Innovations in data visualisation for drug discovery · 2018-07-19 · John Snow and the Broad...
Transcript of Innovations in data visualisation for drug discovery · 2018-07-19 · John Snow and the Broad...
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Innovations in data visualisation for drug discoveryLindsay Edwards DPhil FRSBHead of Digital, Data & AnalyticsGSK Respiratory
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Why are we here?
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Anscombe’s Quartet
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Anscombe’s Quartet
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Visualisation in contrast with machine learning
• Visualisation is a key tool to support decision making
• Leverages human pattern recognition (wetware)
• Machine learning / statistics provide an answer (with
confidence bounds): uses hardware
• Visualisation keeps ‘a human in the loop’ (vs Augmenteed
Intelligence)
• Two famous examples of visualisations that supported
important decisions (one good, one bad)…
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John Snow and the Broad Street pump
• In August / September 1854 there was a cholera outbreak in central London
• In 19th Century London, cholera had a 50% fatality rate
• At least 616 people died
• John Snow correctly tied the outbreak to a pump on Broad Street and removed the handle, thus halting
the outbreak
• How did he know?
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https://www1.udel.edu/johnmack/frec
682/cholera/snow_map.png
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The Broad Street pump
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The Broad Street pump
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• On 28th January 1986, the space
shuttle Challenger exploded, killing
all seven astronauts on board
• The cause was later traced to two
rubber ‘O’-rings that failed at low
temperatures
• This was known to be a risk, but the
launch went ahead anyway
• Why?
• 13 charts were faxed to NASA the
night before by Morton Thiokol (the
‘O’-ring manufacturer)
The Challenger Disaster
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Edward Tufte’s plot
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In data visualisation…
Improvements in browser technology are driving innovation
“Recently the combination of some powerful visualisation libraries
and a massive improvement in JavaScript’s performance have
opened the way to a new type of visualization, one that is easily
accessible, dynamic and actually encourages exploration and
discovery. The clear distinction between data exploration and
presentation is blurred. ..This is nothing short of a revolution.” - Kyran
Dale
Visualisation & data mining
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• How do we effectively visualise high-dimensional data (not just
genomics!)
• How does the way we visualise data impact the decisions that we
make?
If we visualised the data a different way, would we make a different decision?
How sensitive are the decisions we make to the mode of visualisation?
• How can visualisation of our operational data transform our businesses?
• How can we use visualisation to aid the interpretability of machine
learning models?
Some questions for drug discovery