Influenza and Emerging Infectious Diseases Division...Oct 29, 2018 · Saving Lives. Protecting...
Transcript of Influenza and Emerging Infectious Diseases Division...Oct 29, 2018 · Saving Lives. Protecting...
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October 29-30, 2018 | Grand Hyatt • Washington, D.C.
Influenza and Emerging Infectious Diseases Division
Robert Johnson, PhDDirector, Influenza and Emerging Infectious Diseases
October 29, 2018
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Influenza: Domestic Impact
0 50 100 150
Avg. 2010-2015Annual 2017-18
H1N1 2009Hong Kong 1968
Asian 1957Spanish 1918
Economic Loss (Billion $)
Avian H5N1Avian H7N9
Spanish 1918
Asian 1957
Hong Kong 1968
H1N1 2009
Annual 2017-18
0 0.5 1 1.5 2 50 60402.5
0 5 10
Avg 2010-11 ̶ 2015-16Annual 2017-18
H1N1 2009Hong Kong 1968
Asian 1957Spanish 1918
Hospitalizations (Million)
Case Fatality (%)
0 200 400 600
Avg 2010-11 ̶ 2015-16
Season 2017-18
H1N1 2009
Hong Kong 1968
Asian 1957
Spanish 1918
Deaths (Thousands)
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Improving Preparedness and Response
Vacc
ine
Dos
es A
vaila
ble
(Mill
ions
)
0
200
400
600
Weeks
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Key Target Milestones
0 Weeks 12 Weeks 26 Weeks
First Vaccine Dose
Sufficient vaccine for US Population
Event
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One develops disease
Domestic CapacityGaps
Speed/Flexibility
Adjuvantsupply
Ongoing Influenza Countermeasure Initiatives
Antigensupply
Better, Faster, Flu Vaccines
Efficacy
Production
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Pre-pandemic Vaccines for Pandemic PreparednessProcure Pre-pandemic Vaccines and Adjuvants
Monitor Stability of Vaccines & Adjuvants Tests & clinical trials
BRITE study
Flexible & Optimized Stockpile: Antigen +Adjuvant Studies
Broader Protection: Induction of cross-protective immunity
Procure/Maintain
Improve Versatility
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Diagnostics
Faster Diagnosis/ Reduce Transmission
Outbreak Identification
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Pimodivir
Immune modulators
Monoclonal antibodies
One of many potential pathways to target
Baloxavir
Galani 2017 Immunity. 46(5):875
Therapeutics
Current strategy-new mechanisms of action
Strategies of interest
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Respiratory Protective Devices
Strategies we are interested in: Better
Production Capacity
Innovative Approaches
USABILITY &
COMFORT
FITFLEXIBILITY
REUSE
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1st Valley of Death:Advanced Development
and Licensure
2nd Valley of Death:Sustainment/Sustainability
Sustainability
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Seasonal InfluenzaPreparedness
Pandemic Influenza
Preparedness
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End-to-End Strategy
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Emerging Infectious DiseasesPreparedness
Pandemic Influenza
Preparedness