Integrative approach to study the effects of cosmophysical factors on functional state of

human health. International Project

Khorseva N.I.1, Grigoryev P.E.2, Poskotinova L.V.3, Kilessa G.V.4, Glivenko A.V.2

1 Institute of Biochemical Physics named after N.M.Emanuel RAS, Russia, Moscow 1 Space Research Institute RAS, Russia, Moscow

2 Crimea State Medical University named after S.I.Georgievsky, Ukraine, Simferopol

3 Institute of Physiology of Natural Adaptations Ural section of RAS, Russia, Archangelsk

4National University named after V.I. Vernadsky, 95007, Ukraine, Simferopol

The aim of this work to develop the software that enables a comprehensive evaluation of the

functional state of a human and assess the relationship between subjective mental state

and objective psychophysiological and physiological parameters, their monitoring and comparison with environmental (cosmophysic, meteorological, ecological) and other factors.

Main components of the software complex,

which enable to estimate…Phasical activity of

subcortical structures (hippocamp):

sustainability of voluntary attention

(correcture test)

Rate of reaction on external stimuli:

Simple audio-motor reaction

Functional state of motor zones and interhemispheric communication:

Ten-fingers random tapping

Limbic system activity:

Psychoemotional state

(semantic differential questionnairy)

Indices of hemodynamic

(SBP, DBP,HR, PP, KI)

SAMR, 1,5 min

Correcture test, 2 min

random ten-fingers tapping, 2,5 minIndices of psycho-emotional

state, 3 min

Hemodynamic indices, 3-5 min

Database: more than 80

parameters for each person per session

-Capability of pairwise comparison of studied parameters.

-Cross-correlation matrices

The Comparison between parameters of Space weather and complex parameters,

cross-correlation matrices

Structure of the functioning of local software within the framework of an information texnology “universal monitoring of ecological health”Examples to the visualizations of the

results

We have developed the information system (IS) based on the results of long-term pilot experiments and analysis of time trends of daily monitoring

of psychophysiological parameters, uploaded on a web-portal www.umon.org.ua "Universal monitoring of environmental health"

IS has many advantages, including: the availability and affordability, thereis no need to purchase additional devices, sensors and software. Architecture of IS makes it easy to upgrade with new modules and techniques and to expand their scope, as a basis for implementing

a wide range of scientific and practical tasks per request of prospective customers and / or partners.

In addition to IS, we created the separate software product called "Local Universal Monitoring" which provides a registration of additional

psycho-physiological parameters as well as enhanced interpretation of the results. The recorded parameters can be transferred to

the website "Universal monitoring of environmental health" for their further processing.

www.umon.org.ua

Global Universal MonitoringLocal program

Local Universal Monitoring

LUM

Examples of the visualizations of the results

Examples of empirical results received from the data

obtained with the software (UMON and LUM)

-4 -3 -2 -1 0 +1 +2 +3 +4-0.2

-0.15

-0.1

-0.05

0

0.05

0.1

0.15

0.2

время (сутки) геомагнитные возмущения

единицы стандартного отклоненияиз

мен

ения

лат

ентн

ого

врем

ени

ПС

МР Latent time alterations of the simple

Audio-motor reaction (SAMR) (pic .А, B) and the number of delay responses (pic. В)

In the range of ±4 days to the effect of geomagnetic disturbances

(Null day).

X-direction – time (days) before and after geomagnetic disturbance;

Y-direction – parameters of audio-motor reaction

Group effect

-4 -3 -2 -1 0 +1 +2 +3 +4

225

230

235

240

245

врем

я П

СМ

Р (м

с)

нулевой день - начало магнитной бури (всего 52 события)

B

А

-4 -3 -2 -1 0 +1 +2 +3 +4

0.4

0.5

0.6

0.7

0.8

0.9

1

ПС

МР

- ко

личе

ство

зап

азды

ваю

щих

реа

кций

нулевой день - начало магнитной бури (всего 52 события)

C

Examples of individual effects

Simple audio-motor reation

Variations of voluntary attention efficiency(А), accuracy index (B) and the

number of wrongly deleted characters(C) In relation to the dates of

geomagnetic disturbances.

X-direction – time (days) before and after Geomagnetic disturbances;

Y-direction – corresponding indices of the voluntary attention

Indices of voluntary attention

-4 -3 -2 -1 0 +1 +2 +3 +4-0.15

-0.1

-0.05

0

0.05

0.1

0.15

0.2

изм

ен

ен

ия

пр

од

укти

вно

сти

ко

рр

ект

урн

ой

пр

об

ы

единицы стандартного отклонения

время (сутки)геомагнитные возмущения

А Group effect

-4 -3 -2 -1 0 +1 +2 +3 +40.97

0.975

0.98

0.985

0.99

0.995

Корр

екту

рная

про

ба -

точн

ость

нулевой день - начало магнитной бури (всего 52 события)

B

-4 -3 -2 -1 0 +1 +2 +3 +41

1.2

1.4

1.6

1.8

2

2.2

2.4

2.6

Ко

рр

екту

рн

ая п

ро

ба

- ко

ли

чес

тво

нев

ерн

о о

тмеч

енн

ых

знак

ов

нулевой день - начало магнитной бури (всего 52 события)

C

Examples of individual effects

1. Presented Informational system can be used to assess the health state of a man by means of rapid methods implemented in the software, installed onto a PC. The data of regular testing can be transferred to the server database and provides a basis for the further analysis and issue of results and recommendations in the user interface on website www.umon.org.ua. The local program additionally implements a number of psychophysiological techniques and provides rapid diagnosis of the functional state of the subject.

2. The monitoring data of the health state, space weather and other factors allow for a comprehensive analysis of the health status of the subject with respect to its individual standards for each indicator, identify the relationship between indicators of test and parameters of space weather, taking into account the time lag between them. The results obtained are the basis for the prediction of the human condition in relation to the influence of socio-psychological factors and Space Physics..

3. Preliminary conclusions and recommendations obtained in an automated way, are the basis for the further processing of information by experts, physicians and other professionals. The information system has the potential for a variety of researches based on its technology, as well as to implement the rapid diagnosis of people whose professional activity is connected to the specific requirements for their health state.

Начало

Начало тестирования

Тест ПСМР

Корректурная проба

Тест на моторику 2-х рук

(параллельно)

Тест на моторику 1-ой руки (левой)

Тест на моторику 2-х

рук (перекрест)

Тест на моторику 1-ой руки (правой)

Тест на психо-эмоциональное

состояние

Измерения САД, ДАД, ЧСС

Регистрация нового пользователя

Выбор пользователя

(если есть)

Ввод данных

Сообщение об ошибке

нет да

Верификация данных с данными в БД на сервере

Добавление пользователя

Отправка результатов (если есть)

Соединение с сервером

Успешно?

Сообщение об ошибке

нет

Отправка запроса (с результатами)

Ответ от сервера. Успешно?

Сообщение об ошибке

да

нетда

Подтверждение пришло?

Блок отправки результатов Блок тестирования

Блок регистрации пользователя

General algorithm of «program-client» of www.umon.org.ua

Spinal cord

Cerebrum

Structural components of CNS

0,0167 - 0,0139 Hz

α-rhythm 8-12 Hz

Cranio-sacral rhythm, micro alterations of skull and spine size are synchronized to the

rhythms of cerebro-spinal fluid circulation (0,1 – 0,17 Hz)

motoneuronsneurons

synapses

neuroglia

Brain neurons

ЭМП КНЧ

Подкорковые икорковыемотивационныезоны

Ассоциативная исенсорнаяобласти коры

Премоторная идополнительнаядвигательнаяобласти коры

Двигательнаякора, стволовыедвигательныецентры

Рецепторы, внешниестимулы

Спина

льн

ые

сети

Внутреннеепобуждение к

действию

Стратегияи план

движения

Программадвижения

Выбор спинальныхнейронов, модуляция

спинальных сетей

Адаптивные илокальныеобратные связи Двигательные

единицы

Мобилизациядвигательныхединиц

Фаза

под

гото

вки

Фаза

вы

по

лн

ен

ия

Цел

ен

ап

рав

лен

ны

ед

ви

жен

ия

По

за,

си

нер

гии,

д

ви

жен

ия

Цит. по Фотекова Т.А., Ахутина Т.В. Диагностика речевых нарушений школьников с использованием нейропсихологических методов/ Пособие для логопедов и психологов. - М.: 1999АРКТИ. - 115c