Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
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INTRODUCTION TO CNS AND ITS NEUROTRANSMITTERS DR.RAHUL
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Dr Rahul Kunkulol's Power point preparations
Transcript of Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
INTRODUCTION TO CNS AND ITS NEUROTRANSMITTERS
DR.RAHUL
Non specific CNS stimulants
Act by blocking inhibitory neurotransmission Direct excitation EXAMPLES:
Cocaine Alcohol Caffeines Methylxanthines
Levels of CNS Depression
Calming Drowsiness (sedation) Conscious sedation Sleep (hypnosis) Unconsciousness Surgical anesthesia Coma Respiratory collapse Cardiovascular collapse
Death
Topics covered under CNS
Sedative Hypnotics Preanaesthetic
Medications General Anesthesia Opioid analgesics
Anti-parkinsonian agents Antiepileptics Psychopharmacology :
Antipsychotics Antidepressants Anti maniac
EXCITATORY
INHIBITORY
GLUTAMATE RECEPTORS
GABAergic SYNAPSE
GABA
glutamate
glucose
Cl-
GAD
Dopamine SystemDopamine System
Dopamine System
There are four major pathways for the dopaminergic system in the brain:
I. The Nigro-Stiatal Pathway.
II. The Mesolimbic Pathway.
III. The Mesocortical Pathway.
IV. The Tuberoinfundibular Pathway.
Catecholamines
Tyrosine Tyrosine hydroxylase
L-Dopa Dopa decarboxylase
Dopamine (DA) Dopamine hydroxylase
Norepinephrine (NE)(Noradrenaline)
Phenylethanolamine-
-N-methyltransferase
Epinephrine (EPI)(Adrenaline)
Dopamine Synapse
DA
L-DOPA
Tyrosine
Tyrosine
Dopamine System
DOPAMINE RECEPTORS
There are at least five subtypes of receptors:
Receptor
D1
D2
D3
D4
D5
Dopamine Reuptake System
Serotonetgic transmissionSerotonetgic transmission
Neurotransmitter
Substance produced in the neuron (synthesized), contained and secreted by that neuron to transmit information to postsynaptic target.
