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Invalidation Search Sample Report The given sample report showcases a typical Invalidation report focusing on multiplex amplification reaction. The search result has revealed one highly relevant, one low and medium relevancy patent document and one medium relevancy NPL document that can be considered. Signicent Information Solutions LLP 1/15/2013

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Table of Contents Objective .......................................................................................................................................................................................................................................... 3

Key Features ..................................................................................................................................................................................................................................... 3

Summary of Results ......................................................................................................................................................................................................................... 4

Brief Methodology ........................................................................................................................................................................................................................... 5

Patent Results .................................................................................................................................................................................................................................. 6

Result 1: US660XXXXB1 ................................................................................................................................................................................................................ 6

Result 2: EP2194XXXA1 ................................................................................................................................................................................................................ 8

Result 3: JP2011045XXXA............................................................................................................................................................................................................. 9

Non Patent Literature Results ........................................................................................................................................................................................................ 11

Result 1: Multiplex stand displacement amplification (SDA) ..................................................................................................................................................... 11

Search Strategy .............................................................................................................................................................................................................................. 13

Search Databases ....................................................................................................................................................................................................................... 13

Search Strings ............................................................................................................................................................................................................................. 14

Patent search ............................................................................................................................................................................................................................. 14

Non-Patent search ..................................................................................................................................................................................................................... 17

Search Classes ............................................................................................................................................................................................................................ 18

Citation Analysis ......................................................................................................................................................................................................................... 20

Disclaimer....................................................................................................................................................................................................................................... 21

http://www.signicent.com/mailto:[email protected]



Objective

The objective of this study is to the search prior art against the claim 1 of EP1352087, titled Methods for multiplexing amplification reactions having priority date of 6th, June, 2000.

Key Features

Key features in first independent claim (claim 1) are as following:

A method for simultaneously amplifying multiple nucleic acid sequence targets contained in a sample of single stranded nucleic acid by an amplification method comprising: (a) contacting the sample with at least two primer pairs; (b) pre-amplifying the sample for a period of time less than necessary to achieve reaction plateau ; (c) dividing said pre-amplified sample into at least two separate vessels ; and (d) adding at least one of said primer pairs to said amplified sample and amplifying said divided sample.




Summary of Results

S.No. Publication Number

Key Features

Relevancy Amplifying multiple

nucleic acid sequence

contacting the sample with at

least two primer pairs

pre-amplifying

step

two separate vessels

adding at least one of said primer pairs

Patent Results

1 US6605XXXB1 Y Y Y Y Y High

(X-Type document)

2 EP2194XXXA1

Y Y Y Medium (Y-Type

document)

3 JP2011045XXXA Y Y Low

(A-Type document)

Non-Patent Results

4

Multiplex strand displacement amplification (SDA) and detection of DNA sequences from

Mycobacterium tuberculosis and other mycobacteria

Y Y Y Medium (Y-Type

document)

http://www.signicent.com/mailto:[email protected]://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6605451.PN.&OS=PN/6605451&RS=PN/6605451http://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2194147A1&KC=A1&FT=D&ND=&date=20100609&DB=&locale=en_EPhttp://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2194147A1&KC=A1&FT=D&ND=&date=20100609&DB=&locale=en_EPhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC308226/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC308226/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC308226/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC308226/



Brief Methodology

Background

• Understanding Technology

• Reading prior art

• Identifying keywords

Searching

• Keyword based• Class based• Inventor and

Assignee based

• Foreign language based

• Citation analysis

• NPL search

Analsysis

• Analysis of results

• Reiterating searches

• Documentation• Submission

Discussion

• Client Feedback• Revisions, if

required• Resubmission• Guaranteed

satisfaction

Day 0

Day 2

Day 4 Day 12-15

TYPICAL TIME LINE *subject to client

requirement




Patent Results

Result 1: US660XXXXB1

Result No. 1 Relevancy High (X-Type document) Publication Number US660XXXXB1

Title Methods and devices for multiplexing amplification reactions Legal Status Patented Case Application Date 06.06.2000

Abstract

The present invention pertains to methods, reagents, compositions, kits, and instruments for use in simultaneously amplifying multiple targets. In particular, this invention is based on the discovery of a two-step multiplex amplification reaction wherein the first step truncates the standard initial multiplex amplification round to "boost" the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of the primer sets that were used previously in the first or multiplexed booster step. The booster step can occur using an aqueous target nucleic acid or using a solid phase archived nucleic acid.

Publication/ Grant Date 12.08.2003

Assignee Xtrana Inc

Inventor(s) Marmaro Jeffery M, Gerdes John C

INPADOC Family Member(s)

WO0194634A2, WO0194634A3, JP2004511215A, EP2295603A1, CA2410281A1, AU2001265327B2, AU6532701A

Analysis

Key Features found to be

Present: Amplifying multiple nucleic acid sequence | Contacting the sample with at least two primer pairs | Pre-amplifying step | Two separate vessels | Adding at least one of said primer pairs Missing: None

Mapping

Subject Patent Supporting Text

http://www.signicent.com/mailto:[email protected]://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6605451.PN.&OS=PN/6605451&RS=PN/6605451



Claim 1. A method for simultaneously amplifying multiple nucleic acid sequence targets contained in a sample of single stranded nucleic acid by an amplification method comprising: (a) contacting the sample with at least two primer pairs; (b) pre-amplifying the sample for a period of time less than necessary to achieve reaction plateau ; (c) dividing said pre-amplified sample into at least two separate vessels ; and (d) adding at least one of said primer pairs to said amplified sample and amplifying said divided sample.

Summary: Accordingly, it is a general object of this invention to provide a method that permits the multiplex amplification of multiple targets without extensive design and optimization constraints. The second step divides the resulting product achieved in the first step into optimized secondary single amplification reactions, each containing one of the primer sets that were used previously in the first step. Description: The methods and diagnostic kit of the present invention generally involve the use of common multiplex amplification methods and reagents and are more specifically derived from the surprising discovery that if the nucleic acid sample to be analyzed is first pre-amplified so as to merely "boost" the samples copy number slightly, then the resulting product may be split into as many subsequent analysis reactions as required, and thereby circumventing the common limitations of standard multiplexing technology. The effective primer concentrations should be limited to allow only a few logs of amplification but definitely the primer concentration should be exhausted before reaction plateau is reached. Second, the number of amplification cycles should also be minimized. The goal of this first phase of multiplex amplification is to allow only a sufficient amount of amplification to proceed in order to allow the resultant reaction mix to be split up and redistributed into at least the same number of subsequent simple amplification reactions as there are independent primer pairs in the first amplification. FIG. 2a demonstrates the results of the first round of the secondary PCR reactions. Following booster amplification, product was diluted 1:5, then 1:10 volume of this was added to six subsequent reactions in separate normal PCR tubes.

Technical Summary Multiplex amplification using primer pairs and pre-amplification method.




Result 2: EP2194XXXA1

Result No. 2 Relevancy Medium (Y-Type document) Publication Number EP2194XXXA1

Title Multiplex amplification of polynucleotides Legal Status Examination is in progress

Application Date (DDMMYYYY) 26.11.2001

Abstract

The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a multiplex fashion. Also provided are methods for analyzing and improving the efficiency of amplification and for carrying out gene expression analysis.

Publication/ Grant Date (DDMMYYYY)

09.06.2010

Assignee APPLIED BIOSYSTEMS LLC

Inventor(s) ANDERSEN MARK R and RUFF DAVID W

INPADOC Family Member(s)

WO2004051218(A2), WO2004051218(A3), US2004175733(A1), US8323897(B2), JP2013039138(A), JP2010000092(A), JP2006508662(A), EP2031070(A1), EP1594975(A2), EP1594975(A4), AU2003298706(A1) and AU2003298706(A8)

Analysis


Present: Amplifying multiple nucleic acid sequence | Two separate vessels | Adding at least one of said primer pairs Missing: Contacting the sample with at least two primer pairs | Pre-amplifying step

Mapping

Subject Patent Supporting Text Claim 1. A method for simultaneously amplifying multiple nucleic acid sequence targets contained in a sample of single stranded nucleic acid by an amplification method comprising: (a) contacting the

Claim 1. A kit for carrying out multiplex amplifications comprising a plurality of amplification primer sets suitable for carrying out a multiplex amplification packed in a single container. Claim 9. The kit of any of claims 4-8 further comprising a plurality of reaction vessels, each of which comprises a single set of amplification primers

http://www.signicent.com/mailto:[email protected]://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220110213458%22.PGNR.&OS=DN/20110213458&RS=DN/20110213458



sample with at least two primer pairs; (b) pre-amplifying the sample for a period of time less than necessary to achieve reaction plateau ; (c) dividing said pre-amplified sample into at least two separate vessels ; and (d) adding at least one of said primer pairs to said amplified sample and amplifying said divided sample.

suitable for amplifying a sequence of interest.

Technical Summary An intravascular flexible tubular stent made up of steel alloy is having a cylindrical ring at a proximal and a distal end.

Result 3: JP2011045XXXA

Result No. 3 Relevancy Low (A-Type document) Publication Number JP2011045XXXA

Title REACTION VESSEL INCLUDING REAGENT FOR AMPLIFYING NUCLEIC ACID Legal Status Kind of final decision

(Deemed to be withdrawn)

Application Date (DDMMYYYY) 26.08.2001

Abstract

PROBLEM TO BE SOLVED: To provide a reaction vessel including a reagent for amplifying a nucleic acid, and enabling a nucleic acid-amplification product to be fractionated without causing contamination of an organic layer without carrying out an operation for removing the organic layer. SOLUTION: The reaction vessel including the reagent for amplifying the nucleic acid further includes two or more aqueous layers, and the organic layer formed between each of the aqueous layers so as to separate the aqueous layers and having >1.0 of the specific gravity. The reagent for amplifying the nucleic acid, containing a DNA polymerase, a buffer solution, a magnesium compound

Publication/ Grant Date (DDMMYYYY)

09.06.2004

Assignee OLYMPUS CORP

Inventor(s) NISHIKAWA KAZUTAKA




and a dNTP is contained in the aqueous layers by being separated.

INPADOC Family Member(s) None

Analysis


Present: Amplifying multiple nucleic acid sequence | Contacting the sample with at least two primer pairs | Adding at least one of said primer pairs Missing: Two separate vessels | Pre-amplifying step

Mapping

Subject Patent Supporting Text

Claim 1. A method for simultaneously amplifying multiple nucleic acid sequence targets contained in a sample of single stranded nucleic acid by an amplification method comprising: (a) contacting the sample with at least two primer pairs; (b) pre-amplifying the sample for a period of time less than necessary to achieve reaction plateau ; (c) dividing said pre-amplified sample into at least two separate vessels ; and (d) adding at least one of said primer pairs to said amplified sample and amplifying said divided sample.

Claim 1. It is the reaction container containing a reagent for nucleic acid amplification containing the water layer of two or more layers, and the organic layer which has larger specific gravity than 1.0 formed in-between | in-the-meantime so that a water layer might be isolate | separated, respectively, Comprising: It isolate | separates into the said water layer and the reagent for nucleic acid amplification containing a DNA polymerase, a buffer solution, a magnesium compound, and dNTP is included, The reaction container characterized by the above-mentioned. Claim 2. The reaction container of Claim 1 which further includes two or more primer as a reagent for nucleic acid amplification. SOLUTION: The plurality of reaction vessel including the reagent for amplifying the nucleic acid further includes two or more aqueous layers, and the organic layer formed between each of the aqueous layers so as to separate the aqueous layers and having >1.0 of the specific gravity.

Technical Summary Reaction container useful for nucleic acid amplification, comprises water layers, organic layer and reagent




Non Patent Literature Results

Result 1: Multiplex stand displacement amplification (SDA)

Result No. 1 Relevancy Medium (Y-Type document)

Title Multiplex strand displacement amplification (SDA) and detection of DNA sequences from Mycobacterium tuberculosis and other mycobacteria

Inventor(s)

G.Terrance Walker, James G. Nadeau, Patricia A. Spears, James L. Schram, Colleen M. Nycz and Daryl D. Shank

Abstract

Strand Displacement Amplification (SDA) is an isothermal, in vitro method of amplifying a DNA target sequence prior to detection [Walker et al (1992) Nucleic Acids Res., 20, 1691 – 1693]. Here we describe a multiplex form of SDA that allows two target sequences and an internal amplification control to be co-amplified by a single pair of primers after common priming sequences are spontaneously appended to the ends of target fragments. Multiplex SDA operates at a single temperature, under the same simple protocol previously developed for single-target SDA. We applied multiplex SDA to co-amplification of a target sequence (IS6110) that is specific to members of the Mycobacterium tuberculosis-complex and a target (16S ribosomal gene) that is common to most clinically relevant species of mycobacteria. Both targets are amplified 108-fold during a 2 hour, single temperature incubation. The relative sensitivity of the system was evaluated across a number of clinically relevant mycobacteria and checked for crossreactivity against organisms that are closely related to mycobacteria.

Analysis

Subject Patent Supporting Text Claim 1. Strand Displacement Amplification (SDA) is an isothermal, in vitro

http://www.signicent.com/mailto:[email protected]://nar.oxfordjournals.org/content/22/13/2670.shorthttp://nar.oxfordjournals.org/content/22/13/2670.short



A method for simultaneously amplifying multiple nucleic acid sequence targets contained in a sample of single stranded nucleic acid by an amplification method comprising: (a) contacting the sample with at least two primer pairs; (b) pre-amplifying the sample for a period of time less than necessary to achieve reaction plateau ; (c) dividing said pre-amplified sample into at least two separate vessels ; and (d) adding at least one of said primer pairs to said amplified sample and amplifying said divided sample.

method of amplifying a DNA target sequence prior to detection. Here we describe a multiplex form of SDA that allows two target sequences and an internal amplification control to be co-amplified by a single pair of primers after common priming sequences are spontaneously appended to the ends of target fragments. Multiplex SDA operates at a single temperature, under the same simple protocol previously developed for single-target SDA. We applied multiplex SDA to co-amplification of a target sequence (IS6110) that is specific to members of the Mycobacterium tuberculosis-complex and a target (16S ribosomal gene) that is common to most clinically relevant species of mycobacteria. Both targets are amplified 108-fold during a 2 hour, single temperature incubation. The relative sensitivity of the system was evaluated across a number of clinically relevant mycobacteria and checked for crossreactivity against organisms that are closely related to mycobacteria.

Technical Summary Multiplex form of Strand Displacement Amplification (SDA) used a single pair of primer for amplification.




Search Strategy

Search Databases

The search is conducted globally

The search is conducted in the following databases:

Patent Databases Non Patent Databases

• Thomson Innovation • Medline

• Google Patents

• Espacenet

• ProQuest

• Science Direct

• Web of Science

• Scirus

• CINAHL Plus

• Web of Knowledge




Search Strings

Patent search

Database: Thomson Innovation | Geography of search: Global | Date of search: 6th, June, 2000 | Search scope: Full text

Sr. No. Search Strings Unique hits

1 ALL=(((Amplif* OR PCR OR ((polymerase OR polymerized) ADJ2 chain ADJ2 rea?tion*)) AND (DNA OR RNA OR cDNA OR rRNA OR mRNA OR tRNA OR mRNA OR (nucliec ADJ1 acid*1) OR *nucleotide* Or *nucleoside*) AND (Multiple OR great* OR more OR many OR multiplex*) AND (Primer*1) AND (Split* OR divid* OR segregat* OR partition* OR division))) AND PRD



5

AIOE=((C12N001509 OR C12N001510 OR C12N001500) AND (C12Q000168 OR C07H002102 OR C07H002104 OR C12P001934 OR C40B004006)) AND ALL=(((amplifi* or pre-amplifi*5 OR post OR amplifi*5 OR "polymerase chain reaction" OR "ligase chain reaction" OR "strand displacement amplification" OR (Booster NEAR1 Amplifi*) OR "PCR" OR "LCR") NEAR5 (Multiple OR more OR multiplex*3) AND (Primer*1))) AND PRD



OR multiplex*) AND (Primer*1) AND (Split* OR divid* OR segregat* OR partition* OR division)))

Foreign language searches

Chinese

9 ALL=(((DNA OR (Deribo NEAR2 核酸)) NEAR 5 ADJ 扩增) AND (容器 OR 容器 OR 微孔板) AND ((DNA OR (Deribo NEAR 2 ADJ 核酸)) NEAR3 引物)) AND DP>=(19000101);

1

French

10 ALL=(((“Deribo ADJ acide ADJ nucléique” NEAR 5 ADJ amplication*1) OR (DNA NEAR5 amplification*1)) AND (conteneur*2 OR navire*2) AND ((DNA OR “Deribo ADJ acide ADJ nucléique”) NEAR3 primer)) AND DP>=(19000101);

12

German

11 ALL=(((“Deribo ADJ Nukleinsäure” NEAR5 (Amplifikation*1 OR Amplification) OR (DNA NEAR5 Amplifikation*1)) AND (Behälter OR Schiff) AND ((DNA OR “Deribo ADJ Nukleinsäure”) NEAR3 primer))) AND DP>=(19000101);

18

* The search strings in GREY were not analyzed because of too many hits. Instead, they were refined further to narrower queries.




Non-Patent search Date of search: 2nd January, 2013

Medline

Sr. No. Search string Search scope Number of hits

1 multiplex amplification All text 560

2 multiplex PCR primer All text 55

Science Direct

3 multiplex amplification primer pair separate vessels All text 325

4 multiplex PCR primer pair separate vessels All text 357

5 multiple nucleic acid amplification primer separate vessel All text 1306

CINAHL Plus

6 multiplex amplification All text 3

7 multiplex PCR primer All text 0

Web of Knowledge

8 multiplex amplification Title and Abstract 45

9 multiplex PCR primer Title and Abstract 449

PubMed

10 multiplex amplification vessel Title and Abstract 25

11 multiplex PCR primer vessel Title and Abstract 10




Search Classes

Sr. No. IPC/ ECLA/ CPC Classification Definition

1 C12N001509 Chemistry; Metallurgy; Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation Or Genetic Engineering;Micro-Organisms Or Enzymes; Compositions Thereof;Mutation Or Genetic Engineering; Dna Or Rna Concerning Genetic Engineering, Vectors;Recombinant Dna-Technology

2 C12Q000168 Chemistry; Metallurgy; Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation Or Genetic Engineering;Measuring Or Testing Processes Involving Enzymes Or Micro-Organisms; Involving Nucleic Acids

3 C07H002102 Chemistry; Metallurgy; Organic Chemistry;Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids;Compounds Containing Two Or More Mononucleotide Units Having Separate Phosphate Or Polyphosphate Groups Linked By Saccharide Radicals Of Nucleoside Groups;With Ribosyl As Saccharide Radical

4 C07H002104 Chemistry; Metallurgy; Organic Chemistry;Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids;Compounds Containing Two Or More Mononucleotide Units Having Separate Phosphate Or Polyphosphate Groups Linked By Saccharide Radicals Of Nucleoside Groups;With Deoxyribosyl As Saccharide Radical

5 C12P001934

Chemistry; Metallurgy;Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation Or Genetic Engineering;Fermentation Or Enzyme-Using Processes To Synthesise A Desired Chemical Compound Or Composition Or To Separate Optical Isomers From A Racemic Mixture;Preparation Of Compounds Containing Saccharide Radicals;Polynucleotides, E.G. Nucleic Acids, Oligoribonucleotides

6 C40B004006 Chemistry; Metallurgy; Combinatorial Technology; Combinatorial Chemistry; Libraries;Libraries Per Se, E.G. Arrays, Mixtures; Libraries Containing Nucleotides Or Polynucleotides, Or Derivatives Thereof

7 C12N001510 Chemistry; Metallurgy; Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation Or Genetic Engineering; Micro-Organisms Or Enzymes; Compositions Thereof; Propagating, Preserving, Or Maintaining Micro-Organisms; Mutation Or Genetic




Engineering;Mutation Or Genetic Engineering; Dna Or Rna Concerning Genetic Engineering; Processes For The Isolation, Preparation Or Purification Of Dna Or Rna

8 C12N001500 Chemistry; Metallurgy; Micro-Organisms Or Enzymes; Compositions Thereof; Propagating, Preserving, Or Maintaining Micro-Organisms; Mutation Or Genetic Engineering;Mutation Or Genetic Engineering; Dna Or Rna Concerning Genetic Engineering, Vectors

Sr. No. US Classification Definition

1 4350912 Chemistry: Molecular Biology And Microbiology; Microorganism, Tissue Cell Culture, Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition; Preparing Compound Containing Saccharide Radical; Preparing Nitrogen-Containing Saccharide; N-Glycoside; Nucleotide; Polynucleotide; Acellular Exponential Or Geometric Amplification

2 435006 Chemistry: Molecular Biology And Microbiology; Measuring Or Testing Process Involving Enzymes Or Microorganisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip; Involving Nucleic Acid

3 4350911 Chemistry: Molecular Biology And Microbiology; Microorganism, Tissue Cell Culture, Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition; Preparing Compound Containing Saccharide Radical; Preparing Nitrogen-Containing Saccharide; N-Glycoside; Nucleotide; Polynucleotide

4 43509121

Chemistry: Molecular Biology And Microbiology; Chemistry: Molecular Biology And Microbiology; Microorganism, Tissue Cell Culture, Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition; Preparing Compound Containing Saccharide Radical; Preparing Nitrogen-Containing Saccharide; N-Glycoside; Nucleotide; Polynucleotide; Acellular Exponential Or Geometric Amplification; Involving The Making Of Multiple Rna Copies

5 4350915 Chemistry: Molecular Biology And Microbiology; Microorganism, Tissue Cell Culture, Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition; Preparing Compound Containing Saccharide Radical; Preparing Nitrogen-Containing Saccharide; N-Glycoside; Nucleotide; Polynucleotide; Acellular Preparation Of Polynucleotide

6 43509151

Chemistry: Molecular Biology And Microbiology; Microorganism, Tissue Cell Culture, Or Enzyme Using Process To Synthesize A Desired Chemical Compound Or Composition; Preparing Compound Containing Saccharide Radical; Preparing Nitrogen-Containing Saccharide;N-Glycoside; Nucleotide; Polynucleotide; Acellular Preparation Of Polynucleotide; Involving Rna As A Starting Material Or Intermediate

8 5360231 Organic Compounds; Carbohydrates And Derivatives; Nitrogen Containing; N-Glycosides, Polymers Thereof, Metal Derivatives; Dna Or Rna Fragments Or Modified Forms Thereof




Citation Analysis

We conduct two level of citation analysis to find relevant results i.e. backward, backward of backward and forward of backward.




Disclaimer

Signicent Information Solutions LLP (hereinafter referred to as Signicent) is not a law firm. No employee, partners, agent, or officer of Signicent provides legal advice in any domestic or foreign jurisdiction. Signicent is not engaged in the practice of law in any domestic or foreign jurisdiction. Services provided by Signicent are merely informational and/or technical and is not to be considered as legal advice. Signicent is not liable for any action taken by the reviewer pursuant to this report or on the basis of this report. Signicent is not liable for any loss beyond what Signicent has charged for preparing this report.

This communication is privileged communication is protected as attorney client/attorney assistant work product. The work product is limited by time limit set by the attorney and also by several other factors including the legibility of the data. In selecting information sources and carrying out the search we use all caution possible. However, we cannot guarantee you the correctness or completeness of the data we receive. Only those documents which have already been published can be searched. In general, patent applications are published 18 months after their submission. Thus, it is possible that other relevant patent applications exist which are not available at the time of the search. Search results will always be limited by what is available at the time of your request. In order to stay within the cost limits for requests which have been broadly formulated regarding the state-of-the-art, we select those documents which, in our opinion, most optimally represent the state-of-the-art. This can have the effect that documents can be found which were not included in the first search results if a more narrowly targeted search on the same subject is done. If you change the search target we recommend that you request a new search. The Firm offers complete secrecy regarding requested and completed searches. The Search offers a technical analysis of the evaluated results, it is reiterated that an independent analysis of the compilation may be carried out to verify the results.

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ObjectiveKey FeaturesSummary of Results/Brief MethodologyPatent ResultsResult 1: US660XXXXB1Result 2: EP2194XXXA1Result 3: JP2011045XXXA

Non Patent Literature ResultsResult 1: Multiplex stand displacement amplification (SDA)

Search StrategySearch DatabasesSearch StringsPatent searchNon-Patent searchSearch ClassesCitation AnalysisWe conduct two level of citation analysis to find relevant results i.e. backward, backward of backward and forward of backward.

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