Innovation in wireless in-body devices - the power of ... · Innovation in wireless in-body devices...
Transcript of Innovation in wireless in-body devices - the power of ... · Innovation in wireless in-body devices...
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Innovation in wireless in-body devices - the power of wireless -
3rd MC meeting and 3rd technical meeting
Dr. Sebastian Schostek
Vice President Division Diagnostic Systems
Ovesco Endoscopy AG Tübingen, Germany
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2 About us
Product portfolio: interventional endoscopy
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3 About us
R&D pipeline: diagnostic systems
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4 About us
Strong history in European R&D projects
FP4
FP5
FP6
FP7
H2020
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5 The power of wireless
2001: Market launch of the M2A (mouth to anus) capsule endoscope, Given imaging, Israel
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6 The power of wireless
M2A (later: ‚Pillcam‘) led to a paradigm shift in GI diagnosis
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7 The power of wireless
M2A (later: ‚Pillcam‘) led to a paradigm shift in GI diagnosis
Hagenmüller et al, 2014
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8 The power of wireless
Pillcam: Pioneering the field of small bowel diagnosis
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9 The power of wireless
Pillcam, an integrated battery powered system
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10 The power of wireless
The race began – research gone wild
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11 The power of wireless
Today‘s competitors – an USD 600 million market in 2017, CAGR 8,7%
Today‘s competitors
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12 The power of wireless
Both Ovesco divisions synergetically address the same clinical indication areas from both, diagnostic and therapeutic sides.
Ovesco Endoscopy
AG
Division Diagnostic
Systems
Division Therapeutic
Devices
Bleeding
Closure
Tumor detection and removal
Further areas
Clinical indication
areas
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13 The power of wireless
Innovation in wireless in-body devices: A field just starts to unfold
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14 The power of wireless
HemoPill acute (market launch 2017): Quick check that can safe lives
Patient swallows HemoPill acute
HemoPill acute sends sensor data
Sensor data displayed on the receiver in real-time
Application Patient with suspected acute UGIB
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15 The power of wireless
HemoPill: the world‘s smallest battery-powered telemetric in-body device
Sensor (20 vol%)
Power (45 vol%)
Communication (30 vol%)
Data processing (5 vol%)
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16 The power of wireless
HemoPill: the world‘s smallest battery-powered telemetric in-body device
Sensor (20 vol%)
Power (45 vol%)
Communication (30 vol%)
Data processing (5 vol%)
Data processing unit (comparable device):
- 20 MHz CPU
- 9 KB internal Memory
- 8 sensing channels
- Timers, comparators, serial interface,
temperature sensor…
- Wireless communication speed:
up to 600 kbit/s
- Dimension: 3mm x 3mm
- Price < 1 EUR
386 SX (1989):
- 16 MHz CPU
- 40MB internal Memory
- Communication speed:
analog max. 40 kbit/s
- Price ~ 1000 EUR
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17 The power of wireless
Innovation in wireless in-body devices: A field just starts to unfold
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18 The power of wireless
Flexible endoscopy… coming of age?
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19 The power of wireless
Today‘s capsule endoscopes have its niche in the small bowel; flexible endoscopes cover >98% of procedures
Small bowel endoscopy:
< 200k procedures p.a.
Colon and gastric screening:
>10M procedures p.a.
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20 The power of wireless
The organ caliber is main limitation of capsule endoscopy.
Esophagus
Ø 1-1,5cm
Small bowel
Ø 1-2,5cm
Stomach
Ø 10-15cm
Colon
Ø 4-6cm
Small bowel endoscopy:
< 200k procedures p.a.
Colon and gastric screening:
>10M procedures p.a.
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21 The power of wireless
Flexible endoscopy is today indispensible for majority of digestive disease diagnoses
Healthy
bowel
mucosa
Invasive
cancer
Relatively few patients
make use of the screening
opportunity, due to:
• Pain and discomfort during the
procedure.
Stretching
the bowel
wall:
Pain
creation
Stretching
the
mesentery:
Pain
creation
Evidence supporting the concept of early detection & treatment:
• Screening endoscopy reimbursed in many EU healthcare systems
• Literature widely supports screening endsocopy
• Literature widely supports early treatment of pre-malignant and
early malignant lesions
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22 The power of wireless
Endoscopists need to be able to position the endoscopic device
1) Detection of a suspicious lesion 2) Capsule is passing the lesion 3) Capsule has passed the lesion
without gathering information
1) Detection of a suspicious lesion 2) Capsule is passing the lesion 3) Capsule uses on-site
locomotion to further
investigate the lesion
Passive locomotion
Selective on site-locomotion
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23 The power of wireless
VECTOR capsules can keep up with flexible endoscopes in terms of steering
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24 The power of wireless
Magneto-robotic position control proves intuitive and allows capsule locomotion
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25 The power of wireless
Flexible endoscopy… coming of age?
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26 The power of wireless
Imaging technology for integrated smart systems is unfolding
Fluorescence imaging
Al-Rawhani et al. 2015
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27 The power of wireless
Flexible endoscopy… coming of age?
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28 The power of wireless
Technology is the bottle neck… every advancement results in inprovement!
Capsule endoscopy today:
Obscure GI bleeding
VECTOR capsule endoscopy:
Fighting GI cancer
• Single-shot imaging (2 per second)
• Resolution 250x250 to 320x320
• Datarate 2 Mbit/s
• Power consumption < ~10 mW
• Fluent video (> 11 fps)
• Resolution 720 x
• Datarate > 10 Mbit/s
• Power consumption < ~40 mW
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29 The power of wireless
Conclusion
Wireless in medical applications is a true enabler – significant examples in
digestive disease diagnosis
Exploitation of wireless technologies in healthcare is years behind other
fields of applications
But…
Healthcare applications come with technological challenges (level of
integration, low power, etc), therefore stimulate and boost research and
innovation
… to be continued
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Innovation in wireless in-body devices - the power of wireless -
3rd MC meeting and 3rd technical meeting
Dr. Sebastian Schostek
Vice President Division Diagnostic Systems
Ovesco Endoscopy AG Tübingen, Germany
Sebastian.scostek
THANK
YOU!