Integrated Biomedical Information for

Better Health

Workprogramme 2005-2006Call 4

IST Conference- Networking Session

NEXTNEXT 10 years (2003-2014)PASTPAST 10 years (1991-2002)

FP2 FP3 FP4 FP5

Computer Applications for

Doctors

Telemedicine systems and services

Budget20M €

Budget100M €

Budget140M €

Budget200M €

Projects30

Projects

63Projects158

Projects125

ResultsFeasibility Study

ResultsAIM

Community

Results1st batch

of Products

ResultsEU

Health Telematic

s Industry

@@

20 Years of eHealth R&D Context20 Years of eHealth R&D Context

Regional Health Info Networks

Home-care systems

Personal Health Systems Health Knowledge Infostructure & HealthGrid

Decision Support Systems

Biomedical Informatics – support to Molecular and genomics Medicine

Personal health systems (Wearable & Implantable) based on biosensors

www.cordis.lu/ist/directorate_c/ehealth/index.html

FP6 Research activities

Background to call 4

Vast amounts of information is collected and published related to 1) Individuals’ health status (confidential information) i) “phenomic/clinical data”phenomic/clinical data”

(clinical info, info collected from in vitro/vivo diagnostics based on imaging and new biosensors, e.g. wearable/implantable systems)

ii) “genomic datagenomic data” – obtained from biochips

2) Human Health (public information)(medical knowledge, clinical research, public health knowledge & research, functional genomics, proteomics, environmental effects on health, nutrition, EMF, …)

Background to call 4

Biomedical information is collected, stored and processed on / in

1)1) Different LevelsDifferent Levels – (molecule, cell, tissue, organ, person, population)

2)2) Different Context - Different Context - (care, research, education, policy/management)

3)3) Different RepresentationDifferent Representation – (format, structures, ontologies)

4)4) Many many different places Many many different places - Medical info resources (health records, personal/wearable health

systems, clinical research databases, drug/pharma databases, NLM, …)

- Public health info resources (epidemiological data and studies, national and WHO databases on diseases, …)

- Biomolecular Info resources (DNA & protein sequences, microrarray data, protein interactions, human genome annotations ..)

- Environmental/Chemical/Biodiversity info resources

Synthesis of all “Health Information levels”Synthesis of all “Health Information levels”

Integrating biomedical data for better health

Bioinformatics

Medical Imaging

MedicalInformatics

Public HealthInformatics

Objectives of Call 4

To support research and development of ICT based systems that process and integrateprocess and integrate all possible relevant biomedical biomedical information from different levels and from many different information from different levels and from many different placesplaces with the purpose to improve

1. Health knowledge discovery and understanding2. Health status of an individual, i.e to improve disease prevention, diagnosis, treatment

It is less about developing new technologies ( e.g. wearable monitoring systems) and more about optimal utilization of existing relevant information resources (data, signals, knowledge)

Scope of Call 4

Focus 1: Methods and systems for improved medical knowledge understanding through integration and processing of biomedical information

Examples: - patient specific computational models of anatomy and physiology for disease modeling and simulation from molecular level to organ level e.g. new approaches to drug discoveries

-methods to map and seamlessly link clinical and genetic information resources e.g. using grid technologies, electronic health records including genetic information

- ICT methods for “in vivo” visualisation of biological processes on molecular level (ICT in support of molecular imaging)

Scope of Call 4

Focus 2: Innovative systems and services for disease prevention, diagnosis and treatment based on integrated biomedical information.

Examples: - patient safety e.g. prevention of drug adverse effects

- support to development of new “personalised” drug and/or nutrition

- training tools for health professionals

- improvements to diagnostic methods e.g. molecular imaging

Scope of Call 4

ALL proposals must point or show: measurable benefits, respect legal & ethical guidelines

IPs: should address both focus 1 and 2 and should address the issue of integration and interoperability

STREP: should focus on development of innovative system or service with clearly specified problem and target group

Scope of Call 4

Calling for roadmaps (Specific Support Measures) that lead to - recommendations for an R&D actions on EU level - should also consider other aspects ( legal, industrial, financial)- should indicate beneficial intermediate milestones

i) Interoperability of eHealth systems – realistic approaches to this concept with clinical applicability. Special emphasis on semantic interoperability and the further R&D needed in the area of biomedical ontologies

ii) In silico model of human being (virtual or physiological human) from eCell to eOrgan. Should indicate possible realistic and exploitable milestones e.g. each 3-4 years.

iii) beneficial uptake of HealthGrid technologies and applications