Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and...
-
Upload
abner-jefferson -
Category
Documents
-
view
218 -
download
0
Transcript of Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and...
![Page 1: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/1.jpg)
Is Cancer a Disease of Self-
Seeding?
Larry Norton Joan Massagué
presented by: Giulia Dulá and Alina Gatowski
![Page 2: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/2.jpg)
Current Understanding
Aberrant Migration Invasion Metastasis
Increased proliferation: cell death Dichotomies
Invasion vs. metastasis Tumorigenesis vs. metastatic behavior
![Page 3: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/3.jpg)
What is self-seeding?
Cell mobility is key for primary tumor growth (not just metastasis)
Think about weeds in a field: NOT by one plant
growing large Continuous growth of
new weeds within original site and at periphery
![Page 4: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/4.jpg)
The logic of self-seeding
![Page 5: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/5.jpg)
Mathematics of self-seeding
Fractal geometry
• Gompertzian growth
![Page 6: Is Cancer a Disease of Self-Seeding? Larry Norton Joan Massagué presented by: Giulia Dulá and Alina Gatowski.](https://reader036.fdocuments.us/reader036/viewer/2022082422/56649e9e5503460f94b9f77d/html5/thumbnails/6.jpg)
How does self-seeding fit current understanding?
Increased growth rate and increased total volume of malignancy
Satellite lesions
Larger tumor mass cell density
Aggressive seeding could be cause for large tumor masses with high metastatic potential