NOVARTIS START-UP COMPETITIONAND EXHIBITION VIVA TECHNOLOGYPARIS / JUNE 30 – JULY 2

2

NOVARTIS INNOVATION Novartis is a global healthcare company based in Switzerland with roots dating back more than 150 years. We provide healthcare solutions that address the evolving needs of patients and societies worldwide. Novartis products are available in more than 180 countries and they reached nearly 1 billion people globally in 2015.

We develop innovative medicines to help people live better. Our mission is to discover new ways to improve and extend people’s lives.

Rapid aging of the population, greater access to healthcare in emerging markets and advances in science create opportunities to enhance the lives of patients through innovation.

We focus on improving health outcomes for patients by leveraging medical science, and advancing the creative use of new digital technology.

3

WE ARE SELECTING 50 START-UPS FOR 3 DAYS OF EXHIBITION AND CO-WORKING.

4

WHERE/WHEN

• JUNE 30 – JULY 2 in PARIS, the “EUROPEAN CES”

• 30-50k ATTENDEES and 5,000 STARTUPS

• 20 THEMED LABS (Healthtech, Fintech, Edutech, etc.)

• This large event has two main objectives:

– explore DIGITAL TRANSFORMATION

– reinforce LINKS between START-UPS, MULTI-NATIONAL CORPORATIONS & INVESTORS

Our Goals:• ENGAGE with start-ups to solve innovation CHALLENGES • Evaluate and select relevant START-UPS for potential partnership

MORE INFO: http://www.vivatechnologyparis.com

5

INNOVATION LABNovartis is the exclusive sponsor of a 500m2 LAB, where 50 START-UPS will be pre-selected to PITCH and participate in CO-WORKING and MEETINGS with Novartis executives.

6

CHALLENGES WE INVITE START-UPS TO HELP US SOLVE THESE CHALLENGES

1. NEUROSCIENCE: Digital solution sensitive enough to detect early changes in cognitive function and reliably measure decline/progress over time

2. RESPIRATORY: Digital solution to improve the life of asthma patients

3. RETINA: Affordable, digital, home eye monitoring tool that permits patients to self-monitor and transmit results to doctors, thus avoiding unnecessary and expensive clinic visits

4. MOVEMENT: Any solution that can measure movement, activity, physical ability & capacity more accurately than what is available today

5. PATIENTS: Any solution that can help patients manage a disease, monitor symptoms, optimize a treatment, get real time feedback and disease history visualization

6. HEART FAILURE: Digital biomarkers and other diagnostic solutions to identify at risk patients, diagnosed and/or undertreated

APPLY HERE

7

WHY PARTICIPATE?• PERSONAL EXHIBITION SPACE in the Novartis Health Tech Lab• 2 ADMISSIONS per start up• 3 days of CO-WORKING and NETWORKING• PERSONALIZED MENTORING & coaching by Novartis executives and/or guest

experts • Gain VALUABLE FEEDBACK on your ideas• Explore COLLABORATION and discuss potential projects• EXPOSURE at a premium event happening on a global stage • Have fun and MAKE VALUABLE CONNECTIONS to help propel

your start-up forward• Potential meeting with Novartis Investment team • Potential invitation to a follow-up meeting at Novartis HQ in Basel Switzerland

Please be in touch with the.dal@novartis.com if you have a start-up that would be interested in applying.

8

THE CHALLENGES

THE COGNITIVE CHALLENGEPreserve Brain Health

OpportunityEarly detection of cognitive changes in people living with neurological conditions can enable early/accelerated intervention; ultimately positively impact their and their caregivers’ lives

Challenge Digital solution that is sensitive enough to detect early changes in cognitive function and reliably measures decline/progress overtime

Specific areas for consideration/ criteria for success

Identify early indicators of cognitive impairment and/or decline (Passively) monitor changes in cognition over time Predict progression of cognitive decline and risk stratify patients Develop meaningful cognition-related outcomes (relevant to patient, caregivers,

clinicians, payor) Identify/detect differences in cognitive impairment related to different disease

areas (AD, MS, Parkinson's) Correlation/link between cognitive and functional decline

Prerequisites for the solution Language and culture neutral Independent of gross motor skills Not related to knowledge (educational level)

Other things to consider What is the baseline the solution is measuring against? Is one solution sensitive enough for both MS/AD?

9

THE MOVEMENT CHALLENGEUnderstanding Physical Activity & Capacity

Opportunity Physical movement is often a great indicator of the evolution of a disease or the efficacy of a treatment.

Challenge Any solution that can measure movement, activity, physical ability & capacity, more accurately than what is available today.

Specific areas for consideration/ criteria for success

Measure movement, possibly to distinguish a variety of different movements Guarantee precision and accuracy of these measurements of movement Compare all actual movement measurement solutions /activity trackers (sensors,

phone, etc) Understand how the body progresses in the environment around it Imagine a home or a broader environment that understands a patient’s physical

activity (IoT, smart homes, etc.) Measure activity of people in wheelchairs, using walkers, crutches, prosthetics Easy to read/understand data visualization of the tracking

Prerequisites for the solution The solution has to be as straightforward as possible (no manual input, no need

for frequent battery charge, etc.)

10

THE PATIENT CHALLENGEHelping Patients Manage Their Condition

OpportunityAfter being diagnosed with a disease or a chronic condition, patients are left with a multitude of daily decisions to make to improve their condition, prevent deterioration or episodes.

Challenge Any solution that can help patients manage a disease, monitor symptoms, optimize a treatment, get real time feedback and disease history visualization.

Specific areas for consideration/ criteria for success

Monitor symptoms and episodes: record flare-ups / seizures / exacerbation, Monitor evolution / deterioration / progression of the disease Prepare relevant information for the physician appointment Give advice for day to day decisions Connect with other ecosystems (HealthKit, CareKit, Withings, etc.) Connect with other patients / physicians / nurses / family & friends, and help find

emotional support Solution could be IoT related (mirror, fridge, bed, etc.)

Prerequisites for the solution

Solutions should help patients with chronic conditions like Asthma, Psoriasis, Epilepsy, Trigeminal Neuralgia, Acne, Migraine, etc. in the long run

The solution has to be very easy to use with as little manual input as possible Continuous and passive monitoring is preferable Beautiful and engaging look&feel of the solution

11

THE RESPIRATORY CHALLENGEImproving Asthma Treatment

Opportunity

Asthma patients have to manage their disease on a day-to-day basis. The physician does not have sufficient information at hand and too little time to fully assess the patient, or guide him, while the patient has too little information about his own condition to effectively participate in the discussion or manage his condition by himself.

Challenge Digital solution that will improve the life of patients with Asthma.

Specific areas for consideration/ criteria for success

Optimize the limited time with the patient at ‘point of care’, for example by allowing the patient to provide information to the physician ahead of time and facilitate the, evaluation of the disease

Decision making tools (about treatments and lifestyle choices) to both the patient and the physician

Improve patients’ experience and treatment outcomes Understand the climatic conditions and pollen load as potential triggers, to predict

and avoid exacerbations Take the right dose at the right time to optimize comfort, sleep, QoL Help patients better navigate through the healthcare system Allow the payor to measure treatment outcomes value for their insured population

Prerequisites for the solution

Solutions can be based on the signals collected from the eBreezhaler (tech specifications on demand).

Language and culture neutral Leverages existing technology (e.g., mobile devices) and non-proprietary systems. Not related to knowledge (educational level)

12

THE RETINA CHALLENGEReduced Patient Burden, Better Outcomes

OpportunityPatients with retina diseases need to have different eye examinations in the clinic on regular schedule to monitor their disease activity and decide if treatment is needed. These visits are a burden on patients and providers and drive unnecessary expense.

ChallengeAffordable, digital, at home monitoring tool that permits patients to self-monitor and transmit results to doctors, thus avoiding unnecessary and expensive clinic visits.

Specific areas for consideration/ criteria for success

Ability to safely view and record high resolution images of the retina – equivalent to images generated by OCT and fundus cameras

Ability to monitor evolution / deterioration / progression of the disease Transmit information to physician and / or prepare relevant information for the

physician appointment Remind patients of scheduled time for self—evaluation / monitoring Record and store images / information generated by the device / solution Home-based, low patient burden – without need for frequent recharging

Prerequisites for the solution Affordable – less than $100 Simple, safe, and easy to use, especially for older, less tech-savvy patients Not related to knowledge (educational level)

Other things to consider Can the device/solution be used both by the patient and by a novice caregiver? Is a separate solution required for pediatric patients, for geriatric patients?

13

THE HEART CHALLENGEPredicting Heart Failure

OpportunityHeart failure is a gradual condition often mistaken for signs of aging. Early prediction of heart failure could help more than 12 million patients live longer, more normal lives and reduce significantly the extraordinary cost burden through reduced rates and length of hospitalization.

ChallengeDigital biomarkers or similar early diagnostic solutions to identify as early as possible patients either at risk for heart failure or diagnosed for heart failure but undertreated.

Specific areas for consideration/ criteria for success

Early diagnosis of heart failure – 1-2 years earlier than current standard of care Uses digital biomarker/big data-predictive algorithm to diagnose/predict heart

failure or patients potentially at risk of heart failure (Passively) monitors disease progression or symptoms progression and identify

likely undertreatment. Risk-stratification algorithm or other data-driven mechanism to identify high risk

patients Leverages user-supplied data or existing/available data (e.g. credit card data) to

support predictive, learning algorithms

Prerequisites for the solution Language and culture neutral Globally/universally applicable Not related to knowledge (educational level)

Other things to consider Is a single approach possible for undiagnosed patients as well as diagnosed but likely undertreated patients?

14