Introduction to Evidance Based Dentistry
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Transcript of Introduction to Evidance Based Dentistry
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Introduction to Evidence-Based DentistryDr Hakan ÇolakDDS, PhDIshık University School of DentistryDepartment of Restorative Dentistry
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In this chapter, you will learn about:• The evolution of the dental knowledge base
• The evolution and definition of evidence-based dentistry (EBD)
• The three components of EBD: scientific evidence, the clinician’s expertise, and the patient’s needs and preferences
• Best evidence
• Applying EBD in practice
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Definition• According to the ADA…
– Evidence-based dentistry (EBD) is an approach to oral health care that requires the judicious integration of systematic assessments of clinically relevant scientific evidence, relating to the patient’s oral and medical condition and history, with the dentist’s clinical expertise and the patient’s treatment needs and preferences.
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Three Components of EBD• Is an approach to oral health
care
• Is a method to acquire, understand and apply the most current science
Evidence
Patient preferences
& needs
Clinical expertise
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Evidence-Based Dentistry Is NOT….
• Cookbook dentistry
• A standard of care
• A mandate of what must be done
• A substitute for clinical judgment
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How the Dental Knowledge Base Has Evolved
• The dental knowledge base is simply the collection of all that is known about oral health and disease and treatment methods and outcomes.
• Its contents comprise all of the – extant dental journal articles
– textbooks,
– the minds of all oral health practitioners.
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The dental knowledge base• the foundation of the dental professions and the principal
determinant of how dentists and dental hygienists practice
• informs professional decision making, and portions of it comprise the content of predoctoral and postdoctoral dental school curricula.
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The dental knowledge base
new information and understandings have been contributed by researchers, practitioners, and manufacturers.
the dental knowledge base has grown over time
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The four eras in the evolution of the dental knowledge base
The age of the expert
The age of science
The age of evidence
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The age of the expert• Evidence of the treatment of teeth
extends far back into human prehistory,and early writings discuss “tooth worms,” the supposed cause of toothache at that time.
• Ancient Roman, Greek, Egyptian, and Asian cultures all contain examples of dental technology related to replacing, retaining, and crowning teeth.
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The age of the expert• Barber-surgeons and
toothdrawers extracted teeth for pain relief.
• The knowledge and skills underlying all of this early activity was strictly experiential; practitioners learned by doing
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The age of professionalization • 18th century
• Pierre Fauchard– comprehensive textbook
– This textbook exemplified a new era in knowledge synthesis, enabled by better access to knowledge created by other
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The age of science• Beginning of the 20th century,
• presaging the profession’s gradual shift from proprietary to university-based educational institutions
• Scientific studies– protocol-based
– controlled experimentation became more common,
– causes and prevention of dental diseases.
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The age of science
• Synthesis of knowledge evolved from simple statements of “fact” based on an expert’s experience and opinion to
identification and consideration of the available information in the scientific literature.
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The age of science• Knowledge dissemination enjoyed its most active period yet
• early rapid growth of university-based predoctoral and postdoctoral dental curricula,
• the proliferation of dental journals,
• organized continuing dental education
• congress
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The age of evidence• knowledge creation in this era can be
characterized by the dominance of the randomized controlled trial (RCT), – represents the research design most likely
to produce an accurate and valid finding
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The age of evidence• The hallmark of the age of evidence
is the systematic review
• represent a substantial change in the paradigm of knowledge synthesis by – ensuring inclusion of all relevant
evidence,
– de-emphasizing the role of the expert,
– minimizing bias through strict protocols demanding objectivity and transparency in the review process
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How EBD Developed and How It Is Defined• EBD is a direct descendent and analog of a similar evolution
of the medical knowledge base, termed evidence-based medicine (EBM).
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How EBD Developed
Personal experience of a single individual
synthesized observations of multiple practitioners
the results of simple, single research studies
synthesized results of several research studies (ie, literature review).
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Evidence-based movement
Archie Cochrane David Sackett
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Archie Cochrane
• Scottish physician and epidemiologist
• advocated the application of scientific methods, especially RCTs, to evaluate the effectiveness and efficiency of medical treatments.
• He is best known for his influential book– published in 1972
– Effectiveness and Efficiency: Random Reflections on Health Services
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Archie Cochrane
• The principles he clearly set out in this book were straightforward:– Because resources would always be limited, they should be used to
provide those forms of health care that had been shown in properly designed evaluations to be effective.
– Evidence from RCTs, he stressed, are likely to provide much more reliable information than other sources of evidence.
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The Cochrane Collaboration• The Cochrane Collaboration, named after
Archie Cochrane, is an international network of volunteers that prepares and updates systematic reviews on a broad variety of topics as well as maintains the largest collection of records of RCTs in the world
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Evidence-based medicine.
• Created by Sackett
• first used at McMaster University in 1990
• describe “an attitude of enlightened skepticism toward the application of diagnostic, therapeutic, and prognostic technologies in day-to-day patient management.
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Evidence-based medicine. • The term was first published in 1991 and reached widespread
visibility in 1992 with the publication of a description of the concept in the Journal of the American Medical Association.
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Evidence-based medicine. • The classic definition of evidence-based medicine emerged a
few years later from the same group at McMaster University who pioneered the movement: – “the conscientious, explicit and judicious use of current best evidence
in making decisions about the care of the individual patient.”
• This definition focuses on the integration of individual clinical expertise with the best available external clinical evidence.
• This definition was refined a few years later to incorporate patient preferences and values
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“An approach to oral healthcare that requires the judicious integration of systematic
assessments of clinically relevant scientific evidence, relating to the patient’s oral and
medical condition and history, with the dentist’s clinical expertise and the patient’s
treatment needs and preferences.”
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The three components of EBD
Scientific evidence
Patient’s needs and preferenc
es
Clinician’s
expertise
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Evidence as the Hallmark of EBD• best evidence and systematic reviews
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Best evidence• Not all evidence is created equal.
• Some evidence is more likely to be valid than other evidence
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Best evidence• Validity
– measures how accurately the evidence reflects what is true, and it is an essential characteristic of evidence.
• Some types of evidence are more vulnerable to bias than others,
bias is the principal enemy
of validity
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Best evidence• Bias is the existence of factors or processes that can influence
the results or conclusions of a trial.
• Bias occurs when there are important differences in – (1) the way in which subjects or groups of subjects are treated or
observed or
– (2) how data is measured or analyzed.
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Best evidence• evolution of the
dental knowledge base
single observer
RCT
reduce the risk of bias in the information, or
evidence, that is created.
Maturation of evidance
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Best evidence• EBD demands that the evidence upon which treatment
decisions are based have the lowest possible risk of bias.
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Systematic reviews
Randomizedcontrolled trials
Cohort studies
Case-control studies
Case series/reports
Ideas, editorials, Expert opinion
Animal research
In vitro (test tube) research
Levels of evidence for preventive or therapeutic studies.
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• RCTs or other low-bias evidence are not available to support every decision a
practitioner must make.
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Best evidence• the term best evidence really means the best available
evidence based on this hierarchy of study designs.
• If higher levels of evidence are not available (ie, systematic reviews or RCTs), then one must seek studies lower in the hierarchy while at the same time acknowledging the potential for increased bias.
• In some instances, little more than expert opinion may be the best evidence currently available.
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Systematic reviews
• The systematic review is quickly surpassing (exceeding) the traditional literature review as the preferred method for summarizing and synthesizing relevant research evidence.
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Systematic reviews • Advantage
• providing clinically relevant information to aid in decision making– reducing the biases inherent in traditional literature reviews.
• follow strict protocols
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Traditional review Systematic review
not to be well-focused on a specific problem
focus on specific clinical questions
ot including all of the relevant studies
including all of the relevant studies
Not combining the information from the studies
combining the information from the studies
Subjective objective
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PICO format• identifying the problem or disease of interest,
• the intervention or treatment in question,
• the comparison treatment (usually the alternative treatment),
• the outcome through which the intervention and comparison treatments will be evaluated
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Systematic review
• narrower focus permits a much more careful and complete search and selection process to identify and include all relevant studies that have addressed the question of interest.
• Because the topic is limited, the number of articles that contain information is also usually quite limited so that their careful analysis is feasible
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Systematic review• Systematic review is to think of it as
a scientific study that is guided by the development of a protocol that outlines all steps in the review process
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Systematic reviews
Systematic reviews are not simple surveys of the literature
systematic reviews are designed to minimize bias, they require the prior
determination of search methods, inclusion criteria, and evaluation
criteria, which reduces the chance of bias in deciding what studies to
include and in evaluating the strength of
those studies
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Advantages of a
systematic review
Follow strict protocols
Require prior determination
of search methods
Reduce bias
Include only clinically relevant
information
Focus on specific clinical
questions
Have evaluation
criteria
Evaluate the strength of
the available evidence
The results of a systematic
review will represent the best, most current
evidence available that addresses a specifi c clinical
question
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Implications of EBD for DentalPractice• Using EBD in clinical practice essentially involves identifying
and using the best available scientific evidence in caring for patients
• EBD also incorporates the clinician’s expertise and the individual patient’s needs and personal preferences during treatment decision making. – These decisions are ultimately made by the patient and are very
personal, and thus they will vary from patient to patient.
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Implications of EBD for DentalPractice
!!!!
accessing and using current best available
evidence is at the forefront of the decision-
making process.
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Fundamental steps in using EBD
• to help patients make individual decisions regarding the treatment that is right for them
1. Ask
2. Access
3. Apprais
e4. Apply
5. Assess
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Step 1• Ask
– relevant to the condition of the patient.
– The clinical question is frequently described in a PICO format, as described previously
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Step 2• Access
– systematically access the most current scientific evidence on the clinical question
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Step 3• critically appraise the identified literature.
• provides insight into the strengths and weaknesses of the study, which is necessary when deciding if and how to use evidence from a study in practice.
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