Iodine Status Has No Impact on Thyroid Function
-
Upload
irah-mansur22 -
Category
Documents
-
view
215 -
download
0
Transcript of Iodine Status Has No Impact on Thyroid Function
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
1/14
IODINE STATUS HAS NOIMPACT ON THYROID
FUNCTION INEARLY HEALTHYPREGNANCY
YULIANA RAMADANI
14120130074
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
2/14
INTRODUCTIONpentung
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
3/14
METHOD
Design :
Su!e"# : In order to select pregnant women with normalthyroid tests, we proposed a thyroid screen to all women
who age > 18 years, without personal history of thyroid disease consulting at the obstetric clinic of our hospital
before 12 weeks of amenorrhea (WA) with a singleton
pregnancy between uly 2!!" and uly 2!!#
S$%&'ing : We included 11! $%&'negatie women withstrict criteria of normal thyroid tests who agreed to
participate and signed a consent form
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
4/14
NE(T))
An$'*sis : tatistical analyses were
performed using the software A ersion *+1+alues were considered significant when P <
0.05. All tests were two-sided.
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
5/14
RESULTS Clinical Characteristics of the 110 Included
o!en
1+ $heir median age was 2"+- y (1#./!),
2+ their body mass inde0 (I) was 22+/ (13./-+4)4+ a weight at inclusion of 31+- kg (/4.12# kg)
/+ they were nuliparous in //+-5+
-+ -45 had neer smoked, 1#5 were former
smokers, and 2#5 were current smokers+3+ 1-5 had a family history of thyroid disease
"+ #25 were born in 6rance (including -35 in the
authors area)+
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
6/14
RESULTample characteristic
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
7/14
TA+LE 1, IODURIA AND THYROID TESTSPERFORMED AT - .EE/S OF AMENORRHEA
12 IN THE 110 INCLUDED .OMENmedian mean ± SD Min Max
Ioduria µg/L 116 139 ± 98 < 15 399
FT4 pmol/L 14,35 14,57 ± 1,65 12.0 19,16
TS !"I/L 1.18 1.24 ± 0.58 0.13 2.47
FT3 pmol/L 5.0 5.1 ± 0,5 3.8 6.7
TT4 #mol/L 110.7 111,1 ± 23 50,7 167,4
T$% m g/mL 26,7 28,1 ± 7,2 12,8 50
Tg #g/mL 17.4 22,3 ± 17,2 1.3 100
β&'% "I/L 62.724 65.289 ± 47.845 1025 220.731
rT3 #mol/L 0,27 0,27 ± 0,07 0.13 0.51
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
8/14
DISCUSSION
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
9/14
DISCUSSIONA+ $he median 7I8 in our population with no iodine
supplementation was 113 "#$%, which is &elow the
currently recommended threshold in pregnancy (1-!
"#$%', in the range of mild iodine deficiency 913+
While spot ioduria is useless to establish thediagnosis of I; at an indiidual leel, gien its
ariation from day to day 91, so far it remains the
gold standard at the population leel 91"+
+ ased on 7I8, in our study of selected women with
normal thyroid function in early pregnancy, I; waspresent in 335 of cases, using a threshold of 1-!
"#$%. (his pre)alence was si!ilar to those many
studies worldwide performed at the same gestational
age, e0cept for rander in wit
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
10/14
NE(T))=+ 7I8 did not correlate with any parameters of
maternal thyroid function at this stage of pregnancy
in our selected healthy population+ We had already
reported this lack of correlation in our preious
study performed during the third trimester 92+;+ &f note, we report a strong correlation of *hC+
with 7I8+ &ne physiological e0planation could be
that *hC+ stimulates rela0in secretion by the
corpus luteum, which plays an importantphysiologic role in the maternal renal adaptation to
pregnancy 941+ We speculate that this could
contribute to gestational increased 7I8 during the
first trimester+
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
11/14
Ioduria
()ga*i+ "ia i-u r 0.2 0.05
olum) *iroid r 0.22 0.03
oi*i+ β'% r 0.27 < 0.01
TS
()ga*i+ +T4 r 0.27 < 0.005
rT3 r 0.24 0.01
β&'% r 0.36 < 0.0001
oi*i+ $)ra* -ada# i-u r 0.19 0.06
+T4
()ga*i+ $)ra* -ada# i-u r 0.2 0.05
oi*i+ TT4 r 0.44 < 0.0001
rT3 r 0.44 < 0.0001
/ 3 &'% r 0.18 0.058
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
12/14
+T3
oi*i+ Tg r 0.22 0.02
rT3
()ga*i+ !)roo 0.001
oi*i+ β&'% r 0.4 < 0.0001
+T4 r 0.44 < 0.0001
TT4 r 0.5 < 0.0001
T$% r 0.33 0.0005
Tg
oi*i+ +T3 r 0.22 0.02
!)roo 0.0001
- &'%
()ga*i+ TS r 0.36 < 0.0001
oi*i+ Ioduria r 0.27 < 0.01
TT4 r 0.3 < 0.005
FT4 r 0.18 0.058
rT3 r 0.4 < 0.0001
T$% r 0.40 < 0.0001
olum) *iroid
()ga*i+ Ioduria r 0.22 0.05oi*i+ !)roo 0.02
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
13/14
CONCLUSION$he absence of correlation between 7I8 and thyroid tests at that stage of pregnanc$he absence of correlation between 7I8 and thyroid tests at that stage of pregnanc
-
8/18/2019 Iodine Status Has No Impact on Thyroid Function
14/14