

11.30-12.00 ISBS SPECIAL LECTURE: STRESS RESPONSES AND MU OPIOID RECEPTOR

EXPRESSION, I Sora, Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan

12.00-12.25 ISBS SPECIAL LECTURE: A SYSTEMATIC REVIEW OF NEONATAL STRESS ON

BRAIN OF HIGH RISK NEWBORN. H Yamanouchi, M Koshiba, ISBS Fellow, Department of Pediatrics and Biochemistry, Saitama Medical University School of Medicine, Saitama, Japan

12.25-12.45 POSTTRAUMATIC STRESS DISORDER-LIKE BEHAVIORS IN FABP3 NULL MICE. K Fukunaga, Y Yabuki, I Takahata, Y Owada, N Shioda, Tohoku University Graduate School of Pharmaceutical Sciences, Yamaguchi University School of Medicine, Sendai, Japan

12.45-13.50 LUNCH BREAK (FREE TIME) Afternoon session: 13.50-18.20 SYMPOSIUM 1. ZUKOWSKA SYMPOSIUM ON STRESS NEUROSCIENCE

Chairs: AV Kalueff (USA) and S Nakamura (Japan) 13.50-14.00 INTRODUCTION: PROFESSOR ZOFIA M ZUKOWSKA


14.00-14.15 ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 IS NECESSARY FOR RESTRAINT-INDUCED CONDITIONED PLACE PREFERENCE. YY Mei, JS Li, Department of Psychology, National Chung Cheng University, Chia-Yi, Taiwan

14.15-14.30 EFFECTS OF AGING AND EARLY LIFE STRESS ON SEXUAL MOTIVATION IN

MALE RATS. TG Amstislavskaya, AS Dolodoev, MA Tikhonova, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

14.30-14.45 ROLE OF CENTRAL MUSCARINIC CHOLINERGIC MECHANISMS IN SEX

BEHAVIOR REALIZATION UNDER THE CONDITION OF STRESS. NS Sapronov, AA Bairamov, NN Petrova, EV Petrova, Institute of Experimental Medicine RAS, II Mechnikov Northwestern State Medical University, St. Petersburg, Russia

14.45-15.00 MENTAL DISORDERS IN OFFSPRING OF PARENTS WITH BIPOLAR DISORDER IN SOUTH KOREA. SH Shim, Soonchunhyang University Hospital, Cheoan, South Korea

15.00-15.15 OREXIN OX(1) RECEPTOR ANTAGONIST SB-408124 POTENTIATES THE

INHIBITORY ACTION OF SULPIRIDE ON AMPHETAMINE-ACTIVATED BUT NOT SPONTANEOUS SELF-STIMULATION. PD Shabanov, AA Lebedev, RO Roik, VI Morozov, Military Medical Academy, Institute of Experimental Medicine RAS, St. Petersburg, Russia

15.15-15.30 IS VIDEO SCENERY AS APPEALING AS REAL LANDSCAPE? AN EEG STUDY.

NC Chiang, SCL Huang, Department of Social Psychology, Department of Tourism, Shih Hsin University, Taipei, Taiwan

15.30-15.45 MELATONIN, CORTISOL AND DAYTIME SLEEPINESS AFTER NIGHTTIME

EXPOSURE OF LIGHT EMITTING DIODE (LED) WITH AND WITHOUT BLUE LIGHT: A RANDOMIZED, DOUBLE-BLINDED, CROSS-OVER, PLACEBO-CONTROLLED COMPARISON. HJ Jeon, Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

15.45-16.00 COFFEE BREAK AND EXHIBITION 16.00-16.25 SPECIAL FOCUS TALK: MECHANISM OF ANXIOLYTIC EFFECT OF SSRI. T

Izumi, M Yoshioka, ISBS Fellow, Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

16.25-16.45 EXERCISE ENHANCES STRESS COPING DESPITE INCREASING

CORTICOSTERONE, LIKELY BY UPREGULATING THE DOPAMINE LEVEL IN THE MEDIAL PREFRONTAL CORTEX. C Chen, S Nakagawa, Y Kitaichi, Y An, Y Omiya, N Song, M Koga, T Inoue, I Kusumi, Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan

16.50-17.05 ABNORMAL INTRA-GROUP VOCAL COMMUNICATION WITHIN PRIMATE

FAMILY INCLUDING A KID OF MODEL OF AUTISM. K Mimura, N Ichinohe, Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan


17.05-17.20 COMMON MARMOSETS DEVELOP GENERATION-SPECIFIC PEER SOCIAL EXPERIENCES THAT MAY AFFECT THEIR ADULT BODY WEIGHT ADAPTATION TO CLIMATE.G Karino, M Shukuya, S Nakamura, ISBS Fellow, T Kunikata, H Yamanouchi, M Koshiba, ISBS Fellow. Department of Pediatrics, Saitama Medical University, Saitama, Tokyo University of Agriculture and Technology, Tokyo, Tokyo City University, Kanagawa, National Center of Neurology and Psychiatry (NCNP), The Japan Society for the Promotion of Science, Tokyo, Japan

17.20-17.40 INCLUSIVE INTERVENTION FOR PSYCHO-DEVELOPMENT WITH BEHAVIOR

ANALYSIS USING QUANTITATIVE EMOTIONAL STATE TRANSLATION (BOUQUET). M Koshiba, ISBS Fellow, G Karino, K Mimura, H Tokuno, S Usui, I Tanaka, Y Honda, T Kodama, K Sato, H Kishino, M Shukuya, T Kunikata, S Nakamura, ISBS Fellow, H Yamanouchi, Saitama Medical University, Saitama, Tokyo University of Agriculture and Technology, Tokyo, TMIM, National Center of Neurology and Psychiatry (NCNP), University of Tokyo, Tokyo City University, Tokyo, Japan

17.40-17.50 AN ATTIDUDE SURVEY OF IMPORTANCE OF LEARNING NEONATAL CARDIO-

PULMONARY RESUSCITATION (NCPR) IN MIDWIFERY COURSE STUDENT. M Yoda, Y Inai, Saitama Medical University College, Saitama, Japan

17.50-18.10 REDUCING FATIGUE OF OPERATORS BY PERIPHERAL VISUAL INSPECTION

METHODS. A Ishii, A Sasaki, M Koshiba, ISBS Fellow, Kagawa University, Kagawa, Peripheral Visual Inspection Lab, Kanagawa, Saitama Medical University, Saitama, Japan

18.10-18.20 GENDER DIFFERENCES IN THE DEMAND CONTROL MODEL OF WORK

STRESS: AN EXAMINATION OF DATA FROM SONGKHLA PROVINCE, THAILAND. K Janyam, Faculty of Liberal Arts, Prince of Songkla University, Songkhla, Thailand


Day 2. Mon, July 27, 2015 Shinryoku-Kaikan (Alumnus Hall), School of Medicine, University of Kobe, Kusunokicho, Chuo-ku, Kobe, Japan 09.00-14.00 REGISTRATION Morning session: 9.00-10.50 SYMPOSIUM 2. NATURAL AND SOCIAL DISASTERS

Chairs: K Niwa and M Maeda (Japan) 9.00-9.30 CURRENT SITUATION OF THE INETERNAL RADIATION EXPOSURE

SCREENING PROGRAM IN MINAMISOMA, FUKUSHIMA, AND THE FUTURE TASKS. M Tsubokura, University of Tokyo, Minamisoma Municipal General Hospital, Japan.

9.30-10.00 HOW IS THE FEAR OF LOW-DOSE RADIATION EXPOSURE ALTERING

BEHAVIORS AND APPERCEPTION OF FUKUSHIMA RESIDENTS? A Hori, Hibarigaoka-Hospital, NPO Minano-Tonari-Gumi, Department of Disaster and Comprehensive Medicine, Fukushima Medical University, Fukushima, Japan

10.00-10.30 MULTIDIMENSIONAL PSYCHOSOCIAL ISSUES IN FUKUSHIMA: HOW SHOULD

WE OVERCOME THEM? M Maeda, Department of Disaster Psychiatry, School of Medicine, Fukushima Medical School, Fukushima, Japan

10.30-10.50 EFFECTS OF SOCIO-DEMOGRAPHIC STATUS ON THE NEUROCOGNITIVE

CORRELATES OF POST-TRAUMATIC STRESS RELATED TO THE GREAT EAST JAPAN EARTHQUAKE: DESIGN, OVERVIEW AND PERSPECTIVE. L Landr, B Thyreau, A Sekiguchi, Y Taki, Tohoku University, Tohoku Medical Megabank, Tohoku, Japan

10.50-11.20 COFFEE BREAK 11.20-13.05 SYMPOSIUM 3. LAPIN SYMPOSIUM ON BIOLOGICAL PSYCHIATRY

Chairs: M Koshiba (Japan), AV Kalueff (USA) 11.20-11.35 INTRODUCTION: PROFESSOR IZYASLAV (SLAVA) LAPIN 11.35-11.50 A STUDY OF SATISFACTION AND E-HEALTH LITERACY AMONG USERS WHEN

USING TWITTER TO SEEK PSYCHIATRIC CONSULTATION: A RECENT TREND IN SAUDI ARABIA. N Zakaria, A Jamal, S AlDossari, R Barri, K AlMufawez, College of Medicine, King Saud University, Riyadh, Saudi Arabia

11.50-12.05 NON-INVASIVE CRANIAL ELECTROSTIMULATION (CES) OF ENDORPHINERGIC

AND SEROTONINERGIC STRUCTURES OF THE BRAIN VIA NEWLY ELABORATED CES DEVICE FOR TREATMENT OF MILD TO MODERATE DEPRESSION. Y Katsnelson, H Beckhoff, E Berk, Yu Palkin, N Lisyanskaya, A Tereo, N Baranova, Premier Annecto Technologies, PA, USA; 7 Pavlov St.


Petersburg Psychiatric Hospital, St. Petersburg, Tver Railroad Clinical Center, Tver, Russia

12.05-12.20 ON THE ENGINEERED PSYCHOLOGICAL EDUCATION OF GROWING

ECONOMIES. I Nasr, NLP Centers Canada, Burlington, ON, Canada 12.20-12.35 EFFECTS OF PET INSECTS ON PSYCHOLOGICAL HEALTH AMONG

COMMUNITY-DWELLING ELDERLY: A RANDOMIZED-CONTROLLED TRIAL. HJ Ko, CH Youn, SH Kim, SY Kim, Department of Family Medicine, Kyungpook National University School of Medicine, Daegu, South Korea

12.35-12.50 AN EXPERIMENTAL STUDY TO ASSESS THE EFFECT OF PHYSICAL

EXERCISES ON ANGER MANAGEMENT AMONG SUBSTANCE DEPENDENCE SUBJECTS ADMITTED IN DRUG DE-ADDICTION AND TREATMENT CENTRE (DDTC) OF PGIMER, CHANDIGARH. K Das, P Malhotra, S Sharma, National Institute of Nursing Education, D Basu Department of Psychiatry, PGlMER, Chandigarh, India

12.50-13.05 SOURCES AND LEVEL OF STRESS AMONG SOCIAL DEVELOPMENT

STUDENTS, FACULTY OF LIBERAL ARTS, UBON RATCHATHANI UNIVERSITY, THAILAND. T Panchana, Ubon Ratchathani University, Ubon Ratchathani, Thailand

13.05-14.30 LUNCH BREAK (FREE TIME) Afternoon session 14.30-17.40 SYMPOSIUM 4. INTERACTIVE MODERATED POSTER SESSION

Chairs: M Koshiba, S Nakamura (Japan), AV Kalueff (USA) THE ROLE OF GLUTAREDOXIN IN AGING AND PARKINSONS DISEASE. SG Chen, WM Johnson, P Curran, PS Krishnan, K Choe, B Shivakumar, AL Wilson-Delfosse, JJ Mieyal, Departments of Pathology and Pharmacology, Case Western Reserve University, Cleveland, OH, USA ELECTROACUPUNCTURE ATTENUATES THE MICROGLIA ACTIVATION INDUCED BY A PRURITOGEN IN THE MOUSE SPINAL CORD. YH Chen, CH Tseng, Graduate Institute of Acupuncture Science, China Medical University, Taiwan A SYSTEMATIC REVIEW OF STRESS AND LIFE QUALITY ON CARDIOVASCULAR DISEASE AMONG PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA. NT Chang, PY Kang, SF Tsai, School of Nursing, College of Medicine, National Taiwan University and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan, Departments of Nursing, Mackay Medical College, New Taipei, Taiwan THE INVESTIGATIONOF ELDERLY DEPRESSION TENDENCY, FALL AND QUALITY OF LIFE OF SANZHI AREA IN TAIWAN. S-F Tsai, H-Y Yang, Y-H Chen, TC Hung, T-H Huang, Department of Nursing, Mackay Medical College, Tamsui Community Health Center, Mackay Memorial Hospital, New Taipei, Taiwan RELATIONSHIPS BETWEEN CARDIO-RESPIRATORY FUNCTION AND HEART RATE VARIABILITY PARAMETERS IN PATIENTS WITH SCHIZOPHRENIA. S-L Cheng, C-Y Chiu,


Nursing Department, Mackay Medical College, New Taipei, Department of Cosmetric Science and Application, Lan Yang Institute of Technology, Toucheng Township, Taiwan PERFORMANCE AND COGNITIVE STRATEGIES OF RATS IN THE PLACE AVOIDANCE TASK: EFFECT OF NON-COMPETITIVE NMDA RECEPTOR ANTAGONISTS. T Nekovarova, E Antosova, K Englerova, D Klement, K Vales, National Institute of Mental Health, Klecany, Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University, Institute of Physiology AS, Prague, Czech Republic OLFACTORY DISTURBANCES, CYTOKINES AND PAIN SENSITIVITY IN ADDICTION. T Nevidimova, ISBS Fellow, E Batukhtina, D Savochkina, N Bokhan, Mental Health Research Institute, Tomsk, Russia AN ANIMAL MODEL OF PSTD IS ASSOCIATED WITH A LONG-LASTING DECREASE IN SYNAPTIC SPINES AND INCREASED MICROGLIA WITHIN FRONTO-HIPPOCAMPAL NETWORKS. KL Smith, MS Kassem, D Clarke, S Todd, D Brown, M Bennett, J Lagopoulos, J Arnold, Brain and Mind Research Institute, University of Sydney, Sydney, Australia PARTICIPATION OF THE EXTENDED AMYGDALA SYSTEM OF THE BRAIN IN MECHANISMS OF REINSTATEMENT OF PLACE PREFERENCE OF AMPHETAMINE IN RATS. AA Lebedev, VI Morozov, PD Shabanov, Institute of Experimental Medicine, St. Petersburg, Russia ASSOCIATIONS OF SOCIAL FUNCTIONING ASSESSMENT AND NEEDS OF CARE IN THE LONG-TERM PSYCHIATRIC UNIT. LC Huang, WT Chen, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan MONTITORING ANXIETY OF TAIWANESE STUDENTS UNDER THE STRESS OF AN ENGLISH PRESETATION VIA PHOTOPLETHYSMOGRAPHY. JR Yeh, JS Shieh, SZ Fan, Research Center for Adaptive Data Analysis, National Central University, Department of Mechanical Engineering, Yuan Ze University, Department of Anesthesia, National Taiwan University Hospital, Taipei, Taiwan PP14 FUNCTIONS AS A REPRESSOR INVOLVED IN THE TRANSLATION INHIBITION MEDIATED BY THE INHIBITORY UPSTREAM OPEN READING FRAME OF HUMAN CHOP GENE. CC Hsieh, HC Lee, HC Nien, JC Sheu, HJ Tsai, Institute of Molecular and Cellular Biology, National Taiwan University, Liver Disease Prevention and Treatment Research Foundation, Taipei, Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan USING ZEBRAFISH TO IDENTIFY THE NOVEL GENE INVOLVED IN REGULATING THE HUORFCHOP-MEDIATED TRANSLATIONAL INHIBITION DURING ER STRESS. HC Lee, HJ Tsai, Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan THE EFFECT OF FOUR-AGENTS-DECOCTION ON MODULATION OF EXCITATORY AMINO ACID IN MORPHINE TOLERANT RATS. S-L Lin, C-H Cherng, C-C Yeh, C-S Wong, Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan THE RELATIONSHIP BETWEEN MEASURES OF METACOGNITION AND OBSESSIVE COMPULSIVE DISORDER. SY Sohn, JI Kang, K Namkoong, SJ Kim, Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea


EFFECTS OF EARLY-LIFE STRESS ON COGNITIVE FUNCTION AND NEUROMORPHOLOGY IN ADULT RATS WITH NORMAL OR ACCELERATED SENESCENCE. MA Tikhonova, TG Amstislavskaya, AV Shevchenko, YJ Ho, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk State Medical University, Novosibirsk, Russia; School of Psychology, Chung Shan Medical University, Taichung, Taiwan ESTROGEN STRESS-RELATED PHENOTYPE DIFFERENCE IN MIGRAINEURS BY HAPLO-GENOTYPES. H-J Park, M Kim, Department of Neurology, Seoul National University Hospital, Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea EARLY-LIFE STRESS ATTENUATES THE CAPACITY OF ADULT NEURAL PRECURSOR CELLS TO DIFFERENTIATE INTO NEURONS VIA METHYLATION OF RETINOIC ACID RECEPTOR GENE PROMOTER. S Boku, Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan A QUALITATIVE APPROACH TO EXPLORING PSYCHIATRIC PATIENTS PRIVACY ISSUES RELATING TO NEW TECHNOLOGY: PRACTICAL STEPS. N Zakaria, R Ramli, Medical Informatics and e-learning Unit, Medical Education Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia; School of Computer Sciences, University Sains Malaysia, George Town, Malaysia MEASUREMENT OF ANTICIPATORY ANHEDONIA USING A NOVEL CONFLICT TEST IN THE MOUSE. D Jeon, BS Kim, S Jeong, Y Jeong, S Kim, Korea Advanced Institute of Science and Technology, Daejeon, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea FEMALE INFERTILITY: A PSYCHOLOGICAL PROFILE. D Pavlova, I Grechenliev, H Pamukchiiski, Medical University of Sofia, Sofia, Bulgaria AN EXPLORATORY STUDY ON THE EFFECT OF ACTIVITY SCHEDULING ON THE NEGATIVE SYMPTOMS OF PATIENTS WITH SCHIZOPHRENIA IN PSYCHIATRY WARD, NEHRU HOSPITAL, PGIMER, CHANDIGARH. AK Kaur, M Dogra, K Das, A Avasthi, NINE, PGIMER, Chandigarh, India THE RELATIONSHIP BETWEEN PERSONALITY, SENSE OF EFFICACY AND STRESS IN KOREAN TEACHERS. S Park, Y Kim, Seoul National Hospital, Seoul, South Korea A NOVEL 3D METHOD OF LOCOMOTOR ANALYSIS IN ADULT ZEBRAFISH: IMPLICATIONS FOR AUTOMATED DETECTION OF CNS DRUG-EVOKED PHENOTYPES. AM Stewart, ISBS Fellow, F Grieco, RAJ Tegelenbosch, A Kaluyeva, LPJJ Noldus and AV Kalueff, ISBS Fellow, ZENEREI Research Center and the International Zebrafish Neuroscience Research Consortium, (ZNRC), Slidell, USA; Noldus Information Technology BV, Wageningen, Netherlands; Research Institute for Marine Nutrition and Drugs (RIMND) and College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia 17.40-18.00 CLOSING CEREMONY

ANNOUNCING FORTHCOMING ISBS CONFERENCES


CONFERENCE ABSTRACTS


Day 1. Sun, July 26, 2015 Shinryoku-Kaikan (Alumnus Hall), School of Medicine, University of Kobe, Kusunokicho, Chuo-ku, Kobe, Japan Morning session OPENING PLENARY LECTURE: ADVERSE SENSORY INPUT OF THE ABUSE MODIFIED BY EARLY EXPERIENCE. A Tomoda, Research Center for Child Mental Development, University of Fukui, Fukui, Japan INTRODUCTION: Childhood maltreatment markedly increases the risk for psychopathology and is associated with structural and functional brain differences. For example, exposure to parental verbal abuse (PVA) and/or interparental violence during childhood is associated with negative outcomes, such as depression, PTSD and reduced cognitive abilities. Other forms of childhood abuse have been found to be associated with alterations in brain structure. METHODS: Optimized voxel based morphometry was performed on unmedicated, right-handed subjects (18-25 years) with histories of PVA or witnessing interparental violence (WDV) during childhood, and psychiatrically healthy controls of comparable age and gender. Group differences in gray matter volume (GMV) covaried by age, gender, parental education, financial stress, and total GMV were assessed using high-resolution, T1-weighted, volumetric MRI data sets. The information presented is based on a collaborative study with the Psychiatry Department at Harvard Medical School on the relationship between brain functions and the human mind. RESULTS: GMV was increased by 14.1% in the left superior temporal gyrus (STG, BA 22) (P = 0.004, corrected cluster level). GMV in this cluster was associated most strongly with levels of maternal ( = 0.544, P < 0.0001) and paternal ( = 0.300, P < 0.02) verbal aggression and inversely associated with parental education ( = 0.577, P < 0.0001). Conversely, WDV subjects had a 6.1% GMV reduction in the right lingual gyrus (BA18) (P = 0.029, False Discovery Rate corrected peak level). DISCUSSION: Brain regions that process and convey the adverse sensory input of the abuse may be specifically modified by these experiences, particularly in subjects exposed to a single type of maltreatment. Exposure to multiple types of maltreatment is more commonly associated with morphological alterations in corticolimbic regions. These findings fit with preclinical studies showing that sensory cortices are highly plastic structure. RESEARCH SUPPORT: This work was supported by a Grant-in-Aid for Scientific Research (B) and Challenging Exploratory Research (Houga) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (KAKENHI grants 24300149 and 25560386). ISBS PRESIDENTIAL LECTURE: MODELING AFFECTIVE DISORDERS IN ZEBRAFISH. AV Kalueff, ISBS Fellow, S Li, Y Liu, P Chen, L Yang, JJ Wang, A Kaluyeva, AM Stewart, ISBS Fellow, C Song, Guangdong Ocean University, Zhanjiang, China; ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), New Orleans, USA; Institute for Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia The zebrafish (Danio rerio) is rapidly emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (anxiety, depression, PTSD, and drug abuse), we will discuss the high value of zebrafish aquatic models in translational neuroscience, with a particular focus on emotionality/affective deficits. I will also evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, this talk will discuss recent applications and existing challenges in this field, as well as outline the potential of


zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening for CNS drug discovery. ISBS SPECIAL LECTURE: STRESS RESPONSES AND MU OPIOID RECEPTOR EXPRESSION, I Sora, Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan Opioid systems have been well studied with regard to mechanisms of reward and analgesia, both of which are affected by stressful experiences. In addition, differences in opioid function can modify acute stress responses, and stress-related neurochemical and behavioral changes have been documented. The use of mu opioid receptor (MOR) knockout (KO) mice has provided novel insights into molecular mechanisms underlying stress-induced emotional responses. MOR-KO mice displayed significantly decreased immobility time in both the tail-suspension and repeated forced swim tests and significantly reduced stress-induced increases in plasma corticosterone concentrations compared with wild-type mice. MOR-KO mice also entered more, and spent more time in, the open arms of the elevated plus maze. Moreover, aversion to social contact was induced by chronic social defeat stress in wild-type mice but was reduced in MOR-KO mice. MOR-KO mice were resistant to stress exposure and exhibit fewer stress-induced emotional responses (i.e., anxiety- and depression-like behaviors) compared with wild-type mice. These results suggest that mu opioid receptor play an important role in stress sensitivity and/or stress-induced emotional responses, including anxiety- and depression-like responses. ISBS SPECIAL LECTURE: A SYSTEMATIC REVIEW OF NEONATAL STRESS ON BRAIN OF HIGH RISK NEWBORN. H Yamanouchi, M Koshiba, ISBS Fellow, Department of Pediatrics and Biochemistry, Saitama Medical University School of Medicine, Saitama, Japan

POSTTRAUMATIC STRESS DISORDER-LIKE BEHAVIORS IN FABP3 NULL MICE. K Fukunaga, Y Yabuki, I Takahata, Y Owada, N Shioda, Tohoku University Graduate School of Pharmaceutical Sciences, Yamaguchi University School of Medicine, Sendai, Japan INTRODUCTION: We have recently reported that fatty acid binding protein 3 (FABP3, H-FABP) binds to the intracellular loop of dopamine D2L receptor and that FABP3 null mouse reveals dysfunction of dopamine-regulated motor coordination (Shioda and Fukunaga, 2010). We here document that FABP3 null mouse shows an enhancement of anxiety and locomotor behaviors. METHODS: Wild type mice (C57BL6) and FABP3 null mice underwent fear conditioning once day with consecutive 5 days and measured the fear acquisition and extinction for 35 days. When mice were given melatonin receptor agonist, the drug was orally adminisered once a day before given conditional stimuli. RESULTS AND DISCUSSION: FABP3 null mice had deficits in extinction of conditional fear memory. The acquisition of conditional fear memory in FABP3 null was not distinguished from those in wild type mice. In one month after exposure to conditional stimulation, wild type mice significantly reduced the elapsed time form the chamber given foot shock. However, the elapsed time remained elevated in FABP3 null mice. Likewise, the c-Fos expression after exposure to conditional stimulation remained elevated in FABP3 mice but declined in the wild type mice. More importantly, the PTSD-like behaviors in FABP3 null mice ameliorated by treatment with melatonin receptor agonist. Taken together, FABP3 null mice are a novel model of PTSD, useful for drug development to improve the PTSD-like behaviors. RESEARCH SUPPORT: This work is supported by Kakenhi 25460090 (to NS).


Afternoon session SYMPOSIUM 1. ZUKOWSKA SYMPOSIUM ON STRESS NEUROSCIENCE Chairs: AV Kalueff (USA) and S Nakamura (Japan)

INTRODUCTION: PROFESSOR ZOFIA M ZUKOWSKA This regular ISBS symposium is dedicated to Professor Zofia Zukowska (1949-2012). Professor Zukowska received her M.D. and Ph.D., trained in cardiovascular medicine at the Warsaw Medical Academy (Poland). She pursued post-doctoral training at the NIH, working with such renowned scientists as Irwin I. Kopin, Scientific Director of NINDS, and Julie Axelrod, Nobel Laureate. It was during this research period when her interest in stress and neuropeptides became galvanized. For the last 25 years, she was a professor (and, later, Chair) of the Department of Physiology and Biophysics at Georgetown University, before moving to the University of Minnesota as a new Stress Physiology Center Director. She assessed how stress affects cardiovascular and metabolic health and diseases, and the role of peptides, in particular neuropeptide Y (NPY), a sympathetic neurotransmitter

and a stress mediator. She was the first to determine that NPY mediates stress-induced prolonged vasoconstriction and vascular mitogenic and pro-atherosclerotic effects (via Y1 receptors) and potent angiogenic actions (via Y2 receptors), establishing the role of NPY in ischemia, retinopathy, tumors and obesity. Professor Zukowska was a strong supporter of ISBS and our conferences. Her scientific vision, extraordinary creativity, kindness to colleagues, and the talent to be daring, continue to inspire her ISBS colleagues and their research. ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR 1 IS NECESSARY FOR RESTRAINT-INDUCED CONDITIONED PLACE PREFERENCE. YY Mei, JS Li, Department of Psychology, National Chung Cheng University, Chia-Yi, Taiwan During a stress experience, glucocorticoid (GC) and corticotropin-releasing factor (CRF) are 2 well-known hormones released from the hypothalamic-pituitary-adrenal axis. In recent years, acute mild stress, such as restraint, and intra-accumbens injection of CRF, have been found to be able to induce conditioned place preference (CPP) in rats and mice respectively, suggesting that stress could have a direct role in the reinforcement mechanism. Here we hypothesized that: (a) GC and/or CRF might possess rewarding properties; (b) GC and/or CRF might mediate restraint-induced CPP in rats by way of nucleus accumbens core. In Experiment 1, the peripheral applications of corticosterone (1, 3, 5 and 10 mg/kg) did not induce CPP. Furthermore, a GC antagonist mifepristone (10, 40, and 100 mg/kg) also failed to block restraint-induced CPP. In Experiment 2, both intracerebroventricular and intra-accumbens administrations of a selective CRFR1 antagonist antalarmin (1 and 0.125 g, respectively) completely blocked restraint-induced CPP. However, contrary to the study in mice, intra-accumbens injection of CRF (5, 50 and 500 ng) failed to induce CPP in Wistar rats. In summary, activation of intra-accumbens CRFR1, but not glucocorticoid, is essential for restraint-induced CPP in rats. Further studies are necessary to clarify the discrepancy between mice and rats reaction to the intra-accumbens injection of CRF. RESEARCH SUPPORT: The study was partially supported by a grant of National Science Council, Taiwan (NSC 102-2410-H-194-023-MY2).


EFFECTS OF AGING AND EARLY-LIFE STRESS ON SEXUAL MOTIVATION IN MALE RATS. TG Amstislavskaya, AS Dolodoev, MA Tikhonova, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia INTRODUCTION: Both aging and stress affect reproductive function in males. However, the effects of their combination remain unclear. OXYS rat strain with hereditary defined accelerated senescence (Kolosova et al., 2014) is a promising model for studying the interaction of early life stress effects and the development of genetically defined aging-related deficits. We studied the effects of maternal separation (MS), aging, and their interaction on sexual motivation and hormonal response during sexual arousal in male rats of Wistar and OXYS strains. The role of ERK/MAPK signal transduction pathway in the dysfunctions of male sexual motivation was also examined. METHODS: MS procedure was performed daily for 15 or 180 min from the 1st to 21st postnatal days. At the age of 4 months, males of the experimental groups underwent the test for sexual arousal. The dynamics of the parameters of behavioral and hormonal response in male rats at different duration of exposure to a receptive female was also registered in 12-month old Wistar and OXYS rats. Sexual motivation was estimated by its behavioral correlate, a time spent by a male at the transparent perforated partition separating it from a receptive female. Plasma testosterone levels and the levels of ERK/pERK were measured using specific ELISA kits. RESULTS AND DISCUSSION: Time spent by 12-month old Wistar males at the partition gradually decreased during 1-h exposure to a receptive female, and the peak of interest was observed during the first 10 min of the exposure. In 12-month old OXYS males, the parameters did not differ significantly between all time-points, and were significantly reduced compared to Wistar males. Similar dynamics was observed in 4-month old rat males. In MS-subjected Wistar males, the expression of sexual motivation was dramatically decreased in comparison with control Wistar males. This effect was found both in males separated daily for 15 and 180 min. Thus, we first demonstrated that even short-term chronic stress at early post-natal stage of development could cause the attenuation of sexual motivation in adult males. OXYS males subjected to the MS procedure did not differ from the control OXYS males with the reduced sexual motivation. Wistar males were characterized by the peak of testosterone at the 30th min of the test and the following decrease of the hormone level. OXYS males had a gradual increase of the testosterone level in plasma that became significant at min 40, and was further maintained till at least min 60. We suggest that the differences in dynamics of testosterone level were associated with the disturbances in OXYS male related to an increased frequency and number of Leidig cell adenomas in their testes. The involvement of ERK/MAPK signal transduction pathway in the regulation of the initial phase of sexual behavior (sexual arousal) was examined. ROLE OF CENTRAL MUSCARINIC CHOLINERGIC MECHANISMS IN SEX BEHAVIOR REALIZATION UNDER THE CONDITION OF STRESS. NS Sapronov, AA Bairamov, NN Petrova, EV Petrova, Institute of Experimental Medicine RAS, II Mechnikov Northwestern State Medical University, St. Petersburg, Russia INTRODUCTION: Physiological stress is the mechanism of active adaptation to changeable environment factors. Under the influence of different pathogenic factors and stressor actions, the reproductive function and sex behavior (SB) also change. Detailed investigation of different stressor actions (e.g., immobilization, electric shock, could water, noise exposure) on sex behavior of male-rats showed that it depends on character and duration of stressor action. METHODS: In order to activate the central M-cholinergic mechanisms, half of animals were treated with anticholinesterase drug Galanthaminum (1 mg/kg) and N-cholinoblocker Gangleronum (5 mg/kg) 30 min before stressor. One hour after stressor action there were registered the parameters of SB (a number of attempts ATT; intromissions IMS; ejaculations EJA; latency of EJA; interval between EJA; renewal period RP), as well as the content of neuromediators (DA, NE, 5-HT) in various brain formations (dorsal hippocampus, hypothalamus, n. caudatus, amygdala, substance nigra). RESULTS AND


DISCUSSION: The results of the experiments showed that the activation of M-cholinergic mechanisms under the stress conditions provided the protected effect on the manifestations of SB and moreover leaded to the activation of its components. At the same time there was restored the balance of neuromediators in brain formations studied up to the level registered in intact animals. The introduction of cholinotropic drugs also significantly restored the content of testosterone and tropic adenohypophyseal hormones (LH, FSH) in peripheral blood. CONCLUSION: The mechanism of activating action of cholinotropic drugs on SB under stress is determined by direct influence on the central M-cholinergic mechanisms of brain as well as by the regulation of neuroendocrine and neuromediatory systems regulating SB. MENTAL DISORDERS IN OFFSPRING OF PARENTS WITH BIPOLAR DISORDER IN SOUTH KOREA. SH Shim, Soonchunhyang University Hospital, Cheoan, South Korea BACKGROUND: A meta-analysis and more recent studies report rates of bipolar disorder between 4-15% in the offspring of parents with bipolar disorder, and between 0-2% in the offspring of healthy parents. Whether offspring of parents with bipolar disorder are at specifically high risk to develop bipolar disorder and other psychiatric disorders has not been adequately studied. Furthermore, in South Korea, there have been no studies of lifetime prevalence and specificity of psychiatric disorders in offspring of parents with bipolar disorder. The aim of this study was to examine the prevalence of mental disorders in the offspring of individuals with BP. METHODS: The sample consisted of 100 child and adolescent offspring (aged 6.018.9 years; mean S.D. = 13.63.9 years) from 65 nuclear families having at least one parent with bipolar disorder (36 with bipolar disorder type I and 29 with bipolar disorder type II). Probands and biological co-parents were interviewed by psychologists using a semi-structured diagnostic interview and the offspring were evaluated using the Korean version of the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). Tools for the evaluation of the offspring were Korean version of Mood Disorder Questionnaire, Korean ADHD Rating Scales for Parents, Childrens Depression Inventory(CDI), and Revised Childrens Manifest Anxiety Scale(RCMAS). RESULTS: For depression, 100 child and adolescent offspring were an average CDI scores of 15.75.6. 31.2% of them exceeded the clinical cut-off for depression. For anxiety, 100 child and adolescent offspring were an average RCMAS scores of 17.57.6, who exceeded the clinical cut-offs for anxiety. Sixty one of the 100 participants met the criteria for at least one mental disorder. Of these, 35 participants had a mood disorder, 35 had an anxiety disorder, and 29 had attention-deficit hyperactivity disorder (ADHD). Thirty nine of the offspring just had no psychiatric diagnosis. Of the 35 with a mood disorder, 22 were diagnosed with bipolar disorder, 16 children received a diagnosis of any depressive disorder, 16 (45.7%) had comorbid ADHD and 18 (51.4%) had comorbid anxiety disorders. The mean age at onset of mood symptoms among the subjects with bipolar and major depressive disorder was 11.82.3 years. However, the child with bipolar disorder type 1 (n = 1) developed her first mood symptoms at eight years of age. Moreover, the child with bipolar disorder type I had episodic courses, exhibiting irritable or elated moods during manic episodes, and had a prior history of psychiatric hospitalization. CONCLUSION: Offspring of parents with bipolar disorder are at high risk for depression, anxiety and any mental disorders. The study of offspring of bipolar parents who are at high risk for developing bipolar disorder themselves is essential to identify potential prodromal manifestations of the disorder and to eventually establish targeted early intervention strategies. Longitudinal studies are needed to confirm the prodromal manifestations of bipolar disorder and risk factors associated with the development of specific diagnoses in children and adolescent. OREXIN OX(1) RECEPTOR ANTAGONIST SB-408124 POTENTIATES THE INHIBITORY ACTION OF SULPIRIDE ON AMPHETAMINE-ACTIVATED BUT NOT SPONTANEOUS SELF-


STIMULATION. PD Shabanov, AA Lebedev, RO Roik, VI Morozov, Military Medical Academy, Institute of Experimental Medicine RAS, St. Petersburg, Russia BACKGROUND: The orexin (hypocretin) family of hypothalamic neuropeptides has been participated in reinforcement mechanisms relevant to both food and drug reward. There are dense concentrations of orexin receptors in the extended amygdala and mesocoricolimbic structures implicated in drug reinforcement processes. Behavioral studies with antagonists at the orexin A-selective receptor OX(1) have demonstrated its involvement in behavioral sensitization, conditioned place-preference, self-administration and reinstatement of drugs abuse. Because of suggestion, that OX1 and D2 dopamine receptors could form heteromeric complex, for example, orexin A + quinpirol, a D2 dopamine agonist, or SB-408124, an antagonist of OX1 receptors, with sulpiride, we used both latter drugs in our experiments to prove or disprove this admission. The possible interaction between orexin OX1 and dopamine D2 receptors in alcohol abuse has recently shown in the experiment on rodents. Here, we attempt to clarify whether SB-408124, an antagonist of the orexin A-selective receptors OX(1) injected into the central amygdale, can interact with antagonist D2 receptor sulpiride on inhibition of reinforcing effects of amphetamine on self-stimulation of the lateral hypothalamus in rats. METHODS: The 51 Wistar male rats were implanted bipolar electrodes into the lateral hypothalamus to study self-stimulation reaction in the Skinner box. Simultaneously, the microcannules were implanted into the central nucleus of amygdala (CA) to inject the drugs studied (1 g in 1 l in volume for each injection). Antagonist of the orexin A-selective receptors OX(1) SB-408124 was administered intrastructurally (into CA) and antagonist of D2 receptor sulpiride was injected intraperitoneally followed by pharmacological analysis. RESULTS AND DISCUSSION: SB-408124 injected into the extended amygdala region (CA) alone had no effect on self-stimulation of the lateral hypothalamus. Sulpiride in low dose (5 mg/kg) did not affect both the spontaneous and amphetamine-activated self-stimulation (1 mg/kg). Amphetamine as a rule increased self-stimulation measured as lowering the threshold and enhancing the frequency. Amphetamine-induced stimulatory effects on intracranial self-stimulation were reduced by injections of SB-408124 into the CA up to the background level. Simultaneous administration of SB-408124, an antagonist of the orexin A-selective receptors OX(1), and sulpiride i.p. (5 mg/kg) inhibited amphetamine-induced self-stimulation in more degree than background level, that was sulpiride potentiated the inhibitory effect of SB-408124. These data demonstrate that OX(1) receptors play an important role in regulating the reinforcing and reward-enhancing properties of amphetamine and suggest that orexin transmission (neuromodulation) is likely essential for establishing and maintaining the amphetamine habit in human addicts. However, the observations that OX1 antagonism reduces brain reward and blocks stress- and cue-induced reinstatement of drug-seeking suggesting that class of compounds may be useful additions to stress-reduction and other behavioral therapies in the treatment of substance abuse disorders. CONCLUSION: Our findings suggest that the combined use of low doses of D2 antagonists (e.g., sulpiride) and antagonists of the orexin A-selective receptors OX(1) (e.g., SB-408124) is necessary to reorganize the central mechanisms underlying the addiction, in order to correct drug abuse. RESEARCH SUPPORT: Supported by the RFBR grant 13-04-00186. IS VIDEO SCENERY AS APPEALING AS REAL LANDSCAPE? AN EEG STUDY. NC Chiang, SCL Huang, Department of Social Psychology, Department of Tourism, Shih Hsin University, Taipei, Taiwan INTRODUCTION: The use of videos for environmental representation is common in modern society. In fact, video images have been adopted in perceptual research more often than before. However, studies devoted to examining whether people responses to real landscape are the same as those to video scenery, are limited. This study adopted objective EEG measurements, alpha and beta brainwaves, to examine the brainwave patterns to real landscape, and those to simulated video scenery. METHODS: Twenty participants were recruited from different colleges in Taiwan. The study


setting was a man-made lake located in a university campus. Ten participants personally experienced the lake landscape, while other ten watched the simulated lake scenery on the video. A portable EEG headset was used to measure the participants brainwave responses. RESULTS AND DISCUSSION: Our results indicate that the participants low-alpha rhythms in the on-site condition fluctuated more often, and reached more extreme peaks than those in the video condition. Whereas, their high-beta rhythms were in the opposite patterns, which showed higher peaks in the video condition than in the on-site condition. The results suggested that the participants in the on-site condition might unconsciously be more alert to the on-site stimuli than the video participants. However, they might need to devote more cognitive processing to understand the environmental content on the video than the real environment. Furthermore, the brainwave responses for the video condition were matched with what the participants saw on the video, and thus, the physical features in the environment that caused the bursts or peaks of brain rhythms across time were identified. Based on the findings, the implications of brainwave patterns in environmental psychology, as well as the application of videos as visual surrogates, are discussed. MELATONIN, CORTISOL AND DAYTIME SLEEPINESS AFTER NIGHTTIME EXPOSURE OF LIGHT EMITTING DIODE (LED) WITH AND WITHOUT BLUE LIGHT: A RANDOMIZED, DOUBLE-BLINDED, CROSS-OVER, PLACEBO-CONTROLLED COMPARISON. HJ Jeon, Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea INTRODUCTION: Light is the primary stimulus for regulating circadian rhythms. The short wavelengths (446-477nm) are the most potent wavelengths providing circadian input for regulating melatonin secretion. Exposure to light from smart-phone display may be linked to increased risk for sleep disorders because these devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. The purpose of the present study was to test the melatonin suppression and to test circadian phase delay effects of a smart-phone display comprising in healthy adult male volunteers. METHODS: This study was prospective, double-blind, randomized crossover study. A total of 22 healthy male subjects with a mean age of 30.95 years (SD 4.15) were finally recruited to participate in the study by advertisement, 21 complete the study. RESULTS AND DISCUSSION: Participants with standard smart-phone display had lower levels and later onset of melatonin secretion than the adjusted group. The 150-min exposure to light from standard smart-phone display induced a 14.4-min phase delay of DLMO50% (Dim light melatonin onset 50%) compared with adjusted smart-phone display. RESEARCH SUPPORT: Samsung Display. SPECIAL FOCUS TALK: MECHANISM OF ANXIOLYTIC EFFECT OF SSRI. T Izumi, M Yoshioka, ISBS Fellow, Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan INTRODUCTION: The amygdala is a crucial brain structure for anxiety, and it is speculated that the serotonergic neural system in this structure plays an important role in regulating anxiety. In our previous study, we indicated that systemic administration of selective serotonin reuptake inhibitor (SSRI) had anxiolytic effect in fear-conditioned rats, and conditioned fear-induced c-Fos expression in the basolateral nucleus of amygdala (BLA) was blocked by SSRI. In the present study, we investigated the effect of local injection of SSRI and 5-HT1A antagonist into BLA on animal models of anxiety. METHODS: Male Wistar/ST rats (9-14 W) were used. All animal protocols were approved by the Hokkaido University Animal Care and Use Committee. Guide cannula were implanted 2 mm above BLA (3.0 mm, 5.7 mm, 6.6 mm from dura). Eight days after the surgery, contextual fear conditioning and elevated plus-maze were performed. Ten minutes before tests, citalopram (SSRI, 0.3, 1 and 3 g/side) and WAY-100635 (5-HT1A antagonist, 0.005, 0.05 and 0.5 g/side) were


bilaterally injected to BLA. RESULTS AND CONCLUSION: Local injection of citalopram into the bilateral BLA dose-dependently attenuated conditioned fear-induced freezing behavior in rat, and this effect was dose-dependently blocked by local co-administration of WAY100635. Elevated plus maze test was no change with citalopram and/or WAY100635 injection. From these results, it is speculated that SSRI exerts anxiolytic effect on memory-dependent fear via 5-HT1A receptors in BLA. RESEARCH SUPPORT: This study was supported by a Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology 06770740 (TI). EXERCISE ENHANCES STRESS COPING DESPITE INCREASING CORTICOSTERONE, LIKELY BY UPREGULATING THE DOPAMINE LEVEL IN THE MEDIAL PREFRONTAL CORTEX. C Chen, S Nakagawa, Y Kitaichi, Y An, Y Omiya, N Song, M Koga, T Inoue, I Kusumi, Department of Psychiatry, Hokkaido University Graduate School of Medicine, Japan INTRODUCTION: Although exercise can improve stress coping, the underlying neurotransmitter mechanisms of this effect remain largely unknown. Furthermore, exercise activates the hypothalamicpituitaryadrenal HPA axis and increases glucocorticoid (CORT), the stress hormone, which impairs stress coping. Thus, exercise should, through some mechanism, override the detrimental effects of elevated CORT. The purpose of the present study is to investigate by what neurotransmitter(s) exercise can override the detrimental effect of elevated CORT within the medial prefrontal cortex (mPFC), the brain center of stress coping. METHODS: Exercise rats were raised with three weeks of free access to wheels, while control rats were raised in same cages but without wheels. The forced swim test was performed at 19:00, the time at which lights are switched off, and around which the (circadian) CORT levels peak. A separate group of rats were raised the same way, and mPFC microdialysis sampling was performed before and after the forced swim test. We used the high-performance liquid chromatography (HPLC) system to detect neurotransmitters, and an ELISA kit to measure CORT. RESULTS AND DISCUSSION: Three weeks of voluntary wheel running reduced immobility time in the forced swim test, suggesting stress coping effect. Basal level of extracellular CORT (17:00-19:00, around circadian peak) in the mPFC was higher in exercise than control rats. When subjected to forced swim, both exercise and control rats showed increased CORT. However, CORT in exercise rats decreased to basal level earlier than in control rats. Extracellular dopamine level in the mPFC was increased in exercise rats, both at the basal level and after forced swim. Basal level of extracellular glutamate level in the mPFC tended to be reduced in exercise rats. There was no group difference with regard to serotonin, noradrenaline, glutamine, glycine, taurine, or alanine. These results suggest that elevated dopamine level in the mPFC may be a mechanism by which exercise improves stress coping, and overrides the effect of increased basal CORT. This interpretation is in line with evidence that dopamine promotes stress coping, and antidepressants also achieve therapeutic effects through dopamine neurotransmission in rodents. RESEARCH SUPPORT: Hokkaido University Clark Memorial Foundation. ABNORMAL INTRA-GROUP VOCAL COMMUNICATION WITHIN PRIMATE FAMILY INCLUDING A KID OF MODEL OF AUTISM. K Mimura, N Ichinohe, Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan INTRODUCTION: Autism spectrum disorder (ASD) is one of the most common developmental disorders. Children with ASD have trouble of communication (DMS-V, 2013) also with family, and thus, probably, communication style of parents should be changed. In rodents, exposure embryos to valproic acid (VPA), known as the risk factor of ASD in human (Christensen, 2013), are widely used as an animal model (Crawley, 2012). Here we show that common marmoset (Callithrix jacchus) families with a juvenile with exposure to VPA show vocalization abnormality. METHODS: The


experiment was conducted using 4 families (2 families with a mother exposed by VPA during pregnant: VPA family and 2 families with un-exposed by VPA: UE family) of marmosets. In experimental situation, each family consists of one or two juveniles (ranging from 3 to 4 months of age) and their respective parents. VAP mother received seven oral administrations of sodium valproate at 200mg/kg/day from day 60 to 66 after conception. To evaluate the familial social communication, family (one juvenile and its parents) vocalizations were recorded for 30 minutes in their home cage carried at shield room. Vocal spectrogram was used to define and count 7 call types. All procedures were approved by the Animal Research Committee at the National Institute of Neuroscience in Tokyo, Japan. RESULTS AND DISCUSSION: There were significant differences of call-uses between VPA and UE families. In VPA families, the phee call aiming distant other marmosets was more frequent than in UE, on the other hand, the trill call, which is supposed to related to feeling affinity, was less frequent. VPA family member might feel farther mental distance among each other (e.g., less empathy and sympathy) than UE family. Further analysis and experiments could lead us to understand communication problem of ASD model primates, which have less repertoire of languages. RESEARCH SUPPORT: This research was supported by the JSPS Research Fellowship. COMMON MARMOSETS DEVELOP GENERATION-SPECIFIC PEER SOCIAL EXPERIENCES THAT MAY AFFECT THEIR ADULT BODY WEIGHT ADAPTATION TO CLIMATE.G Karino, M Shukuya, S Nakamura, ISBS Fellow, T Kunikata, H Yamanouchi, M Koshiba, ISBS Fellow. Department of Pediatrics, Saitama Medical University, Saitama, Tokyo University of Agriculture and Technology, Tokyo, Tokyo City University, Kanagawa, National Center of Neurology and Psychiatry (NCNP), The Japan Society for the Promotion of Science, Tokyo, Japan INTRODUCTION: Peer social interaction plays a pivotal role in psychological development. From birth, parent-infant interaction modulate fundamental brain processes (Bolhuis and Honey, 1998; Weaver, et al., 2004; Law, et al., 2009), whereas more complex psychological development occurs in socializing with peers (Laible, et al., 2000; van Geel, et al., 2014). We have hypothesized that critical learning period, based on social interaction with peers, is one of possible causes of communicational and emotional disabilities, such as autism spectrum disorder (ASD). Here, we attempted to test the hypothesis of susceptible period learning with peers by investigating the effects on acclimatization in adulthood of common marmosets (Callithrix jacchus). METHODS: Two experimental groups were set as a primate developmental model. The animals experienced interactions with the same aged peer monkey, either early in an infant (group Early) or late in a juvenile period (group Late). To assess developmental differences in adulthood between these two groups, their bodyweight changes, one of well-validated markers of physiological and psychological health, were traced with indoor/outdoor temperature and humidity. To further explore differences in the monkeys physical adaptability in metabolic modulation depending on the environmental modifiers, their blood glucose concentrations were measured. To globally evaluate the correlation between bodyweight and environmental factors, a multivariate analysis based on principal component analysis (PCA) by correlation matrix, BOUQUET (Koshiba, et al., 2013), was performed. After acquiring suggestive parameters correlated with bodyweights, the differences in bodyweights between the Early and Late groups were compared. RESULTS AND DISCUSSION: The analyses performed reveal that bodyweight changes in group Early decreased at lower outdoor humidity, while group Late was unaltered or increased. In addition, this characterized bodyweights negatively correlated with blood glucose concentrations. This pilot report of our ongoing longitudinal monitoring of marmoset development suggests a potential susceptible period for peer-social learning, and the effect on the development of their autonomic nervous systems adjusting function as climatic adapting responses. RESEARCH SUPPORT: This work was supported by JSPS KAKENHI Grants 25282221, 21200017, 25119509, 15J06978 and JST-ALCA, JST-a-step in Japan.


INCLUSIVE INTERVENTION FOR PSYCHO-DEVELOPMENT WITH BEHAVIOR ANALYSIS USING QUANTITATIVE EMOTIONAL STATE TRANSLATION (BOUQUET). M Koshiba, ISBS Fellow, G Karino, K Mimura, H Tokuno, S Usui, I Tanaka, Y Honda, T Kodama, K Sato, H Kishino, M Shukuya, T Kunikata, S Nakamura, ISBS Fellow, H Yamanouchi, Saitama Medical University, Saitama, Tokyo University of Agriculture and Technology, Tokyo, TMIM, National Center of Neurology and Psychiatry (NCNP), University of Tokyo, Tokyo City University, Tokyo, Japan INTRODUCTION: Psychological functions of vertebrates, including humans, develop during longitudinal interaction between genes and environments. To consider any treatments of psychological disorders per individual differently, some information processing methods based on quantitative observation and analyses on the vertebrates life-long development must be used. Here, we outline factors of the interplay between animals and environments, and assess them using multivariate correlation, to generate adequate inclusive intervention programs with currently advanced sensing systems. METHODS: As the model of human development, we observed behavioral, physiological and psychological development of domestic chicks and common marmosets under simultaneous monitoring of environmental indices. We further attempted to apply these processes to comprehend infant development in the environments of our neonatal intensive care unit (NICU). This work was approved by the institutional review board in Saitama Medical University (13-092). RESULTS AND CONCLUSION: In the analytic space constructed by multiple dimensions of behavioral, physiological, psychological and environmental data, we identified arbitrary aspects integrated with their mutual affects. Within the information, the acquired age-specific transition seemed to indicate some qualitative changes with various linear regressions. This approach is expected to empower the development of future therapeutic interventions. RESEARCH SUPPORT: This work was supported by JSPS KAKENHI Grants 25282221, 21200017, 25119509, 15K15404 and JST-ALCA, JST-a-step in Japan. AN ATTIDUDE SURVEY OF IMPORTANCE OF LEARNING NEONATAL CARDIO-PULMONARY RESUSCITATION (NCPR) IN MIDWIFERY COURSE STUDENT. M Yoda, Y Inai, Saitama Medical University College, Saitama, Japan BACKGROUND: Midwife usually assists normal delivery, but recently has an increasing chance of aiding high-risk deliveries. Thus, it is important for a midwife to be skilled in resuscitation. Resuscitation training, necessary for student in midwifery course, was started in our neonatal cardio-pulmonary resuscitation (NCPR) program. RESEARCH OBJECTIVES: Motivating students for learning resuscitation, we surveyed factors influencing their motivated attitude of learning the program before the NCPR training. RESEARCH METHOD: We asked questions described below before the NCPR training program and obtained 19 answers from 20 students. The protocol of this research was approved by the ethical committee in Saitama Medical University College. The questions included educational background of the students, how and when they knew about the program, their school year, recognition of necessity of learning resuscitation, and expectation of learning NCPR program. As more detailed question about the expectation, we asked the expected usefulness in passing the state examination for the license as midwife, experience in midwifery course, incentive of job opportunity, skill-up, and being self-confident. RESULT AND DISCUSSION: Many of students did not know the program is open. However, they recognize the necessity of the NCPR training. This attitude was more clear in the graduate students than in undergraduates. The main outcomes of the survey was that we need to emphasize the clinical importance of NCPR skills, which can result in a significant decline in neonatal morbidity and mortality under burden related to caring for a high-risk infant.


REDUCING FATIGUE OF OPERATORS BY PERIPHERAL VISUAL INSPECTION METHODS. A Ishii, A Sasaki, M Koshiba, ISBS Fellow, Kagawa University, Kagawa, Peripheral Visual Inspection Lab, Kanagawa, Saitama Medical University, Saitama, Japan INTRODUCTION: The industrial products are made by manufacturers and shipped to the customers. In each manufacturing process, inspections are performed on whether or not a product is made by the standards. Products or semi-manufactured products which did not meet the inspection standards are removed as defective, as only quality goods proceed to the next level. One of the inspections includes a visual appearance inspection. For many appearance inspections, automation of the inspection by machine vision is performed. However, for complex objects difficult to assess in an automated manner, the visual inspection by a person is performed. Humans greatly differ from machine vision in several ways. (1) Required specifications: Machine vision can be designed to fit required specifications, but you cannot design the inspector to fit the specifications. (2) Ability for inspection: Inspection ability among operators varies, and the operators may not maintain stable ability for the whole day. (3) Recognition and judgment: It is difficult to understand how the operator judges the product visually from the in-work motions. The presented peripheral visual inspection method was introduced by A Sasaki, one of our authors, during his work on productivity improvement of visual inspection. The significant points of the method are how to use eyes, handling of the work, and the usage of illumination. How to use eyes in particular is important. If you master how to use eyes, you will be able to inspect with high speed and without missing defective items. It can reduce the fatigue of eyes dramatically. Introduction of Peripheral Visual Inspection: The following three basic matters on understanding the peripheral visual inspection method have been explained. (1) Inappropriate instruction for operators. (2) Why the difference (defective) can be found instantly. (3) Perception of light and shade. Then, points of the introduction of the method into the actual site are presented. EXPERIMENT AND RESULTS: The method has been applied to the visual inspection site and investigated for 1.5 years. As a result, two major improvements were obtained. For work efficiency, the inspection time was reduced by 1/3. For health conditions, pain in the eyes, neck and shoulders (resulting from fatigue of the eyes) has been alleviated. DISCUSSION: Why was the inappropriate instruction of operators performed for a long time? Why is the high-speed inspection for a long time for skillful operators possible? We will discuss these questions from the viewpoint of cranial nerve science. GENDER DIFFERENCES IN THE DEMAND CONTROL MODEL OF WORK STRESS: AN EXAMINATION OF DATA FROM SONGKHLA PROVINCE, THAILAND. K Janyam, Faculty of Liberal Arts, Prince of Songkla University, Songkhla, Thailand Occupational stress related to work environment is receiving an increasing attention. There have been many test of Karaseks demand-control model of work stress. However, there is limited research of how the model may differentially apply to male and female workers. Therefore, the current study aims to investigate work stress among male and female workers according to the demand-control model. The subjects of the study, 1,094 workers of seven occupations, included 53.1% males. The subjects mean age was 36.3 years (SD=10.5), and 59.2% of them were holders of bachelors degree or equivalent. The data were collected using a Thai version of the Job Content Questionnaire (JCQ), and analyzed using mean, SD and t-test. The results revealed significant differences between male and female job stressors in the demand control model. Male workers mean score of decision latitude, physical demand, social support, and work hazards was higher than that in females. Due to the demand control model, these results may indicate that male workers had higher work control than female workers. Focusing on the decision latitude, male workers may likely have more opportunities to do the work that improve their skills development (e.g., learning new skills, creativity, skill varieties, work advancement, self-development and decision-making) than female workers. Adjusting to the work demand, male workers also experience higher work demand


than female workers. In addition, male workers had higher social support than their female counterparts. Accordingly, male workers may contribute to the active group more than female workers, and are likely to have lower level of stress than female workers. According to the results of our study, female workers may likely have more stress than male workers. Hence, the organization should consider the appropriateness of the female workers workload and tasks to the level of control they have over them. Increasing the level of work control (e.g., by encouraging the female workers to adapt their work behavior) will eventually lead to proactive learning, motivation in self-improvement and work advancement.

Day 2. Mon, July 27, 2015 Shinryoku-Kaikan (Alumnus Hall), School of Medicine, University of Kobe, Kusunokicho, Chuo-ku, Kobe, Japan Morning session SYMPOSIUM 2. NATURAL AND SOCIAL DISASTERS Chairs: K Niwa and M Maeda (Japan) CURRENT SITUATION OF THE INETERNAL RADIATION EXPOSURE SCREENING PROGRAM IN MINAMISOMA, FUKUSHIMA, AND THE FUTURE TASKS. M Tsubokura, University of Tokyo, Minamisoma Municipal General Hospital, Japan INTRODUCTION: Since the Fukushima Dai-ichi nuclear power plant disaster on 11.03.2011, a regular internal radiation exposure screening program has been in place in Fukushima. From the results, we know that the level of chronic internal exposure among residents has been kept at a very low level. The results from the food inspection programmes and a whole body counter examination for infants (Babyscan) also showed the similar results. MATERIALS, METHODS AND RESULTS: However, the level of awareness and the feeling of anxiety that the residents have experienced about the current situation vary by individuals. When the number of residents who are no longer interested in radiation and avoid discussing about it is increasing, people who avoid to consume locally grown produce also exist, especially among the young generation. Within Minamisoma city, approximately 75 % of parents with small children have answered that they intentionally avoid eating locally grown produce, and many of them are also worried about water safety. When the number of individuals who attend information seminars or study session is decreasing, there is a strong opposition against using locally produced rice. Furthermore, many students are continuing to feel worried about their future especially about their health, pregnancy and delivery. DISCUSSION: There are various possible causes to the current trend such as the distrust relationship between farmers and consumers, issues associated with compensations and radiation-contamination levels, and the cultural differences. While education and risk communication could be one of the solutions to the current complexity in Fukushima, it is in the process of trial and error. The education on radiation and health is not merely about radiation protection, but it is also a part of the public education aiming for children to regain their self-esteem and to avoid isolation. Similarly, the interventions in place after the disaster including the internal radiation screening program are not just for measuring and reducing the levels of exposure. It is also important for maintaining the individuals dignity, and for protecting the regional culture and history. In this session, I will discuss current local situation in the context of radiation issues and other public health problems that have arisen after the incident, and the direction in which we may move forward.


HOW IS THE FEAR OF LOW-DOSE RADIATION EXPOSURE ALTERING BEHAVIORS AND APPERCEPTION OF FUKUSHIMA RESIDENTS? A Hori, Hibarigaoka-Hospital, NPO Minano-Tonari-Gumi, Department of Disaster and Comprehensive Medicine, Fukushima Medical University, Fukushima, Japan INTRODUCTION: Psychiatric practice was severely interrupted after the 11.03.2011 disaster, especially along the northern part of Fukushimas Pacific coast. Three of four psychiatric hospitals were located within 20 km of the Fukushima Daiichi nuclear power plant and had to be closed. My own Hibarigaoka Hospital was temporarily closed because it is within 30 km from the atomic power plant. CASE STUDY: A 61-year-old housewife had been working at a factory since her young days. Immediately after the earthquake, a close friend asked to be driven to another friends house. The patient accepted this request. After that, the tsunami came and her friend was among the lost. The patient started to blame herself for this tragedy. The manufacturing plant where she was working employed many foreigners who evacuated for fear of radiation. The patient and other employees were expected to persevere. Still, she was emotionally unstable and found it difficult. Her boss was more scolding than supportive. Eventually, she was hospitalized in Hibarigaoka Hospital. During her hospitalization, I talked with the patient about her feelings of guilt and the sense of being detested by the tsunami victims. After three months hospitalization, she improved but continued care in our outpatient clinic. One year later, strong fear relapsed without evident cause and she was hospitalized once more. During the second hospitalization, she recalled that she herself was nearly engulfed by the tsunami, and that it was really a traumatic event. After she talked about this memory in a psychotherapeutic setting, she showed great recovery. DISCUSSION: This clinical case suggests that local residents may show indifference to their own distress and appear to be more concerned with their community. There is also prejudice against psychiatric care. After the disaster, local communities in Minamisoma were confronted with population decline and accelerated aging. Moreover, lots of works have been expected after the disaster for the purpose of reconstruction of the local district. Some residents have been driven into severely busy situation. Ordinary moral in Japanese society, by Yoshio Yasumaru, has a strong influence on the disasterstricken area. It makes people capable of enduring the severe situation. At the same time, residents easily hesitate to claim their own rights because of this ordinary moral. Some social issues will be discussed in this presentation. MULTIDIMENSIONAL PSYCHOSOCIAL ISSUES IN FUKUSHIMA: HOW SHOULD WE OVERCOME THEM? M Maeda, Department of Disaster Psychiatry, School of Medicine, Fukushima Medical School, Fukushima, Japan The Great East Japan Earthquake brought serious effects on the vast area of Fukushima prefecture. The coastal area in Fukushima was heavily affected by the huge tsunami, and 1,817 people were presumed dead. However, the most serious and long-term effects on the people in Fukushima were caused by several explosions of the Fukushima Daiichi nuclear power plant after the total electric power loss. The explosions of the three reactor buildings resulted in radioactive contamination in a vast area of the Fukushima prefecture. Although the Japanese government declared a cold shutdown of the plant nine months after the accident, the process to completely decommission the reactors is estimated to take more than 30 years at least. Over 130,000 people were still evacuated to various places in or out of Fukushima. Considering the widespread effects caused by the accident, the psychological problems of the people living in or evacuated from Fukushima should be noted. Here, I will demonstrate the long-term and complicated psycho-social effects on the residents in Fukushima. Various mental health problems can be summarized as follows: post-traumatic stress response, chronic anxiety and guilt, ambiguous loss, separated families and communities, and stigma. Furthermore, serious burn-out or exhaustion of many workers working in disaster area


should be noted. I will review them briefly and try to consider the psychological interventions needed to decrease Fukushima peoples anxieties. We, Japanese, met numerous natural disasters (such as typhoons, earthquakes and tsunamis) in our long history. However, the Fukushima disaster is a serious event we have not ever experienced before. We should share these issues with as many people as possible, and cooperate with them to overcome many difficulties. EFFECTS OF SOCIO-DEMOGRAPHIC STATUS ON THE NEUROCOGNITIVE CORRELATES OF POST-TRAUMATIC STRESS RELATED TO THE GREAT EAST JAPAN EARTHQUAKE: DESIGN, OVERVIEW AND PERSPECTIVE. L Landr, B Thyreau, A Sekiguchi, Y Taki, Tohoku University, Tohoku Medical Megabank, Tohoku, Japan INTRODUCTION: Recent evidence suggests that neurocognitive mechanisms of post-traumatic stress effect may differ depending on age, gender, and potentially other socio-demographic risk factors. However, to date, no study has allowed assessing the combined effect of these variables in a large, heterogeneous cohort of participants exposed to the same trauma type. The present project aims at identifying the interactions between socio-demographic variables, post-traumatic stress, and cognitive functioning and the brain in the frame of a cohort of 10,000 residents of the Miyagi region exposed to the 2011 disaster. METHODS: 10,000 participants of any age from 20 and both gender are being recruited in the region of Miyagi and included in the study. Neuroimaging assessment includes the acquisition of high-resolution T1 structural images, from which the cortical thickness and the volume of subcortical structures will be extracted using semi-automated morphometry (Freesurfer 5.3.0). Cognitive assessment includes measures of memory, executive functioning, attention and decision making. Questionnaires further include measures of stress related to the 2011 disaster, mood states, personality inventories, coping strategies and self esteem, as well as an extensive evaluation of lifestyle variables and psychiatric assessment. Multivariate statistical analyses will be performed on the resulting datasets. RESULTS AND DISCUSSION: As of the end of March 2015, 1000 participants have been included in the study and had their structural MRI data processed. We present here an overview of these data and the corresponding analysis workflow. We plan on having more than 2,000 datasets processed by April 2016, and will proceed to the statistical analysis from this point. We expect to clarify the moderating role of variables such as age and gender, lifestyle, personality and emotional regulation strategies, and the mediating role of regional gray matter volume in the effects of post-traumatic stress on mental health and cognition. RESEARCH SUPPORT: This work is funded and supported by the Japan Society for the Promotion of Science.


SYMPOSIUM 3. LAPIN SYMPOSIUM ON BIOLOGICAL PSYCHIATRY Chairs: M Koshiba (Japan), AV Kalueff (USA)

INTRODUCTION: PROFESSOR IZYASLAV (SLAVA) P LAPIN This regular ISBS symposium is dedicated to Professor Izyaslav (Slava) P. Lapin (1930-2012), one of the true pioneers of experimental neuropsychopharmacology. He graduated from Pavlov Medical School in St. Petersburg, and shortly after receiving PhD, was invited in 1960 to establish the first psychopharmacology laboratory at the Bekhterev Psychoneurological Institute. The most important scientific contribution of Prof. Lapin was establishing the link between serotonin levels and mood-elevating (thymoleptic) action of antidepressants. He suggested that enhanced central serotoninergic tone is essential for the mood-elevating effects of antidepressants. Lapins serotonin hypothesis of antidepressant action, published in Lancet in 1969, became one the most cited papers published in this journal in the last 50 years. Lapins

studies have contributed greatly to the development of newest serotonergic antidepressants, such as SSRIs, currently representing the most prescribed group of psychotropic drugs in the world. Prof. Lapin was also the first to report the neuroactive effects of kynurenine and its derivatives a discovery that opened another rapidly expanding area of glutamatergic psychopharmacology. A talented professional musician, prolific writer, painter, and an enthusiastic athlete, Prof. Lapin was a strong supporter of ISBS, and generously shared his knowledge at our Stress and Behavior conferences and ISBS summer schools. His enthusiasm, friendship, generous support of junior colleagues, and the deep knowledge as both a clinical and experimental neuropharmacologist (humanists and animalists, as he called them), made a long-lasting impact on his colleagues and students. A STUDY OF SATISFACTION AND E-HEALTH LITERACY AMONG USERS WHEN USING TWITTER TO SEEK PSYCHIATRIC CONSULTATION: A RECENT TREND IN SAUDI ARABIA. N Zakaria, A Jamal, S AlDossari, R Barri, K AlMufawez, College of Medicine, King Saud University, Riyadh, Saudi Arabia INTRODUCTION: The use of microblogging by patients to share experiences and to communicate with and support each other during illness has become widespread. In Saudi Arabia, microblogging social media, especially Twitter, have benefited the public health domain. Recent trends show high Twitter usage in the area of psychiatric consultations. OBJECTIVE: The objective of this study was to determine the impact of socioeconomic status, age, gender, and e-health literacy on the use of Twitter for psychiatric consultations; and to determine the level of satisfaction among those who used Twitter for psychiatric consultation. METHOD: A quantitative cross-sectional study was conducted between February 9 and March 23, 2015 in Saudi Arabia. The target population was Twitter users who sought psychiatric consultation through Twitter. Participants were recruited using convenience sampling. An online questionnaire was used to collect data. The questionnaire was posted on the Twitter accounts of several psychiatrists who agreed to participate in the study. The inclusion criteria were simple: (1) the participant had received at least one psychiatric consultation via Twitter, and (2) the participant, whether Saudi or non-Saudi living in Saudi Arabia, must speak and understand Arabic. The measurements of interest were socio-demographic factors, satisfaction, e-health literacy, Twitter usage for health and psychiatric consultation and how well Twitter solved their problems. RESULTS: Psychiatric consultation via Twitter is being used in Saudi Arabia.


Females used Twitter more often use Twitter for psychiatric consultation than male users, but other demographic factors like age, marital status, education, income and nationality were not significant when it comes to using Twitter for psychiatric consultation. Most participants had a high level of e-health literacy and reported that the Twitter-based psychiatric consultation solved their problem. Participants were satisfied, stating that they were able to get the psychiatric consultation they needed without being set back financially and that the psychiatrist did not make them feel foolish. However, the participants did agree that psychiatric consultation via Twitter needs to be improved. The limitation of this study is the sample size was too small, thus many of the results could not be generalized for other research. In the future, there is a need to recruit more participants to participate in this research. RESEARCH SUPPORT: This study was funded by the College of Medicine Research Center, Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia. NON-INVASIVE CRANIAL ELECTROSTIMULATION (CES) OF ENDORPHINERGIC AND SEROTONINERGIC STRUCTURES OF THE BRAIN VIA NEWLY ELABORATED CES DEVICE FOR TREATMENT OF MILD TO MODERATE DEPRESSION. Y Katsnelson, H Beckhoff, E Berk, Yu Palkin, N Lisyanskaya, A Tereo, N Baranova, Premier Annecto Technologies, PA, USA; 7th Pavlov St. Petersburg Psychiatric Hospital, St. Petersburg, Tver Railroad Clinical Center, Tver, Russia INTRODUCTION: Low concentrations of serotonin and endorphins in the brain structures play important roles in the pathogenesis of depression. Our previous research has shown that cranial electrostimulation with quasi-resonance frequency can effectively activate endorphinergic and serotoninergic systems of the brain alleviating or ameliorating symptoms of depression. The purpose of the present study was to evaluate non-invasive CES utilizing a newly elaborated device (TESA) as a safe and effective treatment for depression. METHODS: In these randomized controlled trials, 30 subjects with depression were treated with a TESA which utilizes a proprietary waveform. Subjects were diagnosed with depression using the Hamilton depression scale HAM-D21, with scores ranging between 10 and 17, and were randomly assigned to one of two treatment groups: (A) TESA device (4.33 mA RMS) and (B) TESA device (15 mA RMS). This study included a one week wash-out period, two weeks of CES (2 cycles of 5 CES sessions, each session lasting 50 min/day), and a 12-week follow up. RESULTS AND DISCUSSION: No significant differences in severity of depression or anxiety were noted between groups measured at baseline and end of wash-out period. Statistical analysis revealed a similarly significant (p


specifically measuring the yield point at which a person cannot take any more psychological stress, or the straw that broke the camels back. We can also measure strain against stress for humans as we do in engineering for materials. Human productivity depends on two elements, HDI (Human Development Index) and ambitiousness; both are mainly connected to psychological stress. CONCLUSION: Restructuring psychological education by adopting a new concept, engineering psychology as in engineering management, and by considering the NLP psychological techniques in different stages of education, will help people achieve high self-control levels, increase productivity, and ultimately will increase the GDP (Gross Domestic Product) per capita. Far-East cultures have built high psychological resilience, capacity, strength, and ambitiousness through practicing meditation and yoga. As such, they have achieved high levels of economic growth as well. EFFECTS OF PET INSECTS ON PSYCHOLOGICAL HEALTH AMONG COMMUNITY-DWELLING ELDERLY: A RANDOMIZED-CONTROLLED TRIAL. HJ Ko, CH Youn, SH Kim, SY Kim, Department of Family Medicine, Kyungpook National University School of Medicine, Daegu, South Korea BACKGROUND: There is evidence that animal-assisted therapy has positive effects on mental health, especially for the elderly. Rearing insects is easy, less expensive, and does not occupy a lot of space. Thus, this study assessed the effects of pet insects on psychological health among community-dwelling elderly. METHODS: The elderly aged over 65 years, who enrolled from April to May 2014, in Daegu, Korea were randomized into an insect group or a control group with a 1:1 ratio and followed for eight weeks. The insect group received pet insects (crickets) to rear with sufficient fodder, a cage, and a detailed instruction manual. Psychometric tests, including the Beck Anxiety Inventory, Geriatric Depression Scale (GDS-15), Mini-Mental Status Examination (MMSE), 36-item Short Form Health Survey (SF-36), Insomnia Severity Index, Fatigue Severity Scale and Brief Encounter Psychosocial Instrument, were administered via direct interviewing. Laboratory inflammatory and oxidative stress markers, including erythrocyte sedimentation rate, high-sensitivity C-reactive protein, biological antioxidant potential and derivatives of reactive oxygen metabolites, were analyzed. RESULTS: The baseline characteristics of the insect (n=46) and control (n=48) groups were similar. In the insect and control groups, the GDS-15 scores were 3.98 and 4.98 (P=0.162), respectively, at baseline, and they changed to 3.20 and 4.90 (P =0.004), respectively, at Week 8. The least squared means of the differences for the GDS-15 adjusted for baseline scores were significantly different between the two groups (-1.12 vs. 0.20, P=0.011). The MMSE scores changed from 26.76 to 27.98 in the insect group, and 27.17 to 27.40 in the control group. The least squared means of the differences adjusted for baseline MMSE scores showed significant differences between the two groups (1.13 vs. 0.31, P=0.045). There were no significant differences between the two groups for other psychometric and laboratory tests. No serious risks or adverse events were reported. CONCLUSION: Rearing insects is cost-effective and safe, and it has positive effects on depression and cognitive function among community-dwelling elderly. Further studies with different age groups and larger samples to investigate the effects of pet insects are warranted. RESEARCH SUPPORT: This study was supported by the Research Program for Agricultural Science and Technology Development (PJ009600032014), National Academy of Agricultural Science, Rural Development Administration, Republic of Korea. AN EXPERIMENTAL STUDY TO ASSESS THE EFFECT OF PHYSICAL EXERCISES ON ANGER MANAGEMENT AMONG SUBSTANCE DEPENDENCE SUBJECTS ADMITTED IN DRUG DE-ADDICTION AND TREATMENT CENTRE (DDTC) OF PGIMER, CHANDIGARH. K Das, P Malhotra, S Sharma, National Institute of Nursing Education, D Basu Department of Psychiatry, PGlMER, Chandigarh, India


INTRODUCTION: Anger is a normal, healthy human emotion. Anger often serves important functions, such as motivating the individual to take protective action, achieve goal or overcome obstacles. However, when it gets out of control and turns destructive, anger can lead to various physiological, psychological and behavioral problems. Substance dependence subjects have a tendency towards angry temperament, a general propensity to express anger and angry reaction, a disposition to express anger when criticized or treated unfairly. To control the anger there are various interventions. Physical exercises are one of the ways to control the anger. OBJECTIVE AND METHODOLOGY: The main aim of present study was to assess the effect of Physical exercises on anger management among substance dependence subjects. Experimental design was employed using purposive sampling technique to allocate 30 subjects each in experimental group and control group. In the experimental group, Physical exercises were used as a part of intervention for 15 days where in control group routine care was provided. Baseline characteristics were recorded in assessment proforma. Subjects anger was assess using State-Trait Anger Expression Inventory- 2TM (STAXI-2TM). Responses were recorded on day before intervention and after fifteen days of intervention in experimental group and also without intervention in control group to monitor the anger management by reduction in angers scoring in both the groups. Both the groups were homogenous with respects to age, gender, marital status, education status, occupation status, diagnosis. RESULTS AND DISCUSSION: There was significant difference in the pre and post intervention anger scores in experimental group (p


20.08 years, SD = 0.95). Reseach results find that 2 students (5%) had mild stress, 19 students (51%) moderate stress, 6 students (16%) high stress, and 10 students (27%) - severe stress. Sources of stress are various. 25 students (67 %) had study stress. 5 students (13%) had family stress. 3 students (8%) had love stress. 3 students (8%) had their own personal stress, and 1 student (2%) - health stress. For those students who have study stress, 10 students (40%) worry about their grading and examination, 9 students (36%) cannot understand the lessons clearly, 2 students (8%) do not like homeworks and assignments, 2 students (8%) think the study lessons are too much for them, and 2 students (8%) disliked the lecturers. From the research results above, it can be seen that undergraduate students in Social Development Program, Faculty of Liberal Arts, Ubon Ratchathani University mainly have moderate stress with special attention to study stress. Study orientation at the beginning of each semester should

ISBS KOBE 2015 Final Program and Proceedings

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