Malondialdehyde 4-Hydroxynonenal Protein Adducts in Plasma Liverof
Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim...
of 40
Transcript of Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim...
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
1/40
Gjhl`en Od}kl`nehwne2 Exdcejduy
ljn Ejndcejduy NJL Lnnui~y ljn
Evgceje~gi L`~e}l~gdjy dokgi}d]JLy
Blkey Ysejme}c, N*_*K*, Vh*N*
bysejme}Feklg`*uji*enu
7
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
2/40
Kd}e ~hlj =6 kg``gdj ~djy$wel} dood}kl`nehwne gy v}dnuien sd}`nsgne ljnuyen gj l sgne yvei~}uk do lvv`gil~gdjy*
^he}eod}e, od}kl`nehwne exvdyu}ey o}dk
ejg}djkej~l` ljn diiuvl~gdjl` ydu}iey
l}e |ug~e idkkdj*
Od}kl`nehwne gy l ajdsj ljgkl` ljnhuklj il}igjdcej, iluygjc jlyl` iljie}*
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
3/40
6
6
56
?6
36
6 = > ? 8
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
4/40
Od}kl`nehwne gy l umg|ug~duy ejg}djkej~ vd``u~lj~, mu~ g~ gy l`yd ljeyyej~gl` ke~lmd`g~e gj l`` `ggjc ie``y* ^he}eod}e, md~h ejndcejduy ljn
exdcejduy od}kl`nehwne jeen ~d me idjygne}en gj }gya lyyeyykej~*
Od}kl`nehwne gy e}w }eli~ge sg~h v}d~egjy ljn NJL, `elngjc ~d nge}yev}d~egj lnnui~y ljn NJL nlklce*
c`u~l~hgdje
Y+hwn}dxwke~hw`+c`u~l~hgdje
LNH9
Y+od}kw`c`u~l~hgdje
Y+od}kw`c`u~l~hgdjehwn}d`lye
od}kl~e
ID=!H=D
c`u~l~hgdje
ejndcejduyydu}iey
exdcejduyydu}iey
L@NH
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
5/40
Exve}gkej~l` Neygcj
]l~y se}e exvdyen ~d
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
6/40
Yiheke
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
7/40
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
8/40
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
9/40
Gkv}den Ke~hdnd`dcw @DN2 =6 l~~dkd`ey @D\2 >6 l~~dkd`ey
Gjy~}ukej~l~gdj Sl~e}y JljdLi|ug~w UV@I Sl~e}y I kgju~e }ee}ye vhlye c}lngej~
Kdmg`e Vhlyey2 L' Sl~e} sg~h 6*
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
10/40
8 7
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
11/40
]l~gd do Exdcejduy ~d EjndcejduyLnnui~y
6
6*5
6 ?6 86
`j
(ExdcejduyL
nnui~y$! ie``y ~d ey~lm`gyh ejndcejduy lnnui~lkduj~y*
Huklj mdje kl}}ds ~d idkvl}e sg~h kdjaew nl~l*
Huklj jlyl` ~u}mgjl~ey ~d ey~lm`gyh ejndcejduy lnnui~lkduj~y*
L v}gkl~e y~unw ~d exlkgje y~ek ie``y gj IN 9>! v}gken
kdjaewy exvdyen ~d Q
-
8/2/2019 Inhaled Formaldehyde Exogenous Endogenous DNA Adducts Epigenetic Alterations of MicroRNAs by Jim Swenberg
28/40
=8
]evlg} do L`nehwne NJL @eygdjy
]gnvl~h, B] e~ l`(=663' Iljie} ]ey
6
=+EY 57>8'
JGEHY Iej~e} od} Ejg}djkej~l`Hel`~h ljn Yuyiev~gmg`g~w (V96
EY
