Pseudotumor Cerebri (Idiopathic Intracranial Hypertension) an Update
Intracranial Hypertension Pediatric Critical Care Medicine Emory University Children’s Healthcare...
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Transcript of Intracranial Hypertension Pediatric Critical Care Medicine Emory University Children’s Healthcare...
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Intracranial Hypertension
Pediatric Critical Care MedicineEmory University
Children’s Healthcare of Atlanta
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Historical Perspective• Alexander Monro 1783 described cranial vault as
non expandable and brain as non compressible so inflow and out flow blood must be equal
• Kelli blood volume remains constant• Cushing incorporated the CSF into equation 1926• Eventually what we now know as Monro-Kelli
doctrine – Intact skull sum of brain, blood & CSF is constant
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Monroe-Kellie Doctrine• Skull is a rigid structure (except in children with
fontanels)• 3 components:
– Brain: 80% of total volume, tissues and interstitial fluid– Blood: 10% of total volume = venous and arterial– CSF: 10% of total volume
– Vintracranial = Vbrain + VCSF + Vblood
• An increase in one component occurs in the compression of another
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Copied from Rogers Textbook of Pediatric Intensive Care
Monroe-Kellie Doctrine
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Brain• 80% of intracranial space = 80% water• Cell types
– Neurons: Cell body, dendrites, axon, pre-synaptic terminal-neurotransmission
– Astrocytes/Pericytes» Support the neurons & other glial cells by isolating
blood vessels, sypnapses, cell bodies from external environment
– Endothelial cells» Joined a tight junctions form BBB
– Oligodendrocytes» Myelin sheath around axons propagates action
potential efficient transmission of information
– Microglia» Phagocytes, antigen-presenting cells, secrete cytokines
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CSF• 10% of total volume• Choroid plexus > 70 % production• Transependymal movement fluid from brain to
ventricles ~30%• Average volume CSF in child is 90cc (150cc in
adult)• Rate of production: 500cc/d• Rate production remains fairly constant
– w/ increase ICP it is absorption that changes (increase up to 3X via arachnoid villa)
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Blood• 10% of intracranial volume• Delivered to the brain via the Circle of Willis
course through subarachnoid space before entering brain
• Veins & sinuses drain into jugular veins• Cerebral blood volume (CBV)
– Contributes to ICP
• Cerebral blood flow (CBF)– Delivers nutrients to the brain
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CBF & CPP• Morbidity related to ICP is effect on CBF• CPP = MAP- ICP or CPP= MAP- CVP• Optimal CPP extrapolated from adults• In intact brain there is auto-regulation
– Cerebral vessels dilate in response to low systemic blood pressure and constrict in response to higher pressures
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CBFCBF
MAP
50 150
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Auto-regulation of CBF• Compensated via vascular tone in the cerebral
circulation to maintain a relatively constant CBF over changes in cerebral perfusion pressure (CPP)
• Brain injury causing ICP may abolish auto-regulation– CPP becomes linearly dependent on MAP
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CBF
PaO2
PaCO2
CPP
CBF
0125
125
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Auto-regulation in Newborns
Narrow CPP range vs. adults, similar lower limit, upper limit ~90-100; Rogers Textbook of Pediatric Intensive Care
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CPP• 2003 Pediatric TBI guidelines recommend
– Maintain CPP>40mmHg
• Will likely be modified to titrate to age-specific thresholds– 40-50mmHg: infants & toddlers– 50-60mmHg: children– >60mmHg: adolescents
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CBF• CBF is usually tightly coupled to cerebral
metabolism or CMRO2
– Normal CMRO2 is 3.2 ml/100g/min
• Regulation of blood flow to needs mostly thought to be regulated by chemicals released from neurons. Adenosine seems to be most likely culprit
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Cerebral Edema• Vasogenic
– Increased capillary permeability disruption BBB– Tumors/abscesses/hemorrhage/trauma/ infection– Neurons are not primarily injured
• Cytotoxic– Swelling of the neurons & failure ATPase Na+
channels
• Interstitial– Flow of transependymal fluid is impaired (increased
CSF hydrostatic pressure
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Monitoring• Intra-ventricular
– Gold standard– Can re-zero– Withdraw CSF– Infection rate about 7% (level our after 5 days)
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Monitoring• Intra-parenchymal
– Placed directly into brain, easy insertion– Can’t recalibrate; monitor drifts over time– Minimal differences between intra-ventricular &
parenchymal pressures» ventricular ~2 mmHg higher
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Wave forms• Resembles arterial wave form• Can have respiratory excursions from changes in
intrathoracic pressure• B waves
– rhythmic oscillations occurring aprox. every minute– with amplitude of up to 50mmHg– associated with unconsciousness/periodic breathing
• Plateau waves– above baseline to a max. of 50-100mmHg– lasting 5-20min– associated baseline ICP > 20mmHg
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Wave forms
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Monitoring• CT
– Helpful if present– Good for skull and soft tissue
• MRI w/ perfusion– Assess CBF– Can detect global and regional blood flow difference
• PET– Gold standard detect CBF
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Monitoring• Kety –Schmidt
– Uses Nitrous as an inert gas tracer and fick principle looking at arteriovenous difference
» CO = VCO2 [ml/min]/(CO2art-CO2ven) [ml/L]
– Labor intensive not practical
• Jugular Bulb– Global data looking at CBF w/ regard to demand– Correlation between number of desats and outcome
• NIRS– Measures average cerebral sats– Usefulness not established
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Management Strategies• CSF• Brain• Blood
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Treatment: CSF • Removing CSF is physiologic way to control ICP• May also have additional drainage through
lumbar drain– Considered as 3rd tier option– Basilar cisterns must be open otherwise will get tonsillar
herniation
• Decreasing CSF production: Acetazolamide, Furosemide– Take several days before seeing the change
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Treatment: Blood• Keep midline for optimal drainage• HOB >30º
– MAP highest when supine– ICP lowest when head elevated– 30º in small study gave best CPP
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Treatment: BloodTemp Control
• Lowers CMRO2
– Decreases CBF
• Neuroprotective– Less inflammation– Less cytotoxicity and thus less lipid peroxidation
• Mild 32-34º– Lower can cause arrhythmias, suppressed immune
system
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Treatment: BloodSedation & NMB
• Adequate sedation and NMB reduce cerebral metabolic demands and therefore CBF and hence ICP
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Treatment: BloodHyperventilation
• Decrease CO2 leads to CSF alkalosis causing vasoconstriction and decrease CBF and thus ICP– May lead to ischemia
• Overtime the CSF pH normalizes and lose effect• Use mainly in acute deterioration and not as a
mainstay therapy
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Treatment: BloodBarbiturate Coma
• Lower cerebral O2 consumption– Decrease demand equals decrease CBF
• Direct neuro-protective effect – Inhibition of free radical mediated lipid peroxidation
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Treatment: BrainOsmotic Agents
• Mannitol– 1st described in 50’s– Historically thought secondary to movement of extra-
vascular fluid into capillaries» Induces a rheologic effect on blood and blood flow
by altering blood viscosity from changes in erythrocyte cell compliance
» Transiently increases CBV and CBF• Cerebral oxygen improves and adenosine levels increase
» Decrease adenosine then leads to vasoconstriction– May get rebound hypovolemia and hypotension
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Treatment: Brain Osmotic agents
• Hypertonic Saline– First described in 1919– Decrease in cortical water– Increase in MAP– Decrease ICP
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Treatment: Decompressive craniotomy
• Trend toward improved outcomes
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Treatment: Steroids• Not recommended• CRASH study actually showed increased
morbidity and mortality