iOMICSUnified Software Suite for NGS and Microarray Data Analysis and Interpretation

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Multi-omics Multi-scale data management, analysis, and interpretation software.

Developed for composite analysis needs and tested with numerous data sets,

this robust platform addresses the complexities of Life Sciences “Big Data”

for driving actionable insights with unprecedented ease.

iOMICS: Omics Software Solution

Apps for every data (omics) type

Intuitive Analysis

Dynamic Visualization

Support proprietary and 3rd party softwares and databases

RESTful

iOMICS

dbNSFP, dbSNP, Uniref100, Uniprot, HumDiv, HumVar,

Ensemble, RefSeq, miRBase KEGG, Interactome, etc

Annotated VariationsEnriched PathwaysPeaks and MotifsKnown and putative genesDifferential Gene ExpressionKnown and Putative miRNAPotential Drug TargetsPhenotype-specific BiomarkersStratified Patient GroupsOff-target effects

App StoreDNA RNA ChIP miRNA

Exome MicroArray MetaGenome

IntegrativeBiology

Ion Torrent, Illumina, Affymetrics, Agilent

PhenotypeModeling

iOMICS: High Level Architecture

FASTQ

CEL

SAM/BAM

CSV/TSV

VCF

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Drug TargetIdentification

PatientStratification

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iOMICS: Scalable, Customizable, Flexible

Flexible and easy to use user interface (UI)

Raw data to results in three steps

– Create

– Analyze

– Visualize

Checkpoint and Re-start

Fast and efficient workflows to process hundred's of samples

Data store to manage high-through put data

Easy integration and customization of in-house, 3rd party tools, annotations, and

databases

Cloud and On-premise versions

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iOMICS: Visualization

Heatmap for significantly expressed genes

Clustering of samples based on significant genes

Enriched peaks based on epigenetic data

Karyotype plot representing the significant genes and peaks

Gene-Pathway Interaction

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Integrative Biology: Overview

ChIP-RNA

Input Inference

DNA-RNA

miRNA-RNA

Called peaks Differential gene

expression

Gene Expression alterations due to epigenetic factors

Variants associated with phenotype

Gene expression

Impact of mutations on gene expression associated wih phenotype

Differential miRNA expression

Differential gene expression

miRNA target association and validation based on gene expression changes

Analytics

LASSO, IDA Causal Inference, Mutual Information

Linear Regression, ANOVA

Likelihood Test, Bayesian Mixture Models

iOMICS 4.0: Significant Features

Indepth Pathway Analysis

Knowledge Base(Omnia)

Multi-Omics DataIntegration

Advanced Biological Filters

High to low level visualization of all types of biological pathways based on the experiment

Visualization includes genes, proteins, metabolites, reactions, and complexes

Curated disease centric knowledge base, constructed using text and data mining techniques

Structured data from multiple high-throughput genomic and transcriptomic experiments, and open-databases

Integration of multi-omics datasets to simulate the genetic flow of information associated with the phenotypes

Powerful statistical tools such as LASSO, Linear regression, Anova etc are used for integrative analysis

User defined filters on all results for easier biological interpretation Built in biologically relevant filters for variant prioritization using

annotated information

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Wide range of biological networks– Protein Interaction Networks

– Metabolic Networks

– Gene Co-expression Networks

– Gene Regulatory Networks

– Pathway-Gene Networks

Sophisticated network analysis– Network topology

– Clustering

– Bayesian Networks

– Constraint based modeling

– In-silico knockout models

Top-down and bottom-up approach for biomarker

identification and functional association using user data

and reference knowledge bases.

iOMICS 4.0: Network Analysis

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JNCASR

Some Of Our Customers

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Corporate Office: India Corporate Office: USAInterpretOmics India Pvt. Ltd., InterpretOmics, Inc.#15 Shezan Levelle, Walton Road #5 Parker Street, LexingtonBangalore – 560 001 MA 02421, USAEmail : prahalad@interpretomics.co Email: info@interpretomics.coTelephone: +91 80 46623 800 Telephone: 415-800-4515URL: www.interpretomics.co URL: www.interpretomics.co

Genomic Sequencing Lab: IndiaInterpretOmics Center for Next Generation Sequencing#329 7th Main, 80 Ft Road, Indiranagar, HAL II StageBangalore – 5600 08/

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