International Course on Functional Stereotactic …...Functions of basal ganglia from J.M. DENIAU...
Transcript of International Course on Functional Stereotactic …...Functions of basal ganglia from J.M. DENIAU...
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International Course on FunctionalStereotactic Neurosurgery,
Beijing, May 2015
- Elements of Basal Ganglia Anatomy
- Physiology of Basal Ganglia
- Physiopathology of Basal Ganglia
- High Frequency Stimulation mechanism hypothesis
Dr Bernard PIDOUX, MD, PhDUniversité Pierre et Marie Curie, Paris 6
Hôpital Pitié-Salpêtrière, Paris, France
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Lasker DeBakey
Clinical Medical Research Award
Alim Louis Benabid and Mahlon DeLong
For the development of deep brain stimulation of the subthalamicnucleus, a surgical technique that reduces tremors and restores motor
function in patients with advanced Parkinson's disease.
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Ventral Posteromedial (VPM) and Ventral Posterolateral
(VPL) nuclei
Centromedian nucleus (CM)
Mediodorsal Nucleus (MD)
Stria Medullaris Thalami (SMT)
Choroid Plexus forming roof of third ventricle (3V)
Crus Cerebri
Substantia Nigra (SN)
Red Nucleus (RN)
Reticular nucleus (R) and Zona Incerta (ZI)
Internal Capsule (IC)
Stria Terminalis (ST)
Body of Lateral Ventricle (LV)
Corpus Callosum (CC)
Fornix (F)
Optic Tract (OT)
Subthalamic Nucleus (STN)
Body of Lateral Ventricle (LV)
Body of Caudate (C)
Putamen (P)
Globus Pallidus (GP)
Oculomotor Nerves (3)
Amygdala
Tail of Caudate (Ct)
Temporal Horn of Lateral Ventricle (TH)
Hippocampus
Amygdala
http://www.meddean.luc.edu/lumen/MedEd/Neuro
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Corpus Callosum (CC)
Fornix (F)
Lateral Ventricle (LV)
Body of Caudate (C)
Stria Terminalis (ST)
Stria Medullaris Thalami (SMT)
Mediodorsal Nucleus (MD)
Lateral Dorsal nucleus (LD)
Choroid Plexus (CP) forming roof of third ventricle (3V)
Internal Medullary Lamina (IML)
Ventral Lateral Nucleus (VL)
Thalamic fasciculus (TF, contains cerebello-thalamic and pallido-
thalamic fibers)
Reticular Nucleus (R) and Zona Incerta (ZI)
Internal Capsule (IC)
Subthalamic Nucleus (STN)
Substantia Nigra (SN)
Crus Cerebri
Extreme Capsule (ExmC)
Claustrum (Cl)
External Capsule (ExlC)
Putamen (P)
Globus Pallidus (GPm, GPl)
Amygdala
Mammillary Bodies (MB)
http://www.meddean.luc.edu/lumen/MedEd/Neuro
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Corpus Callosum (CC)
Lateral Ventricle (LV)
Fornix (F, both dorsally and ventrally)
Body of Caudate (C)
Stria Terminalis (ST)
Stria Medullaris Thalami (SMT, thin band of white matter on
medial surface of MD)
Choroid Plexus forming roof of third ventricle (3V)
Mediodorsal Nucleus (MD)
Lateral Dorsal Nucleus (LD)
Internal Medullary Lamina (IML)
Ventral Lateral Nucleus (VL)
External Medullary Lamina (EML)
Reticular Nucleus (R) and Zona Incerta (ZI)
Subthalamic Nucleus (STN)
Internal Capsule (IC)
Extreme Capsule (ExmC)
Claustrum (Cl)
External Capsule (ExlC)
Putamen (P)
Globus Pallidus (GPm, GPl)
Optic Tract (OT)
Amygdala
Lenticular Fasciculus (LF)
Thalamic Fasciculus (TF, contains pallido-thalamic and
cerebello-thalamic fibers)
Mammillothalamic Tract (MTT)
Tuber cinereum (TC, contains median eminence of
hypothalamo-hypophyseal portal system)
http://www.meddean.luc.edu/lumen/MedEd/Neuro
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Corpus Callosum (CC)
Lateral Ventricle (LV)
Fornix (F, dorsally and ventrally)
Body of Caudate (C)
Stria Terminalis (ST)
Stria Medullaris Thalami (SMT)
Choroid Plexus (CP) forming roof of third ventricle (3V)
Mediodorsal Nucleus (MD)
Anterior Nucleus (A)
Internal Medullary Lamina (IML)
Ventral Anterior Nucleus (VA)
Reticular Nucleus (R) and Zona Incerta (ZI)
Internal Capsule (IC)
Extreme Capsule (ExmC)
Claustrum (Cl)
External Capsule (ExlC)
Putamen (P)
Globus Pallidus (GPm, GPl)
Optic Tract (OT)
Amygdala
Ansa Lenticularis (AL, pallidothalamic projections to VA)
Anterior Commissure (AC)
Mammillothalamic Tract (MTT)
Massa Intermedia (MI)
http://www.meddean.luc.edu/lumen/MedEd/Neuro
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Sagittal view
AC-PC plane
Schaltenbrand
and Wahren
stereotactic
atlas
Swsl12
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SwSL22
Sagittal view
AC-PC plane
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Swfp30
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Frontal slices of monkey STN
Levels : Anterior Middle Posterior
D'une manière générale, le territoire sensorimoteur est dorsal et latéral donc plus postérieur que l'associatif.
Le limbique s'il est vraiment confirmé serait à la pointe la plus médiale et ventrale, donc antérieur._______________________________
Dr. J. YELNIK - INSERM U289 - Pavillon Claude Bernard - Hopital de la Salpêtrière - 47 Bd de l'hopital - 75013, Paris FRANCE
Tel : 33 (0)1 42 16 06 32 Fax : 33 (0)1 45 82 88 93 email:[email protected]
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Accumbens, caudate nucleus, putamen
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GPe
GPi
Globus pallidus
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THRPT
CP
STN
H2
RUZI
SN
Sub-thalamic nucleus, substancia nigra, red nucleus
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Thalamus
VIM
VPIPF/CM
VL
MD
VIM
VPE
VL
MD
VA
PU
VL
VIM
PU
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Functional territories
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Atlas 3D histologique
déformable des
ganglions de la base
(NGC)
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Functions of basal gangliafrom J.M. DENIAU
Cerebral Cortex
Thalamus
ilm
Hippocampus
Amygdala
Basal
Ganglia
Sensorimotor,
cognitive, emotional,
motivational, memory
Environmental contextual analysis and organisation of a
contextually adaptated behavior
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instructionaction signal
mvt
startreward
Movement execution
Movement initiation
Movement preparation
Somatosensoy response
Visual response
Auditory response
Short term memory
Work memory
Prediction, waiting
Waiting for a reward
Reward
Striatum is active along all key phases of behavior organisation
From W. Schultz
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Cortex
STN
Striatum
GPi / SNR
GPe / VPl
Reticular pathways brainstem,
medulla
Non specific
Thalamus
Amygdala
Caudate, Putamen, N. Acc. « core »
Prefrontal, cingular, motor
N.Acc
« Shell »
hippocampus
Distinct output pathway
Ventral Pallidum (VPm)
SNc (DA)
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Basal ganglia modulate variousprefrontal cortical areas,
premotor, motor, temporal and parietal cortex
via thalamic projections
of Substantia Nigra and Globus Pallidus
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Informations originating from cortical areas are transmitted to
output structures of basal ganglia through three
main pathways:
A direct trans-striatal circuit,
An indirect trans-striatal circuit,
A direct trans-subthalamic circuit
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Cortex
Striatum
GPi / SNR
Direct trans-striatal circuit activates target pathways of basal
ganglia via a disinhibition mechanism
Thalamus
Brainstem
+ Glutamate
- Gaba
- Gaba
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Trans-subthalamic pathways perform a temporal and spatial configurationof the striatal dis-inhibiting signal
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Cortical stimulation evoques a triphasic response (excitation-inhibition-excitation) in SNR neurones.1- Early excitation results from the activation of direct trans-subthalamic pathway, 2- inhibition results from the activation of direct trans-striatal circuit and 3- late activation from indirect striato-pallido-subthalamo-nigral pathway.
Recording
Stimulation
1 2 3
- - -
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Functionnally associated
cortical areas
SNR/GPi
Direct
subthalamic
circuit
+ +
Direct striatal
circuitIndirect
circuit
_Calibration of dis-inhibiting
striatal signal duration
Temporal calibration within a chanel
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Cerebral cortex
GPe
Striatum
STN
GPi / SNr
D1D2
SNc
VTA
RR
DADA+_
Physiopathological models
- hypothesis of a distinct neuronal origine of direct and indirect trans-striatal pathways
- differential control by dopamine on these two sub populations of striatal neurones.
Glutamate +
Gaba, Enk -
Glutamate +
Gaba, P subst -
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Hypokinetic disorders
Parkinson’s disease
neuroleptics parkinsonian syndrom
MPTP monkey parkinsonism model
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Parkinson’s disease
• Akinésia
• Rigidity
• Resting tremor 4-6 Hz
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Cerebral cortex
Thalamus
VA
VL
midbrain
spinal chord
Indirecte inhibiting pathway
FR, NPP, CS, TQA
Caudate/Putamen
STN
GPe
SNc
Gpi/SNrDirecte excitarory pathway1
1
2
2
Excitaion (Glu)
Inhibition (GABA)
AKINESIA / PARKINSON
+-
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Cerebral cortex
Thalamus
VA
VL
midbrain
spinal chord
Indirecte inhibiting pathway
FR, NPP, CS, TQA
Caudate/Putamen
STN
GPe
SNc
Gpi/SNrDirecte excitatory pathway1
1
2
2
Excitation (Glu)
Inhibition (GABA)
AKINESIA / NEUROLEPTICS
D1D2
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Tremor
Central pace maker ?
Peripheral reflex loop
Central loops
- transcerebellum
- transcortical
-motoneurone
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Neuronal pace-maker
Somatic Na
potential
KCa
Calcium
dendrites
potential
Calcium potential
somatic rebound
AHP
Burst phenomenon facilitated by hyperpolarisation
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Parkinson’s disease tremor cells
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D. Albe – Fessard, 1967
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Hyperkinetic disorders
Huntington’s chorea
Ballism
L-dopa Induced Dyskinesia (LID)
Tardive dyskinesia (neuroleptics)
Tics / Syndrome de Gilles de la Tourette
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Chorea
• Huntington choreaprogressive neurodegenerativeHereditary
• Loss of enkephalinergic
« medium spiny neurons »
Chorea, depression, cognitive
decline
• Other causes
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Two sub-population of striatal « medium spiny neurons »
From Squire, 2003
Substance P / Dynorphine, D1 recept
Enképhalines, D2 receptors
Direct pathway Indirect pathway
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Cerebral cortex
Thalamus
VA
VL
Midbrain
Spinal chord
Indirect inhibiting pathway
FR, NPP, CS, TQA
Caudate/Putamen
STN
GPe
SNc
Gpi/SNrdirect excitatory pathway1
1
2
2
Excitation (Glu)
Inhibition (GABA)
HUNTINGTON’s CHOREA
Enk SPrD1rD2
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Ballism
bicucculine STN perfusion
(L Tremblay et D Grabli, U679)
Focal lesion of right
STN
(cerebral toxoplasmose )
Bicucculine: GABA-A antagonist
Depolarisation bloc with high dosage
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Cerebral cortex
Thalamus
VA
VL
Midbrain
Spinal chord
indirect inhibiting pathway
FR, NPP, CS, TQA
Caudate/Putamen
STN
GPe
SNc
Gpi/SNrdirect excitatory pathway1
1
2
2
Excitation (Glu)
Inhibition (GABA)
HEMIBALLISM
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Tourette’s Syndrom
• Simple motor tics
• Normal but inappropriate motor sequences
• Simple or complexe vocal tics
« Urge to move » and rebound effects after a voluntary control
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bicucculine injection into limbic GPe
• Stereotypes
• Leaking
• « Touching »
Bicucculine: GABA-A antagonist
GABA-A Inhibiting effect with moderate dosages
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Cerebral cortex
Thalamus
VA
VL
Midbrain
Spinal chord
indirect inhibiting pathway
FR, NPP, CS, TQA
Caudate/Putamen
STN
Limbic
Gpe
SNc
Gpi/SNrdirect excitatory pathway1
1
2
2
Excitation (Glu)
Inhibition (GABA)
EXPERIMENTAL STEREOTYPES
Bicucculine
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Deep Brain Stimulation :
excitation or inhibition ?
How is it that High Frequency Stimulation mimics the effects of
lesion of the target structure ?
- Vim HFS tremor suppression like thalamotomy
- GPi HFS removes Levodopa Induced Dyskinesia like pallidotomy
- STN HFS suppress PD symptoms like STN coagulation.
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Deep Brain Stimulation :
excitation or inhibition ?
Two opposite hypothesis :
- DBS generates a functional ablation by suppressing or inhibiting the
stimulated nucleus
- DBS results in activation of the stimulated nucleus that is transmitted
throughout the network
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0
10
20
30
40
50
60
0
10
20
30
40
50
60
0
5
10
15
20
0
2
4
6
8
A
AVANT PENDANT APRES
Stimulation HF homolatérale
B
Procedure ‘Placebo’
AVANT PENDANT APRES
AVANT PENDANT APRESAVANT PENDANT APRES
IRREGULIER
REGULIER
BURSTING
PAS D’ ACTIVITE
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0
10
20
30
40
50
60
AVANT PENDANT APRES AVANT PENDANT APRES AVANT PENDANT APRES
14 Hz 40 Hz 80 Hz
0
2
4
6
8
10
AVANT PENDANT APRES AVANT PENDANT APRES AVANT PENDANT APRES
IRREGULIER
REGULIER
BURSTING
PAS D’ ACTIVITE
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Kita H, Tachibana Y, Nambu A, Chiken S.
Balance of monosynaptic excitatory and disynaptic inhibitory response of the
globus pallidus induced after stimulation of the subthalamic nucleus in the
monkey. J. Neurosci. 2005; 21:8611-8619.
STN stim GPe recordings
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Kita H, Tachibana Y, Nambu A, Chiken S.
Balance of monosynaptic excitatory and disynaptic inhibitory response of the globus pallidus
induced after stimulation of the subthalamic nucleus in the monkey. J. Neurosci. 2005; 21:8611-
8619.
STN - BHFS GPi recordings : strong inhibition
Inhibition
during
BHFS
Inhibition
suppressed
by GABA
blocker
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Kita H, Tachibana Y, Nambu A, Chiken S.
Balance of monosynaptic excitatory and disynaptic inhibitory response of the globus pallidus
induced after stimulation of the subthalamic nucleus in the monkey. J. Neurosci. 2005; 21:8611-
8619.
STN stimulation GPi recordings
Suppressed GPi
inhibition by
GPe blockade
with GLU &
GABA blockers
Suppressed GPi
excitation after
GPi application of
GLU & GABA
blockers
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Kita H, Tachibana Y, Nambu A, Chiken S.
Balance of monosynaptic excitatory and disynaptic inhibitory response of the globus pallidus
induced after stimulation of the subthalamic nucleus in the monkey. J. Neurosci. 2005; 21:8611-
8619.
Authors conclusion
STN HFS might inhibit the majority of the neurons in
the GPi
due to the fact that STN-GPe-GPi inhibitory response
dominates over the STN-GPi excitatory response in
GPi
(however) « there may be also a disruption by HFS of
the abnormal discharge patterns in the GPi »Hashimoto T, Elder CM, Okun MS, Patrick SK, Vitek JL.
Stimulation of the subthalamic nucleus changes the firing pattern of
pallidal neurons. J Neurosci. 2003 Mar 1;23(5):1916-23
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谢谢您!