Institutional Research of Meningioma Final

8/17/2019 Institutional Research of Meningioma Final

1/23

MENINGIOMA RESEARCH IN

OUR INSTITUTION

Rr. SuzyIndharty

Rr Suzy Indharty, et al


2/23

Age, WHO grade, and extent of resectionrepresent strong prognostic factors inmeningiomas. The majority of further cinicafactors and a!oratory "ndings re#ect diseaseaccording to the WHO grade. Therefore, researchshoud focus on heterogeneity of prognosticfactors $ithin a gi%en WHO grade. This may ao$to identify predicti%e factors for response tosystemic therapy, and to promote the design of

studies $hich stratify according to these factors

Roelcke, Ulrich. Prognostic Factors in Meningioma. Eur Assoc Neuroncol Mag!"#$% $ &$'( #""


3/23

Laboratory Markers

& 'I ()

& *strogen receptor

& +rogesteron receptor

& *-& -/

& *-R

& I-01& Teomerase acti%ity

Roelcke, Ulrich. Prognostic Factors in Meningioma. Eur Assoc Neuroncol Mag!"#$% $ &$'( #""


4/23


5/23

R*2ATIO3SHI+4*TW**3 *STRO-*3R*5*+TORS A36 'i0()

2A4*22I3- I36*7 I38*3I3-IO8A

9Abdurrahman Mousa)


6/23

& Some studies meningioma gro$th ::in

; 2utea phase and pregnant, !ut , /???@.& +roiferation Index measured= Anti!ody

8I401 antigen 'i0(). 9-erdes > et a, 1BC@.

Relationshi)s *et+een Estrogenrece)tor and meningioma cell

)roli-eration is still controersial


7/23

*strogen Receptors In 8eningioma

& In norma meninges $ere not found 95ode Horst et a,

1D@.& 4ouiot et a 1C E/ patients $ith histoogica

grading of maignant meningioma no estrogenreceptors.

& *strogen receptor expression in meningioma moreaggressi%e 9+ra%denFo%a S et a, /??(@, !ut otherstudies on atypica meningioma didnGt "nd *strogenReceptor 9'onstantinidou A* et a, /??D@

& Fakhrou et a! "#$" Estro%en re&e'tor e('ressonmenn%oma s a %ood 'ro%nost& *a&tor+

& 'orhornen et a /?1/ :: estrogen receptors in8eningioma -rade I, !ut


8/23

Relationshi) /et+een Estrogen Rece)tors and 0i12

3a*elling Inde4 &I56' in meningioma

P alue 7 ".122 sho+ed no signi-icant association *et+een Estrogen Rece)tor e4)ression

+ith 0I12.

3a*elling Inde4 /a*u et al &!"##' inestigated0I12 3a*eling inde4 in meningioma +ith $""

sam)les, and concluded that there is a a )ositie correlation *et+een 0I12 8rading 3a*eling

inde4 +ith meningioma.


9/23

-ender reations and 2a!eing Index 92I@

& 5hi0suare test p ?.1/1 9 3o gender reationship $ith

'i0()@

The reationship !et$een age and 2a!eing Index 92I@

) 7 ".!"9 no relationship between age and Ki-67.


10/23

Stann% Intensty,ased -ro%esterone

Re&e'tor n

Menn%omaC!ass.&aton

9Ste%en Tandean@


11/23

Staining Intensity )rogesterone rece)tors 0i12 3I +ith )".19! &not

signi-icant'

3iterature(

Staining o- )rogesterone rece)tors +ere stronger and +ere o-ten -ound in

grade I meningioma com)ared to grade II and III &:aghi)our &!""2',

mulecka &!""1', and El/ada+y &!"#$'

SI +e$arnaan reseptor

progesteron8eningioma

grade I

8eningioma

-rade II8eningioma

grade III

3egatif 1C / 1

2emah D 0 0

'uat 1? 0 0

Tota /) / 1

mulecka, A., Pa)ierz, ;., Na+rocka0unecka, A., 3e+y:renda, I., !""1. Immunohistochemical e4)ression o- )rogesterone and estrogen rece)tors in

meningiomas. Folia Neuropathol 99 &!'( ##### '( #2!#El/ada+y, N.M., Farid, R.M., Nagi*, 3.N., I*rahim, R.A., !"#$. Role o- )rogesterone rece)tor e4)ression and )roli-eratie actiity in )redicting the recurrence o-

meningioma. Egyptian Journal of Pathology $$( 21?#


12/23

Reationship !et$eeni!ro!ast -ro$th actor / 9-

/@ 2e%e With WHO5assi"cation 6egrees inIntracrania 8eningioma

(Marsal Risfandi)


13/23

Introdu&ton

NO Resear&h

1 -ro$th factor aJecting meningioma gro$th is +ateet 6eri%ed-ro$th actor, *piderma -ro$th actor, ascuar *ndotheia-ro$th actor, and i!ro!ast -ro$th actor /,!a&k0 "#$#)

/ An imunohistoFimia study sho$ed reationship !et$een !asic

- and -0receptor in meningioma ces. /,!a&k0 "#$#)

D 6ereguation of - signaing coud cause change in tissuehomeostasis and %ery reated to the occurence of gro$thdistur!ance syndromes and aso the occurence of many !raintumors incuding meningioma /E!!en0 "#$#)

C rom %arious researches, it $as found that an increasing -coud cause se%era tumor gro$ths in human incudingmeningioma /Chn0 "##1 dan Toyoka2a0 "##3)

E Ki Wei et a 9/??C@ = -0/ concentrate $as increasing in

coherence $ith the increase in WHO cassi"cation e%es /4e0

"##5)


14/23

Analysis o- the relationshi) *et+een the leels o- F8F ! +ith a -e+ other

aria*les, such as age, histo)athology, and the degree o- the ;5

classi-ication and Pearson 6orrelation test.

Tabe! 5+ Tes 6ore!as 6adar FGF "

p r

'adar - 0 Lsia ?,?BE ?,D(?

'adar - M Histopatoogi ?,B)? ?,11)

6adar FGF 7 8eraat 4HO #0##9 #+1":

The higher levels of FGF 2 the greater the degree a!!ording to "#$

!lassifi!ation %eningio%a. :he concentration o- serum F8F ! a re-erence

one o- the -actors )redictors o- )rognosis.

@i ;ei et al &!""9' descri*ed the leels o- FGF-2 in!reased with in!reasing

degrees of the "#$ !lassifi!ation due to F8F! is an angiogenic gro+th -actor

stimulation )otential to stimulate )roli-eration o- endothelial cells o- *lood essels

and +ere inoled in neo)lastic angiogenesis o- seeral tumors, including

meningiomas.


15/23

4HO GRA8E $

4HO GRA8E "

4HO GRA8E :

; $$# '%


16/23

Insuin -ro$th actor01Receptor *xpression In

Intracrania 8eningioma

(ndre 1iahaan)


17/23

Insuin -ro$th actor01 Receptors 9I-01R@*xpression in Intracrania 8eningioma

) 7 ".9!$ No relationshi) *et+een I8F# R e4)ression

and ;5 grading.


18/23

E)idermal 8ro+th Factor

Rece)tor E4)ression In

Intracranial Meningioma

(Rr 1)


19/23

Histopathoogy meningioma 9H*,C?? x@. a.8aignant meningioma 9WHO grade III@N !.Angiomatous meningioma 9WHO grade I@N c.+sammomatous meningioma 9WHO grade I@Nd. i!ro!astic meningioma 9WHO grade I@N e.

Transitiona meningioma 9WHO grade I@N f.

8eningotheia meningioma 9WHO grade I@

Imunostaining IH5 *-R, enargement C??x. 1@ *-Rnegati%e.

/@ *-R 1 +ith +eak intensity

D@ *-R / $ith moderate intensity

C@ *-R D +ith strong intensity.


20/23

Ta!e 1. 6egree of *-R staining, n 9P@

-ato!o%

EGFR stann% ntensty Corre!aton

? 1 / D

r0?,/?)

p?,?BEQ

WHO I / 9D,/@ 1D 9/1@ ( 9,)@ C1 9((,1@

WHO II ? 9?@ C 9((,)@ ? 9?@ / 9DD,D@

Meningioma degrees ;5 ! and $ generally indicates the degree o- E8FR I56 staining is lo+er than the

degree o- ;5 #. A total o-


21/23

The Corre!aton o*Serum >EGF

Con&entraton 2th-TEI n Intra&rana!

Menn%oma

(Tho%as To%)


22/23

& +T*I 9+eritumora *dema Index@ = di%iding tumor %oume andedema measurements.

& Serum *- 9ascuar *ndotheia -ro$th actor@concentration $as measured !y sand$ich *2ISA method.

& /? sampes $ith femae predominanceN 8edian age CC yo.N the highestfreuency $as in third and fourth decade of ifeN the most ocation of tumor

$as con%exityN and the most histopathoogy type $as meningotheiameningioma. 8edian +T*I 1,(C pgm2 98ax08in = ),/C M 1,?D@. Serum *-concentration 8edian 1CB,(C pgm2 98ax08in = 1B,/( M C/,((@.

& 4y correation test of hypothesis, $e had positi%e correation $ith o$

strength and no s%n.&an&e !et$een serum *- $ith +T*I 9r?,/C(,p?,?E@ &om'are= positi%e correation $ith o$ strength and nosigni"cance !et$een serum *- $ith +T*I 9r?,/C(, p?,?E@ 9OtsuFa,eta /??)@


23/23

Con&!usonAccording to our institutiona research in meningioma=

&3o association !et$een *strogen Receptor expression $ith 'I0(). 4a!uet a 9/?11@ positi%e correation

&3o association !et$een +rogesterone receptors expression $ith 'i0() 2I 9Taghipour 9/??)@, OmuecFa 9/??(@, and *04ada$y 9/?1D@ progesteronereceptors $ere stronger and $ere often found in grade I meningioma

&The h%her !e?e!s o* FGF "0 the %reater the de%ree a&&ordn% to

4HO menn%oma &!ass.&aton Ki Wei et a 9/??C@ -0/ increased$ith increasing degrees of the WHO cassi"cation

&No asso&aton bet2een 4HO menn%oma de%ree 2th the !e?e! o*EGFR e('resson /IHC) Smth et a! /"##9) ne%at?e &orre!aton

&No s%n.&an&e !et$een serum *- $ith +T*I OtsuFa,et a /??)positi%e correation

Institutional Research of Meningioma Final

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