Infection and Immunity...Kuby Immunology, 7th Edition Immune Response Against Helminths Delves,...
Transcript of Infection and Immunity...Kuby Immunology, 7th Edition Immune Response Against Helminths Delves,...
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Infection and Immunity
Nesmiyanov P.P., Associate Prof.,
Immunology and Allergy Department
Volgograd State Medical University
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Outline
1. Introduction 2. Overview of Antibacterial Immunity/Evasion 3. Overview of Antiviral Immunity/Evasion 4. Overview of Antifungal Immunity/Evasion 5. Overview of Immunity to Parasites - Protozoa - Helminths - Ectoparasites (ticks, mites)
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Introduction
Chronic infections with persistent pathogens such as helminths, mycobacteria, Plasmodium, and hepatitis viruses affect more than a third of
the human population
Worldwide influenza annual epidemics result in about 3-5 million cases of severe illness, and about 250 000 to
500 000 deaths.
In 2010, malaria caused an estimated 660 000 deaths (with an uncertainty range of 490 000 to 836 000)
In 2011, 8.7 million people fell ill with TB and 1.4 million died from TB.
There were approximately 35.3 million people living with HIV in 2012
Facts (WHO):
…
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Introduction
Owen, Punt, Stranford. Kuby Immunology, 7th Edition
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Adaptive Immune Response to Extracellular Bacteria
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Injurious Effects of Immune Response
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
*SEB – Staphilococcal Enterotoxin B
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Dendritic cells and Infection
Jacques Banchereau. The Long Arm of the Immune System. Scientific American 18, 56 - 63 (2008)
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Immune Evasion by Extracellular Bacteria
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Evasion by Extracellular Bacteria
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Immune Evasion by Extracellular Bacteria
Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.
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Immune Evasion by Extracellular Bacteria
Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.
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Immune Response to Intracellular Bacteria (Listeria)
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Response Against Viruses
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Mechanisms of Induction of Type I Interferons by West Nile Virus
Mehul S. Suthar, Michael S. Diamond & Michael Gale Jr. West Nile virus infection and immunity. Nature Reviews Microbiology 11, 115-128 (February 2013)
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West Nile virus and Immunity
Mehul S. Suthar, Michael S. Diamond & Michael Gale Jr. West Nile virus infection and immunity. Nature Reviews Microbiology 11, 115-128 (February 2013)
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Immune Evasion by Viruses
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Evasion by Viruses (continued)
Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.
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Antigenic Drift and Shift
Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.
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Influenza Virus
Owen, Punt, Stranford. Kuby Immunology, 7th Edition
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Influenza Virus
Owen, Punt, Stranford. Kuby Immunology, 7th Edition
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Antigenic Shift
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Inhibition of Antigen Processing and Presentation by Viruses
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Persistence and Reactivation of Herpesviruses
Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011
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Animation/Reactivation of Herpesviruses
Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011
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Cell types in Which HV Initiate Infection/Latency
Penkert, Rhiannon R; Kalejta, Robert F. Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae Vol. 2 Issue 1, 2011
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Immune Response to Fungi
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Response to Fungi
Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.
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Immune Response to Fungi
Brad Spellberg. Antifungal Immune Response. The Scientist, 2011
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Immune Response to Fungi
Uday Kishore, Suhair M. Abozaid and Mohammed N. Al-Ahdal. Anti-Fungal Innate and Adaptive Immune Responses. From the book Microbial Pathogenesis: Infection and Immunity, 2013 (Landes Biosciences and Springer)
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Immune Response Against Parasites
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Response Against Helminths: Schistosoma
Owen, Punt, Stranford. Kuby Immunology, 7th Edition
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Immune Response Against Helminths
Delves, Martin, Burton, Roitt. Roitt’s Essential Immunology, 12th Edition.
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Immune Evasion by Parasites
Abbas , Lichtman, Pillai. Cellular and Molecular Immunology, 7th Edition.
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Immune Evasion by Protozoa: Trypanosome
Kenneth Murphy. Janeway's Immunobiology, Eighth Edition.
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Bystander Chronic Infections
Erietta Stelekati, E. John Wherry. Chronic Bystander Infections and Immunity to Unrelated Antigens. Cell Host&Microbe, Volume 12, Issue 4, 18 October 2012, Pages 458–469
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Thank you!