Introduction to theKnowledge Discovery DepartmentInstitute for Infocomm Research

Limsoon WongDeputy Executive Director (Research)

I2R: Imagination to reality

I2R

• mission: Advance Infocomm Technology to benefit humanity and create prosperity for S’pore

• core values: Dedication to excellence, passion for innovation, integrity & respect

• size: 350 RSEs

SERCBMRC

IHPCDSI

IMRE

SIMTECH

IME

ICES

EDB-iDA ICT Cluster Map

• Next Gen IP• End-to-end QoS• Mobile Middleware• Mobile Adhoc Networks• Mobile Sensor Networks

Organization

I2R

Communications & DevicesServices & Applications Media

Media Processing

Human ComputerInteraction

Media Semantics

Infocomm Security

E-Service Infrastructure

Knowledge Discovery

Radio Systems Networking LightwaveEmbedded Systems

Digital Wireless

• Mutimedia Signal Processing

• Noise Reduction

• Media Adaptation• Mixed Media Mining• Natural Language Synergy

• Pervasive Media

• Perceptual Human Media

• Speech & Dialogue• Biometrics

• Cryptography• Network security• Information security

• Service Composition

• Service creation• Data-in-Network• Connected Home• Secure Filesystem/ DBMS

• Modem Technology• Multiple Access• Smart Antenna Array Systems

• Network Design• WDM Systems• Fibre Technology

• Terminal• Software Defined Radio

• Transceiver system• Antenna• Radio Over Fiber• UWB

• Knowledge Extraction

• Decision Systems• Discovery Systems

Information Security

E-services Infrastructure

Knowledge Discovery

Services & Applications

Knowledge ExtractionData fusion from sensors, knowledge extraction technologies. Applications in functional genomics & gene regulatory networks

Decision SystemsData Mining technologies. Applications in clinical data analysis and protein network analysis

Discovery SystemsData cleansing, modeling & knowledge management technologies. Applications in immunoinformatics and venominformatics

Service CreationPolicy-based framework for creating/managing application, storage and network services

Data-in-Network High-speed data cache and IPC on optical network

Service Composition Tech for consumers to create personalized services from component e-services

Connected HomeReference design for an OSGi compliant residential gateway

CryptographyCryptographic techniques for privacy protection, high-speed encryption, group digital signatures and new public key infrastructure

Information SecurityTechniques for privacy protection, peer-to-peer system security and media security

Network SecurityWireless network security, intrusion detection and technology to trace attackers

Secure FilesystemSteganographic and reliable file systems/DBMSs on externally managed platforms

IntegrationTechnology(Kleisli)

Cleansing & Warehousing (FIMM)

MHC-PeptideBinding(PREDICT)

Protein InteractionsExtraction (PIES)

Gene Expression & Medical RecordDatamining (PCL)

Gene FeatureRecognition (Dragon)

VenomInformatics

1994 19981996 2000 2002

8 years of bioinformaticsR&D in Singapore

ISS KRDL LIT/I2R

GeneticXchange

MolecularConnections

Biobase

History

Directions

Knowledge Extraction• gene regulatory network• endocrinology info system

Discovery Systems• immunoinformatics• venominformatics

Decision Systems• clinical data analysis• protein interaction

network

Technologies for• data mining• data fusion• data cleansing• data modeling• knowledge extraction• knowledge management

Advance data mining technologies in decision systems for complexproblems

Translate inspiration from biological systems into advancement in life and computing sciences

Decision Systems Lab Highlight

PCL Technology• Machine learning of

emerging patterns• Rules learned by

computers easily understood by doctors

• High accuracy

Yeoh et al.Cancer Cell 1, 133-143, 2002

FANTOM2 ConsortiumNature 420, 563-573, 2002

Discovery Systems Lab Highlight

• Brusic et al. Cytokine-related genes identi-fied from the RIKEN full-length mouse cDNA dataset. Genome Res. (in press)

• Silva et al. Identifica-tion of novel human disease-related gene candidates from the RIKEN full-length mouse cDNA dataset. Genome Res. (in press)

KE Lab Highlight

• Dragon Promoter Finder and Dragon Gene Start Finder

• Very high accuracy, order of magnitude improvement

• Licensed to Biobase, integrated with TRANSPLORER and TRANSFAC

Qualification

• 18 full-time staff (9 PhD, 6MSc, and 3 BSc) and 10-20 students at any time

• Our faculty holds adjunct professorial positions (SANBI, Univ. of Canberra, NUS, and NTU)

• During the last two years 8 MSc students graduated under our supervision

Professional Activities

•Journals: 3 chief editorial roles, and 9 editorial board memberships

•International Conferences (last 5 years): 4 conference chairs, and more than 40 program committee roles, 10 keynote lectures, and dozens of plenary talks

Track Record

•Publications (last 5 years): More than 100 in last 5 years, many in top journals (e.g. Nature, PNAS, Cancer Cell, JACM) and top conferences.

•Patents (last 5 years): 1 granted and 6 pending

•Commercialization (last 5 years): 2 international start-ups and one software licensed

People

Decision SystemsHead: Dr. See-Kiong NgPI: A/Prof. Limsoon Wong, Dr. Jinyan Li Staff: Huiqing Liu, Zhuo Zhang, Soon-Heng TanPost Doc: Dr. Shaowu Meng

Discovery Systems Head: A/Prof. Vladimir BrusicStaff: Judice Koh, Guanglan Zhang, Seng Hong SeahPost Doc: Dr. Rekha Pillai

Knowledge ExtractionHead: Prof. Vladimir B. BajicStaff: Hao Han, SPT Krishnan, Allen Chong, Sin Lam TanPost Doc: Dr. Suisheng Tang

Here they are...