infectious hepatitis
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INFECTIOUS HEPATITIS
RDH KARUNADASA2011 BATCH
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INFECTIOUS HEPATITIS
Hepatitis A Was Called Infectious Hepatitis . Infectious hepatitis is an acute infectious
disease of the liver caused by the hepatitis A virus.
HEPATITIS A Hepatitis A is a disease caused by the hepatitis
A virus which results in inflammation of the liver
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DEFINITION HEPATITIS
Hepatitis means inflammation of the liver
Hepat (liver) + itis (inflammation)= Hepatitis
Viral hepatitis means there is a specific virus that is causing your liver to inflame (swell or become larger than normal)
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ETIOLOGY
Hepatitis A virus (HAV) HAV can not cause cytopathy, replicate within
cytoplasma of hepatocytes and via bill are discharged with feces
Only one antigen-antibody system. Anti-HAV IgM is diagnostic evidence of recent infection, IgG is protective antibody.
Resistance of HAV: 56°C, 30 min, usually temperature 1 week, dry feces at 25°C 30 days, fresh water, sea water ,shellfish or soil for several months. 70% alcohol at 25°C , 3 min, 100°C, 5 min and ultraviolet, 1 min
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PATHOLOGY
DegenerationNecrosisRegenerationInfiltration of inflammatory cellsHyperplasia of interstitial cells
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WHO GETS HEPATITIS A?
Anyone can get hepatitis A, but it occurs more often in children.
But most adults who develop
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HAV
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HEPATITIS A CLINICAL FEATURESIncubation period 28 days (range 15-50
days)
Illness not specific for hepatitis A
Likelihood of symptomatic illness directly related to age
Children generally asymptomatic, adults symptomatic
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HEPATITIS A EPIDEMIOLOGYReservoir Human. Endemic
Transmission Fecal-oral
Temporal pattern None
Communicability 2 weeks before to1week after onset
incubating period 02-06 weeks
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EPIDEMIOLOGIC FACTORS
Fecal oral transmission Poor hygiene High population density Day care centers and minor epidemics
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SIGNS AND SYMPTOMSThe first symptoms are usually
Fever, Loss of appetite, Nausea, Vomiting, and Malaise
Dark colored urine Abdominal pain Diarrhea Jaundice (yellowing of the skin and the whites of the eyes).
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DIAGNOSIS
History of illness Physical examination AST (SGOT) ALT (SGPT) Igm IgG
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TREATMENT
Acute hepatitis Isolation
HA: 3 weeks after onset
Rest DietAnti-virus therapyhepatinice
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PREVENTION
Control of source of infection Cut off the route of transmission Protection of susceptible population
Active immunity Passive immunity
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THANKS YOU