Introduction to Cell Biology Review of a few basics first.
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Transcript of Introduction to Cell Biology Review of a few basics first.
Introduction to Cell Biology
Review of a few basics first
Always keep the range of scale in mind.
Examples:
You can not see molecules (even DNA) with a light microscope.
A transmission electron micrograph is not useful for looking at whole cells.
Differential centrifugation
•What’s going on in this series of pictures?
Be sure to review concepts learned in last year
Search for examples of different types of microscopy so you understand what the possibilities are.
http://www.olympusmicro.com/galleries/index.html
Light microscopes refract visible light passing through a specimen.
Phase contrast enhances contrast in unstained cells making it useful for looking a living specimens
Electron microscope reveals structure(often called ultrastructure)
No cell looks like this
Cytoskeletal elements
• Microtubules – 25 nm dia, hollow tubes
• Microfilaments – 7 nm dia, intertwined strands
• Intermediate filaments – 8-12 nm, supercoiled proteins
• See Table 6.1, pg 113
Support, Motility, Regulation
Plant cell walls
What’s outside of the cell?
What is between the cells?
Biochemistry Games
• http://nobelprize.org/educational_games/
• Nobel Prize for Chemistry: play the chirality game
• Nobel Prize for Medicine:play Cell and Its Organelles, “Megacell”