July 9 & 10, 2020Institut Pasteur

6th edition

Organized by

Scientific committeeQuentin AnsteePierre BedossaLaurent Castera

Jean-François DufourScott Friedman

Fabio MarraPhilippe Mathurin

Veronica MillerManuel Romero-Gómez

Frank TackeMichael Trauner

Arun Sanyal

Virginia CommonwealthUniversity School of Medicine,

Richmond, Virginia, USA

Hôpital HautepierreHôpitaux Universitairesde Strasbourg, France

Lawrence Serfaty

July 9 & 10, 2020, ParisSCIENTIFIC PROGRAM

International Think Tank

THURSDAY, JULY 9, 2020

10:00 - 10:30 am COFFEE BREAK AND POSTERS

Generating real world evidence from efficacy to effectiveness.Michael Fried (USA)

Chairs: Philippe Mathurin (France) and Lawrence Serfaty (France)

10:30 - 10:45 am Gene-environment interactions in NASH.

10:45 - 11:00 am Metabolic flexibility is the key to the biology of NASH.

11:00 - 11:15 am What can we learn from lipodystrophies about NASH. Jocelyne Magré (France)

11:15 - 11:30 am Pharmacogenomics for NASH: current state of the art.

Mohammad Siddiqui (USA)

Stefano Romeo (Sweden)

09:30 - 10:00 am Discussion

10:30 - 12:00 am SESSION 2 • GENETIC AND METABOLIC DRIVERS OF DISEASE PROGRESSION

08:00 - 08:30 am CONFERENCE OPENING

08:30 - 08:35 am Welcome remarks - Lawrence Serfaty (France)

08:35 - 08:45 am Inauguration Address - Director Pasteur Institute

08:45 - 10:00 am SESSION 1 • PUBLIC HEALTH AND POLICY Chairs: Patrick Marcellin (France) and Arun Sanyal (USA)

08:45 - 09:00 am A patients journey with NASH. Eu patient

09:00 - 09:15 am Primary care referral for NAFLD: the UK experience.

09:15 - 09:30 am

11:30 - 12:00 pm Discussion

Quentin Anstee (United Kingdom)

Emmanuel Tsochatzis (United Kingdom)

02:30 - 04:00 pm SESSION 3 • CLINICAL ASPECTS OF NAFLD

03:30 - 04:00 pm Discussion

Lawrence Serfaty (France)

Philippe Mathurin (France)

Arie Regev (USA)

Jean-François Dufour (Switzerland)

TBC

12:00 - 12:30 pm STATE OF THE ART LECTURE Chair: Arun Sanyal (USA)

02:30 - 02:45 pm Does NASH contribute to clinical course of patients after successful HCV therapy

02:45 - 03:00 pm Gender difference in NASH susceptibility

Chairs: Quentin Anstee (United Kingdom) and Fabio Marra (Italy)

03:00 - 03:15 pm When disease activity can be confused with DILI in the patient

03:15 - 03:30 pm Modeling the risk of HCC in NAFLD

04:00 - 04:30 pm COFFEE BREAK AND POSTERS

July 9 & 10, 2020, ParisSCIENTIFIC PROGRAM

International Think Tank

Bile acid-Microbiome interactions in the development of human disease.

LUNCH BREAKOUT SESSION - CASE BASED DISCUSSIONS

Industry symposiumGROUP 1:

GROUP 2:

GROUP 3:

How to integrate NASH assessment and management into the care of the patient with metabolic syndrome.Laurent Castera (France) and Mary Rinella (USA)

Management of obesity by targeting gut hormonesLuc Van Gaal (Belgium) and Bart Staels (France)

12:30 - 02:30 pm

08:00 - 09:15 am SESSION 5 • INNOVATIONS IN TRIAL DESIGN AND OUTCOMES ASSESSMENT Chairs: Laurent Castera (France) and Jean-François Dufour (Switzerland)

08:00 - 08:15 am Assessment of causality in suspected DILI.

08:15 - 08:30 am Innovations in imaging to assess metabolic stress, inflammation and function of the liver.

08:30 - 08:45 am Hierarchical endpoints for NASH.

08:45 - 09:15 am Discussion

Lars Johansson (Sweden)

Alexander Gerbes (Germany)

Dianne Finkelstein, (USA)

09:15 - 09:45 am COFFEE BREAK

FRIDAY, JULY 10, 2020

WELCOME DESK OPENING07:45 - 08:00 am

July 9 & 10, 2020, ParisSCIENTIFIC PROGRAM

International Think Tank

04:30 - 06:00 pm SESSION 4 • TECHNOLOGICAL INNOVATIONS IN NASH Chairs: Manuel Romero-Gómez (Spain) and Franck Tacke (Germany)

04:30 - 04:45 pm Progress in histological assessment of NASH: new classifications, digital imaging,

machine learning.

04:45 - 05:00 pm Can iPSC derived from circulating cells be used to obtain insights on liver disease

status?

05:00 - 05:15 pm What can we learn from cardiopoietic therapy approaches to resolve cirrhosis?

05:15 - 05:30 pm Application of single cell seq in understanding NASH and liver fibrosis.

05:30 - 06:00 pm Discussion

Bani Mukhopadhyay (USA)

Pierre Bedossa (France)

Scott Friedman (USA)

Thomas Baumert (France)

06:00 pm POSTER AWARD

LUNCH BREAKOUT SESSION

Industry symposium GROUP 1:

GROUP 2:

GROUP 3:

Review of recent clinical trials of NASH. Raluca Pais (France) and Mary Rinella (USA)

Endoscopic bariatric and metabolic therapies.Jacques Devière (Belgium) and Jean-Michel Gonzalez (France)

12:00 - 02:00 pm

04:00 pm Concluding remarks

July 9 & 10, 2020, ParisSCIENTIFIC PROGRAM

International Think Tank

02:20 - 04:00 pm SESSION 8 • INDUSTRY CORNER

09:45 - 11:30 am SESSION 6 • ADVANCES IN NASH PHARMACOLOGY Chairs: Arun Sanyal (USA) and Michael Trauner (Austria)

09:45 - 10:00 am The FGF axis in NASH. Comparison of FGF21 and FGF19 analogs.

10:00 - 10:15 am The impact of SGLT2 inhibition on metabolic homeostasis.

10:15 - 10:30 am Small molecule therapy.

11:00 - 11:30 am Debate: The best approach to NASH is to treat the root cause rather than a pure anti-

fibrotic strategy.

For: Philip Newsome (United Kingdom)

Against: Fabio Marra (Italy)

11:00 - 11:30 am Discussion

Moderators: Scott Friedman (USA) and Lawrence Serfaty (France)

David Mangelsdorf (USA)

Michael Roden (Germany)

Manuel Romero Gómez (Spain)

11:30 - 12:00 pm SPECIAL LECTURE

Redefining the metabolic syndrome as a systemic steatosis-inflammation-fibrosis syndrome.

02:00 - 2:20 pm SESSION 7 • REGULATORY UPDATE Chair: Lawrence Serfaty (France)

Veronica Miller (USA, Liver Forum)

Chairs: Arun Sanyal (USA) and Lawrence Serfaty (France)

Arun Sanyal (USA)

Arun Sanyal (USA)

Chair: Philippe Mathurin (France)

July 9 & 10, 2020, ParisSCIENTIFIC PROGRAM

International Think Tank

FACULTY 2020

BEDOSSA Pierre

CASTERA Laurent

BAUMERT Thomas

DUFOUR Jean-François

DEVIÈRE Jacques

FRIED Michael

FINKELSTEIN Dianne

FRIEDMAN Scott

JOHANSSON Lars

GERBES Alexander

GONZALEZ Jean-Michel

MARCELLIN Patrick

MAGRÉ Jocelyne

MANGELSDORF David

MARRA Fabio

MUKHOPADHYAY Bani

NEWSOME Philip

MILLER Veronica

SANYAL Arun

RINELLA Mary

SERFATY Lawrence

SIDDIQUI Mohammad Shadab

STAELS Bart

TSOCHATZIS Emmanuel

VAN GAAL Luc

TRAUNER Michael

TACKE Franck

www.paris-nash.org

ROMEO Stefano

PAIS Raluca

RODEN Michael

MATHURIN PhilippeANSTEE Quentin

REGEV Arie

ROMERO-GÓMEZ Manuel

July 9 & 10, 2020, Paris

INSTITUT PASTEUR

28 Rue du Docteur Roux75015 PARIS • FRANCE

Congress SecretariatTAMING HEALTHCARE24 rue des Bons Raisins

92150 Suresnes - France+33 1 87 15 30 30

Contact:

www.paris-nash.org

contact@paris-nash.org