Integumentary SystemSkin Disorders and Diseases

Contact Dermatitis (p 172)

• Inflammation of the skin

• Immune induced or irritating substance

Laundry Detergent reaction

Pituitary Tumors

• Abnormal skin pigmentation

• Deep bronze tan• Increase secretion of

MSH: melanocyte-stimulating hormones

Jaundice • Abnormal Skin pigmentation

• Excess bilirubin in the blood. (Bilirubin is produced by the normal breakdown of red blood cells. Normally bilirubin passes through the liver and is excreted as bile through the intestines)i

• Jaundice occurs when bilirubin builds up faster than the liver can break it down and pass it from the body.

• Vitiglio:– loss of

melanocytes– loss of color

Decubitus Ulcers

• Bed sores• Occurs from pressure

on superficial blood vessels

• Lack of circulation kills epidermal cells

(p172)

Baldness• Androgenic alopecia

– Associated with testosterone

• Alopcecia areata – Blood makes

antibodies that attack hair follicles

• Causes: estrogen levels, medicines, high fever.

Skin Cancers

• UV radiations causes mutation in the DNA of a skin cell

• 75% of cancers are skin cancers

• Most common cancers are caused by prolonged exposure to UV radiation from sunlight

Types of Skin Cancer• Three major types:

– Basal Cell Carcinoma• Most common type of skin cancer

• 2/3 of these cancers appear from chronic UV exposure

Skin cancer– Squamous cell carcinoma

• Frequent in light, pale skin over 40 years old

• Slow growing

• Surgical removal or radiation

Skin Cancer– Malignant Melanoma

• Arise from melanocytes

• Usually in trunk of body and from a mole

• Hard to treat

Basal Cell Carcinoma

                                                                                

                                                                                          

Squamous Cell Carcinoma                                                                                          

Originates from epithelial cells

Malignant Melanoma

Difficult to treat due to fast growing and invasion of deep tissues

Risk increases with short, intermittent exposure to high-intensity sunlight.

Do you have Moles?Watch SUN Exposure!

• A-asymmetry

• B-Border

• C-Color

• D-diameter

• Cyanosis– Bluish skin tint– Caused by severe reduction in blood flow or

oxygenation• Jaundice:

– buildup of bile produced by liver– yellow color

• Addison’s disease:– and other diseases of pituitary gland– skin darkening

• Vitiglio:– loss of melanocytes– loss of color