INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh...
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Transcript of INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh...
![Page 1: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/1.jpg)
INS
Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for
ART in MozambiqueIlesh Jani1, Nádia Sitoe 1, Eunice Alfai1,
Patrina Chongo1, Jonathan Lehe2, Beatriz Rocha2, Jorge Quevedo2 and Trevor Peter2
1 Instituto Nacional de Saúde, Mozambique2 Clinton Health Access Initiative
![Page 2: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/2.jpg)
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Background• The scaling-up of ART is facing problems due to
delays in ART initiation and high patient loss-to-follow-up (LTFU)
• These challenges are partly due to limitations in access to CD4 testing
• Emerging Point Of Care (POC) technologies for CD4 counting could improve patient outcomes by:
Increasing access to CD4 testingReducing LTFU after HIV diagnosisShortening CD4 test turn-around timeReducing total time from enrollment to
initiation of ART in eligible patients
![Page 3: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/3.jpg)
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• Alere PIMATM was evaluated in Mozambique and showed good agreement with the FACSCaliburTM (Bias=-50.6 cells/µL; see Jani et al. abstract THAB0104)
Objective
• The main objective is to measure the impact of POC CD4 counting (and haemoglobin determination) implementation in primary health care settings
![Page 4: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/4.jpg)
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Methodology
• Pilot implementation of POC CD4 (and haemoglobin) at 7 sites
• Chart review for data collection performed at baseline and post-implementation (data presented for Matola Health Centre only – POC installed in the lab)
• Parameters measured included:– Complexity of patient process
flow– Total time for enrollment to
ART initiation– Access to initial CD4 result
![Page 5: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/5.jpg)
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The complexity of patients flow decreased after implementation of
POC CD4
1. HIV diagnosis2. Patient enrollment3. CD4 requisition4. Blood drawn5. CD4 test
performed6. CD4 result received7. CD4 result given to
patient8. Clinical
consultation9. ART initiation
1. HIV diagnosis2. Patient enrollment3. CD4 requisition, CD4
test performed, CD4 result given to patient
4. Clinical consultation5. ART initiation
Before POC CD4 After POC CD4
![Page 6: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/6.jpg)
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44 days
89 days
21 days
N=849
N=125
N=140
Total time to ART initiation was reduced from 44 days to 21 days
![Page 7: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/7.jpg)
INS 0%
20%
40%
60%
80%
100%
Before POC CD4 Pilot After POC CD4 Pilot
Per
cent
age
Patient access to initial CD4 result improved from 57% to 93%
![Page 8: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/8.jpg)
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The improvement of access to CD4 result in not uniform across
all clinics
Factors Limiting Universal Access To CD4 Testing:
•Limited HR capacity•Patient overflow•Clinic workflow still in process of adapting
93%
4% 3%Matola
CD4 Result on time
No CD4 result
Transferred with outdated CD4 result
76%
24%
Machava
![Page 9: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/9.jpg)
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Conclusions
• The Introduction of POC CD4 in Matola ART clinic resulted in:
− Reduction in complexity of patients’ flow− Decrease in total time to ART initiation (from 44
days to 21 days)− Improvement in access to initial CD4 result (from
57% to 93%)
• The initial impact of the introduction of POC technologies may not be uniform across all sites
![Page 10: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/10.jpg)
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Next steps
– Measure the impact of POC CD4 in other ART clinics involved in the pilot
– Measure the impact on patient important outcomes after 6 and 12 months
– Measure impact on the health system– Perform cost-efficiency analysis– Investigate needs (e.g. human resources) for
large-scale implementation of POC technologies
![Page 11: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/11.jpg)
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Acknowledgements
• Patients• Provincial Health Directorates (Maputo City,
Maputo Province, Sofala, Niassa)• Staff at Pilot Sites• INS Staff• CHAI Staff• ARK• UNITAID
![Page 12: INS Point-Of-Care CD4 Improves Patient Retention and Time-To-Initiation for ART in Mozambique Ilesh Jani 1, Ndia Sitoe 1, Eunice Alfai 1, Patrina Chongo.](https://reader035.fdocuments.us/reader035/viewer/2022062413/5a4d1b757f8b9ab0599b6bc5/html5/thumbnails/12.jpg)
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Northern shore of Lake Niassa (Lake Malawi) - This mobile unit brings CD4/Heam