Index [pharmrev.aspetjournals.org] · 2005. 7. 26. · INDEX 469 intissues withremote involvement...
Transcript of Index [pharmrev.aspetjournals.org] · 2005. 7. 26. · INDEX 469 intissues withremote involvement...
0031-6997/79/2914-0617$02.00/OPHARMACOLOGICAL REVIEWS
Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics
Index
Pharmacological Reviews
Volume 30
1978
Vol. 30, No.4Printed in U.SA
Aaronson, P. See van Breemen et a!., 167
Absorption, drug. See Drug absorptionAcetaminophen
-induced hepatotoxicity by phenacetin in the mouse,
inhibition of (table), 466
metabolism, pathways of (fig.), 464
metabolites, and liver necrosis, relationship between
glutathione levels in liver and cobinding of
(table), 465
Acetylcholine
as local hormone, 117
cell-cell communication and, 117
determination of, 71
environmental messenger, 116formation of
by coupled synthesis, 74
from coenzyme A and choline, 74
growth and, 118
in erythrocytes, 96
in spermatozoa, 99
maturation, development, and, 118
other choline esters and, 68
permeability and, 117
placental, effect of drug abuse on intrauterine
growth, 113
roles of, in non-nervous tissues, 116
trophic factors and, 118
Acetyicholine noise, surface of an uninnervated my-
otube (fig.), 421
Acetylcholine power spectra, and synaptic currents,at neonatal and adult rat endplates (fig.),422
Acetylcholine receptor, 71
acetylcholinesterase and, accumulation at newlyformed nerve-muscle synapses, 411
brain extract-induced increase in, in cultured my-
otubes (fig.), 420clusters of, 412
on uninnervated myotubes, 413; (fig.), 415distribution of, on an innervated muscle fiber (fig.),
414modification of, 420
synapse formation in vitro, 412Acetylcholine sensitivity, mean channel open time as
function of (fig.), 421Acetylcholinesterase
accumulation of, 423acetylcholine receptors and, accumulation of, at
newly formed nerve-muscle synapses, 411
activities of, in sperm from various segments ofepididymis, 99
curare-treated myotubee stained for (fig.), 425
in erythrocytes, substances that inactivate and their
effects on properties of erythrocyte8 (table),96
in platelets, 96
in sperm fractions, 100
release from platelets, 97
Acetylcholinesterase stain and synaptic current decay,correlation between (fig.), 424
Acetyltransferase, choline. See Choline acetyltranafer-
ase
Adaptation and homeostasis, 352Adenine nucleotides, release from platelets, 97
Adenylate cyclase, hormonal modulation of, 405
Adipocytes, alpha-adrenoceptors and ion permeability
regulation, 235Adrenergic inhibition and excitation and cardiac mem-
brane currents, 42a-Adrenoceptors and cardiac currents, 44/3-Adrenoceptors and cardiac membrane current sys-
tems, 45Adrenocorticotrophin, estimates of in vivo half-lives
in the rat, dog, sheep, pig, and man (table),260
Age-dependent changesin drug distribution, 447
hepatic drug metabolism, 448
hepatic microsomal drug-metabolizing system, 452
in hepatobiliary function, 454
noninicrosomal hepatic drug metabolism, 453
renal clearance of drugs, 448Age-related changeS
in drug disposition, 445
intestinal drug absorption, 446
Amino acids of glycophorin A (fig.), 375Anaphylaxis with thromboxane A2, prostacyclin, and
prostaglandin endoperoxides, 317
Angiotensins I and II, vasoactive peptides, 253Anodonta cygnea cellensis, components of cholinergic
system in gills of, 79Antiarrhythmic drugs. See under Drugs
Antioxidants, antimutagenic effects of, 549
Antipyrine, genetic factors and variations in elimina-tion rates of (fig.), 559
Arachidonic acidmetabolic pathways of (fig.), 294
metabolism, 295
617
618 INDEX
Arrhythmias, cardiac. See Cardiac arrhythmias
Arrhythmogenesis
altered excitability and, 31
membrane factors in, 24
Ascorbic acid-induced sensitization of human fibroblasts to 4-
nitroquinoline 1-oxide (fig.), 495
mutagemc action and DNA-damaging capacity of
oxidation products of (table), 496
Ataxia telangiectasia, sister chromatid exchange for-
mation in, 526
Bacteria, components of cholinergic systems in, 75
Batzinger, Robert P. See Bueding et al., 547
Becker, Bernard. See Newbeme et al., 335
Bennett, Hugh P. J., and Cohn McMartin. Peptide
hormones and their analogues: Distribution,
clearance from the circulation, and inactiva-
tion in vivo, 247
Bioassay of acetylcholine, 71
Bishydroxycoumarin, genetic factors and variations inelimination rates of (fig.), 559
Blohm, Thomas R. Drug-induced lysosomal lipidosis:Biochemical interpretations, 593
Blood cells, cholinergic systems in, 93
Bloom’s syndrome, sister chromatid exchange forma-
tion in, 526
Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to
drugs, 429
Bousquet, William F. See Newberne et al., 335
Bradykinin, vasoactive peptide, 253
Bromobenzene metabolism, pathways of (fig.), 463
5-Bromo-2’-deoxyuridinemethodology for sister chromatid exchange, 501
staining protocols for detecting incorporation of,
into metaphase chromosomes (table), 502
techniques, sister chromatid differentiation (fig.),502
Bueding, Ernest, Robert P. Batzinger, Young-Nam
Cha, Paul Talalay, and Christopher J. Moli-neaux. Protection from mutagemc effects of
antischistosomal and other drugs, 547
Calcitonin, 266
arteriovenous differences in radioimmunoassayableconcentrations of, across organs in the dog
(table), 268
decay of blood peptide concentrations in vitro and
in vivo, 266
estimates of in viva half-lives in preparations in the
rat, dog, pig, and man (table), 267Calcium
role, in receptor regulation of membrane permeabil-ity, 209
sodium-, interactions. See Sodium-calcium interac-
tionsCalcium current, agents which modify, 50
Calcium transport and sequestering systems, interre-
lation of, with respect to control of cytoplas-mic ionic calcium (fig.), 201
Calliphora salivary gland, 226Cancer impact of compound, total (table), 353
Carcinogen action
complex patterns of, 496
modulating effect of noncarcinogenic chemical
agents on, 494
CarcinogensDNA and, interactions, 493-DNA interactions, modulating factors, 494
hepatic activation of (table), 483risk assessment and acceptable risk, 364
Carcinogenic/mutagenic impact, by chemicals (table),353
Carcinogenesis bioassays, maximum tolerated dose
(MTD), lessons learned from, 362
Cardiac arrhythmias
ionic mechanisms in heart muscle in relation togenesis and pharmacological control of, 5
reentry and depressed conduction, 29; (fig.), 30
Cardiac membrane currents
a-adrenoceptors and, 44f1-adrenoceptors and, 45adrenergic inhibition and excitation and, 42; (fig.),
44
Cardiac muscle, acetylcholine action on, 84
Cardiovascular disease, serum dopamine fl-hydroxyl-
888 activity in, 157Cell-cell communication and acetylcholine, 117
Cell membranehormone receptor interactions at, 393
organization of, development of a model, 394
Cell nucleus in toxicological investigations (workshop
summary), 342
Cell surface, implications for toxicology (workshopsummary), 336
Cha, Young-Nam. See Bueding et al., 547
Chediak-Higashi syndrome, 589
Chemical agents
noncarcinogenic
inhibitory action of, on DNA repair, 495
modulating effect of, on carcinogen action, 494
Chemical interference with mitochondrial function,
606
Chiorthion effect on metabolism of testosterone byliver microsomes (table), 460
Cholecystokinin, 265
Choline acetyltransferases, 70
activities of, in sperm from various segments of
epididymis, 99
biosynthesis of acethycholine, 73
in spermatozoa, 99in sperm fractions, 100
Cholinergic system
components of
in cultured cells and developing cell systems, 90in tissues with nervous and non-nervous compo-
nents, 83
in organisms and tissues without nerves, 75
INDEX
469
in tissues with remote involvement with nervoussystem, 80
in blood cells, 93in developing nerve structures, properties of first
and second phase (table), 92in non-nervous tissues, 65in placenta, 102
in plants, 115in spermatozoa, 98
Cholinesterase, 70
assay of, 73
in spermatozoa, 99
Chromatin fiber, 470
folding of, in metaphase chromosomes, evidence forradial loops, 470
organization of, in radial loop model (fig.), 474
Chromosomal assays, mammalian cell models, 542
Chromosome
-damaging metabolites, catalytic activity of Cu�
ions on thiol compounds in generating (ta-
ble), 496
metaphase
folding of chromatin fiber in, evidence for radialloops, 470
histone-depleted (fig.), 471
surface topology of, electron micrograph (fig.), 473swollen with EDTA, cross section of chromatid of
(fig.), 472
Cilia, acetyicholine role in diary movement, 81
Circadian rhythm, serum dopamine /3-hydroxylase,
150
Clastogens, sister chromatid exchange induction by,
505
Cocaine, relationship between membrane “clamp” po-tential and rise of action potential (fig.), 38
Codeine and morphine, plasma concentrations afteroral aspirin-codeine phosphate combination
(fig.), 462
Copper, catalytic activity of, on thiol compounds ingenerating DNA- and chromosome-damag-ing metabolites (table), 496
Core battery
selection criteria, 544short-term tests (table), 545
Cornea
acetyicholine as sensory mediator, 86
acetyicholine in regulation of water and ion traits-port, 87
Cotten, Marion deV., tribute to, 3Coumarin anticoagulant drugs, pedigree of family in-
dicating incidence of resistance to (fig.), 558
C-peptide, 272Cyclophosphamide, sister chromatid exchanges in
mouse liver cells by (fig.), 522
Cysteine
effect on covalent binding of acetaminophen to
mouse liver protein (table), 465effect on mutagemc action and DNA-damaging ca-
pacity of MNNG (table), 495Cytochrome P-450
619
catalytic activity of (table), 461physical properties of (table), 461
Cytoplasm, membrane systems of, implications for
toxicology (workshop summary), 339
DBH. See Dopamine $-hydroxylase
Deoxyribonucleic acid
-carcinogen interactions, modulating factors of, 494
damage, assays for, 541
damage, repair, and synthesis, relationship of sisterchromatid exchange to, 524
-damaging metabolites, catalytic activity of Cu��ions on thiol compounds in generating (ta-
ble), 496
effectiveness of covalent binding of various standard
substances to (table), 611elution during 5-bromo-2’-deoxyuridine dye-Giemsa
procedure (fig.), 503
fragmentation and repair assays, applications of (ta-ble), 498
fragmentation and repair of mammalian cells, mdi-cater for complex interactions between car-
cinogens and modulating factors, 493
organization levels of, in eucaryotic chromosomes,
repair
inhibitory action of noncarcinogemc chemical
agents on, 495
modulating effect of hyperthermia on, 497; (fig.),497
mechanisms, 493systems responding to alkylation (table), 353
sister chromatid interchange, evidence for, at DNA
level, 528; (fig.), 529
synthesis, unscheduled, 543
Diabetes, serum dopamine 16-hydroxylase activity in,159
Diener, Robert M. See Newberne et al., 335Diethyl maleate, effect on covalent binding of acet-
aminophen to mouse liver protein (table), 465Diphenylhydantoin action on cardiac membrane, 40
Dopamine $-hydroxylasebiochemical characteristics, 134
adrenal, 134
serum, 135
circadian rhythm effects, 150
enzymatic activity, assay of, 136release of, from an adrenergic varicosity (fig.), 143
serum, 133
activity of, in man and experimental animals (ta-ble), 140
assay procedures for, 136; (fig.), 137, 139
drug and hormone effects on activity of, 150
effects of
growth and development on, 146inheritance on, 147; (fig.), 148
stress on, 151immunoassay of, 141in cardiovascular disease, 157in endocrine disease, 158
Dopamine $-hydroxylase-continued
in familial dysautonomia, 157
in human disease, 154
in hypertension, 154
in manic depression, 158
in neuroblastoma, 158
in neurological disease, 157
in renal disease, 156
in schizophrenia, 158
in torsion dystonia, 157normal values, 140
regulation of, 145
source and fate of, 143Doxorubicin, ventricular tissue of rat treated with
injections of (fig.) 608Droperidol, cardiac electrophysiological properties of,
38
Drug absorption, intestinal, age-related changes in,
446
Drug abuse, interference with placental acetylcholine,effect on intrauterine growth, 113
Drug and steroid hydroxylation, requirements for (ta-
ble), 460
Drug distribution, age-dependent changes in, 447
Drug dispositionage-related changes in, 445
in experimental animals, variables affecting (table),
560
Drug-induced changes in phospholipid composition of
tissues (table), 599
Drug-induced lysosomal lipidosia, biochemical inter-
pretations, 593Drug metabolism. See under Metabolism
Drug-metabolizing enzyme system, hepatic micro-somal, age-dependent changes in, 452
Drug-phospholipid complex formation, 596
Drug response
gene-environment interactions, role of, as determi-
nants of drug response, 560
individual factor in, 555
antiarrhythmic
action mechanisms, 33
chemical structures (fig.), 35
classification of (table), 34
antischistosomal and other, protection from muta-
genie effects of, 547
commonly used, pharmacogenetics field expandedto include, 558
coumarin anticoagulant, pedigree of family mdicat-
ing incidence of resistance to (fig.), 558
effect on
ciliary movement of Mytilus edulis (table), 78serum dopamine fl-hydroxylase activity, 150
Hodgkin-Huxley theory, application to heart musclein relation to action of, 51
liver response to
model for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429
mutagemc activation of, by enteric microorganisms,
548
620 INDEX
production of abnormal response in pharmacoge-
netic conditions (table), 556
renal clearance of, age-dependent changes, 448toxicology of, workshop on, 335
Electrophysiology, myocardial, 5Endocrine disease, serum dopa.mine f3-hydroxylase ac-
tivity in, 159Endoperoxide analogues, structure of (fig.), 303
Endoperoxides, metabolism of, 319
Endorphins, opiate receptor agonists, 251
Enkephalins, opiate receptor agonists, 251
Enteric microorganisms, mutagemc activation of drugs
by, 548Environmental messenger, acetylcholine as, 116
Environment
mutagens and antiniutagens in, 359
mutagens from, source (table), 361Enzymatic catalytic site, distinction from ligand roe-
ognition site, 405
Enzyme, effect of infusion of, on glycogen concentra-
tion and recovery of infused enzyme in liverand muscle in glycogen storage disease Ha
(table), 578Enzyme deficiency diseases, relationship to lysosomal
lipidosis, 593Enzyme system, hepatic microsomal drug-metaboliz-
ing, age-dependent changes in, 452
Enzyme treatment, in five lysosomal disorders, 565Enzymes, inhibition of, in the biosynthetic pathway,
295
Epinephrine, effect of infusion of on glycogen concen-
tration in muscle and liver in glycogen storagedisease II (table), 577
Erythrocytes
acetylcholine in, 96acetylcholinesterase activity in, 93choline acetyltransferase in, 96musearinic receptors in, 96
Estrogen-receptor complexes, 479; (fig.), 480
RNA synthesis and, 485Estrogen-receptor interaction in target cells, 479
Eukaryotic chromosomes, DNA organization levels in,469
Eukaryotic microorganisms, point mutation assays,
540
Exocrine glands
calcium and stimulus-permeability coupling mech-
anisms, 214ion movements, role in, 214
mammalian, receptor control ofpermeability in, 225Exocrine pancreas. See under Pancreas
Familial dysautonomia, serum dopamine $-hydroxyl-
ase activity in, 157
Fanconi’s anemia, sister chromatid exchange forma-tion in, 526
Fatty acidsunstable derivatives of, 315
in platelets, 316Fibroblasts, acetylcholine action in, 90Fischbach, Gerald D., Eric Frank, Thomas M. Jessell,
INDEX
Lee L. Rubin, and Stephen M. Schuetze.
Accumulation of acetylcholine receptors and
acetylcholinesterase at newly formed nerve-
muscle synapses, 411
Food, mutagens in (table), 361
Food coloring, conversion of, by microflora (fig.), 360
Frank, Eric. See Fischbach et al., 411
Frog esophagus, acetylcholine and ciliary movement
in, 81, 82Frog skin, cholinesterases in, 81
Gap junctionshigh resistance, 383
information passed through, 389
in mouse liver (fig.), 384, 385electron micrograph (fig.), 386isolated, high-resistance (fig.), 387
low resistance, 388Gap junction dynamics and intercellular commurnca-
tion, 383
Gas chromatography, acetylcholine, 71Gastrin, 263
estimates of in vivo half-lives in the cat, dog, andman (table), 264
Gastrointestinal epithelia, calcium and stimulus-permeability coupling, 234
Gastrointestinal hormones, 263
Gastrointestinal tract, prostacyclin in, 317Gene conversion, mitotic, assays for mitotic recombi-
nation and, 541
Gene-environment interactions, role, as determinants
of drug response, 560
Gene mutation assays
mammalian cell models, 542
point or, bacterial, 540
Genes directly affecting drug disposition, intraspecies
differences in frequency of, 555
Gestation period, placental acetyicholine and trans-
port across placenta as function of, 112, 113
Glucagon, 271
Glucose 6-phosphatase, relative specific activity of,with endoplasmic reticulum (fig.), 434
a-Glucosidase activity in mouse liver after injection of
perfiuorinated particles (fig.), 582
Glutathione levels in liver, relationship with covalent
binding of acetaminophen metabolites andliver necrosis (table), 465
Glutathione depression and hepatic molecular binding,
related to exposure to vinyl chloride (fig.),357
Glycogeneffect of
enzyme infusion on concentration and recoveryof, infused enzyme in liver and muscle of agirl with glycogen storage disease Ha (table),
578
epinephrine infusion on concentration of, in mus-cle and liver in glycogen storage disease II
(table), 577Glycogen degradation, cytoplasmic phosphorylase
pathway of, activated by epinephrine infusion
621
(fig.), 568
Glycogenesis type H, prototype of lysosomal disease,
566
Glycogen storage disease
classification of (table), 567II
treatment, 575
haamniotic fluid cell of an 18-week-old fetus with
(fig.), 583
effect of enzyme infusion on glycogen concentra-
tion and recovery of infused enzyme in liver
and muscle of a girl with (table), 578liver biopsy specimen (fig.), 576
after enzyme infusion (fig.), 579
after epinephrine infusion (fig.), 577
after 3 weeks of enzyme infusion (fig.), 578
before infusion of enzymes (fig.), 568, 569
liver specimen of 18-week-old fetus (fig.), 571
muscle biopsy specimen (fig.), 570
skin fibroblasts of, that have ingested gold parti-
des (fig.), 580
hlbheart autopsy specimen (fig.), 573, 574
muscle biopsy specimen (fig.), 572muscle biopsy specimen in 11-year-old boy with
no clinical signs of the disease (fig.), 575
Glycophorin A
amino acids of (fig.), 375
lipid layer of intact red cell membrane, 376
multimeric forms, 377
phosphorylated molecules of, 378
Glycophorins, 374
Glycoprotein hormones, 278
anterior pituitary, 276
Golberg, Leon. Toxicology: Has a new era dawned?
351
Goodenough, Daniel A. Gap junction dynamics and
intercellular communication, 383
Granuloma pouch assay, 613
Gray, Jack E. See Newberne et al., 335Growth
acetylcholine and, 118
development and, effects on serum dopamine ,8-hy-droxylase, 146
intrauterine, retardation of, relationship to placental
acetylcholine and drugs of abuse, 113Growth control, receptor regulation and, 400
Growth hormone, 276
release inhibiting hormone or somatostatin, 258
Haemostasis, prostacyclin, and thromboxane A1-thrombosis, 313
Halothane metabolism, oxidative and reductive path-ways of, schematic representation (fig.), 358
Hauswirth, Otto, and Bramah N. Singh. Ionic mech-anisms in heart muscle in relation to thegenesis and the pharmacological control of
cardiac arrhythmias, 5Heart. See aLso entries under Cardiac, Myocardial
Heart muscle
622 INDEX
Immunochemical approaches to receptor studies, 487Inflammation, thromboxane A2, prostacyclin, and
Heart muscle-continued
Hodgkin-Huxley theory application to, in relationto drug action, 51
ionic mechanisms in, in relation to genesis and phar-macological control of cardiac arrhythmiaa,
5
Hemopoietic stem cell, component of cholinergic sys-tem in, 92
Hepatic activation of carcinogens (table), 463
Hepatic drug metabolism. See under Metabolism
Hepatic microsomal drug-metabolizing enzyme sys-tem, age-dependent changes in, 452
Hepatic molecular binding and glutathione depression,
related to exposure to vinyl chloride (fig.),
357Hepatobiliary function, age-dependent changes in, 454Hepatocytes
hypothetical, containing a single spherical nucleus,
changes occurring within (fig.), 435
stereological sorting of subpopulations of (fig.), 441
Hepatotoxicity, acetaminophen-induced, inhibition by
phenacetin in the mouse (table), 466Hexachiorophen and two stereoisomers, chemical
structures showing neurotoxicity (fig.), 607Hodgkin-Huxley concept, mechanisms of excitation,
10; (fig.), 11, 12, 14, 15, 17Hodgkin-Huxley model. modification of, 17; (fig.), 18,
19Hodgkin-Huxley theory, application to heart muscle
in relation to drug action, 51Hollenberg, Morley D. Hormone receptor interactions
at the cell membrane, 393
Homeostasisadaptation and, 352; (fig.), 354
vascular, prostacyclin release and role in, 310
Hormone
adenylate cyclase modulation by, 405
bound, intracellular localization of, 479effects on serum dopamine �8-hydroxy1ase activity,
150
hypothalamic, 256
local, acetylcholine as, 117
neurohypophyseal
analogues of, 255oxytocin and vasopressin, 254
pancreas, 271
parathyroid, 269
circulating forms of, 270
half-life in blood in vitro and in vivo, 269role of tissues in clearance and conversion of, 270
peptide
analogues and, distribution, clearance from cu-
culation, and inactivation in viva, 247anterior pituitary, 259assay, characterization and identification of, 249
bioassay of, 249
biological experimental methods, 250
chromatography, 249
comparison of metabolism of, 279concentrations in blood, role of tissues in decay
of, 264
identification of, 249
isotopically labelled, 249levels
blood, decay of, in vitro and in vivo, 255
role of tissues in decay of, 255
low molecular weight, primary structures of (fig.),
252
mechanisms of clearance and distribution, 280
metabolism. See under Metabolism
pyrolysis products isolated from (fig.), 361radioimmunoassay of, 249vasoactive, 253
protein, of anterior pituitary, 276
receptor modulation by, 400
receptor regulation and tachyphylaxis, 401
steroid, interaction of, with the nucleus, 477
Hormone acceptors versus receptors, 398
Hormone action
ligand internalization and, 402
membrane fluidity and mobile receptor paradigm of,395
mobile receptor model of (fig.), 394
predictions based on mathematical analysis of,
395receptor aggregation and, 396
receptor cooperativity and, 404
Hormone binding in target tissues, 478; (fig.), 478Hormone receptors
acceptors and, the problem of nonspecific binding,397
interactions at cell membrane, 393
regulation, 398
versus acceptors, 398
Hot spots, nerve-induced, 418; (fig.), 416Hottendorf, F. H. See Newberne et al., 335
Hug, George. Pre- and postnatal pathology, enzyme
treatment, and unresolved issues in five ly-sosomal disorders, 565
Human chromosome fragility diseases, sister chroma-
tid exchange formation in, 526Human respiratory epithelium, acetylcholine and cull-
sty activity in, 82Hurler’s disease, 583
cerebral cortex specimen of 19-week-old fetus with(fig.), 588
liver specimen of 19-week-old fetus with (fig.), 587
skin fibroblasts of, that pinocytosed colloidal gold
(fig.), 586
Hycanthone, radioactivity in sperm ejaculated after
injection of (table), 6135-Hydroxytryptamine, release from platelets, 97
Hypertension, serum dopamine fl-hydroxylase activityin, 154
Hyperthermia, modulating effect of, on DNA repair,497; (fig.), 497
Hypothalamic hormones, 256
INDEX 623
prostaglandin endoperoxides in, 317Inheritance, effects of, on serum dopamine $-hydrox-
ylase, 147Insulin, 272
estimates of in vivo half-lives of, in pig, baboon, and
man (table), 273Intercellular communication and gap junction dynam-
ics, 383
Intestine
acetylcholine in, 83
drug absorption in, age-related changes, 446
Intracellular interaction mechanism, 482
Ionic mechanisms, in heart muscle in relation to gen-
esis and pharmacological control of cardiac
arrhythmias, 5
Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 477
Jessell, Thomas M. See Fischbach et al., 411
Lacrimal glands, ion permeability control, 221Latt, Samuel A., Rhona R. Schreck, Kenneth S. Love-
day, and Charles F. Shuler. In vitro and invivo analysis of sister chromatid exchange,
501
Leucocytes, cholinergic system components in, 98Lidocaine action on cardiac membrane, 40
Ligand internalization and hormone action, 402
Ligand recognition site, distinction from enzymatic
catalytic site, 405
Lipid matrix, amphipathic, 371
Liver. See also Hepatic
adaptive changes that permit maintenance of lowconcentration of the toxic agent in (rat) (fig.),
355
autopsy specimen after injection with perfluorinatedparticles and colloidal gold (fig.), 581
correlation between content of polychlorinated bi-
phenyl and the mitochondrial #{246}-aminolevu-
linic acid synthetase activity (fig.), 356membrane permeability modulation by calcium and
cyclic AMP, 228morphological and biochemical data, relationship,
431response to drugs
model for assessment of, 430; (fig.), 431, 432, 433
morphometric analysis in assessment of, 429
Liver cellmouse
sister chromatid exchange in (fig.), 521
sister chromatid exchange induction in, by cyclo-phosphamide (fig.), 522
Liver microsomal drug metabolism (table), 458Liver necrosis, glutathione levels in liver, covalent
binding and, relationships with (table), 465
Liver protein, effect of diethyl maleate or cysteine on
covalent binding of acetaminophen to
(mouse) (table), 465
Loutzenhiser, R. See van Breemen et al., 167
Loveday, Kenneth S. See Latt et al., 501
Luteinizing hormone/follicle-stimulating hormone-re-
leasing hormone or luliberin, 257
e8tlmates of in vivo half-lives in rat, dog, pig, and
man (table), 257Luteinizing hormone-releasing hormone
blood concentrations
decay of, in vitro and in viva, 257
role of tissues in decay of, 258
Lymphocytes, cholinergic system components in, 97Lysinoalanine toxicity (fig.), 360
Lysosomal disease
glycogenesis type II, the prototype of, 566
in toxicology (workshop summary), 347
Lysosomal disorders, pro- and postnatal pathology,enzyme treatment, and unresolved issues in,565
Lysosomal enzyme activities in “normal” cultured fi-broblasts (table), 579
Lysosomal lipidosis
drug-induced, biochemical interpretations, 593
relationship to enzyme deficiency diseases, 593Lysosomes
function and dysfunction of, 565function of, as intracellular disposal system (fig.),
566
in toxicology (workshop summary), 347membrane stabilization with, 597
Lysosomotropism, 598
Mammalian cells
DNA fragmentation and DNA repair of, indicator
for complex interactions between carcinogens
and modulating factors, 493microbial and, application to assessment of muta-
genicity, 537models, 542
Manic depression, serum dopamine /3-hydroxylase ac-
tivity in, 158
Marchesi, Vincent T. Functional components of sur-
face membranes: Potential targets for phar-
macological manipulation, 371
Maturation and development, acetylcholine and, 118Meiotic cells, sister chromatid differentiation in, 522
a-Melanocyte-stimulating hormone, (melanostatin)
256, 259
Membrane. See also Cardiac, Cell, and Surface mem-
braneMembrane permeability, role of calcium in receptor
regulation of, 209
Membrane response to uniform current, 9Membrane systems of cytoplasm, implications for tox-
icology (workshop summary), 339
Metabolic activation procedures, 541
Metabolic conjugation, time-scale in discovery of (ta-
ble), 352Metabolism
acetaminophen, pathways of (fig.), 464
arachidonic acid, 295; (fig.), 294
bromobenzene, pathways of (fig.), 463
drug
624 INDEX
Metabolism-continued
in liver, age-dependent changes in, 448liver microsomal (table), 458
toxicological implications, 457nonmicrosomal hepatic, age-dependent changes
in, 453
endoperoxides, 319
halothane, oxidative and reductive pathways of,
schematic representation (fig.), 358
peptide hormone
arteriovenous differences in vivo, 250
blood and plasma in vitro, 250
blood or plasma kinetics in viva, 250
clearance processes involved in (table), 283comparison of, 279distribution studies in vivo, 250
isolated perfused organs and tissues, 250
processes involved in, 248prostacydlin, 320
testosterone, by rat liver microsomes, chiorthioneffect on (table), 460
thromboxane A2, 320
Metabolites, DNA- and chromosome-damaging cata-
lytic activity ofCu� ions on thiol compounds
in generating (table), 496
Metachromatic leucodystrophy (MW), 588
3-Methylcholanthrene, effect on liver microsomal cy-
tochrome P-450 and benzo(a)pyrene hydrox-
ylase activity (rat) (fig.), 459
Methylguanidine, nitrosation prevention by sodium
ascorbate (fig.), 494
Microbial cellassays, 537
mammalian and, application to assessment of mu-
tagenicity, 537
Mitochondria, effects ofthickening agents on oxidative
phosphorylation in (rat) (table), 609
Mitochondrial function, chemical interference with,606
Mitomycin C, sister chromatid exchanges in humanperipheral lymphocyte by (fig.), 506
Moncada, S., and J. R. Vane. Pharmacology and en-dogenous roles of prostaglandin endoperox-
ides, thromboxane A2, and prostacyclin, 293
Morphine and codeine, plasma concentrations after
oral aspirin-codeine phosphate combination(fig.), 462
Morphometry and the future, 441
Mucocutaneous membranes, cholinesterases in, 81Mucopolysaccharidosis type I (MPS I), Hurler’s die-
ease, 583
Mucosulfatidosis
cerebral cortex biopsy specimen in (fig.), 585
liver biopsy specimen of (fig.), 584multiple sulfatase deficiency, 588
Multiple sulfatase deficiency. See Mucosulfatidosis
Muscle. See Cardiac, Heart, Skeletal, and Smoothmuscle.
Musculotendinous junctions, acetylcholinesterase
concentration at, 80
Mutagenesis, implications for toxicology (workshop
summary), 344
Mutagemc activity, reduction of, by pretreatment with2,(3)tert-butyl-4-hydroxyanisole or coadmin-
istration of erythromycin (table), 550Mutagemc effects, protection from, of antischistoso-
mal and other drugs, 547Mutagenicity
application of microbial and mammalian cells to
assessment of, 537
testing procedures (table), 538testing requirements (table), 544
Mutagensantimutagens and, environmental, 359
environmental, sources (table), 361infood(table),361
Mutations, preadaptive, affecting the disposition of
and response to foreign compounds, 555Myocardial electrophysiology, 5
Mytilus edulis
components of cholinergic systems in gill plates of,
77
drug effects on ciliary movement of (table), 78
Neoplastic disease, serum dopamine fl-hydroxylase ac-
tivity in, 158
Nerve-muscle synapses
acetylcholine receptors and acetylcholinesterase ac-
cumulation at, 411
functionally identified, electron micrograph (fig.),
419Nerve structures, developing, properties of first and
second phases of cholinergic system in (ta-ble), 92
Nerves
hot spot induction, 418; (fig.), 416motor, induction of new receptor clusters, 416organisms and tissues without, components of cho-
linergic systems in, 75Nervous tissues, non-
acetylcholine roles in, 116
cholinergic systems in, 65Neuroblastoma
cholinergic system component in, 92serum dopamine ,8-hydroxylase activity in, 158
Neuroblasts, development of cholinergic system in, 91Neurohypophysial hormone. See under Hormone
Neurological disease, serum dopamine /1-hydroxylase
activity in, 157Neuromuscular junctions, adult, acetylcholine recep-
tors and acetylcholinesterase at, 411Neurotoxic activation (fig.), 359
Neurotoxicity of hexachiorophene and two stereoiso-
mers, chemical structures of (fig.), 607
Neutrophils, leukocyte function and receptor activa-tion, dependence upon calcium, 236
Newberne James W., Bernard Becker, William F.
Bousquet, Robert M. Diener, Jack E. Gray,
G. H. Hottendorf, Emil A. Pfitzer, Gregory S.
Probst, Virgil B. Robinson, Richard L Steel-
INDEX
man, and Robert J. van Ryzin. Summary of
the workshop on cellular and molecular tox-icology, 335
Non-nervous tissues. See Nervous tissues, non-Nuclear interaction, nature of, 483
Nucleosome, 469
Nucleus, steroid hormone interaction with, 477
Opiate receptor agonists, enkephalins and endorphins,251
Oxidative phosphorylation, effects of thickening
agents on, in rat mitochondria (table), 609
Oxytocin, 254
Pacemaker potential, mechanism of, 20; (fig.), 21
Pancreas
exocrine cells of, changes in surface area (fig.), 437
exocrine, role for calcium in modulating ion perme-
abilities in, 223
hormones of, 271
Parathyroid hormone. See under Hormone
Peptide, C-, 272
Peptide hormone. See under Hormone
Peptide hormone metabolism. See under MetabolismPermeability and acetylcholine, 117Permeability coupling, stimulus-. See Stimulus-perme-
ability coupling
Permeability, membrane. See Membrane permeabilityPfitzer, Emil A. See Newberne et al., 335
Pharmacogenetics
expansion of field to include commonly used drugs
and more subjects, 558pedigree of family indicating incidence of resistance
to coumarin anticoagulant drugs (fig.), 558with putative aberrant enzyme, mode of inheritance,
frequency, and drugs that can elicit the signsand symptoms of the disorder (table), 556
Phenacetin, inhibition ofacetaminophen-induced hep-
atotoxicity by (mouse) (table), 466
Phenobarbitaleffect on
liver microsomal cytochrome P.450, ethylmor-phine N-demethylase activity, and antipyrine
(rat) (fig.), 459
surface area of the endoplasmic reticulum andoxidative demethylase (fig.), 439, 440
Phospholipid composition of tissues, drug-inducedchanges in (table), 599
Phospholipid-drug complex formation, 596
Physical and chemical agents, homeostatic mecha-
nisms of a multicellular organism and its
adaptive responses to (fig.), 354
Pituitary, anterior, protein and glycoprotein hormonesof, 276
Placenta
cholinergic system in, 80
cow, acetyicholine-like activity in, 114human
acetylcholine, 103
and transport of chemicals across placenta as
625
function of gestation, 112, 113
effects on blood vessels, 109
receptor in, 109
synthesis in, precursors for, 108uptake by fragments of, 108
biogenic amines and other endogenous sub-stances, effect on perfusion pressure of (ta-
ble), 110choline acetyltransferases in, 103
cholinesterases in, 103drug interference with placental acetylcholine, ef-
fect on intrauterine fetal growth, 113monkey, choline acetyltransferase activity, 113mouse, choline acetyltransferase activity, 115
rabbit, acetylcholine-like substances in, 114rat, choline acetyltransferase activity, 115
species variation in cholinergic systems of, 115Placental lactogen, 277
Plants, cholinergic system in, 115
Plasma metabolism, tissue homogenates or slices, 250
Platelet aggregation, prostaglandin endoperoxides andthromboxane A2 in, 302
Plateletsacetylcholine and acetylcholine receptor in, 97acetylcholinesterase in, 96choline acetyltransferase activity in, 975-hydroxytryptamine, adenine nucleotides and ace-
tylcholinesterase release from, 97unstable derivatives of fatty acids in, 316
Point mutation assayseukaryotic microorganisms, 540
gene or, bacterial, 540
mammalian cell models, 542
Polychiorinated biphenyl, liver content of, correlationwith 6-aminolevulinic acid synthetase activ-ity (fig.), 356
Postnatal pathology in five lysosomal disorders, 565
Potassium currents, compounds influencing, 47; (fig.),
48
Prenatal pathology in five lysosomal disorders, 565
Procainamide, antiarrhythmic and arrhythmogenic
properties of, 39, 40Probst, Gregory S. See Newberne et al., 335
Proinsulin, 272
estimates of half-lives of, in the pig, baboon, and
man (table), 273Prolactin, 277
Prostacyclin, 306
metabolism of, 320
prostaglandin endoperoxides, thromboxane A2 and,pharmacology and endogenous roles of, 293
therapeutic potential of, 315thromboxane A2-thrombosis, hemostasis and, 313release and role in vascular homeostasis, 310thromboxane A2, imbalance in other pathological
states, 320
synthetase, 296tissues described in (table), 298
Prostaglandin endoperoxides
rabbit aorta contracting substance and, 296
626 INDEX
Prostaglandin endoperoxides-continued
thromboxane A2 and, in platelet aggregation, 302
prostacyclin and, pharmacology and endogenous
roles of, 293
Protein hormones of the anterior pituitary, 276Protein
mouse liver, effect of diethyl maleate or cysteine on
covalent binding ofacetaminophen to (table),465
“functional,” isolation and characterization of, 379
membrane, properties of, 373
pyrolysis products isolated from (fig.), 361
Protozoa, components of cholinergic systems in, 76Psychiatric disease, serum dopamine /3-hydroxylase
activity in, 158
Purkinje fiber, action potential (fig.), 23
Putney, James W., Jr. Stimulus-permeability coupling:
Role of calcium in the receptor regulation ofmembrane permeability, 209
Pyridine nucleotide, reduced form of, electron traits-
port to drug substrate (fig.), 458
Pyrolysis products from proteins, peptides and their
amino acids (fig.), 361
Quinidine, cardiac electrophysiological effects of, 39
Ray, Verne A. Application of microbial and mamma-
lian cells to the assessment of mutagemcity,
537Receptor. See also Acetylcholine, Hormone, Estrogen,
and Salivary glandactivation, 481
adenylate cyclase coupling, 406
studies, immunochemical approaches to, 487translocation, 480
mechanism, evidence for (table), 481
Red blood cellcalcium and regulation of membrane permeability
to K, 211
components of cholinergic system in, 79membrane, lipid bilayer, glycophorin A and, 376
Renal clearance of drugs, age-dependent changes in,
448
Renal disease, serum dopamine fl-hydroxylase activity
in, 156
Repolarization, underlying mechanisms, 22; (fig.), 23Reproductive system, prostacyclin in, 317Ribonucleic acid synthesis, estrogen-receptor corn-
plexes and, 485
Robinson, Virgil B. See Newberne et al., 335Rubin, Lee L. See Fischbach et al., 411
Sadavongvivad, C. See Sastry and Sadavongvivad, 65
Salarnanders, acetylcholine and limb regeneration in,
88
Salivary glandscalcium channel, nature of, 218calliphora, ion transport and water movement, con-
trol by membrane receptors, 226other ionic fluxes, 220
receptors; Ca and K flux, 214; (fig.), 216
stimulus-permeability coupling mechanisms, modelfor study, 214
San, R. H. C. See Stich et al., 493
Sarcolemma, cholinesterases in, 80, 81Sarcoplasm, cholinesterases in, 80,81Sastry, B. V. Rama, and C. Sadavongvivad. Choliner-
gic systems in non-nervous tissues, 65
Schizophrenia, serum dopamine f3-hydroxylase activ-
ity in, 158
Schmucker, Douglas L. Age-related changes in drug
disposition, 445
Schreck, Rhona R. See Latt et al., 501
Secretin, 265Shuetze, Stephen M. See Fischbach et al., 411
Shuler, Charles F. See Latt et al., 501
Singh, Bramah N. See Hauswirth and Singh, 5
Sister chromatid differentiation5-bromo-2’-deoxyuridine-dye techniques (fig.), 502
induction of, in Chinese hamster ovary chromo-
somes (fig.), 504
in meiotic cells, 522Sister chromatid exchange
agents capable of inducing, strongly positive (table),507
agents exhibiting mixed or weak induction behavior
(table), 516agents found not to induce (table), 519
analysis of, 501
basic information, 505
biological significance of formation of, 525
5-bromo-2’-deoxyuridine dye methodology for, 501
extension of studies of, from in vitro to in vivosystems, 505
formation of, in human chromosome fragility dis-
eases, 526human lymphocytes (fig.), 504
induction ofby clastogens, 505
in human peripheral lymphocyte by mitomycin C(fig.), 506
in mouse liver cells by cyclophosphamide (fig.),522
induction tests, interpretation of, 523in mouse liver cell (fig.), 521
mechanism of formation of, 528
relationship ofinduction of, to DNA damage, repair,and synthesis, 524
Sister chromatid interchange, evidence for, at the
DNA level, 528; (fig.), 529
Skeletal muscle, components of cholinergic systems in,80
Smooth muscleacetylcholine action in, 83
alimentary tractouabain and zero potassium, inhibition of sodium,
potassium adenosine triphosphatase, 188
potassium elevation, effects of, 183
sodium substitution experiments, 175mammalian, sodium-calcium interactions in, 167
mechanisms and coupling factors in membranepermeability, 231
INDEX 627
ureter
Na,K pump blockade, effects of, 199
sodium substitution, effects, 197
uterine
Na,K ATPase inhibition, effects of, 196
sodium substitution, 194
vascular
effects of sodium substitution, 170
sodium, potassium, and adenosine triphosphatase
inhibition, 173
Sodium-calcium interactions
in mammalian smooth muscle, 167
molecular mechanisms, 167; (fig.), 168
specific cellular sites for, 170
Sodium current, fast, compounds influencing, 37Sodium gradient and muscle tension, theoretical rela-
tionship between (fig.), 202
Somatostatin, 258
Somatotrophin, 276
Sperm
from various segments of epididymis, choline ace-
tyltransferase and acetylcholinesterase activ-
ities in, 99
human, effect of cholinergic and cholinergic block-ing drugs on motility of, 101
sea urchin, effects of cholinergic and cholinergicblocking agents on motility of sperm from,
100; (table), 101Spermatozoa
cholinergic system in, 79,80,98
sterility and, 102Sperm fractions, choline acetyltransferase and acetyl-
cholinesterase in, 100
Sperm motility, effects of cholinergic and cholinergicblocking agents on, 100
Spider, acetylcholine in silk glands of, 87
Spleen, acetylcholine and propionylcholine in, 84
Steelman, Richard L. See Newberne et a!., 335Sterility, spermatozoal cholinergic system and, 102Steroid and drug hydroxylation, requirements for (ta-
ble), 460Stich, H. F., R F. Whiting, L Wei, and R H. C. San.
DNA fragmentation and DNA repair of
mammalian cells as an indicator for the corn-plex interactions between carcinogens and
modulating factors, 493Stimulus-permeability coupling, role of calcium in re-
ceptor regulation of membrane permeability,
209
Stress, effects on serum dopamine /3-hydroxylase ac-
tivity, 151Surface membranes, functional components of, targets
for pharmacological manipulation, 371
Symposium, workshop on cellular and molecular tox-
icology, 335
Synaptic current
acetylcholine power spectra and, at neonatal andadult rat endplates (fig.), 422
decay, variation in rate of (fig.), 424
Tachyphylaxis and receptor regulation, 401
Target cells, estrogen-receptor interaction in, 479
Target tissues, hormone binding in, 478; (fig.), 478
Testosterone, chlorthion effect on metabolism of, byrat liver microsomes (table), 460
Tetrodotoxin, influence on fast sodium current, 37Thickening agents, effects of, on oxidative phoapho-
rylation in rat mitochondria (table), 609Thiol compounds, catalytic activity of Cu� ions on,
in generating DNA- and chromosome-dam-aging metabolites (table), 496
Thromboxane synthetase, 296Thromboxane A2, 301
metabolism of, 320
prostacydlin and, imbalance in other pathological
states, 320
prostaglandin endoperoxides and, in platelet aggre-
gation, 302
prostaglandin endoperoxides, prostacydlin and,
pharmacology and endogenous roles of, 293
-thrombosis, prostacydlin, and hemostasis, 313
synthetase, tissues described in (table), 2973H-Thymidine, radioactivity in rabbit sperm after in-
jection of (fig.), 613
Thyroid and parathyroid, calcium regulating hor-
mones of, 266
Thyroid disease, serum doparnine$-hydroxylase activ-
ity in, 159
Thyroliberin, 256
Thyrotropin-releasing hormone or thyroliberin, 256
Tissues
nonexcitable, calcium and receptor-mediated con-
trol of ion permeability, 233non-nervous, cholinergic systems in, 65
remote involvement with nervous system, compo-
nents of cholinergic systems in, 80
Torsion dystonia, serum dopamine �8-hydrozylase ac-
tivity in, 157
Toxic agents
in rat liver, adaptive changes that permit mainte-
nance of low concentration of (fig.), 355time scale in discovery of metabolic conjugation
(table), 352
Toxicant, interrelationships between sequence of bio-
chemical changes caused by, and associated
pathological events (fig.), 357Toxicity effect on homeostasis, 352Toxicological investigations, cell nucleus and related
factors�in (workshop summary), 342
Toxicological testing, scientific approaches to, 606
Toxicologyapplication of basic concepts to research in, 605
summary of workshop on, 347basic science in, request for more, 605cellular and molecular
summary of workshop on, 335
workshop on, 335
implications for
membrane systems of cytoplasm (workshop sum-
mary), 339
mutagenesis (workshop summary), 344on the cell surface (workshop summary), 336
�‘�±(“�1 Library
.- � . : � � :OSPITAL
628 INDEX
Toxicology-continued
lysosornal diseases in (workshop summary), 347
lysosomes in (workshop summary), 347
new era, 351
summary of workshop on, 335
pharrnacokinetic and metabolic considerations, 611pharmacological approach to, 610
Trachea, acetylcholine and cilia movement in (rabbit),82
Trophic factors and acetylcholine, 118
van Breemen, C., P. Aaronson, and R. Loutzenhieer.
Sodium-calcium interactions in mammaliansmooth muscle, 167
Vane, J. R. See Moncada and Vane, 293
van Ryzin, Robert J. See Newberne et aL, 335
Vasopressin, 254
Vesell, Elliot S. Intraspecies differences in frequency
of genes directly affecting drug disposition:
The individual factor in drug response, 555
Vinyl chloride, hepatic macromolecular binding andglutathione depression related to exposure to
(fig.), 357Voltage clamp versus standard electrophysiological
techniques, 37; (fig.), 37,38Wei, L. See Stich et al., 493
Weinshilboum, Richard M. Serum dopamine �-hy-droxylase, 133
Welch, Richard M. Toxicological implications of drug
metabolism, 457Whiting, R. F. See Stich et al., 493Workshop on cellular and molecular toxicology, 335
Zbinden, Gerhard. Application of basic concepts toresearch in toxicology, 605
Zonula occludens in mouse liver (fig.), 384, 385
629
0031-6997/79/3004-0629$02.O0/OPHARMACOLOGICAL REVIEWSCopyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics
Author Index
Pharmacological Reviews
Volumes 1-30
1949-1978
Vol. 30, No.4Printed in USA.
Abraham, E. P. The cephalosporins, 14, 473Adler, T. K. See Way and Adler, 12, 383
Aggeler, Paul M. See O’Reilly and Aggeler, 22, 35Ahiquist, R. P. The receptors for epinephrine and
norepinephrine, a discussion, 11, 441
Akera, Tai, and Brody, Theodore M. The role of
Na�,K�-ATPase in the inotropic action of digitalis,
29, 187
Albert, Adrien, Ionization, pH, and biological activity,4, 136
Allen, David G. See Blinks et al., 28, 1Allen, Julius C. See Schwartz et al., 27, 3
Ambache, N. Choline esters as local hormones, 6, 113
, The use and limitations of atropine for phar-
macological studies on autonomic effectors, 7, 467Anderson, Hamilton R., and Hansen, Eder L. The
chemotherapy of amebiasis, 2, 399
Andersson, Bengt, and Larsson, Stig. Physiological
and pharmacological aspects of the control of hun-ger and thirst, 13, 1
Angeletti, Piero U. See Levi-Mont.alcini and Angeletti,
18, 619Archer, J. A. See Gorden et al., 25, 179Ari#{235}ns, E. J., van Rossum, J. M., and Simonis, A. M.
Affinity, intrinsic activity, and drug interactions, 9,218
Armentrout, Steven A. See Beard et al., 21, 213Armstrong, Marvin D., and McMillan, Armand. Stud-
ies on the formation of 3-methoxy-4-hydroxy-D-
mandelic acid, a urinary metabolite of norepineph-
line and epinephrine, 11, 394
Ashmore, James. See Mayhew et al., 21, 183
Atack, C. V. See Carlsson et al., 24, 371
Aviado, Domingo M. The pharmacology of the pul-monary circulation, 12, 159
Axelrod, Julius. The metabolism of catecholamines in
viva and in vitro, 11, 402-, Methylation reactions in the formation and me-
tabolism of catecholamines and other biogenic
amines, 18, 95
, Dopamine-$-hydroxylase: regulation of its syn-
thesis and release from nerve terminals, 24, 233, See Glowinski and Axelrod, 18, 775, See Lemberger et al., 23, 371
Bacq, Z. M. Metabolism of adrenaline, 1, 1-, Summary ofdiscussion and commentary, 18, 313Baer, John E. See Beyer and Baer, 13, 417Baird, Joyce D. See Duncan and Baird, 12,91
Baker, J. B. E. The effects of drugs on the foetus, 12,37
Baliga, B. S. See Wurtman et aL, 24, 411
Banks, P., and Blaschko, H. Chromaffin tissue, 18, 453Barnes, J. M., and Denz, F. A. Experimental methods
used in determining chronic toxicity, 6, 191
-, and Stoner, H. B. The toxicology of tin com-
pounds, 11, 211
Batzinger, Robert P. See Bueding et al, 30, 547
Beard, N. Shelley, Jr., Armentrout, Steven A., andWeisberger, Austin S. Inhibition ofmaminalian pro-tein synthesis by antibiotics, 21, 213
Becker, Bernard. See Newberne et al., 30, 335Beecher, Henry K. The measurement of pain, 9, 59Beets, M. G. J. The molecular parameters of olfactory
response, 22, 1
Bein, H. J. The pharmacology of Rauwolfia, 8, 435Bell, Christopher. Autonomic nervous control of re-
production: circulatory and other factors. 24, 657Belleau, B. Steric effects in catecholamine interactions
with enzymes and receptors, 18, 131Bennett, Ivan L., Jr., and Cluff, Leighton E. Bacterial
pyrogens, 9, 427Berger, F. M. Spinal cord depressant drugs, 1, 243Bergstrom, Suite, Carbon, Lars A., and Weeks, James
R. The prostaglandins: a family ofbiologically active
lipids, 20, 1Berkowitz, Barry. See Spector et al., 24, 191
, See Spector et al., 25, 281
Berliner, David L., and Dougherty, Thomas F. Hepatic
and extrahepatic regulation of corticosteroids, 13,
329Berliner, Robert W., and Orloff, Jack. Carbonic an-
hydrase inhibitors, 8, 137
Bertaccini, Giulio. Active polypeptides of nonmam-malian orgin, 28, 127
Bertler, A., Falck, B., Owman, Ch., and Rosengrenn,
E. The localization of monoaminergic blood-brainbarrier mechanisms, 18, 369
Bertler, Ake, and Rosengren, Evald. Possible role of
brain dopamine, 18, 769
Beutler, Ernest. Drug-induced hemolytic anemia, 21,73
Beyer, Karl H. Functional characteristics of renaltransport mechanisms, 2, 227
, and Baer, John E. Physiological basis for theaction of newer diuretic agents, 13, 517
Bickel, M. H. The pharmacology and biochemistry of
N-oxides, 21, 325
630 AUTHOR INDEX, VOLUMES 1-30
Bigelow, G., Griffiths, R., and Liebson, I. Experimental
human drug self-administration: methodology and
application to the study of sedative abuse, 27, 523
Bishop, Charles, and Talbott, John H. Uric acid: itsrole in biological processes and the influence upon
it of physiological, pathological, and pharmacologi-cal agents, 5, 231
Bizzi, A. See Garattini and Bizzi, 18,243Bjur, R. See Weiner et al., 24, 203Blaschko, H. Amine oxidase and amine metabolism,
4, 415
-, Metabolism of epinephrine and norepinephrine,
6, 23, The development of current concepts of cate-
cholamine formations, 11, 307
, Chairman. First Session, Section I: Enzymology,
18, 39-84; Introductory remarks, 39
-, See Banks and Blaschko, 18,453Blinks, John R., and Koch-Weser, J. Physical factors
in the analysis of the actions of drugs on myocardial
contractility, 15, 531
, Prendergast, Franklyn G., and Allen, David G.
Photoproteins as biological calcium indicators,
28, 1
, See Koch-Weser and Blinks, 15,601Blohm, Thomas R Drug-induced lysosomal lipidosis:
biochemical interpretations, 30, 593
Bloom, Floyd E., Wedner, H. James, and Parker,
Charles W. The use of antibodies to study cell
structure and metabolism, 25, 343
Bobbin, Richard P. See Guth et al., 28, 95Bodansky, Oscar. Methemoglobinemia and methe-
moglobin-producing compounds, 3, 144
Bohr, David F. Electrolytes and smooth muscle con-
traction, 16, 85
Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to drugs, 30,429
Borison, Herbert L., and Wang, S. C. Physiology andpharmacology of vomiting, 5, 193
Boullin, D. J. See Costa et al., 18, 577Bousquet, William F. See Newberne et al., 30, 335
Bowman, Robert L. Fluorescence and its measure-ment, 11, 256
Bowman, W. C., and Nott, M. W. Actions of sympa-
thomimetic amines and their antagonists on skeletalmuscle, 21, 27
Boyd, Eldon M. Expectorants and respiratory tractfluid, 6, 521
Boyland, E. Mutagens, 6,345Brady, J. V. See Griffith et aL, 27,357Brand, J. J., and Perry, W. L M. Drugs used in motion
sickness. A critical review of the methods available
for the study of drugs of potential value in its
treatment and of the information which has beenderived by these methods, 18, 895
Braun-Menendez, E. Pharmacology of ream and hy-pertensin, 8, 25
Braunwald, Eugene. See Chidsey and Braunwald, 18,685
, See Higgins et al., 25, 119
Brawley, Peter, and Duffield, James C. The pharma-cology of hallucinogens, 24, 31
Brendel, K. See Breeder et al., 21, 105Bresnick, Edward. Report on the discussion of the
Third Session, 25, 315Bressler, R., Corredor, C., and Brendel, K. Hypoglycin
and hypoglycin-like compounds, 21, 105Brestkin, A. P. See Kabachnik et aL, 22, 355
Brink, Frank. The role of calcium ions in neural pro-cesses, 6, 243
Brodie, Bernard B., Davies, J. I., Hynie, S., Krishna,G., and Weiss, B. Interrelationships of catechol-amines with other endocrine systems, 18, 273
-, Spector, Sydney, and Shore, Parkhurst A. Inter-action ofdrugs with norepinephrine in the brain, 11,548
-, See Costa et al., 18, 577
Brody, Theodore M. The uncoupling of oxidative
phosphorylation as a mechanism of drug action, 7,335
-, Summary ofdiscussion and commentary, 18, 253
, See Akera and Brody, 29, 187
Brownlee, George. The wider aspects of the chemo-therapy of tuberculosis, 5, 421
Br#{252}cke, F. Dicholinesters ofa,�,-dicarboxylic acids and
related substances, 8, 265Bucher, K. Pathophysiology and pharmacology of
cough, 10, 43
Buchthal, Fritz. The effect of acetylcholine-like sub-stances on sensory receptors, 6, 97
Bueding, Ernest. Summary ofdiscussion and commen-tary, 18, 211
-, Batzinger, Robert P., Cha, Young-Nam, Talalay,
Paul, and Molineaux, Christopher J. Protectionfrom mutagenic effects of antischistosomal and
other drugs, 30, 547
�, and Swartzwelder, Clyde. Anthelmintics, 9, 329-, See Saz and Bueding, 18, 871Buffoni, F. Histaminase and related amine oxidases,
18, 163
Bunker, John P., Chairman, and Vandam, Leroy D.,
Co-chairman. Effects of anesthesia on metabolismand cellular functions: a workshop held under theCommittee on Anesthesia of the National Academy
of Sciences-National Research Council, 17, 183
Burgen, A. S. V. Central and sensory transmission, 6,95
Burn, J. H. Acetylcholine as a local hormone for ciliary
movement and the heart. 6, 107-, Chairman. Section V: Adrenergic transmission,
18, 459-540; Introductory remarks, 459Burnstock, G. Evolution of the autonomic innervation
of visceral and cardiovascular systems in verte-
brates, 21, 248, Purinergic nerves, 24, 509
-, and Holinan, Mollie E. Junction potentials at
adrenergic synapses, 18, 481
Bush, I. E. Chemical and biological factors in theactivity of adrenocortical steroids, 14, 317
AUTHOR INDEX, VOLUMES 1-30 631
Bushby, S. H. M. The chemotherapy ofleprosy, 10, 1Butcher, R. W. Cyclic 3’,S’-AMP and the lipolytic
effects of hormones on adipose tissue, 18, 237Butler, Thomas C. Theories of general anesthesia, 2,
121Butler, Vincent P., Jr. The immunological assay of
drugs, 29, 103-, Watson, John F., Schmidt, Donald H., Gardner,
Jerry D., Mandel, William J., and Skelton, C. Lynn.
Reversal of the pharmacological and toxic effects of
cardiac glycosides by specific antibodies, 25, 239
Cafruny, Edward J. The site and mechanism of actionof mercurial diuretics, 20, 89
Calabresi, Paul. Report on the discussion ofthe Fourth
Session, 25, 359Campbell, T. Cohn, and Hayes, Johnnie R. Role of
nutrition in the drug-metabolizing enzyme system,26, 171
Canaan, Lars A. Blood and tissue changes induced bynorepinephrine-stimulated mobilization offree fatty
acid, 18, 241
-‘ See Bergstrom et al., 20, 1Carbon, Loren D. The role of catecholamines in cold
adaptation, 18, 291
Carlsson, Arvid. Detection and assay of dopamine, 11,300
-, The occurrence, distribution, and physiological
role of catecholamines in the nervous system, 11,
490
-, Pharmacological depletion of catecholamine
stores, 18, 541
-, Kehr, W., Lindqvist, M., Magnusson, T. and
Atack, C. V. Regulation of monoamine metabolism
in the central nervous system, 24, 371Can, Edward A. Drug allergy, 6, 365
Case, Rosemary. Obituary, 18,6Catania, A. C. Drug effects and concurrent perfor-
mances, 27, 385Cha, Young-Nam. See Bueding et al., 30, 547
Chenoweth, Maynard B. Monofluoroacetic acid andrelated compounds, 1, 383
-, Chelation as a mechanism of pharmacologicalaction, 8, 57
, and McCarty, L. P. On the mechanisms of thepharmacophoric effect of halogenation, 15, 673
Chidsey, Charles A., and Braunwald, Eugene. Sym-pathetic activity and neurotransmitter depletion in
congestive heart failure, 18, 685China, Herman I., and Smith, Paul K. Motion sick-
ness, 7, 33Christenson, James G. See Dairman et al., 24,266Clark, J. M., and Lambertsen, C. J. Pulmonary oxygen
toxicity: a review, 23, 39Clark, W. G. Studies on inhibition of L-dopa decarboz-
ylase in vitro and in vivo, 11, 330
Clarkson, T. W. See Passow et al., 13, 185
Cloutier, G. See Weiner et al., 24, 203
Cluff, Leighton E. See Bennett and Cluff, 9, 427Code, Charles F. The inhibition of gastric secretion: a
review, 3, 59Cohen, Gerald. Techniques to improve the specificity
of the trihydroxyindole procedure, 11, 269
Cole, Jonathan 0. See Kierman and Cole, 17, 101
Conney, A. H. Pharmacological implications of micro-somal enzyme induction, 19, 317
Cooper, Theodore. Surgical sympathectomy and ad-renergic function, 18, 611
Con, Carl, Chairman. Carbohydrate Metabolism, See-tion II: Metabolic Effects of Catecholamines, 18,
145-213
, See Helmreich and Cori, 18, 189Corredor, C. See Bressler et aL, 21, 105
Costa, E., Boullin, D. J., Hammer, W., Vogel, W., andBrodie, B. B. Interactions of drugs with adrenergicneurons, 18, 577
-, Green, A. R, Koslow, S. H., LeFevre, H. F.,
Revuelta, A. V., and Wang, C. Dopamine and nor-
epinephrmne in noradrenergic axons: a study in vivo
oftheir precursor product relationship by mass frag-
mentography and radiochemistry, 24, 167Crout, J. Richard. Some spectrophotofluorimetric ob-
servations on blood and urine catecholamine assays,
11, 296
, Pheochromocytoma, 18,651Curtis, D. R The pharmacology of central and periph-
eral inhibition, 15, 333, and Watkins, J. C. The pharmacology of amino
acids related to gamma-aminobutyric acid, 17, 347
Cuthbert, A. W. Membrane lipids and drug action, 19,
59
Dahlstr#{246}m, Annica. See Hillarp et al., 18, 727
Dairman, Wallace, Christenson, James G., and Uden-
friend, Sidney. Changes in tyrosine hydroxylase anddopa decarboxylase induced by pharmacological
agents, 24, 266
Dale, Sir Henry H. The beginnings and the prospects
of neurohumoral transmission, 6, 7Dalgaard-Mikkelsen, Sv., and Poulsen, Emil. Toxicol-
ogy of herbicides, 14, 225Daly, M. de Burgh. Acetylcholine and transmission at
chemoreceptors, 6, 79
Dam, Henrik. Influence of antioxidants and redox
substances on signs of vitamin E deficiency, 9, 1Daniels-Severs, Anne E. See Severs and Daniels-Sev-
era, 25, 415
Danowski, T. S., and Elkinton, J. R. Exchanges of
potassium related to organs and systems, 3, 42Darken, Marjorie A. Puromycin inhibition of protein
synthesis, 16, 223Davies, B. N., and Withrington, P. G. The actions of
drugs on the smooth muscle of the capsule andblood vessels of the spleen, 25, 373
Davies, J. I. See Brodie et al., 18, 273Davis, Jean P. See Toman and Davis, 1, 425Dawes, G. S. Experimental cardiac arrhythmias and
quinidine-like drugs, 4,43de Champlain, Jacques. Report on the discussion of
the Fourth Session, 24, 431
632 AUTHOR INDEX, VOLUMES 1-30
DeLange, Robert J. See Krebs et al., 18, 163
Delmonte, Lilian, and Jukes, Thomas H. Folic acidantagonists in cancer chemotherapy, 14, 91
De Matteis, F. Disturbances of liver porphyrin metab-
olism caused by drugs, 19, 523Dengler, Hans J. See Titus and Dengler, 18, 525
De Robertis, Eduardo. Adrenergic endings and vesi-des isolated from brain, 18, 413
de Wied, D. Chiorpromazine and endocrine function,19, 251
Dews, P. B. Introduction: Schedule-induced polydipsiaand oral intake of drugs, 27, 447
, Are the techniques and results of studies of self-administration of drugs useful in other areas of
psychobiology, 27, 545
Diener, Robert M. See Newberne et al., 30, 335
Doak, George 0. See Eagle and Doak, 3, 107Domino, Edward F., Hardman, Harold F., and Seevers,
Maurice H. Central nervous system actions of some
synthetic tetrahydrocannabinol derivatives, 23, 317
, See Hardman et al., 23, 295
Dontas, A. S. See Hoobler and Dontas, 5, 135Dorfman, Albert. Metabolism of the mucopolysaccha-
rides of connective tissue, 7, 1
Dornhorst, A. C. Adrenergic blockade in cardiovascu-lar disease, 18, 701
Dougherty, Thomas F. See Berliner and Dougherty,
13, 329
Douglas, W. W. Is there chemical transmission at
chemoreceptors?, 6, 81
, The mechanism of release of catecholamines
from the adrenal medulla, 18, 471
Downs, D. A., and Woods, J. H. Naloxone as a negative
reinforcer in rhesus monkeys: effects of dose, sched-
ule, and narcotic regimen, 27, 397Drill, Victor A. Hepatotoxic agents: mechanism of
action and dietary interrelationship, 4, 1Duncan, Leslie J. P., and Baird, Joyce D. Compounds
administered orally in the treatment of diabetesmellitus, 12, 91
Duffield, James C. See Brawley and Duffield 24, 31Dustin, P., Jr. New aspects of the pharmacology of
antimitotic agents, 15, 449
Dyrenfurth, I. See Vande Wiele and Dyrenfurth, 25,
189
Eagle, Harry, and Doak, George 0. The biologicalactivity of arsenosobenzenes in relation to their
structure, 3, 107Edvinsson, Lars, and MacKenzie, Eric T. Amine mech-
anisms in the cerebral circulation, 28, 275
Ehrenpreis, Seymour, Fleisch, Jerome H., and Mittag,
Thomas W. Approaches to the molecular nature ofpharmacological receptors, 21, 131
Eldjarn, Lorentz. See Pihi and Eldjarn, 10, 437Elion, G. B. See Hitchings and Elion, 15, 365
Elkinton, J. R. See Danowski and Elkinton, 3, 42Ellis, Sydney. The metabolic effects of epinephrine
and related amines, 8, 485
, Relation of biochemical effects of epinephrine to
its muscular effects, 11, 469Elmadjian, Fred. Excretion and metabolism of epi-
nephrmne, 11, 409
Emmelin, N. Supersensitivity following “pharmaco-
logical denervation,” 13, 17Engbaeck, Lisa. The pharmacological actions of mag-
nesium ions with particular reference to the neuro-
muscular and the cardiovascular system, 4, 396
Er#{228}nk#{246},Olavi. Demonstration of catecholamines andcholinesterases in the same section, 18, 353
Erlanger, Bernard F. Principles and methods for the
preparation of drug protein conjugates for immu-nological studies, 25, 271
Erspamer, V. Pharmacology of indoleakylamines, 6,
425
Exton, J. H., and Park, C. H. The stimulation of
gluconeogenesis from lactate by epinephrine, glu-
cagon, and cyclic 3’,5’-adenylate in the perfused ratliver, 18, 181
Fain, John N. Biochemical aspects of drug and hor-
mone action on adipose tissue, 25, 67Fairhurst, Alan S. See Jenden and Fairhurst, 21, 1Falck, B. See Bertler et al., 18, 369
Falk, J. L., and Samson, H. H. Schedule-induced phys-ical dependence on ethanol, 27, 449
F#{228}nge,H. Pharmacology ofpoikilothermic vertebratesand invertebrates, 14, 281
Fastier, F. N. Structure-activity relationships of aim-dine derivatives, 14, 37
Featherstone, H. M., and Muehlbaecher, C. A. The
current role of inert gases in the search for anesthe-
sia mechanisms, 15, 97
Feldberg, W. S. Central and sensory transmission, 6,
85Feldberg, W., Chairman. Section VIII: Adrenergic
Mechanisms in the Nervous System, 18, 713-803Introductory remarks, 713
Fischbach, Gerald D., Frank, Eric, Jessell, ThomasM., Rubin, Lee L., and Schuetze, Stephen M. Ac-cumulation of acetyicholine receptors and acetyl-
cholinesterase at newly formed nerve-muscle syn-
apses, 30, 411Fisher, James W. Erythropoietin: pharmacology, bio-
genesis, and control of production, 24, 459Fleisch, Jerome, H. See Ehrenpreis et al., 21, 131Flesch, P. Inhibition of keratinizing structures by sys-
temic drugs, 15, 653Flower, Roderick J. Drugs which inhibit prostaglandin
biosynthesis, 26, 33
Flynn, Edward J. See Spector et al., 25, 281Forney, Robert B. Toxicology of marihuana, 23, 279
Fox, B. N., and Fox, Margaret. Biochemical aspects ofthe actions of drugs on spermatogenesis, 19, 21
Fox, Margaret. See Fox, B. N., and Fox, Margaret, 19,21
Frank, Eric. See Fischbach et al., 30, 411Franklin, Edward C. Report on the discussion of the
Second Session, 25, 269
Fraser, H. F. See Isbell and Fraser, 2, 355
AUTHOR INDEX, VOLUMES 1-30 633
Freedman, Daniel X. See Giarman and Freedman, 17,
1
French, J. E. See Robinson and French, 12, 241
Freyburger, Walter A. See Moe and Freyburger, 2, 61Friedenwald, Jonas S. Histochemistry-a review, 7,83
Friedman, Stanley. See Kaufman and Friedman, 17,71
Furchgott, Robert F. The pharmacology of vascular
smooth muscle, 7, 183
-, The receptors for epinephrine and norepineph-
rime (adrenergic receptors), 11, 429
-, Summary ofdiscussion and commentary, 18,641Fuxe, Kjell. See Goldstein et a!., 24, 293
-, See Hillarp et al., 18, 727
Gaddum, Sir John H. Bioassays and mathematics, 5,87
-, Theories of drug antagonism, 9, 211-, Bioassay procedures, 11, 241
, Obituary, 18, 5Gale, E. F. Mechanisms of antibiotic action, 15, 481Garattini, S., and Bizzi, A. Effect of drugs on mobili-
zation of free fatty acid, 18, 243
Gardner, Jerry D. See Butler et al., 25, 239Gavin, J. R., III. See Gorden et al., 25, 179Gerard, R. W. Closing remarks to symposium on neu-
rohumoral transmission, 6, 123Germuth, Frederick G., Jr. The role of adrenocortical
steroids in infection, immunity, and hypersensitiv-ity, 8, 1
Giarman, Nicholas J., and Freedman, Daniel X. Bio-chemical aspects of the actions of psychotomimetic
drugs, 17, 1
Gibbins, R. J� See Kalant et al., 23, 135
Gill, C. A. See Holz and Gill, 27, 437
Gillespie, J. S. Summary of discussion and commen-
tary, 18, 537Gilman, Alfred, and Koelle, G. B. Anticholinesterase
drugs, 1, 166
Ginsborg, B. L. Ion movements in junctional traits-mission, 19, 289
Gitlow, S. E. Summary ofdiscussion and commentary,
18, 707
Glaval, E. See Nikodijevi#{233} et a!., 18, 705Glick, Seymour M. Report on the discussion of the
First Session, 25, 209
Glowmski, J., and Axelrod, J. Effects of drugs on the
disposition of H3-norepinephrmne in the rat brain,
18, 775
Glowinski, Jacques, and Baldessarini, Ross J. Metab-
olism of norepinephrine in the central nervous sys-
tern, 18, 1201
Glynn, I. M. The action of cardiac glycosides on ionmovements, 16, 381
Godovikov, N. N. See Kabachnik et al., 22, 355
Goffart, M. The action of l-noradrenaline and adre-
nochrome on unfatigued mammalian muscle, 6, 33Golberg, Leon. Keynote Address. Toxicology: Has a
new era dawned?, 30, 351
Goldberg, Leon I. Cardiovascular and renal actions of
dopamine: potential clinical applications, 24, 1
Goldberg, S. R. Stimuli associated with drug injections
as events that control behavior, 27, 325, and Kelleher, R. T. Introduction: schedules of
termination of drug injections, 27, 395
, See Kelleher and Goldberg, 27, 291, 341
Goldfien, Alan. Effects of glucose deprivation on the
sympathetic outflow to the adrenal medulla and
adipose tissue, 18, 303
Goldstein, Avram. Interactions of drugs and plasma
proteins, 1, 102
Goldstein, M. Inhibition of norepinephrine biosyn-thesis at the dopamine-$-hydroxylation stage, 18,
77, Fuxe, K., and H#{246}kfelt, T. Characterization and
tissue localization ofcatecholamine synthesizing en-
zymes, 24, 293
Goodall, McC. Metabolic products of adrenaline andnoradrenaline in human urine, 11, 416
Goodenough, Daniel A. Gap junction dynamics andintercellular communication, 30, 383
Gorden, P., Gavin, J. R., ifi, Kahn, C. R., Archer, J.A., Lesniak, M., Hendricks, C., Neville, D. M., Jr.,
and Roth, J. Application of radioreceptor assay to
circulating insulin, growth hormone, and to theirtissue receptors in animals and man, 25, 179
Gorkin, V. Z. Monoamine oxidases, 18, 115Goz, Barry. The effects of incorporation of 5-haloge-
nated deoxyuridines into the DNA of eukaryotic
cells, 29, 249
Graessle, Otto E. See Molitor and Graessle, 2, 1Grant, W. Morton. Physiological and pharmacological
influences upon intraocular pressure, 7, 143Gray, Jack E. See Newberne et al., 30, 335
Green, A. R. See Costa et al., 24, 167
Griffith, R. R., Wurster, R. M., and Brady, J. V.
Discrete-trial choice procedure: effects of naloxoneand methadone on choice between food and heroin,27, 357
Griffiths, R. See Bigelow et al., 27, 523Grub, Mary A. Electron microscopy of sympathetic
tissues, 18, 387
Guldberg, Hans C., and Marsden, Charles A. Catechol-0-methyl transferase. Pharmacological aspects and
physiological role, 27, 135
Gunnison, Janet B. See Jawetz and Gunnison, 5, 175Guth, Paul S., Norris, Charles H., and Bobbin, Richard
P. The pharmacology of transmission in the periph-
eral auditory system, 28, 95
Gyermek, Laszlo. 5-Hydroxytryptamine antagonists,
13, 399
Haag, H. B. See Silvette et al., 14, 137
Haber, Edgar, Chairman. Cardiovascular Applica-
tions, The role of antibodies and physiological re-
ceptors in cardiovascular diagnosis, therapy, andresearch, 25, 215
-, See Smith, T. W., and Haber, 25, 219Haddy, Francis J. See Visscher et aL, 8, 389
Hagen, P. The storage and release of catecholamines,
634 AUTHOR INDEX, VOLUMES 1-30
11, 361
Haggendal, Jan. Newer developments in catechol-
amine assay, 18, 325
Hahn, F. Analeptics, 12, 447
Hajdu, Stephen, and Leonard, Edward. The cellularbasis of cardiac glycoside action, 11, 173
Hammer, W. See Costa et al., 18, 577Hansen, Eder L. See Anderson and Hansen, 2, 399
Hardman, Harold F., Domino, Edward F., and Seevers,
Maurice H. General pharmacological actions of
some synthetic tetrahydrocannabinol derivatives,
23, 295
-, See Domino et al., 23, 317Hartman, Boyd K., and Udenfriend, Sidney. The ap-
plication of immunological techniques to the studyof enzymes regulating catecholamine synthesis and
degradation, 24, 311Harris, Louis S. General and behavioral pharmacol-
ogy, 23, 285
Hasselbach, Wilhelm, and Weber, Annemarie. Models
for the study of the contraction of muscle and of cell
protoplasm, 7, 97Haugaard, Niels, and Hess, Marilyn E. Actions of
autonomic drugs on phosphorylase activity and
function, 17, 27-, and Hess, Marilyn E. The influence of catechol-
amines on heart function and phosphorylase activ-
ity, 18, 197
-, Kukovetz, Walther R., and Hess, Marilyn E. The
effect ofsympathomimetic amines on phosphorylaseactivity of the isolated rat heart, 11, 466
Hawking, Frank. The chemotherapy of filarial infec-
tions, 7, 279Hawkins, Rosemary D. The metabolism of ethanol
and its metabolic effects, 24, 67Hayaishi, Osamu. Enzymic studies on the mechanism
of double hydroxylation, 18, 71Hayes, Johnnie R. See Campbell and Hayes, 26, 171
Hebb, Catherine 0. Acetylcholine metabolism of ner-
vous tissue, 6, 39Heinle, Robert W. See Welch and Heinle, 3, 345
Hellon, R. F. Monoamines, pyrogens, and cations:
their action on central control of body temperature,
26, 289
Helmreich, Ernst, and Cori, Carl F. The activation of
glycolysis in frog sartorius muscle by epinephrine,18, 189
Hendricks, C. See Gorden et al., 25, 179
Hertz, Leif. Drug-induced alterations of ion distribu-
tion at the cellular level of the central nervous
system, 29, 35Hess, Marilyn E. See Haug#{225}ard and Hess, 17,27
-‘ See Haugaard and Hess, 18, 197, See Haugaard et al., 11, 466
Heymans, C. Action of drugs on carotid body andsinus, 7, 119
Higgins, Charles B., Vatner, Stephen F., and Braun-wald, Eugene. Parasympathetic control ofthe heart,
25, 119
Hillarp, Nils-Ake. Obituary, 18, 5
-, Fuxe, Kjell, and Dahlstrdm, Annica. Demonstra-
tion and mapping of central neurons containing
dopamine, noradrenaline, and 5-hydroxytryptamineand their reactions to psychopharmaca, 18, 727
Himms-Hagen, Jean. Sympathetic regulation of me-
tabolism, 19, 367
Hitchings, G. H., and Elion, G. B. Chemical suppres-sion of the immune response, 15, 365
Hoff, E. C. See Silvette et al., 14, 137Hoffmeister, F., and Wuttke, W. Psychotropic drugs
as negative reinforcers, 27, 419
H#{246}kfelt, T. See Goldstein et al., 24, 293
Hollenberg, Morley D. Hormone receptor interactionsat the cell membrane, 30, 393
Hollister, Leo E. Actions of various marihuana deriv-atives in man, 23, 349
Holman, Mollie E. See Burnstock and Holman, 18,481
Holmstedt, Ba. The action of anticholinesterases on
spinal reflexes following intraarterial injection, 6,49
, Pharmacology of organophosphorus cholinester-
ass inhibitors, 11, 567Holtz, Peter. Role of L-dopa decarboxylase in the
biosynthesis of catecholamines in nervous tissue andthe adrenal medulla, 11, 317
, Chairman. Second Session, Section I: Enzymol-ogy, 18, 85-144; Introductory remarks, 85
-, and Palm, Dieter. Pharmacological aspects of
vitamin B�, 16, 113
Holz, W. C., and Gill, C. A. Drug injections as negative
reinforcers, 27, 437
Hoobler, S. W., and Dontas, A. S. Drug treatment of
hypertension, 5, 135Hornykiewicz, Oleh. Dopamine (3-hydroxytyramine)
and brain function, 18, 925Horowicz, Paul. The effects of anions on excitable
cells, 16, 193
Hottendorf, G. H. See Newberne et al., 30, 335
Hug, George. Pro- and postnatal pathology, enzyme
treatment, and unresolved issues in five lysosomaldisorders, 30, 565
Hull, R See Hurst and Hull, 8,199Hunt, Carlton C., and Kuffler, Stephen W. Pharma-
cology of the neuromuscular junction, 2, 96Hunter, F. Edmund, Jr., and Lowry, Oliver H. The
effects of drugs on enzyme systems, 8, 89Hurst, E. Weston, and Hull, R. The chemotherapy of
virus diseases, with brief consideration of the influ-
ence of dietary, hormonal, and other factors in virus
infection, 8, 199
Hynie, S. See Brodie et al., 18, 273
Iglauer, C., Liewellyn, M. E., and Woods, J. H. Currentschedules of cocaine injection in rhesus monkeys:
dose variation under independent and non-indepen-dent variable-interval procedures, 27, 367
Ingram, G. I. C. Anticoagulant therapy, 13, 279Isbell, Harris, Chairman. Marihuana and Its Surro-
gates, Session II, 23, 337-380
Clinical pharmacology of marihuana, 337
AUTHOR INDEX, VOLUMES 1-30 635
-, and Fraser, H. F. Addiction to analgesics andbarbiturates, 2, 355
Jackson, H. Antifertility substances, 11, 135
Jacobowitz, David W. See Kostrzewa and Jacobowitz,26, 199
Jacobsen, Erik. The metabolism of ethyl alcohol, 4,107
Jawetz, Ernest, and Gunnison, Janet B. Antibioticsynergism and antagonism: an assessment of theproblem, 5, 175
Jenden, Donald J., and Fairhurst, Alan S. The phar-macology of ryanodine, 21, 1
Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 30, 477
Jessell, Thomas M. See Fischbach et al., 30, 411Johanson, C. E. Pharmacological and environmental
variables affecting drug preference in rhesus mon-
keys, 27, 343
Johanseon, B#{246}rje.See Meliander and Johansson, 20,117
Johns, Anthony. See Paton et al., 29, 67Jones, Reese T. Marihuana-induced “high”: influence
of expectation, setting, and previous drug experi-
ence, 23, 359
Jukes, Thomas H., and Williams, William L. Nutri-tional effects of antibiotics, 5,381
-‘ See Delmonte and Jukes, 14, 91
Kabachnik, M. I., Brestkin, A. P., Godovikov, N. N.,Michelson, M. J., Rozengart, E. V., and Rozengart,
V. I. Hydrophobic areas on the active surface ofcholinesterases, 22, 355
Kahn, C. R. See Gorden et al., 25, 179Kalant, H., LeBlanc, A. E., and Gibbins, R J. Toler-
ance to, and dependence on some non-opiate psy-
chotropic drugs, 23, 135Kao, C. Y. Tetrodotoxin, saxitoxin, and their signifi-
cance in the study of excitation phenomena, 18,997Kappas, A., and Palmer, R. H. Selected aspects of
steroid pharmacology, 15, 123Karlson, Peter. See Sekeris and Karlson, 18, 89
K#{227}ser,Hans. Catecholamine-producing neural tumorsother than pheochromocytoma, 18, 659
Kaufman, Seymour. Coenzymes and hydroxylases:
ascorbate and dopamine-fl-hydroxylase; tetrahy-
dropteridines and phenylalanine and tyrosine hy-droxylases, 18, 61
-, and Friedman, Stanley. Dopamine-/1-hydroxyl-ass, 17, 71
Kehr, W. See Carlsson et al., 24, 371
Kelleher, R. T. Characteristics of behavior controlled
by scheduled injections of drugs, 27,307
-‘ and Goldberg, S. R. General introduction: controlof drug-taking behavior by schedules of reinforce-
ment, 27, 291
-‘ and Goldberg, S. R. Introduction: Complexschedules of drug injection, 27, 341
-, See Goldberg and Kelleher, 27, 395Kemp, Robert G. See Krebs et al., 18, 163
Kety, Seymour S. The theory and applications of the
exchange of inert gas at the lungs and tissues, 3, 1
-, Central actions of catecholamines, a discussion,
11, 565
-, Catecholamines in neuropsychiatric states, 18,787
-, Chairman. First Session, Increased Synthesis ofCatecholamines without Changes in Enzyme Levels,24, 167-224
Khromov-Borisov, N. V., and Michelson, M. J. Themutual disposition of cholinoreceptors of locomotor
muscles, and the changes in their disposition in the
course of evolution, 18, 1051
Kiese, Manfred. The biochemical production of fern-hemoglobin-forming derivatives from aromatic
amines, and mechanisms of ferrihemoglobin forms-
tion, 18, 1091
Killam, Eva King. Drug action on the brain-stemreticular formation, 14, 175
Kimura, Kazuo K. See Randall and Kimura, 7, 365Kiplinger, Glenn F., and Manno, Joseph E. Dose-re-
spouse relationships to cannabis in human subjects,23, 339
Kirshner, Norman. Biosynthesis of adrenaline andnoradrenaline, 11, 350
-, Summary of discussion and commentary, 18, 83-, and Viveros, 0. H. The secretory cycle in the
adrenal medulla, 24, 385Kizer, John S., Youngbbood, William W., and Nemer-
off, Charles B. Neurotoxic amino acids and struc-turally related analogs, 29, 301
Klaus, Wolfgang. See Lee and Klaus, 23, 193Klerman, Gerald L, and Cole, Jonathan 0. Clinical
pharmacology of imipramine and related antide-
pressant compounds, 17, 101Koch-Weser, J., and Blinks, J. R. The influence of the
interval between beats on myocardial contractility,
15, 601
, See Blinks and Koch-Weser, 15,531Koelle, George B. The localization of specific cholin-
esterase in the retina, 6, 47-, Possible mechanisms for the termination of the
physiological actions of cateeholamines, 11, 381
-, Summary of discussion and commentary, 18,359
-, See Gilman and Koelle, 1,166Kopin, Irwin J. Storage and metabolism of catechol-
amines: the role of monoamine oxidase, 16, 179-, Biochemical aspects ofrelease of norepinephrine
and other amines from sympathetic nerve endings,
18, 513
-, and Silberstein, Stephen D. Axons of sympa-thetic neurons: transport of enzymes in viva andproperties of axonal sprouts in vitro, 24, 245
-‘ See Lemberger et al., 23, 371Koslow, S. H. See Costa et al., 24, 167Kosterlitz, H. W., and Lees, G. M. Pharmacological
analysis of intrinsic intestinal reflexes, 16,301Kostrzewa, Richard M., and Jacobowitz, David W.
Pharmacological actions of6-hydroxydopamine, 26,199
636 AUTHOR INDEX, VOLUMES 1-30
Krasnegor, N. A. Introduction: behavioral factors in
human drug abuse, 27,499Krebs, Edwin G., DeLange, Robert L, Kemp, Robert
G., and Riley, W. Dixon. Activation ofskeletal mus-
cle phosphorylase, 18, 163
Krishna, G. See Brodie et al., 18, 273Krsti#{233},M. See Varagl#{233} and Krsti#{233},18,799Kuffler, Stephen W. See Hurtt and Kuffler, 2,96Kukovetz, Walther R. See Haugaard et al., 11,466
Laemmli, U. K. Levels of organization of the DNA in
eucaryotic chromosomes, 30, 469Lambertsen, C. J. See Clark and Lambertsen, 23,39
Lande, Saul, and Lerner, Aaron B. The biochemistryof melanotropic agents, 19, 1
Lands, A. M. The pharmacological activity of epineph-rune and related dihydroxyphenylalkylamines, 1, 279
Larson, P. 5. See Silvette et al., 14, 137
Larsson, Stig. See Andersson and Larsson, 13, 1Lasagna, Louis. The clinical evaluation of morphine
and its substitutes as analgesics, 16, 47Laties, Victor G. See Weiss and Laties, 14, 1
Latt, Samuel A., Schreck, Rhona R., Loveday, Ken-neth S., and Shuler, Charles F. In vitro and in vivo
analysis of sister chromatid exchange, 30, 501
Lurell, C.-B. Plasma iron and the transport of iron in
the organism, 4, 371
Leander, J. D., and McMillan, D. E. Schedule-induced
narcotic ingestion, 27, 475
LeBlanc, A. E. See Kalant et al., 23, 135
Lee, Kwang S., and Klaus, Wolfgang. The subcellularbasis for the mechanism of inotropic action of car-
disc glycosides, 23, 193Leeper, Lemuel C. Catecholamine formation in intact
tissues, 11, 358
Lees, G. M. See Kosterlitz and Lees, 16,301
LeFevre, H. F. See Costa et aL, 24, 167
LeFevre, Paul G. Sugar transport in the red blood cell:structure-activity relationships in substrates and an-
tagonists, 13, 39
Letkowitz, Robert J. Isolated beta-adrenergic binding
sites: a potential assay vehicle for catecholamines,
25, 259
Lemberger, Louis, Axelrod, Julius, and Kopin, Irwin
J. Metabolism and disposition of �9-tetrahydrocan-
nabinol in man, 23, 371Leonard, Edward. See Hajdu and Leonard, 11, 173Lerner, Aaron B. See Lande and Lerner, 19, 1Lesniak, M. See Gorden et al., 25, 179Levi-Montalcini, Rita, and Angeletti, Piero U. Immu-
nosympathectomy, 18, 619
Levine, Lawrence. Antibodies to pharmacologicallyactive molecules: specificities and some applications
of antiprostaglandins, 25,293Lieberman, Seymour, and Teich, Sylvia. Recent trends
in the biochemistry of the steroid hormones, 5, 285Liebson, I. See Bigelow et aL, 27, 523
Lilienthal, Joseph L., Jr. Carbon monoxide, 2, 324Liljestrand, G. Transmission at chemoreceptors, 6,73
Lindenbaum, John. Bioavailability of digoxin tablets,
25, 229
Lindenmayer, George E. See Schwartz et al., 27, 3Lindqvist, M. See Carlsson et al., 24, 371
Llewellyn, M. E. See Iglauer et aL, 27, 367Loewe, S. Antagonism and antagonists, 9, 237Loewi, Otto. Introduction to symposium on neurohu-
moral transmission, 6, 3Longo, V. G. Behavioral and electroencephalographic
effects of atropine and related compounds, 18, 965
Loveday, Kenneth S. See Latt et aL, 30, 501
Lowry, Oliver H. See Hunter and Lowry, 8,89Lundholm, Lennart, Chairman. Physiological Interre-
lationships, Section II: Metabolic Effects of Cate-cholamines, 18, 255-314; Introductory remarks, 255
MacKenzie, Eric T. See Edvinsson and MacKenzie,
28, 275
Magnusson, T. See Carlsson et al., 24, 371Makinodan, T., Santos, G. W., and Quinn, R. P. Irs-
munosuppressive drugs, 22, 189
Maloof, F., and Soodak, M. Intermediary metabolismof thyroid tissue and the action of drugs, 15, 43
Mandel, H. George. The physiological disposition of
some anticancer agents, 11, 743
Mandel, William J. See Butler et al., 25, 239
Manger, William Muir. Suitability of the ethylenedi-
amine method of Weil-Maiherbe and Bone andmodifications for quantitating plasma pressor
amines, 11, 289
Manno, Joseph E. See Kiplinger and Manno, 23, 339
Mansour, Tag E. Actions ofserotonin and epinephrine
on intact and broken cell preparations from the liver
fluke, Fasciola hepatica, 11,465-, Factors influencing activation of phosphofruc-
tokinase, 18, 173
Marchesi, Vincent T. Functional components of sur-face membranes: potential targets for pharmacolog-
ical manipulation, 30, 371Marley, E. Behavioural and electrophysiological ef-
fects of catecholamines, 18, 753Marrazzi, A. S. Ganglionic and central transmission, 6,
105
Marsden, Charles A. See Guldberg and Marsden, 27,135
Marshall, E. K., Jr. The dosage schedule of chemo-
therapeutic agents, 4,85Martin, W. R. Opioid antagonists, 19, 463
Matthews, R. E. F. Biosynthetic incorporation of me-
tabolite analogues, 10,359Mautner, Henry G. The molecular basis ofdrug action,
19, 107
Mayhew, Dale A., Wright, Peter H., and Ashmore,James. Regulation of insulin secretion, 21, 183
Maynert, E. W. Summary of discussion and commen-tary, 18, 457
, and van Dyke, H. B. The metabolism of barbi-turates, 1, 217
McCarty, L P. See Chenoweth and McCarty, 15, 673
Mcintyre, A. K. Central and sensory transmission, 6,103
AUTHOR INDEX, VOLUMES 1-30 637
McKearney, J. W. Drug effects and the environmental
control of behavior, 27, 429
McLean, Elizabeth K. The toxic actions of pyrrolizi-dine (Senecio) alkaloids, 22, 429
McMillan, Armand. See Armstrong and McMillan, 11,
394
McMillan, D. E. See Leander and McMillan, 27, 475
Meisch, R. A. The function of schedule-induced poly-
dipsia in establishing ethanol as a positive reinfor-
cer, 27, 465
Meldrum, B. S. The actions of snake venoms on nerve
and muscle. The pharmacology of phospholipase A
and of polypeptide toxins, 17, 393
Mellander, Stefan, and Johansson, B#{246}rje.Control ofresistance, exchange, and capacitance functions in
the peripheral circulation, 20, 117
Mello, N. K. Schedule-induced polydipsia and oral
intake of drugs, 27, 489
Michelson, M. J. See Khromov-Borisov and Michel-
son, 18, 1051
, See Kabachnik et al., 22, 355Miller, D. D. See Patil et al., 26, 323Miller, Elizabeth C., and Miller, James A�Mechanisms
of chemical carcinogenesis: nature of proximate car-
cinogens and interactions with macromolecules, 18,
805
Miller, James A. See Miller, E. C., and Miller, J. A.,
18, 805
Millican, R. Carl. See Rosenthal and Millican, 6,489
Mittag, Thomas W. See Ehrenpreis et al., 21, 131Miyamoto, Michael D. The actions of cholinergic
drugs on motor nerve terminals, 29, 221Moe, Gordon K., and Freyburger, Walter A. Gangli-
onic blocking agents, 2, 61
Mohme-Lundholm, Ella. See Lundholm et al., 18, 255Molineaux, Christopher J. See Bueding et al., 30, 547
Molitor, Hans, and Graessle, Otto E. Pharmacologyand toxicology of antibiotics, 2, 1
Moran, Neil C. Pharmacological characterization ofadrenergic receptors, 18, 503
Mordes, John P., and Wacker, Warren E. C. Excessmagnesium, 29, 273
Morse, W. H. Introduction: the control of behavior byconsequent drug injections, 27, 301
-, See Tang and Morse, 27, 407
Muehlbaecher, C. A. See Featherstone and Muehl-baecher, 15, 97
Musacchio, Jose M. Report on the discussion of the
Third Session, 24, 361Muscholl, E. Indirectly acting sympathomimetic
amines, 18, 551Mustard, J. F., and Packham, M. A. Factors influenc-
ing platelet function: adhesion, release, and aggre-
gation, 22, 97
Nahas, Gabriel G. The pharmacology of tris-
(hydroxymethyl)aminomethane (THAM), 14, 447Neff, Norton H. Report on the discussion of the First
Session, 24, 223Nemeroff, Charles B. See Kizer et al., 29, 301
Neville, D. M., Jr. See Gorden et al., 25, 179
Newberne, James W., Becker, Bernard, Bousquet,
William F., Diener, RObert M., Gray, Jack E., Hot-tendorf, G. H., Pfitzer, Emil A., Probst, Gregory S.,
Robinson, Virgil B., Steelman, Richard L., and van
Ryzin, Robert J. Summary of the workshop, 30, 335
Nickerson, Mark. Pharmacology of adrenergic block-ade, 1, 27
-, Nonequiibrium drug antagonism, 9, 246
, Blockade of the actions of adrenaline and nor-
adrenaline, 11, 443
, Summary of discussion and commentary, 18,801
Nikodijevi#{233}, B., Glava�, E., and Polenakovi#{233}, M. Car-
diovascular effects of monoamine oxidase inhibitors,
18, 705
Noble, R. L. Hormonal regulation of tumor growth, 9,
367
Norberg, Karl-Axe!, and Sjoqvist, Folke. New possi-bilities for adrenergic modulation of ganglionic
transmission, 18, 743Norris, Charles H. See Guth et aL, 28, 95Nott, M. W. See Bowman and Nott, 21, 27
O’Brien, C. P. Experimental analysis of conditioningfactors in human narcotic addiction, 27, 533
Olson, James Allen. The metabolism ofvitamin A, 19,
559
O’Reilly, Robert A., and Aggeler, Paul M. Determi-nants of the response to oral anticoagulant drugs in
man, 22, 35Orloff, Jack. See Berliner and Orloff, 8, 137Oswald, Ian. Drugs and sleep, 20, 273
Ottoson, D. Some aspects of the function of the olfac-
tory system, 15, 1
Owman, Ch. Methodology of fluorescense microscopyof catecholamines, 18, 351
, See Bertler et al., 18, 369
Packham, M. A. See Mustard and Packham, 22,97Paintal, A. S. Effects of drugs on vertebrate mecha-
noreceptors, 16, 341
Palm, Dieter. See Holtz and Palm, 16, 113Palmer, R. H. See Kappas and Palmer, 15, 123Pappano, Achilles J. Ontogenetic development of au-
tonomic neuroeffector transmission and transmitter
reactivity in embryonic and fetal hearts, 29, 3
Park, C. R. See Exton and Park, 18, 181
Park, W. K. See Regoli et ci., 26, 69
Parker, Charles W., Chairman. Fourth Session, 25,319-362
, The immunotherapy of cancer, 25, 325
, See Bloom et al., 25, 343
Parrot, Jean-Louis. The place of histamine in neuro-
humoral transmission, 6, 119Passow, H., Rothstein, A., and Clarkson, T. W. The
general pharmacology of the heavy metals, 13, 185
Patil, P. N., Miller, D. D., and Trendelenburg, U.
Molecular geometry and adrenergic drug activity,
26, 323
Paton, David M., Widdicombe, Jonathan H.,
638 AUTHOR INDEX, VOLUMES 1-30
Rheaume, Dorianne E., and Johns, Anthony. Therole of adrenergic innervation of the oviduct in the
regulation of mammalian ovum transport, 29, 67-, and Zaimis, Eleanor J. The methonium com-
pounds, 4, 219
Paton, W. D. Transmission and block in autonomic
ganglia, 6, 59, Histamine release by compounds of simple
chemical structure, 9, 269
Peart, W. S. The renin-angiotensin system, 17, 143
-, Catecholamines and hypertension, 18,667
Pekkarinen, Aimo. Adrenaline and noradrenaline inblood and urine, 6, 35
Perry, W. L. M. Transmission at the motor endplateand ganglionic synapse, 6, 71
-, See Brand and Perry, 18, 895Peskar, Bernard. See Spector et al., 25, 281
Peters, Lawrence. Renal tubular excretion of organic
bases, 12, 1Pfeffer, R. I. See Weiner et al., 24, 203
Pfitzer, Emil A. See Newberne et al., 30, 335
Philips, Frederick S. Recent contributions to the phar-
macology of bis(2-haloethyl) amines and sulphides,2, 281
Pickford, Mary. Antidiuretic substances, 4, 254
Pilil, Alexander, and Eldjarn, Lorentz. Pharmacologi-
cal aspects of ionizing radiation and of chemical
protection in mammals, 10, 437Pitts, Robert F., and Sartorius, Otto W. Mechanism of
action and therapeutic use of diuretics, 2, 161Plaa, Gabriel L., and Priestly, Brian G. Intrahepatic
cholestasis induced by drugs and chemicals, 28, 207
Pletscher, Alfred. Monoamine oxidase inhibitors, 18,121
, Regulation of catecholamine turnover by vans-tions of enzyme levels, 24, 225
-, Chairman. Second Session, Induction or Reduc-tion of Catecholamine Enzymes, 24, 225-292
Pohorecky, Larisaa A., and Wurtman, Richard J.Adrenocortical control of epinephrine synthesis,
23, 1
-, See Wurtman et al., 24, 411Polenakovi#{233}, M. See Nikodijevi#{233} et al., 18, 705
Porter, Curt C. See Stone and Porter, 18,569Potter, Lincoln T. Storage of norepinephrmne in sym-
pathetic nerves, 18, 439
Poulsen, Emil. See Dalgaard-Mikkelsen and Poulsen,14, 225
Pouslen, Knud. Measurements of renin-angiotensin-
aldosterone, 25, 249
Powell, C. E. See Slater and Powell, 11, 462
Prendergast, Franklyn G. See Blinks et al., 28, 1Price, Henry L. Estimation of epinephrine and nor-
epinephrine concentrations in human plasma by thetrihydroxyindole method, 11, 273
Priestly, Brian G. See Plan and Priestly, 28,207Probst, Gregory S. See Newberne et al., 30, 335
Prusoff, William H. Recent advances in chemotherapyof viral diseases, 19, 209
Quay, W. B. Indole derivative of pineal and relatedneural and retinal tissues, 17, 321
Quinn, R. P. See Makinodan et al., 22, 189
Hall, Theodore W. Role of adenosine 3’,5’-monophos-
phate (cyclic AMP) in actions of catecholamines,
24, 399
-, and Sutherland, E. W., Jr. Action of epinephrine
and norepinephrmne in broken cell preparations, 11,464
, See Sutherland and Rail, 12, 265
Randall, Walter C., and Kimura, Kazuo K. The phar-macology of sweating, 7, 365
Raikov#{225}, Helena, and Van#{232}�ek,Jill. Pharmacology of
bacterial toxins, 16, 1
Ray, Verne A. Application of microbial and mamma-lian cells to the assessment of mutagenicity, 30, 537
Recknagel, Richard 0. Carbon tetrachioride hepato-toxicity, 19, 145
Regoli, D., Park, W. K., and Rioux, F. Pharmacology
of angiotensin, 26, 69Rerup, Claus C. Drugs producing diabetes through
damage of the insulin secreting cells, 22, 485Revuelta, A. V. See Costa et al., 24, 167Rheaume, Dorianne E. See Paton et al., 29, 67Riggs, Douglas S. Quantitative aspects of iodine me-
tabolism in man, 4, 284
Hiker, Walter F., Jr. Excitatory and anti-curare prop-
erties of acetylcholine and related quaternary am-monium compounds at the neuromuscular junction,5, 1
Riley, James F. Pharmacology and functions of themast cells, 7, 267
Riley, W. Dixon. See Krebs et al., 18, 163Rioux, F. See Regoli et al., 26, 69
Robinson, D. S., and French, J. E. Heparin, the clear-ing factor lipase, and fat transport, 12, 241
Robinson, Virgil B. See Newberne et al., 30, 335Robison, G. Alan. See Sutherland and Robison, 18,
145
Robson, J. M., and Suffivan, F. M. Antituberculosis
drugs, 15, 169
Roche e Silva, M. Kinetics of recovery from inhibitionby antihistaminics, atropine, and antispasmodics, 9,
259
Roe, Aluf. The metabolism and toxicity of methanol,7, 399
Rosenberg, Thomas. See Wilbrandt and Rosenberg,
13, 109
Rosengren, Evald. See Bertler and Rosengren, 18, 769Rosengrenn, E. See Bertler et al., 18, 369Rosenthal, Sanford M., and Millican, R. Carl. The role
of fluids, electrolytes, and plasma proteins in exper-imental traumatic shock and hemorrhage, 6,489
Roth, J. See Gorden et al., 25, 179Rothballer, Alan B. The effects of catecholamines on
the central nervous system, 11,494Rothstein, A. See Passow et al., 13, 185
Rozengat, E. V. See Kabachnik et al., 22, 355
AUTHOR INDEX, VOLUMES 1-30 639
Rozengart, V. I. See Kabachnik et al., 22,355Rubin, Lee L. See Fischbach et al., 30, 411
Rubin, R. P. The role of calcium in the release ofneurotransmitter substances and hormones, 22,389
Ruthven, C. R. J. See Sandier and Ruthven, 18, 343
Sadler, P. W. Chemotherapy of viral diseases, 15,407Salmoiraghi, G. C. Central adrenergic synapses, 18,
717
Samson, H. H. See Falk and Samson, 27,449
San, R. H. C. See Stich et aL, 30, 493Sandier, Merton, Chairman. Third Session: Multiple
Forms and Localization of Enzymes, 24, 293-364-, and Ruthven, C. R. J. The measurement of 4-
hydroxy-3-methoxymandelic acid and homovanillicacid, 18, 343
-, and Youdim, M. B. H. Multiple forms of mono-
amine oxidase: functional significance, 24, 331Sandow, Alexander, Excitation-contraction coupling
in skeletal muscle, 17, 265
Santos, G. W. See MakinOdan et al., 22, 189Sartorius, Otto W. See Pitts and Sartorius, 2, 161
Sawyer, Wilbur H. Neurohypophysical hormones, 13,225
Saz, Howard J., and Bueding, Ernest. Relationshipsbetween anthelinintic effects and biochemical and
physiological mechanisms, 18, 871Schanker, Lewis S. Passage ofdrugs across body mem-
branes, 14, 501
Scheinberg, I. Herbert, and Sternlieb, Irmin. Copper
metabolism, 12, 355Scheline, Ronald R. Metabolism offoreign compounds
by gastrointestinal microorganisms, 25, 451
Schild, H. 0. Drug antagonism and pAx, 9, 242-, Calcium and the relaxant effect of isoproterenol
in the depolarized rat uterus, 18, 495Schmidt, Donald H. See Butler et al., 25, 239
Schmucker, Douglas L Age-related changes in drug
disposition, 30, 445Schou, Jens. Absorption of drugs from subcutaneous
connective tissue, 13, 441
Schou, Mogens. Biology and pharmacology of the
lithium ion, 9, 17
Schreck, Rhona R. See Latt et al., 30, 501
Schuetze, Stephen M. See Fischbach et al., 30, 411Schumann, Hans-Joachim. Medullary particles, 18,
433
Schuster, C. R. Drugs as reinforcers in monkey and
man, 27, 511Schwartz, Arnold, Lindenmayer, George E., and Allen,
Julius C. The sodium-potassium adenosine triphos-
phatase: pharmacological, physiological, and bio-
chemical aspects, 27, 3Seegers, Walter H. The influence of certain drugs on
blood coagulation and related phenomena, 3, 278Seaman, Philip. The membrane actions of anesthetics
and tranquilizers, 24, 583Seevers, Maurice H. See Domino et al., 23, 317
-, See Hardman et al., 23, 295
Sekeris, Constantin E., and Karlson, Peter. Biosyn-
thesis of catecholamines in insects, 18, 89
Severs, Walter B., and Daniels-Severs, Anne E. Effects
of angiotensin on the central nervous sytem, 25, 415Shanes, Abraham M. Electrochemical aspects of phys-
iological and pharmacological action in excitablecells, 10, 59
-, Electrochemical aspects of physiological and
pharmacological action in excitable cells. Part H.
The action potential and excitation, 10, 165
Shaw, F. H. Transmission and block in sympathetic
ganglia, 6, 69Shaw, James H. Caries-inhibiting agents, 11, 705Shideman, F. F., Chairman. Section VI: Modification
of Sympathetic Function, 18, 541-644
Shore, Parkhurst A. A simple technique involving
solvent extraction for the estimation of norepineph-
line and epinephrine in tissues, 11, 276, Release of serotonin and catecholamines by
drugs, 14, 531
-, The mechanism of norepinephrine depletion byreserpine, merataminol, and related agents. The role
of monoamine oxidase, 18,561, See Brodie et al., 11, 548
Shuler, Charles F. See Latt et al., 30, 501
Silberstein, Stephen D. See Kipin and Silberstein, 24,245
Silvette, H., Hoff, E. C., Larson, P. 5., and Haag, H. B.
The actions of nicotine on central nervous systemfunctions, 14, 137
Simonis, A. M. See Ari#{235}nset al, 9, 218
Siskind, Gregory W. Manipulation of the immune
response, 25, 319
Sjoerdsma, Albert. Catecholamine metabolism in pa-
tients with pheochromocytoma, 11, 374-, Chairman. Section VII: Catecholamines and the
Circulatory System, 18,645-712
, Catecholamine-drug interactions in man, 18, 673
Sj#{246}qvist, Folke. See Norberg and Sjoqvist, 18, 743Skelton, C. Lynn. See Butler et al., 25, 239Slater, I. H., and Powell, C. E. Some aspects of block-
ade of inhibitory adrenergic receptors or adrenocep-
tive sites, a discussion, 11, 462
Smith, A. D. Subcellular localization of noradrenaline
in sympathetic neurons, 24, 435
Smith, Elizabeth R. B. See Weil-Maiherbe and Smith,18, 331
Smith, Paul K. Certain aspects of the pharmacology
of the salicylates, 1, 353, See China and Smith, P. K., 7,33
Smith, Thomas W., and Haber, Edgar. Digitalis. Chit-
ical value of the radioimmunoassay of the digitalis
glycosides, 25, 219Snyder, Solomon H. Report on the discussion of the
Second Session, 24, 291
Sokoloff, Louis. The action of drugs on the cerebralcirculation, 11, 1
Somlyo, A. P., and Somlyo, A. V. Vascular smoothmuscles. I. Normal structure, pathology, biochem-
640 AUTHOR INDEX, VOLUMES 1-30
istry, and biophysics, 20, 197
, and Somlyo, A. V. Vascular smooth muscle. II.
Pharmacology of normal and hypertensive vessels,22, 249
Somlyo, A. V. See Somlyo, A. P., and Somlyo, A. V.,
20, 197
, See Somlyo, A. P., and Somlyo, A. V., 22, 249
Soodak, M. See Maloof and Soodak, 15,43
Sourkes, Theodore L. Dopa decarboxylase: substrates,
coenzyme, inhibitors, 18, 53-, Influence of specific nutrients on catecholamine
synthesis and metabolism, 24, 349
Spaziani, Eugene. Accesory reproductive organs in
mammals: control of cell and tissue transport by sex
hormones, 27, 207Spector, Sydney. Inhibitors of endogenous catechol-
amine biosynthesis, 18, 599
, Chairman. Third Session, 25, 271-318
-, Berkowitz, Barry, Flynn, Edward J., and Peskar,
Bernard. Antibodies to morphine, barbiturates, and
serotonin, 25, 281
-, Taver, James, and Berkowitz, Barry. Effects of
drugs and physiological factors in the disposition ofcatecholamines in blood vessels, 24, 191
, See Brodie et al., 11, 548
Spector, W. G. Substances which affect capillarypermeability, 10, 475
Sperber, Ivar. Secretion of organic anions in the for-
mation of urine and bile, 11, 109
Steelman, Richard L. See Newberne et al., 30, 335
Steinberg, Daniel. Catecholamine stimulation of fatmobilization and its metabolic consequences, 18, 217
Steiner, Alton. Radioimmunoassay for the cyclic nu-cleotides, 25, 309
Stephens, Gwen. See Visscher et al., 8, 389
Sternlieb, Irmin. See Scheinberg and Sternlieb, 12,355
Stich, H. F., Whiting, R. F., Wei, L, and San, R. H. C.
DNA fragmentation and DNA repair of mammaliancells as an indicator for the complex interactions
between carcinogens and modulating factors, 30, 493
Stitzel, Robert E. The biological fate of reserpine, 28,179
Stj#{228}rne, Lennart. Storage particles in noradrenergic
tissues, 18, 425Stone, Clement A., and Porter, Curt C. Methyldopa
and adrenergic nerve function, 18, 569
Stoner, H. B. See Barnes and Stoner, 11, 211Storrie, V. M. See Vanderlaan and Storrie, 7,301
Sullivan, F. M. See Robson and Sullivan, 15, 169Sutherland, Earl W., and Rail, T. W. The relation of
adenosine-3’,5’-phosphate and phosphorylase to the
actions of catecholamines and other hormones, 12,
265
, and Robison, G. Alan. The role of cyclic 3’,5’-
AMP in responses to catecholamines and other hor-mones, 18, 145
, See Rall and Sutherland, Jr., 11, 464
Svedmyr, Nils. See Lundholm et al., 18,255Swartzwelder, Clyde. See Bueding and Swartzwelder,
9, 329
Tabor, Celia W. See Tabor, H., and Tabor, C. W., 16,245
Tabor, Herbert. Metabolic studies on histidine, hista-
mine, and related imidazoles, 6, 299
-, and Tabor, Celia W. Spermidine, spermine, and
related amines, 16, 245
Talalay, Paul. See Bueding et al., 30, 547
Talbott, John H. See Bishop and Talbott, 5, 231
Tang, A. H., and Morse, W. H. Termination of a
schedule complex associated with intravenous injec-tions of nalorphine in morphine-dependent rhesus
monkeys, 27, 407
Tarver, James. See Spector et al., 24, 191Taylor, Dermot B. Some basic aspects of the phar-
macology of synthetic curariform drugs, 3, 412Teich, Sylvia. See Lieberman and Teich, 5, 285
Tepperman, Helen M. See Tepperman, J., and Tep-
perman, H. M., 12, 301
Tepperman, Jay, and Tepperman, Helen M. Someeffects of hormones on cells and cell constituents,12, 301
Thoenen, Hans. Comparison between the effect ofneuronal activity and nerve growth factor on the
enzymes involved in the synthesis of norepinephrine,24, 255
Thron, C. D. Linearity and superposition in pharma-
cokinetics, 26, 3Titus, Elwood, and Dengler, Hans J. The mechanism
of uptake of norepinephrine, 18, 525
Toman, James E. P. Neuropharmacology of peripheral
nerve, 4, 168
�, and Davis, Jean P. The effects of drugs upon the
electrical activity of the brain, 1, 425Trautwein, W. Generation and conduction of impulses
in the heart as affected by drugs, 15, 277
Trendelenburg, U. Supersensitivity and subsensitivity
to sympathomimetic amities, 15, 225-, Mechanisms of supersensitivity and subsensitiv-
ity to sympathomimetic amines, 18, 629
, See Patil et al., 26, 323Truitt, Edward B., Jr. Biological disposition of tetra-
hydrocannabinols, 23, 273
Udenfriend, Sidney. Survey of chemical and physicalmethods for measuring catecholamines, 11, 252
, Tyrosine hydroxylase, 18, 43
, Molecular biology of the sympathetic nervoussystem, 24, 165
, See Dairman et al., 24, 266
-, See Hartman and Udenfriend, 24, 311
Umbreit, W. W. Mechanisms of antibacterial action,5, 275
Uvn#{228}s,B#{246}rje.Antidromic vasodilatation in the paw of
the cat, 6, 99
Vandam, Leroy D. See Bunker and Vandam, 17,183
Vanderlaan, W. P., and Storrie, V. M. A survey of the
factors controlling thyroid function, with especial
reference to newer views on antithyroid substances,
7, 301
Vande Wiele, R. L., and Dyrenfurth, I. Gonadotropin-
AUTHOR INDEX, VOLUMES 1-30 641
steroid interrelationships, 25, 189
van Dyke, H. B. See Maynert and van Dyke, 1, 217
Vane, J. R. The estimation of catecholamines by bio-
logical assay, 18, 317
Van#{232}#{233}ek,Ji�’I. See Ra�kov#{225} and Ven#{233}#{232}ek,16, 1
van Rossum, J. M. See Ari#{246}nset al., 9, 218van Ryzin, Robert J. See Newberne et al., 30, 335
Vaagi#{233}, V., and Krsti#{233}, M. Adrenergic activation by
anticholinesterases, 18, 799
Vatner, Stephen F. See Higgins et al., 25, 119
Vaughan, M., Chairman. Lipid Metabolism, Section
II: Metabolic Effects ofCatecholamines, 18,215-254
Introductory remarks, 215
Vaughan Williams, E. M. The mode of action of drugs
upon intestinal motility, 6, 159Veldstra, H. Synergism and potentiation with special
reference to the combination ofstructural analogues,
8, 339
Vesell, Elliot S. Intraspecies differences in frequency
of genes directly affecting drug disposition: the in-
dividual factor in drug response, 30, 555
Visscher, Maurice B., Haddy, Francis J., and Stephens,
Gwen. The physiology and pharmacology of lungedema, 8, 389
Viveros, 0. H. See Kirshner and Viveros, 24, 385Vogel, W. See Costa et aL, 18, 577
Vogt, Marthe. Norepinephrine and epinephrine in the
central nervous system, 6, 31
-, Points to be considered in running chromato-grams of tissue extracts, 11, 249
-, Catecholamines in brain, 11,483
, Chairman. Section III: Measurement and Detec-
tion ofCatecholamines and Related Compounds, 18,315-364; Introductory remarks, 315
Vogt, Walther. Darmstoff, a gut-stimulating com-pound occurring in the intestinal wall, 6, 117
-, Naturally occurring lipid-soluble acids of phar-macological interest, 10,407
-, Activation, activities, and pharmacologically ac-tive products of complement, 26, 125
Volle, Robert L. Modification by drugs of synaptic
mechanisms in autonomic ganglia, 18,839
-, Guest Editor. Conversations in pharmacology,29, 185
von Euler, Curt. Physiology and pharmacology of tern-
perature regulation, 13, 361von Euler, Ulf S. The nature of adrenergic nerve
mediators, 3, 247-, Adrenaline and noradrenalin. Distribution and
action, 6, 15-, The development and applications of the trihy-
droxyindole method for catecholamines, 11, 262-, Twenty years of noradrenaline, 18, 29-, Chairman. Section IV: Properties of Adrenergic
Tissues, 18, 365-458; Introductory remarks, 365
-, Chairman. Fourth Session: Hormonal Interac-tions, 24, 365-430
-, Regulation of catecholamine metabolism in thesympathetic nervous system, 24, 365
von Studnitz, Wilfred. Chemistry and pharmacologyof catecholamine-secreting tumors, 18,645
Wacker, Warren E. C. See Mordes and Wacker, 29,
273
Wailer, Coy W. Chemistry of marihuana, 23,265
Walop, J. N. The metabolism of acetylcholine, 6, 45
Wang, C. See Costa et al., 24, 167
Wang, S. C. See Borison and Wang, 5, 193
Waser, Peter G. Chemistry and pharmacology of mus-
carine, muscarone, and some related compounds, 13,465
Watkins, J. C. See Curtis and Watkins, 17,347
Watson, John F. See Butler et al., 25, 239
Waud, D. R. Pharmacological receptors, 20, 49
Way, E. Leong, Chairman. Marihuana and It’� Surro-
gates, Session I., 23, 263-336; Cannabis Prelude, 2R.�l-, and Adler, T. K. The pharmacologic implications
of the fate of morphine and its surrogates, J “, 383
Weatherall, M. Drugs and porphyrin metabolism, 6,133
Weber, Annemarie. See Hasselbach and Weber, 7, 97Wedner, H. James. See Bloom et al., 25, 343
Weeks, James R. See Bergstrom et aL, 20, 1W#{233}gria, Ren#{233}.Pharmacology of the coronary circula-
tion, 3, 197Wei, L. See Stich et al., 30, 493
Weil-Malherbe, H. The fluorimetric estimation of cat-echol compounds by the ethylenediamine conden-
sation method, 11, 278-, and Smith, Elizabeth R. B. The estimation of
metanephrine, normetanephrine, and 3,4-dihydrox-ymandelic acid in urine, 18, 331
Weiner, N., Cloutier, G., Bjur, R., and Pfeffer, R. I.Modification of norepinephrine synthesis in intacttissue by drugs and during short-term adrenergic
nerve stimulation, 24, 203Weisberger, Austin S. See Beard, Jr. et at., 21, 213Weisburger, Elizabeth K. See Weisburger, J. H., and
Weisburger, E. K., 25, 1Weisburger, John H., and Weisburger, Elizabeth K.
Biochemical formation and pharmacological, taxi-cological, and pathological properties of hydroxyl-
amines and hydroxamic acids, 25, 1Weiss, Bernard, and Laties, Victor G. Enhancement of
human performance by caffeine and the amphet-amines, 14, 1
, See Brodie et al., 18, 273
Welch, Arnold D., and Heinle, Robert W. Hematopoi-etic agents in macrocytic anemias, 3, 345
Welch, Richard M. Toxicological implications of drug
metabolism, 30,457West, G. B. The distribution and metabolism of adre-
nergic mediators, 6, 29Whiting, R. F. See Stich et al., 30, 493Whittaker, V. P. Catecholamine storage particles in
the central nervous system, 18,401Widdicombe, Jonathan H. See Paton et aL, 29, 67
Wieland, Otto. See Wieland, T., and Wieland, 0., 11,87
Wieland, Theodor, and Wieland, Otto. Chemistry andtoxicology of the toxins of Amanita phalloides, 11,87
Wilder, Abraham. Sites and mechanisms of action of
642 AUTHOR INDEX, VOLUMES 1-30
morphine and related drugs in the central nervous
system, 2, 435
Wilhelm, D. L The mediation of increased vascular
permeability in inflammation, 14,251Willbrandt, Walther, and Rosenberg, Thomas. The
concept of carrier transport and its corollaries in
pharmacology, 13, 109
Williams, William L See Jukes and Williams, 5,381Williamson, John R. Kinetic studies of epinephrine
effects in the perfused rat heart, 18,205Winterstein, Hans. The actions of substances intro-
duced into the cerebrospinal fluid and the problem
of intracranial chemoreceptors, 13, 71
Withrington, P. G. See Davies and Withrington, 25,
373
Wolf, Stewart. The pharmacology ofplacebos, 11,689
Wollenberger, Albert. The energy metabolism of the
failing heart and the metabolic action of the cardiacglycosides, 1, 311
Woodbury, Dixon M. Relation between the adrenal
cortex and the central nervous system, 10, 275Woods, J. H. See Downs and Woods, 27, 397
-, See Iglauer et al., 27, 367Woods, L A. The pharmacology of nalorphine (N-
allylnormorphine), 8, 175Wright, G. Payling. The neurotoxins of Clostridium
botulinum and Clostridium tetani, 7, 413Wright, Peter H. See Mayhew et al., 21, 183
Wurster, R. M. See Griffith et aL, 27, 357
Wurtman, R. J., Pohorecky, L A., and Baliga, B. S.Adrenocortical control of the biosynthesis of epi-
nephrine and proteins in the adrenal medulla, 24,411
-, See Pohorecky and Wurtman, 23, 1
Wuttke, W. See Hoffmeister and Wuttke, 27, 419
Yalow, Rosalyn S. Radioimmunoassay methodology:
application to problems of heterogeneity of peptidehormones, 25, 161
-, Chairman. First Session: Background-Theoret-
ical and Practical, 25, 161-214Yanagita, T. Some methodological problems in assess-
ing dependence-producing properties of drugs in an-
imals, 27, 503
Youdim, M. B. H. See Sandier and Youdim, 24, 331Youngblood, William W. See Kizer et al., 29, 301
Zaimis, Eleanor J. The interruption of neuromusculartransmission and some of its problems, 6, 53
-, See Paton and Zaimis, 4, 219Zbinden, G. Application of basic concepts to research
in toxicology, 30, 605
Zeller, E. A. The role ofamine oxidases in the destruc-
tion of catecholamines, 11, 387-, Summary ofdiscussion and commentary, 18, 141
643
0031-6997/79/3004-0643$02.O0/0PHARMACOLOGICAL REVIEWS
Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics
Subject Index
Pharmacological Reviews
Volumes 1-30
1949-1978
Vol. 30, No. 4Printed in USA.
Absorption
of drugs, from subcutaneous connective tissue, 13,441
Acetylcholine
-like substances, effect of, on sensory receptors, 6,
97
local hormone for ciiary movement and the heart,
6, 107
metabolism, 6, 45of nervous tissue, 6, 39
receptors, acetylcholinesterase and, accumulation at
newly formed nerve-muscle synapses, 30, 411related quaternary ammonium compounds and, ex-
citatory and anti-curare properties of, at the
neuromuscular junction, 5, 1transmission and, at chemoreceptors, 6, 79
Acetylcholinesterase, acetylcholine receptors and, ac-cumulation at newly formed nerve-muscle
synapses, 30, 411Acid. See specific name or type of acid
Addiction
analgesics and barbiturates, 2, 355
narcotic (man), experimental analysis of condition-
ing factors in, 27, 533
Adenosine-3’,5’-cycic monophosphate (cyclic AMP)and lipolytic effects of hormones on adipose tissue,
18, 237phosphorylase and, relation to actions of catechol-
amines and other hormones, 12, 265
role in actions of catecholamines, 24, 399
role in responses to catecholamines and other hor-
mones, 18, 145
Adenosine triphosphatase, Na� ,K�
pharmacological, physiological, and biochemical as-pects, 27, 3
role of, in the inotropic action of digitalis, 29, 1873’,5’-Adenylate
gluconeogenesis stimulation from lactate by, in per-
fused rat liver, 18, 181
Adipose tissue. See under Tissue(s)
Adrenal cortex and central nervous system, relation
between, 10, 275Adrenal medulla
adrenocortical control of biosynthesis of epineph-
rime and proteins in, 24, 411
glucose deprivation effects on sympathetic outflowto, 18, 303
mechanism of release of catecholamines from, 18,
471
nervous tissue and, role of L-dopa decaboxylase inthe biosynthesis ofcatecholamines in, 11, 317
secretory cycle in, 24, 385Adrenaline (See also Epinephrine)
metabolism of, 1, 1‘noradrenaline and
biosynthesis of, 11, 350
blockade of the actions of, 11, 443
in blood and urine, 6, 35metabolic products of, in human urine, 11, 416
Adrenergic activation by anticholinesterases, 18, 799
$-Adrenergic binding sites, isolated, potential assay
vehicle for catecholamines, 25, 259
Adrenergic blockade
in cardiovascular disease, 18, 701
pharmacology of, 1, 27
Adrenergic drugs. See under Drug(s)
Adrenergic endings and vesicles, isolated from brain,18,413
Adrenergic function and surgical sympathectomy, 18,
611
Adrenergic innervation of the oviduct, role in the
regulation ofmammalian ovum transport, 29,67
Adrenergic mediators
distribution and metabolism of, 6, 29
nature of, 3, 247Adrenergic modulation of ganglionic transmission,
new possibilities, 18, 743
Adrenergic nerve
function, methyldopa and, 18, 569
stimulation, modification of norepinephrine synthe-
sis during, 24, 203
Adrenergic neuron(s), interactions of drugs with, 18,577
Adrenergic receptorsadrenoceptive sites or, aspects of blockade of inhib-
itory, 11, 462
for epinephrine and norepinephrine, 11, 429, 441
pharmacological characterization of, 18, 503
Adrenergic synapse. See under SynapseAdrenoceptive sites or adrenergic receptors, blockade
of inhibitory, 11, 462Adrenochrome and 1-noradrenaline, action of, on un-
fatigued mammalian muscle, 6, 33
644 SUBJECT INDEX, VOLUMES 1-30
Adrenocortical control
of biosynthesis of epinephrine and proteins in ad-
renal medulla, 24, 411
of epinephrmne synthesis, 23, 1
Adrenocortical steroidsactivity of, chemical and biological factors in, 14,
317
role in infection, immunity, and hypersensitivity,
8, 1
Age-related changes in drug disposition, 30, 445
Aldosterone-renin-angiotensin, measurements of, 25,249
Alkaloids, pyrrolizidine (Senecio), toxic actions of, 22,429
Allergy, drug, 6, 365N-Allylnormorphine (nalorphine), pharmacology of, 8,
175
Amanita phalloides, toxins of, chemistry and toxicol-
ogyof, 11,87Amebiasis, chemotherapy of, 2, 399
Amidine derivatives, structure-activity relationships,14, 37
Amines
biogenic, and catecholamines, methylation reactions
in formation and metabolism of, 18, 95epinephrine-related, metabolic effects of, 8, 485spermidine, spermine, and related amines, 16, 245
See also Aromatic, Hydroxyl-, Plasma pressor, andSympathomimetic amines
Amine mechanisms in cerebral circulation, 28, 275Amine oxidase
amine metabolism and, 4, 415histaminase and, 18, 1163
role of, in the destruction ofcatecholamines, 11, 387Amino acids
neurotoxic, structurally related analogs and, 29,301related to y-aminobutyric acid, pharmacology of, 17,
347-y-Aminobutyric acid, pharmacology of amino acids
related to, 17, 347Amphetamines and caffeine, enhancement of human
performance by, 14, 1
Analeptics, 12, 447
Analgesicsbarbiturates and, addiction to, 2, 355clinical evaluation of morphine and its substitutes
as, 16, 47
Analogues. See Metabolite and Structural analogues
Anemias
hemolytic, drug-induced, 21, 73macrocytic, hematopoietic agents in, 3, 345
Anesthesiaeffects of, on metabolism and cellular functions, 17,
183
general, theories of, 2, 121mechanisms, role of inert gases in, 15, 97
Anesthetics and tranquilizers, membrane actions of,
24, 583
Angiotensin-aldosterone-renin, measurements of, 25, 249
effects on central nervous system, 25, 415pharmacology of, 26, 69
remit-, system, 17, 143Anions
effects of, on excitable cells, 16, 193organic, secretion of, in formation of urine and bile,
11, 109
Antagonisms
antagonists and, 9, 237metabolite, in bacteria, 9, 264
Antagonists
antagonisms and, 9, 237folic acid, in cancer chemotherapy, 14, 915-hydroxytryptamine, 13, 399
opioid, 19, 463sympathomimetic arnines and, actions on skeletal
muscle, 21, 27Anthelmintics, 9,329
effects of, and biochemical and physiological mech-anisms, relationships between, 18, 871
Antibacterial action, mechanisms of, 5, 275
Antibiotic action, mechanisms of, 15, 481
Antibiotics
inhibition of mammalian protein synthesis by, 21,213
nutritional effects of, 5, 381
pharmacology and toxicology of, 2, 1
Antibodies
physiological receptors and, role in cardiovascular
diagnosis, therapy, and research, 25, 215specific, reversal of pharmacological and toxic ef-
fects of cardiac glycosides by, 25, 239use of, to study cell structure and metabolism, 25,
343
Anticancer agents, physiological disposition of, 11, 743
Anticholinesterase drugs. See under Drug(s)Anticholinesterases
action of, on spinal reflexes following intraarterialinjection, 6, 49
adrenergic activation by, 18, 799Anticoagulant drugs. See under Drug(s)
Anticoagulant therapy, 13, 279Antidepressant compounds, imipramine and related,
clinical pharmacology of, 17, 101Antidromic vasodilatation in the paw of the cat, 6, 99Antifertility substances, 11, 135Antihistaminics, atropine, and antispasmodics, kinet-
ins of recovery from inhibition by, 9, 259
Antimitotic agents, new aspects of pharmacology of,
15, 449
Antioxidants and redox substances, influence on signs
of vitamin E deficiency, 9, 1
Antiprostaglandins, specificities and some applicationsof, antibodies to pharmacologically active
molecules, 25, 293
Antispasmodics, antihistaminics, and atropine, kinet-ics of recovery from inhibition by, 9, 259
Antithyroid substances, survey of factors controlling
thyroid function with especial reference to, 7,301
SUBJECT INDEX, VOLUMES 1-30 645
Aromatic amines, biochemical production of ferrihe-
moglobin-forming derivatives from, and
mechanisms of ferrihemoglobin formation,
18, 1091
Arrhythmias, cardiac. See Cardiac arrhythmias
Arsenosobenzenes, biological activity of, in relation totheir structure, 3, 107
Ascorbate and dopamine-,6-hydroxylase, 18, 61Assay, immunological. See Immunological assay
Atropineantihistaminics, antispasmodics, and, kinetics of re-
covery from inhibition by, 9, 259related compounds and, behavioral and electroen-
cephalographic effects of, 18, 965
use and limitations of, for pharmacological studieson autonomic effectors, 7, 467
Auditory system, peripheral. See Peripheral auditory
system
Autonomic drugs. See under Drug(s)Autonomic effectors, use and limitations of atropine
for pharmacological studies on, 7, 467Autonomic ganglia
synaptic mechanisms in, modification by drugs, 18,
839
transmission and block in, 6, 59Autonomic innervation of visceral and cardiovascular
systems in vertebrates, evolution of, 21, 247Autonomic nervous control of reproduction, circula-
tory, and other factors, 24, 657Autonomic neuroeffector transmission and transmit-
ter reactivity in embryonic and fetal hearts,
ontogenetic development of, 29, 3
Bacteria
metabolite antagonisms in, 9, 264
toxins of, pharmacology of, 16, 1
Bacterial pyrogens, 9, 427Barbiturates
analgesics and, addiction to, 2, 355metabolism of, 1, 217morphine, serotonin, and, antibodies to, 25,281
Behavior
control of by consequent drug injections, 27, 301
controlled by scheduled injections of drugs, chaac-teristics of, 27, 307
drug-taking, control of by schedules of reinforce-
ment, 27, 291
electroencephalography and, effects of atropine andrelated compounds on, 18, 965
stimuli associated with drug injections as events
that control, 27, 325Bile and urine, secretion oforganic anions in formation
of, 11, 109
Bioassay procedures for catecholamines, 11, 241
Bioassays and mathematics, 5, 87Biological activity, ionization, and pH, 4, 136
Biosynthesis of prostaglandin, inhibition by drugs, 26,33
Bis(2-haloethyl) amines and suiphides, pharmacology
of, 2, 281
Blockade, adrenergic. See Adrenergic blockade
Blocking ag��nts, ganglionic. See Ganglionic blockingagents
Bloodand tissue changes, induced by norepinephrine-
stimulated mobilization of free fatty acid, 18,241
coagulation and related phenomena, influence of
certain drugs on, 3, 278
urine andadrenaline and noradrenaline in, 6, 35catecholamine assays, spectrophotofluorimetric
observatins on, 11, 296Blood-brain barrier, monoaminergic, localization of
mechanisms, 18, 369
Blood vessels
capsule and, of the spleen, drug action on smoothmuscle of, 25, 373
catecholamines in, effects ofdrugs and physiological
factors in disposition of, 24, 191
Body temperature, actions of monoamines, pyrogens,
and cations on central control of, 26, 289
Brain
adrenergic endings and vesicles isolated from, 18,413
catecholamines in, 11, 483
electrical activity of, effects of drugs upon, 1, 425interaction of drugs with norepinephrine in, 11, 548rat, effects ofdrugs on disposition of H3-norepineph-
rine in, 18, 775
Brain dopamine, possible role of, 18, 769Brain function and dopamine (3-hydroxytyramine),
18, 925Brain-stem reticular formation, drug action on, 14, 175
Caffeine and amphetamines, enhancement of humanperformance by, 14, 1
Calcium
and the relaxant effect of isoproterenol in depolar-
ized rat uterus, 18, 495role of
in the receptor regulation of membrane permea-
bility, 30, 209in release of neurotransmitter substances and hor-
mones, 22, 389-sodium interactions in mnmmRlian smooth muscle,
30, 167Calcium indicators, biological, photoproteins as, 28, 1
Calcium ions, role of, in neural processes, 6, 243
Canceranti-, agents, physiological disposition of, 11, 743chemotherapy, folic acid antagonists in, 14, 91immunotherapy, 25, 325
Cannabis, dose-response relationships to, in human
subjects, 23, 339Cannabis prelude, 23, 263
Capillary permeability, substances which affect, 10,475
Carbon monoxide, 2,324Carbon tetrachloride, hepatotoxicity, 19, 145
646 SUBJECT INDEX, VOLUMES 1-30
cholinesterases and, demonstration of, in the same
section, 18, 353stores, pharmacological depletion of, 18, 541
symposium on, 11, 233-566
Carbonic anhydrase inhibitors, 8, 137Carcinogenesis, chemical, mechanisms of, nature of
proximate carcinogens, and interactions withmacromolecules, 18, 805
Carcinogens
modulating factors and, DNA fragmentation andDNA repair of mammalian cells as indicators
for complex interactions between, 30, 493
proximate, nature of, and interactions with macro-molecules, 18, 805
Cardiac arrhythmias
experimental, and quinidine-like drugs, 4, 43ionic mechanism in heart muscle in relation to the
genesis and the pharmacological control of,30, 5
Cardiac glycosides
action ofcellular basis of, 11, 173on ion movements, 16, 381
metabolic action of, and energy metabolism of fail-
ing heart, 1, 311
reversal of pharmacological and toxic effects of, byspecific antibodies, 25,239
subcellular basis for mechanism of inotropic actionof, 23, 193
Cardiovascular and renal actions of dopamine, poten-tin! clinical applications, 24, 1
Cardiovascular diagnosis, therapy, and research, roleof antibodies and physiological receptors in,25, 215
Cardiovascular disease, adrenergic blockade in, 18, 701Cardiovascular effects of monoamine oxidase inhibi-
tore, 18, 705Cardiovascular and visceral system, evolution of au-
tonomic innervation of, in vertebrates, 21,247
Canes-inhibiting agents, 11, 705Carotid body and sinus, action of drugs on, 7, 119
Carrier transport and its corollaries in pharmacology,concept of, 13, 109
Cat, antidromic vasodilatation in paw of, 6, 99Catechol compounds, fluorimetric estimation of, by
ethylenedismine condensation method, 11,
278
Catechol-O-methyl transferase, pharmacological as-pacts and physiological role, 27, 135
Catecholamine
assays
blood and urine, spectrophotofluorimetric obser-vations on, 11, 296
newer developments, 18, 325
behavioural and electrophysiological effects of, 18,753
bioassay procedures, 11, 241
biosynthesis of, in insects, 18,89central actions of, 11, 565chemical and physical methods for measuring, 11,
252
development and applications of the trihydroxyin-dole method for, 11, 262
-drug interactions in man, 18, 673effects of, on the central nervous system, 11, 494
endogenous, inhibitors of biosynthesis, 18, 599
estimation of, by biological assay, 18, 317
fluorescence microscopy of, methodology, 18, 351formation
development of current concepts of, 11, 307in intact tissues, 11, 358
hypertension and, 18, 667in blood vessels, effects of drugs and physiological
factors in the disposition of, 24, 191
in brain, 11, 483in nervous tissue and the adrenal medulla, role of L-
dopa decarboxylase in biosynthesis of, 11,317
in neuropsychiatric states, 18, 787
in the nervous system, occurrence, distribution, and
physiological role of, 11, 490
influence on heart function and phosphorylase ac-tivity, 18, 197
interactions with enzymes and receptors, steric ef-
fects in, 18, 131
interrelationships with other endocrine systems, 18,
273
isolated $-adrenergic binding sites, a potential assay
vehicle for, 25, 259
mechanisms for termination of the physiologicalactions of, 11, 381
mechanism of release from adrenal medulla, 18, 471metabolism
in patients with pheochromocytoma, 11, 374in vivo and in vitro, 11, 402regulation of, in the sympathetic nervous system,
24, 365
other biogenic amines and, methylation reactions information and metabolism of, 18, 95
other hormones andrelation of adenosine-3’,5’-phosphate and phos-
phorylase to actions of, 12, 265
role of cyclic 3’,5’-AMP in responses to, 18, 145
-producing neural tumors other than pheochromo-cytoma, 18, 659
role, in cold adaptation, 18, 291
role ofadenosine 3’,5’-monophosphate in actions of,24, 399
role of amine oxidases in the destruction of, 11, 387role of monoamine oxidase in storage and metabo-
ham of, 16, 179
-secreting tumors, chemistry and pharmacology of,18, 645
serotonin and, release of, by drugs, 14, 531stimulation of fat mobilization and its metabolic
consequences, 18, 217storage and release of, 11, 361storage particles in the central nervous system, 18,
401
SUBJECT INDEX, VOLUMES 1-30 647
symposium on (second), 18, 1-804
synthesis and degradation, immunological tech-niques applied to study of enzymes regulat-ing, 24, 311
synthesis and metabolism, influence of specific nu-
trients on, 24,349-synthesizing enzymes, characterization and tissue
localization of, 24, 293
turnover, regulation by variation of enzyme levels,24, 225
Cations, monoamines, and pyrogens, actions on central
control of body temperature, 26, 289
Cell(s)action potential and excitation, 10, 165
cell constituents and, effects of hormones on, 12,301
excitable
effects of anions on, 16, 193electrochemical aspects ofphysiological and phar-
macological action in, 10, 59, 165insulin-secreting, drugs producing diabetes through
damage of, 22, 485
intercellular communication, gap junction dynamics
and, 30, 383mammalian, DNA fragmentation and DNA repair
of, indicators for the complex interactionsbetween carcinogens and modulating factors,
30, 493mast, pharmacology and functions of, 7, 267
microbial and mammalian, application to assess-
ment of mutagenicity, 30, 537resting, and its alteration by extrinsic factors, 10,59
Cell constituents and cells, effects of hormones on, 12,301
Cell membrane, hormone-receptor interactions at, 30,393
Cell nucleus, steroid hormone interaction with, 30, 477
Cell preparationsbroken, action of epinephrine and norepinephrine
in, 11, 464
broken and intact, from liver fluke Fasciola hepa-twa, actions of serotonin and epinephrmne on,11,465
Cell protoplasm, contraction of muscle and, models
for study of, 7, 97
Cell structure and metabolism, use of antibodies tostudy, 25, 343
Cell transport, control in mammals by sex hormones,
27, 207Cellular functions and metabolism, effects of anesthe-
sin on, 17, 183
Central nervous system
actions of nicotine on functions of, 14, 137actions of some synthetic tetrahydrocannabinol de-
rivatives, 23, 317adrenal cortex and, relation between, 10, 275angiotensin effects on, 25, 415catecholamine storage particles in, 18, 401
drug-induced alterations of ion distribution at the
cellular level of, 29, 35
effects of catecholamines on, 11, 494
metabolism of epinephrine in, 18, 1201
norepinephrine and epinephrine in, 6, 31regulation of monoamine metabolism in, 24, 371
sites and mechanism of action of morphine and
related drugs in, 2,435
Central neurons containing dopamine, noradrenaline,
and 5-hydroxytryptamine, demonstration
and mapping of, and their reactions to psy-
chopharmaca, 18, 727Central transmission
ganglionic and, 6, 105
sensory and, 6, 85, 95, 103Cephalosporins, 14, 473
Cerebral circulationaction of drugs on, 11, 1
amine mechanisms in, 28, 275Cerebrospinal fluid, actions of substances introduced
into, and the problem of intracranial chemo-
receptors, 13, 71
Chelation as mechanism of pharmacological action, 8,
57
Chemical carcinogenesis. See under Carcinogenesis
Chemical protection and ionizing radiation, in mars-
mals, pharmacological aspects of, 10, 437Chemoreceptors
acetylcholine and transmission at, 6, 79chemical transmission at, 6, 81intracranial, problem of, and the actions of sub-
stances introduced into cerebrospinal fluid,
13, 71
transmission at, 6, 73
Chemotherapeutic agents, dosage schedule of, 4, 85
Chemotherapy
amebiasis, 2, 399
cancer, folic acid antagonists in, 14, 91ifianal infections, 7, 179
leprosy, 10, 1tuberculosis, wider aspects of, 5, 421viral diseases, 15, 407
advances in, 19, 209
influence of dietary, hormonal, and other factors,
8, 199
Chiorpromazine and endocrine function, 19, 251Cholestasis, intrahepatic, induced by drugs and chem-
icals, 28, 207Choline esters as local hormones, 6, 113Cholinergic drugs. See under Drug(s)
Cholinergic systems in non-nervous tissues, 30,65
Cholinesterases
catecholamines and, demonstration of, in the same
section, 18, 353drugs, anti-. See under Drug(s)
hydrophobic areas on active surface of, 22, 355inhibitors, organophosphorus, pharmacology of, 11,
567
localization of specific, in the retina, 6, 47Cholinoreceptors of locomotor muscles, mutual dis-
position of, and changes in their dispositionin the course of evolution, 18, 1051
648 SUBJECT INDEX, VOLUMES 1-30
Chromaffin tissue, 18, 453Chromatid exchange, sister, in vitro and in vivo anal-
ysis of, 30, 501
Chromatograms, running, of tissue extracts, points to
be considered, 11, 249
Chromosomes, eukaryotic. See Eukaryotic chromo-
somes
Ciliary movement and heart, acetylcholine as local
hormone for, 6, 107
Circulation. See Cerebral, Coronary, Peripheral, and
Pulmonary circulation
Clostridium botulinum, and Cl. tetani, neurotoxins of,
7,413
Clostridium tetani� Cl. botulinum and, neurotoxans of,
7,413
Coagulant, anti-, therapy, 13, 279Cocaine injection, concurrent schedules of, in rhesus
monkeys, dose variations under independent
and dependent variable-interval procedures,27, 367
Coenzymes
dopa decarboxylase, 18, 53hydroxylases and, ascorbate and dopamine-/3-
hydroxylase, tetrahydropteridines and phen-ylalanine and tyrosine hydroxylases, 18, 61
Cold adaptation, role of catecholamines in, 18, 291
Complement activation, activities and pharmacologi-cally active products of, 26, 125
COMT. See Catechol-O-methyl transferase
Connective tissue. See wider Tissue
Conversations in pharmacology, 29, 185-247
Copper metabolism, 12, 355Coronary circulation, pharmacology of, 3, 197Corticosteroids, hepatic and extrahepatic regulation
of, 13, 329
Cough, pathophysiology and pharmacology of, 9, 43Curariform drugs. See under Drug(s)
Cyclic nucleotides, radioimmunoassay for, 25, 309
Darmstoff, gut-stimulating compound occurring in the
inte8tinal wall, 6, 117Decarboxylase, dope. See Dope decarboxylase
Denervation, pharmacological, supersensitivity fol-lowing, 13, 17
Deoxyribonucleic acidfragmentation and repair of mammalian cells as
indicators for complex interactions between
carcinogens and modulating factors, 30, 493
in eukaryotic chromosomes, levels of organization
of, 30, 469of eukaryotic cells, effects of incorporation of 5-
halogenated deoxyuridines into, 29,249
Deoxyuridines. 5-Halogenated. See 5-Halogenateddeoxyuridines
Diabetes, drugs producing, through damage of insulinsecreting cells, 22, 485
Diabetes mellitus, oral treatment of, 12,91a,w-Dicarboxylic acids, related substances and, dicho-
linesters of, 8, 265
Dicholinesters of a,w-dicarboxylic acids and related
substances, 8, 265
Dietary interrelationship and mechanism of action ofhepatotoxic agents, 4, 1
Digitalis, role of Na�,K�-ATPase in the inotropic ac-
tion of, 29, 187Digitalis glycosides, radioimmunoassay of, clinical
value, 25, 219
Digoxin tablets, bioavailability of, 25, 229
3,4-Dihydroxymandelic acid in urine, estimation of,
18, 331Dihydroxyphenylalkylamines, epinephrine-related,
pharmacological activity of, 1, 279
Diuretics
mechanism of action and therapeutic use of, 2, 161
mercurial, site and mechanism of action of, 20, 89physiological basis for action of, 13, 517
DNA. See Deoxyribonucleic acidDope decaboxylase
substrates, coenzyme, inhibitors, 18, 53tyrosine hydroxylase and, changes induced by phar-
macological agents, 24, 269
L-Dopa decarboxylasein vitro and in vivo, studies on inhibition of, 11, 330role in biosynthesis of catecholamines in nervous
tissue and the adrenal medulla, 11, 317
Dopamine
brain, possible role of, 18, 769cardiovascular and renal actions of, potential clinical
applications, 24, 1
detection and assay of, 11, 3006-hydroxy-. See 6-Hydroxydopamine
noradrenaline, 5-hydroxytryptamine and, demon-stration and mapping of central neurons con-
taming, and their reactions to psychophar-maca, 18, 727
norepinephrine and, in noradrenergic axons, precur-
sor product relationship study by mass frag-
mentography and radiochemistry, 24, 167Dopamine-$-hydroxylase, 17, 71
ascorbate and, 18, 61regulation of its synthesis and release from nerve
terminals, 24, 233
serum, 30, 133
Dopamine-f3-hydroxylation stage, norepinephrmne bio-synthesis inhibition at, 18, 77
Dopamine (3-hydroxytyramine) and brain function,
18, 925
Drug(s)absorption of, from subcutaneous connective tissue,
13, 441
abuse, human, behavioral factors in, 27,499action
membrane lipids and, 19,59molecular basis of, 19, 107on brain-stem reticular formation, 14, 175on carotid body and sinus, 7, 119
on cerebral circulation, 11, 1on intestinal motility, 6, 159
on myocardial contractility, physical factors in
analysis of, 15, 531
SUBJECT INDEX, VOLUMES 1-30 649
-taking behavior, control by schedules of reinforce-
on smooth muscle of the capsule and blood vesselsof the spleen, 25, 373
on spermatogenesis, biochemical aspects of, 19,21
uncoupling of oxidative phosphorylation as a
mechanism of, 7, 335
addiction (human), experimental analysis of condi-
tioning factors in, 27, 533
adrenergic, activity of, molecular geometry and, 26,323
allergy, 6, 365antagonism
nonequiibrium, 9, 246
pA1 and, 9, 242theories of, 9, 211
anticholinesterase, 1, 166
anticoagulant, oral, determinants of the response to,
in man, 22, 35
antischistosomal and other, protection from muta-genic effects of, 30, 547
antituberculosis, 15, 169assessment of dependence producing properties in
annuals, methodological problems in, 27, 503
autonomic, actions of, on phosphorylase activity andfunction, 17, 27
catecholamine-, interactions in man, 18, 673chemicals and, intrahepatic cholestasis induced by,
28, 207cholinergic, actions on motor nerve terminals, 29,
221
consequent injections, control of behavior by, 27,
301
curariform, synthetic, basic aspects of pharmacology
of, 3, 412depressant, action on spinal cord, 1, 243
disposition, age-related changes in, 30, 445
disturbances of liver porphyrin metabolism caused
by, 19, 523effects, and concurrent performances, 27, 385effects of
and physiological factors in the disposition ofcatecholamines in blood vessels, 24, 191
on electrical activity of the brain, 1, 425
on enzyme systems, 8, 89on the disposition of H3-norepinephrine in rat
brain, 18, 775on the foetus, 12, 37on the mobilization of free fatty acid, 18, 243
on vertebrate mechanoreceptors, 16, 341
experimental self-administration (human), method-
ology and application to study of sedativeabuse, 27, 523
heart impulses affected by, 15, 277
hormone and, action on adipose tissue, biochemical
aspects of, 25, 67
hypertension treatment, 5, 135
immunological assay of, 29, 103
immunosuppressive, 22, 189
-induced alterations of ion distribution at the cellu-lar level of the central nervous system, 29,35
-induced hemolytic anemia, 21, 73-induced lysosomal lipidosis, biochemical interpre-
tations, 30, 593influence of, on blood coagulation and related phe-
nomena, 3, 278influence of previous experience, expectation, and
setting on maihuana-induced “high”, 23,359
injection
complex schedules of, 27, 341
negative reinforcers, 27, 437
schedules of termination of, 27, 395
stimuli associated with, as events that control
behavior, 27, 325interactions,
affmity, intrinsic activity, and, 9, 218with adrenergic neurons, 18, 577
with norepinephrine in the brain, 11, 548intermediary metabolism of thyroid tissue and ac-
tion of, 15, 43intraspecies differences in frequency of genes di-
rectly affecting disposition of, individual fac-tor in drug response, 30, 555
metabolism, toxicological implications of, 30, 457-metabolizing enzyme system, role of nutrition in,
26, 171
modification of norepinephrine synthesis in intacttissue by, 24, 203
motion sickness, use in, 18, 895non-opiate psychotropic, tolerance to and depen-
dence on, 23, 135oral intake of, schedule-induced polydipsia and, 27,
447, 489passage of, across body membranes, 14, 501
plasma proteins and, interactions of, 1, 102
porphyrin metabolism and, 6, 133
preference in rhesus monkeys, pharmacological andenvironmental variables affecting, 27, 343
producing diabetes through damage of insulin se-creting cells, 22, 485
prostaglandin biosynthesis inhibition by, 26,33protein conjugates, principles and methods for prep-
aration of, for immunological studies, 25, 271psychotomimetic, biochemical aspects ofthe actions
of, 17, 1
psychotropic, as negative reinforcers, 27, 419quinidine-like, experimental cardiac arrhythmias
and, 4, 43reinforcers in monkey and man, 27, 511
release of serotonin and catecholamines by, 14, 531response, individual factor in, 30, 555
response of liver to, morphometric analysis in as-sessment of, 30, 429
scheduled injections of, characteristics of behavior
controlled by, 27, 307
sleep and, 20, 273synaptic mechanisms in autonornic ganglia, modifi-
cation by, 18, 839systemic, inhibition ofkeratinizing structures by, 15,
653
SUBJECT INDEX, VOLUMES 1-30
electrolytes, plasma proteins and, role in experimen-
650
Drugs-continued
ment, 27, 291
techniques and results of studies of self-adininistra-
tion of, use in other areas of psychobiology,
27, 545
Edema, lung, physiology and pharmacology of, 8, 389Electrical activity of brain, effects of drugs upon, 1,
425
ncephalography and behavior, effects of atro-pine and related compounds on, 18, 965
Electrolytesfluids, plasma proteins and, role in experimental
traumatic shock and hemorrhage, 6, 489
smooth muscle contraction and, 16, 85
Electron microscopy of sympathetic tissues, 18, 387Endocrine function and chlorpromazine, 19,251Endocrine systems, interrelationships of catechol-
amines with other, 18, 273Endoperoxides, prostaglandin. See under Prostaglan-
din(s)
Enzyme(s)catecholamine-synthesizing, characterization and
tissue localization of, 24, 293
involved in synthesis of norepinephrine, effect ofneuronal activity and nerve growth factor on,24, 255
levels, regulation of catecholamine turnover by var-iations of, 24, 225
microsomal, pharmacological implications in induc-
tion of, 19, 317receptors and, steric effects in catecholamine inter-
actions with, 18, 131regulating catecholamine synthesis and degradation,
immunological techniques applied to study
of, 24, 311
transport of, in viva, by axons of sympathetic neu-rons, 24, 245
Enzyme systems
drug-metabolizing, role of nutrition in, 26, 171
effects of drugs on, 8,89Enzyme treatment, pre- and postnatal pathology, and
unresolved issues in five lysosomal disorders,
30, 593Enzymic studies on the mechanism of double hydrox-
ylation, 18, 71
Epinephrine
effects in perfused rat heart, kinetic studies, 18,205excretion and metabolism of, 11, 409gluconeogenesis stimulation from lactate by, in per-
fused rat liver, 18, 181glycolysis activation in frog sartorius muscle by, 18,
189
norepinephrine and
action of, in broken cell preparations, 11, 464
adrenergic receptors for, 11, 429,441
distribution and action, 6, 15estimation of concentrations of in human plasma,
by the trihydroxyindole method, 11, 273in the central nervous system, 6, 31
in tissues, technique involving solvent extractionfor estimation of, 11, 276
metabolism of, 6, 233-methoxy-4-hydroxy-D-mandelic acid, a urinary
metabolite, formation of, 11, 394
proteins and, in the adrenal medulla, adrenocorticalcontrol of the biosynthesis of, 24, 411
related amines and, metabolic effects of, 8, 485related dihydroxyphenylalkylamines and, pharma-
cological activity of, 1, 279relation of biochemical effects of, to its muscular
effects, 11, 469serotonin and, actions of, on intact and broken cell
preparations from the liver fluke, Fasciola
hepatica, 11,465synthesis, adrenocortical control of, 23, 1
Erythropoietin pharmacology, biogenesis, and controlof production, 24, 459
Ethanol
metabolism, 4, 107and its metabolic effects, 24,67
positive reinforcer, function of schedule-inducedpolydipsia in, 27, 465
schedule-induced physical dependence on, 27, 449
Ethylenediamine condensation method, fluorimetric
estimation ofcatechol compounds by, 11, 278
Ethylenediamine method ofWeil-Malherbe and Bone,
suitability of and modifications for quantitat-
ing plasma presser amines, 11, 289
Eukaryotic cells, effects of incorporation of 5-halo-genated deoxyuridines into the DNA of, 29,249
Eukar.yotic chromosomes, DNA in, levels of organi-zation of, 30, 469
Excitation-contraction coupling in skeletal muscle, 17,165
Excitation phenomena, tetrodotoxin and saxitoxin, sig-nificance in the study of excitation phenom-
ens, 18, 997Excretion
metabolism and, of epinephrine, 11, 409renal tubular, of organic bases, 12, 1
Expectorants and respiratory tract fluid, 6, 521
Fasciola hepatica, actions of serotonin and epineph-rime on intact and broken cell preparations
from 11, 465Fat mobilization, and its metabolic consequences,
catecholamine stimulation of, 18, 217Fat transport and heparin (clearing factor lipase), 12,
241
Fatty acid, free. See Free fatty acid
Ferrihemoglobin formation, mechanisms of, the bio-chemical production of ferrihemoglobin-
forming derivatives from aromatic amines,
18, 1091
Fertility, anti-, substances, 11, 135
Filanal infections, chemotherapy of, 7, 279
Fluid(s)
SUBJECT INDEX, VOLUMES 1-30 651
tel traumatic shock and hemorrhage, 6, 489
respiratory tract, and expectorants, 6, 521
Fluorescence and its measurement, 11, 256
Fluorescense microscopy of catecholamines, method-ology, 18, 351
Foetus, effects of drugs on, 12, 37
Folic acid antagonists in cancer chemotherapy, 14, 91
Food and heroin, effects of naloxone and methodone
on choice between, 27, 357
Free fatty acidblood and tissue changes induced by norepineph-
rime-stimulated mobilization of, 18, 241
effect of drugs on mobilization of, 18, 243
Frog sartorius muscle, glycolysis activation in, by epi-
nephrine, 18, 189
Ganglia. See Autoziomic and Sympathetic ganglia
Ganglionic blocking agents, 2, 61Ganglionic synapse. See under SynapseGanglionic transmission
adrenergic modulation of, new possibilities, 18, 743
central and, 6, 105
Gap junction dynamics and intercellular j�ommunica-tion, 30, 393
Gas, inert See Inert gas
Gastric secretion, inhibition of, 3, 59
Gastrointestinal microorganisms, metabolism of for-eign compounds by, 25, 451
Genes directly affecting drug disposition, intraspeciesdifferences in frequency of, 30, 555
Glucagon, gluconeogenesis stimulation from lactateby, in perfused rat liver, 18, 181
Gluconeogenesis stimulation from lactate by epineph-rime, glucagon, and cyclic 3’,5’-adenylate in
perfused rat liver, 18, 181Glucose deprivation, effects on sympathetic outflow to
adrenal medulla and adipose tissue, 18, 303
Glycolysis, activation of, in frog sartorius muscle byepinephrine, 18, 189
Glycoside(s). See Cardiac and Digitalis glycoside(s)Gonadotropin-steroid interrelationships, 25, 189
Growth hormone. See under Hormone(s)Gut-stimulating compound, Darmstoff, occurring in
intestinal wall, 6, 117
Hallucinogens, pharmacology of, 24, 315-Halogenated deoxyuridines, effects of incorporation
of, into the DNA of eukaryotic cells, 29, 249
Halogenation, pharmacophoric effect, mechanisms of,
15, 673
Heart
ciliary movement and, acetylcholine as local hor-mone for, 6, 107
drug action on myocardial contractility, physicalfactors in analysis of, 15, 531
drug effects on generation and conduction of im-pulses, 15, 277
embryonic and fetal, ontogenetic development of
autonomic neuroeffector transmission andtransmitter reactivity in, 29, 3
failing, energy metabolism of, and metabolic action
of cardiac glycosides, 1, 311
failure, congestive, sympathetic activity and neuro-transmitter depletion in, 18, 685
muscle. See under Muscle
myocardial contractility, influence of interval be-
tween beats on, 15,601parasympathetic control of, 25, 119phosphorylase activity and, catecholamine influence
on function of, 18, 197
ratisolated, effect of sympathomimetic amines on
phosphorylase activity of, 11, 466
perfused, kinetic studies of epinephrine effects,18, 205
Heavy metals. See Metals
Hematopoietic agents in macrocytic anemias, 3, 345
Hemorrhage and experimental traumatic shock, role
offluids, electrolytes, and plasma proteins in,6,489
Heparin and fat transport, 12, 241
Hepatic and extrahepatic regulation of corticosteroids,
13, 329
Hepatotoxic agents, mechanism of action and dietary
interrelationship, 4, 1Hepatotoxicity of carbon tetrachloride, 19, 145
Herbicides, toxicology of, 14, 225Heroin and food, naloxone and methadone effects on
choice between, 27, 357Histamine
histidine, and related imidazoles, metabolic studieson, 6, 299
place of, in neurohumoral transmission, 6, 119release by compounds of simple chemical structure,
9, 269Histaminase and related amine oxidases, 18,1163Histidine, histamine, and related imidazoles, metabolic
studies on, 6, 299Histochemistry, a review, 7,83
Homovanilhic acid, measurement of, 18, 343Hormone(s)
catecholamines and, relation of adenosine-3’,5’-phosphate and phosphorylase to actions of,
12, 265
cyclic 3’,5’-AMP and the lipolytic effects of, onadipose tissue, 18, 237
drug and, action on adipose tissue, biochemical as-pects of, 25, 67
effects of, on cells and cell constituents, 12, 301
growth, and tissue receptors, application of radiore-ceptor assay to, 25, 179
localacetylcholine for ciliary movement and the heart,
6, 107choline esters as, 6, 113
neurohypophysial, 13, 225neurotransmitter substances and, role of calcium in
the release of, 22, 389peptide
and their analogues, distribution, clearance from
652 SUBJECT INDEX, VOLUMES 1-30
Hormone(s)-continuedcirculation, and inactivation in vivo, 30, 247
radioimmunoassay methodology applied to het-
erogeneity of, 25, 161-receptor interactions at the cell membrane, 30, 393role of cyclic 3’,5’-AMP in responses to, 18, 145
sex, control of, cell and tissue transport in mammals,27, 207
steroid
biochemistry of, recent trends in, 5, 285
interaction of with the nucleus, 30, 477tumor growth regulation by, 9,367
Human performance, enhancement of, by caffeine andamphetamines, 14, 1
Human plasma. See under Plasma
Hunger and thirst, physiological and pharmacological
aspects of control of, 13, 1Hydrophobic areas on the active surface of cholines-
terases, 22, 355
Hydroxamic acids, and hydroxyl amines, biochemicalformation and pharmacological, toxicological,
and pathological properties of, 25, 16-Hydroxydopamine, pharmacological actions of, 26,
199
Hydroxylamines and hydroxamic acids, biochemicalformation and pharmacological, toxicological,
and pathological properties of, 25, 1Hydroxylases and coenzymes, ascorbate and dopa-
mine-f3-hydroxylase, tetrahydropteridinesand phenylaline and tyrosine hydroxylases,18, 61
dopamine-fl-. See Dopamine-fl-hydroxylase
tyrosine. See Tyrosine hydroxylase
Hydroxylation, double, enzymic studies on mechanism
of, 18, 71
4-Hydoxy-3-methoxymandelic acid, measurement of,
18, 343
3-Hydroxytyramine (dopamine) and brain function,18, 925
5-Hydroxytryptamine
antagonists, 13, 399dopamine, noradrenaline, and, demonstration and
mapping of central neurons containing, and
their reactions to psychopharmaca, 18, 727
Hypersensitivity, infection, and immunity, role of ad-renocortical steroids in, 8, 1
Hypertensioncatecholamines and, 18,667drug treatment of, 5, 135
Hypertensin and renin, pharmacology of, 8, 25Hypoglycin and hypoglycin-like compounds, 21, 105
Imidazoles, histadine- and histamine-related mets-bohc studies, 6, 299
Imipramine and related antidepressant compounds,clinical pharmacology of, 17, 101
Immune response
clinical suppression of, 15, 365
manipulation of, 25, 319Immunity, infection, and hypersensitivity, role of ad-
renocortical steroids in, 8, 1
Immunological assay of drugs, 29, 103Immunological techniques, application to study of en-
zymes regulating catecholamine synthesisand degradation, 24, 311
Immunopharmacology, symposium on, 25, 157-363
Immunosuppressive drugs. See under Drug(s)
Immunosympathectomy, 18, 619
Immunotherapy of cancer, 25, 325Impulses, heart, drug effect on, 15, 277
Indicators, biological calcium, photoproteins as, 28, 1Indolealkylamines, pharmacology of, 6, 425
Indole derivatives of pineal and related neural andretinal tissues, 17, 321
Inert gas
exchange of, at lungs and tissues, theory and appli-
cations of, 3, 1role in anesthesia mechanisms, 15, 97
Infection, immunity, and hypersensitivity, role of ad-renocortical steroids in, 8, 1
Inflammation, mediation of increased vascular perme-
ability in, 14, 251
Inhibition
by antihistaminics, atropine, and antispasmodics,
kinetics of recovery from, 9, 259
central and peripheral, pharmacology of, 15, 333
L-dOpa decarboxylase in vitro and in vivo, studies
on, 11, 330keratinizing structures by systemic drugs, 15, 653
mammalian protein synthesis, by antibiotics, 21, 213norepinephrine biosynthesis at dopamine-$-hydrox-
ylation stage, 18, 77of protein synthesis by puromycin, 16, 223
Inhibitor(s)carbonic anhydrase, 8, 137
dopa decarboxylase, 18, 53monoamine oxidase, cardiovascular effects or, 18,
705
organophosphorus cholinesterase, pharmacology of,
11, 567
Innervationadrenergic. See Adrenergic innervation
autonomic. See Autonomic innervationInotropic action
of cardiac glycosides, subcellular basis for mecha-
nism of, 23, 193of digitalis, role of Na�,K�-ATPase in, 29, 187
Insects, catecholamine biosynthesis in, 18, 89Insulin
circulating, in animals and man, application of ra-
dioreceptor assay to, 25, 179-secreting cells, drugs producing diabetes through
damage of, 22, 485secretion, regulation of, 21, 183
Intestine
Darmstoff, a gut-stimulating compound occurring in
wall of, 6, 117intrinsic reflexes of, pharmacological analysis of, 16,
301
motility of, action of drugs upon, 6, 159
SUBJECT INDEX, VOLUMES 1-30 653
Intraocular pressure, physiological and pharmacolog-ical influences upon, 7, 143
Invertebrates, poikilothermic vertebrates and, phar-macology of, 14, 281
Iodine metabolism in man, quantitative aspects of, 4,
284
Ion distribution, drug-induced alterations of, at thecellular level of the central nervous system,
29, 35Ion movements
action of cardiac glycosides on, 16, 381
in junctional transmission, 19, 289
Ionic mechanisms in heart muscle in relation to the
genesis and pharmacological control of car-disc arrhythmias, 30,5
Ionization, pH, and biological activity, 4, 136Ionizing radiation. See under Radiation
Ironplasma, and transport ofiron in the organism, 4, 371transport of, in the organism, plasma iron and, 4,
371
Isoproterenol, calcium and the relaxant effect of, in
depolarized rat uterus, 18, 495
Junctional transmission, ion movements in, 19, 289
Keratinizing structures, inhibition of, by systemicdrugs, 15, 653
Lactate, gluconeogenesis stimulation from, by epi-
nephrine, glucagon, and cyclic 3’,S’-adenylate
in perfused rat liver, 18, 181
Leprosy, chemotherapy of, 10, 1Lipase clearing factor (heparin), and fat transport, 12,
241
Lipidsmembrane, drug action and, 19, 59prostaglandins, a family of biologically active, 20, 1
Lipidosis, lysosomal, drug-induced, biochemical inter-
pretations, 30, 593
Lipid-soluble acids, naturally occurring, of pharmaco-logical interest, 10, 407
Lithium ion, biology and pharmacology of, 9, 17Liver porphyrin metabolism, disturbances of, caused
by drugs, 19, 523Liver
rat, perfused, gluconeogenesis stimulation from lac-tate by epinephrmne, glucagon, and 3’,5’-ade-
nylate in, 18, 181
response to drugs, morphometric analysis in assess-
ment of, 30, 429
Liver fluke, actions of serotonin and epinephrine onintact and broken cell preparations from, 11,
465
Lungs and tissues, exchange of inert gas at, theory and
applications of, 3, 1Lung edema, physiology and pharmacology of, 8, 389
Lysosomal disorders, pre- and postnatal pathology,enzyme treatment and unresolved issues infive, 30, 565
Lysosomal lipidosis, drug-induced, biochemical inter-pretations, 30, 593
Macrocytic anemias. See under Anemia(s)Macromolecules, interactions with proximate carcin-
ogens, 18, 805
Magnesium, excess, 29, 273Mammals
accessory reproductive organs in, control of cell and
tissue transport by sex hormones, 27, 207
ionizing radiation and chemical protection in, phar-
macological aspects, 10,437
ovum transport in, role of s�renergic innervation ofoviduct in regulation of, 29, 67
protein synthesis inhibition in, by antibiotics, 21,
213Mammalian cells. See under Cell(s)
Mammalian muscle. See under Muscle
Mammalian origin, non-, active polypeptides of, 28,127
Manactions of various marihuana derivatives in, 23,349animals and, application of radioreceptor assay to
circulating insulin, growth hormone, andtheir tissue receptors in, 25, 179
catecholamine-drug interactions in, 18, 673
catecholamine metabolism in patients with pheo-chromocytoma, 11, 374
determinants of response to oral anticoagulants in,22, 35
dose-response relationships to cannabis in, 23, 349
drug abuse, behavior factors in, 27, 499
experimental drug self-administration, methodologyand application to study of sedative abuse,
27, 523iodine metabolism in, quantitative aspects of, 4, 284
metabolism and disposition of �-tetrahydrocanna-
binol in, 23, 371monkey and, drugs as reinforcers in, 27, 511narcotic addiction, experimental analysis of condi-
tioning factors in, 27, 533See also entries beginning “Human”
Marihuana
chemistry of, 23, 265
clinical pharmacology of, 23, 337derivatives, actions of, in man, 23, 349
general and behavioral pharmacology of, 23, 285-induced “high”, influence of expectation, setting,
and previous drug experience, 23,359its surrogates and (symposium), 23, 263-380
toxicology of, 23, 279Mast cells. See under Cell(s)Mathematics and bioassays, 5, 87Mechanoreceptors, vertebrate, effects of drugs on, 16,
341
Medullary particles, 18, 433
Melanotropic agents, biochemistry of, 19, 1Membrane(s)
actions of anesthetics and tranquilizers, 24, 583body, passage of drugs across, 14, 501
654 SUBJECT INDEX, VOLUMES 1-30
Membrane(s)-continued
lipids. See under Lipid(s)permeability, role of calcium in the receptor regu-
lation of, 30, 209
Metabolic products ofadrenaline and noradrenaline inhuman urine, 11, 416
Metabolismacetylcholine, 6,45
of nervous tissue, 6, 39adrenaline, 1, 1amine, amine oxidase and, 4, 415barbiturates, 1, 217
catecholamine
in patients with pheochromocytoma, 11, 374in vivo and in vitro, 11, 402
regulation of, in the sympathetic nervous system,24, 365
cell structure and, use ofantibodies to study, 25, 343cellular functions and, effects of anesthesia on, 17,
183
copper, 12, 355
disposition and, of �9-tetrahydrocannabinol in man,
23, 371distribution and, of adrenergic mediators, 6, 29
drug, toxicological implications of, 30, 457energy, of failing heart, and metabolic action of
cardiac glycosides, 1, 311
epinephrine and norepinephrmne, 6, 23
epinephrine and related amines, 8, 485ethanol and its metabolic effects, 24,67ethyl alcohol, 4, 107excretion and, of epinephrmne, 11, 409foreign compounds by gastrointestinal microorgan-
isms, 25, 451formation and, ofcatecholamines and other biogenic
amines, methylation reactons in, 18, 95histidine, histamine, and related imidazoles, 6, 299
intermediary, of thyroid tissue, and drug action, 15,43
iodine, quantitative aspects of, in man, 4, 284liver porphyrin, disturbances of, caused by drugs,
19, 523monoamine, regulation of, in the central nervous
system, 24, 371mucopolysaccharides of connective tissue, 7, 1
norepinephrine in the central nervous system, 18,1201
porphyrin, drugs and, 6, 133
storage and, of catecholamines, role of monoamine
oxidase in, 16, 179sympathetic regulation of, 19, 367synthesis and, of catecholamines, influence of spa-
cific nutrients on, 24, 349
toxicity and, of methanol, 7, 399
vitamin A, 19,559Metabolite analogues, biosynthetic incorporation of,
10,359Metabolite antagonisms in bacteria, 9,264Metals, heavy, general pharmacology of, 13, 185
Metanephrine in urine, estimation of, 18, 331
Metaraminol, norepinephrmne depletion by, 18, 561
Methadone and naloxone, effects on choice betweenfood and heroin, 27, 357
Methanol, metabolism and toxicity of, 7, 399
Methemoglobin-producing compounds, methemoglo-
binemia and, 3, 144
Methemoglobinemia, and methemoglobin-producing
compounds, 3, 144
Methonium compounds, 4, 2193-Methoxy-4-hydroxy-D-mandelic acid, a urinary me-
tabolite of norepinephrine and epinephrine,
formation of, 11, 394
Methylation reactions, formation and metabolism ofcatecholamines and other biogenic amines,
18, 95Methyldopa and adrenergic nerve function, 18, 569
Microbial cells. See under Cells(s)Molecular basis of drug action, 19, 107Molecular geometry and adrenergic drug activity, 26,
323
Molecular nature of pharmacological receptors, ap-proaches to, 21, 131
Molecular parameters of olfactory response, 22, 1Molecules, pharmacologically active, antibodies to,
specificities and some applications of anti-
prostaglandins, 25, 293
Monkey(s)and man, drugs as reinforcers in, 27, 511rhesus
concurrent schedules of cocaine injection in, dosevariations under independent and non-de-pendent variable-interval procedures, 27, 367
morphine-dependent, termination of a schedule
complex associated with intravenous injec-tions of nalorphine in, 27, 407
naloxone as negative reinforcer in, effects of dose,
schedule, and narcotic regimen, 27, 397pharmacological and environmental variables af-
fecting drug preference in, 27, 343
Monoamine metabolism, regulation of, in the centralnervous system, 24, 371
Monoamines, pyrogens, and cations, actions on centralcontrol of body temperature, 26, 289
Monoamine oxidase(s), 18, 115inhibitors, 18, 121
cardiovascular effects of, 18, 705
multiple forms of, functional significance, 24, 331
role in norepinephrine depletion by reserpine,metaraminol, and related agents, 18, 561
role, in storage and metabolism of catechola.mines,
16, 179Monofluoroacetic acid and related compounds, 1, 383Morphine
and its substitutes as analgesics, clinical evaluation
of, 16, 47and its surrogates, pharmacologic implications of
the fate of, 12, 383barbiturates, serotonin, and, antibodies to, 25, 281
-dependent rhesus monkeys, termination ofa sched-ule complex associated with intravenous in-
SUBJECT INDEX, VOLUMES 1-30 655
Na�,K�-ATPase, role of, in the inotropic action of
jections of nalorphine in, 27, 407
related drugs and, sites and mechanism of action in
the central nervous system 2,435Motion sickness, 7, 33
drugs used in, 18, 895
Motor endplate and ganglionic synapse, transmissionat, 6, 71
Motor nerve terminals. See under Nerve terminals
Mucopolysaccharides ofconnective tissue, metabolism
of, 7, 1Muscarine, muscarone, and related compounds, chem-
istry and pharmacology of, 13, 465
Muscarone, muscarmne, and related compounds, chem-istry and pharmacology of, 13, 465
Muscle
contraction of, and cell protoplasm, models for studyof, 7, 97
heart, ionic mechanisms in, in relation to the genesis
and the pharmacological control of cardiacarrhythmias, 30,5
locomotor, mutual disposition of cholinoreceptors
of, and changes in their disposition in thecourse of evolution, 18, 1051
mammalian
smooth, sodium-calcium interactions in, 30, 167unfatigued, action of l-noradrenaline and adre-
nochrome on, 6, 33
nerve and, actions of snake venoms on, pharmacol-
ogy of phospholipase A and polypeptide tox-ins, 17, 393
-nerve synapses, acetylcholine receptors and acetyl-
cholinesterase accumulation at newlyformed, 30, 411
sartorius, frog, glycolysis activation in, by epineph-rime, 18, 189
skeletalexcitation-contraction coupling in, 17, 265
phosphorylase activation, 18, 163
sympathomimetic amines and their antagonists,actions on, 21, 27
smoothcontraction, electrolytes and, 16, 85of capsule and blood vessels of the spleen, drug
action on, 26, 373vascular, pharmacology of, 7, 183
pharmacology of normal and hypertensive yes-
sels, 22,249structure, pathology, biochemistry, and bio-
physics, 20, 197
Mutagenic effects ofantischistosomal and other drugs,protection from, 30, 547
Mutagenicity, application of microbial and manuna-
han cells to assessment of, 30, 537
Mutagens, 6, 345Myocardial contractility
drug action on, physical factors in analysis of, 15,531
influence of interval between beats on, 15,601
digitalis, 29, 187Nalorphine
in morphine-dependent rhesus monkeys, termina-
tion of a schedule complex associated with
intravenous injections of, 27, 407pharmacology of, 8, 175
Naloxonemethadone and, effects on choice between food and
heroin, 27, 357
negative reinforcer in rhesus monkeys, effects ofdose, schedule, and narcotic regimen, 27, 397
Narcotic ingestion, schedule-induced, 27, 475Nerve(s)
muscle and, actions of snake venorns on, pharma-
cology of phospholipase A and polypeptidetoxins, 17, 393
-muscle synapses, acetylcholine receptors and ace-tylcholinesterase accumulation at newly
formed, 30, 411“pharmacological denervation,” supersensitivity fol-
lowing, 13, 17
See also Adrenergic, Peripheral, Purinergic, andSympathetic nerve
Nerve growth factor, neuronal activity and, effect on
enzymes involved in the synthesis of norepi-nephrine, 24, 255
Nerve mediators, adrenergic. See Adrenergic media-
torsNerve terminals
motor, actions of cholinergic drugs on, 29, 221regulation ofdopamine-fl-hydroxylase synthesis and
release from, 24, 233
Nervous, non-, tissues, cholinergic systems in, 30, 65
Nervous system
catecholamines in, occurrence, distribution, andphysiological role, 11,490
See also Autonomic, Central, or Sympathetic ner-vous system
Nervous tissue. See under TissueNeural processes, role of calcium ions in, 6, 243
Neural tissues. See under Tissue(s)Neurohumoral transmission
beginnings and prospects of, 6, 7place of histamine in, 6, 119
symposium on, 6, 3-132
Neurohypophysial hormones. See under Hormone(s)Neuromuscular junction
excitatory and anti-curare properties of acetylcho-line and related quaternary ammonium corn-pounds at, 5, 1
pharmacology of, 2, 96
Neuromuscular transmission, interruption of, andsome of its problems, 6, 53
Neuron(s). See Adrenergic, Central, and Sympatheticneurons
Neurons! activity and nerve growth factor, effectonenzymes involved in the synthesis of norepi-nephrine, 24, 255
Neuropharmacology of peripheral nerve, 4, 168
Neuropsychiatric states, catecholamines in, 18, 787
SUBJECT INDEX, VOLUMES 1-30
Neurotoxins of Clostridium botulinum and Cl. tetani,
7, 413
Neurotransmitter depletion and sympathetic activity,
in congestive heart failure, 18, 685
Neurotransmitter substances and hormones, role of
calcium in the release of, 22, 389
Nicotine, actions of, on central nervous system func-tions, 14, 137
Noradrenalineadrenaline and
biosynthesis of, 11, 350
blockade of the actions of, 11, 443
in blood and urine, 6, 35metabolic products of, in human urine, 11,-416
dopamine, 5-hydroxytryptamine and, demonstra-tion and mapping of central neurons contain-
ing, and their reactions to psychopharmaca,18, 727
subcellular localisation of, in sympathetic neurons,24, 435
. twenty years of, 18, 29l-Noradrenaline and adrenochrome, action of, on un-
fatigued mammalian muscle, 6,33Noradrenergic axons, dopamine and norepinephrmne
in, precursor product relationship study by
mass fragmentography and radiochemistry,
24, 167Norepinephrine
biosynthesis, inhibition at dopamine-$-hydroxyl-ation stage, 18, 77
comparison of the effect of neuronal activity and
nerve growth factor on enzymes in synthesis
of, 24, 255
depletion by reserpine, metaraminol, and relatedagents, role of monoamine oxidase, 18, 561
dopamine and, in noradrenergic axons, precursor
product relationship study by mass fragmen-
tography and radiochemistry, 24, 167epinephrmne and
action of, in broken cell preparations, 11, 464
adrenergic receptors for, 11, 429, 441
distribution and action, 8, 15estimation of concentrations of in human plasma,
by the trihydroxyindole method, 11, 273in the central nervous system, 6, 31
in tissues, technique involving solvent extractionfor estimation of, 11, 276
metabolism of, 6, 233-methoxy-4-hydroxy-D-mandelic acid, a urinary
metabolite of, formation of, 11, 394H3-, effects of drugs on disposition of, in rat brain,
18, 775interaction of drugs with, in the brain, 11, 548
mechanism of uptake of, 18, 525metabolism of, in the central nervous system, 18,
1201
other amines and, biochemical aspects of release of,from sympathetic nerve endings, 18, 513
-stimulated mobilization offree fatty acid, blood andtissue changes induced by, 18, 241
storage of, in sympathetic nerves, 18, 439synthesis in intact tissue, modification by drugs and
during short-term adrenergic nerve stimula-
tion, 24, 203
Normetanephrine in urine, estimation of, 18, 331
Nucleotides, cyclic. See Cyclic nucleotides
Nutrients, influence on catecholamine synthesis and
metabolism, 24, 349
Nutritioneffects of antibiotics on, 5, 381
role of, in drug-metabolizing enzyme system, 26, 171
Olfactory response, molecular parameters of, 22, 1Olfactory system, function of, 15, 1
Ontogenesis, innervation of the heart and, 29, 3Opioid antagonists, 19,463Organs and systems, exchanges of potassium related
to, 3, 42
Organic, anions. See under Anion(s)Organic bases, renal tubular excretion of, 12, 1
Organophosphorus cholinesterase inhibitors. See un-
der Inhibitor(s)
Oviduct, adrenergic innervation of, role in the regula-tion of mammalian ovum transport, 29, 67
Ovum transport, mammalian, role of adrenergic inner-vation of the oviduct in the regulation of, 29,
67
Oxidase
amine. See Amine oxidase(s)
monoamine. See Monoamine oxidaseOxidative phosphorylation, uncoupling of, as a mech-
anism of drug action, 7, 335
N-Oxides, pharmacology and biochemistry of, 21, 325Oxygen, pulmonary, toxicity, 23, 37
Pain, measurement of, prototype for quantitativestudy of subjective responses, 9, 59
Parasympathetic control of the heart, 25, 119Peptide hormones. See under Hormone(s)Peripheral auditory system, pharmacology of trans-
mission in, 28, 95Peripheral circulation, control of resistance, exchange,
and capacitance functions in, 20, 117Peripheral nerve, neuropharmacology of, 4, 168
Permeability. See Capillary, Membrane, and Vascular
permeability
Permeability coupling, stimulus-. See Stimulus-perme-
ability coupling
pH, ionization, biological activity, and, 4, 136
Pharmacokinetics, linearity and superposition in, 26,3
Phenylalanine and tetrahydropteridines, 18,61Pheochromocytoma, 18,651
catecholamine metabolism in patients with, 11, 374catecholamine-producing neural tumors other than,
18, 659
Phosphofructokinase, activation of, 18, 173Phospholipase A and polypeptide toxins, pharmacol-
ogy of, actions of snake venoms on nerve and
muscle, 17, 393
SUBJECT INDEX, VOLUMES 1-30 657
Phosphorylaseactivity
and function, actions of autonomic drugs on, 17,27
heart and, catecholamine influence on, 18, 197
of isolated rat heart, effect of sympathomimetic
amines on, 11, 466
adenosine-3’,5’-phosphate and, relation to the ac-tions of catecholamines and other hormones,
12, 265skeletal muscle, activation of, 18, 163
Photoproteins as biological calcium indicators, 28, 1
Pineal tissues. See under Tissue(s)
Placebos, pharmacology of, 11, 689
Plasmahuman, estimation of epinephrmne and norepineph-
rime in, by the trihydroxyindole method, 11,273
iron. See under Iron
pressor amines, suitability of the ethylenediamine
method of Weil-Malherbe and Bone andmodifications for quantitating, 11, 289
proteins. See under Protein(s)Platelet function, factors influencing adhesion, release,
and aggregation, 22, 97Poikilotherinic vertebrates. See under Vertebrates
Polydipsia
function ofschedule-induced, in establishing ethanolas positive reinforcer, 27, 465
schedule-induced, oral intake of drugs and, 27, 477,
489
Polypeptide(s)
active, of nonmammalian origin, 28, 127toxins. See under Toxin(s)
Porphyrinliver, disturbances of metabolism caused by drugs,
19, 523metabolism, drugs and, 6, 133
Potassium
exchanges of, related to organs and systems, 3, 42sodium-, adenosine triphosphatase, pharmacologi-
cal, physiological, and biochemical aspects,
27, 3
Potentiation and synergism, with reference to combi-
nation of structural analogues, 8, 339
Prostacyclin and thromboxane A2, prostaglandin en-doperoxides, pharmacology and endogenousroles of, 30, 293
Prostaglandin(s)
anti-. See Antiprostaglandins
biosynthesis inhibited by drugs, 26, 33
endoperoxides, thromboxane A2, and prostacydlin,pharmacology and endogenous roles, 30, 293
family of biologically active lipids, 20, 1
Protein(s)conjugates, drug, principles and methods for prep-
aration of, for immunological studies, 25, 271epinephrmne and, in the adrenal medulla, adrenocor-
tical control of the biosynthesis of, 24, 411photo-. See Photoproteins
plasma
and drugs, interactions of, 1, 102
fluids, electrolytes and, role in experimental trau-
matic shock and hemorrhage, 6, 489
synthesis
mammalian, inhibition by antibiotics, 21, 213puromycin inhibition of, 16, 223
Protoplasm, cell, and contraction of muscle, modelsfor study of, 7, 97
Psychobiology techniques and results ofstudies of self-administration of drugs, use in, 27, 545
Psychomimetic drugs. See under Drugs(s)Psychopharmaca, demonstration and mapping of cen-
tral neurons containing dopamine, noradren-aline, and 5-hydroxytryptamine and their re-
actions to, 18, 727Psychotropic drugs. See under Drug(s)
Pulmonary circulation, pharmacology of, 12, 159Pulmonary oxygen toxicity, 23, 37Purinergic nerves, 24, 509Puromycin, inhibition of protein synthesis by, 16, 223
Pyrogens
bacterial, 9, 427monoamines, cations, and, actions on central control
of body temperature, 26, 289
Pyrrolizidine (Senecio) alkaloids, toxic actions of, 22,
429
Quaternary ammonium compounds, acetylcholine-re-
lated, excitatory and anti-curare propertiesof, at the neuromuscular junction, 5, 1
Quinidine-like drugs. See under Drug(s)
Radiation, ionizing, and chemical protection in mam-mals, pharmacological aspects, 10, 437
Radioimmunoassay
of digitalis glycosides, clinical value of, 25, 219
methodology, application to problems of heteroge-neity of peptide hormones, 25, 161
Radioreceptor assay, application to circulating insulin,
growth hormone, and to their tissue receptorsin animals and man, 25, 179
Rat
heart, perfused, kinetic studies of epinephrine ef-
fects in, 18, 205
isolated heart of, effect of sympathomimetic amineson phosphorylase activity of, 11, 466
liver, perfused, gluconeogenesis stimulation from
lactate by epinephrine, glucagon, and cyclic
3’, 5’-adenylate in, 18, 181
uterus, depolarized, calcium and the relaxant effect
of isoproterenol in, 18, 495
Rauwolfia, pharmacology of, 8, 435Receptor(s)
enzymes and, steric effects in catecholamine inter-actions with, 18, 131
pharmacological, 20, 49approaches to the molecular nature of, 21, 131
physiological, antibodies and, role in cardiovascular
diagnosis, therapy, and research, 25, 215
SUBJECT INDEX, VOLUMES 1-30
Receptor(s)-continued
regulation of membrane permeability, role of cal-
cium in, 30, 209See also Adrenergic, Cholino-, Hormone, Mech-
ano-, Sensory, and Tissue receptors
Red blood cell, sugar transport in, structure-activityrelationships in substrates and antagonists,13,39
Redox substances and antioxidants influence on signs
of vitamin E deficiency, 9, 1Reflexes, intrinsic intestinal, pharmacological analysis
of, 16, 301
Renal and cardiovascular actions of dopamine, poten-
tial clinical application, 24, 1Renal transport mechanisms, functional characteris-
tics of, 2, 227
Renal tubular excretion of organic bases, 12, 1Ream
-angiotensin-aldosterone, measurements of, 25, 249
-angiotensin system, 17, 143
hypertensin and, pharmacology of, 8, 25Reproduction
accessory organs of, in mammals, control of cell andtissue transport by sex hormones, 27, 207
autonomic nervous control of, circulatory and otherfactors, 24, 657
Reserpine
biological fate of, 28, 179norepinephrine depletion by, 18, 561
Respiratory tract fluid and expectorants, 6, 521Retina, localization of specific cholinesterase in, 6, 47Retinal tissues. See under Tissue(s)
Rhesus monkeys. See under Monkey(s)
Ryanodine, pharmacology of, 21, 1
Salicylates, pharmacology of, certain aspects, 1, 353Saxitoxin and tetrodotoxin, significance in the study
of excitation phenomena, 18, 997
Secretion, gastric. See Gastric secretion
Secretory cycle in the adrenal medulla, 24, 385
Sedative abuse, experimental human drug self-admin-
istration, methodology and application tostudy of, 27, 523
Senecio (pyrrolizidime alkaloids), toxic actions of, 22,429
Sensory and central transmission, 6, 85, 95, 103Sensory receptors, effect of acetylcholime-like sub-
stances on, 8, 97
Serotonin
catecholamines and, release of, by drugs, 14, 531
epinephrine and, actions on intact and broken cellpreparations from the liver fluke, Fasciola
hepatica, 11, 465
morphine, barbiturates, and, antibodies to, 25, 281
Serum dopamine $-hydroxylase, 30, 133
Sex hormones. See under Hormone(s)Sister chromatid exchange. See under Chromatid ex-
change
Shock, experimental traumatic, and hemorrhage, role
of fluids, electrolytes, and plasma proteins in,
6, 489
Sinus and carotid body, action of drugs on, 7, 119Sleep and drugs, 20, 273
Skeletal muscle. See under MuscleSnake venoms, actions of, on nerve and muscle, phar-
macology of phospholipase A and polypep-tide toxins, 17, 393
Sodium
-calcium interactions in mammalian smooth muscle,
30, 167-potassium adenosine triphosphatase, pharmacolog-
ical, physiological, and biochemical aspects,
27, 3
Spermatogenesis, actions of drugs on, biochemical as-
pects of, 19, 21Spermidine, spermine, and related amines, 16, 245Spermine, spermidine, and related amines, 16, 245
Spinal cord, depressant drugs, 1, 243
Spinal reflexes, action of anticholinesterases on, fol-
lowing intra-arterial injection, 6, 49
Spleen, drug action on smooth muscle of capsule and
blood vessels of, 25, 373Steroid(s)
adrenocortical. See Adrenocortical steroids
cortico-. See Corticosteroids
gonadotropin-, interrelationships, 25, 189hormones. See under Hormone(s)
pharmacology, selected aspects of, 15, 123
Stimulus-permeability coupling, role of calcium in thereceptor regulation of membrane permeabil-ity, 30, 209
Storage and metabolism of catecholamines, role ofmonoamine oxidase in, 16, 179
Structural analogues
synergism and potentiation with special reference tothe combination of, 8, 339
Sugar transport in red blood cell, structure-activity
relationships in substrates and antagonists,
13, 39Sulphides and bis(2-haloethyl) amines, pharmacology
of, 2, 281
Surface membranes, functional components of, poten-tial targets for pharmacological manipula-
tion, 30, 371Sweating, pharmacology of, 7, 365
Sympathectomy, immuno-, 18, 619Sympathectomy, surgical, and adrenergic function, 18,
611
Sympathetic activity and neurotransmitter depletionin congestive heart failure, 18, 685
Sympathetic ganglia, transmission and block in, 6, 69
Sympathetic nerve endings, release of norepinephrineand other amines from, biochemical aspects,18, 513
Sympathetic nervesstorage of norepinephrine in, 18, 439
Sympathetic nervous system
molecular biology of, 24, 165
SUBJECT INDEX, VOLUMES 1-30 659
regulation of catecholamine metabolism in, 24, 365
Sympathetic neuron(s)
axons of, transport of enzymes in vivo and prop-erties of axonal sprouts in vitro, 24, 245
subcellular localization of noradrenaline in, 24,
435
Sympathetic outflow to adrenal medulla and adipose
tissue, effects of glucose deprivation on, 18,303
Sympathetic regulation of metabolism, 19, 367
Sympathetic tissues. See under Tissue(s)
Sympathomimetic amines
actions of, and their antagonists on skeletal muscle,
21, 27
effect of, on phosphorylase activity of isOlated ratheart, 11, 466
indirectly acting, 18, 551
mechanisms of hypersensitivity and subsensitivity,
18,629
supersensitivity and subsensitivity to, 15, 225
Symposia
Catecholamimes, 11, 233-566Catecholamines (second), 18, 1-804
Control of Drug-taking Behavior by Schedules ofReinforcement, 27, 291-545
Drug Antagonism, 9, 211-268Immunopharmacology, 25, 157-363Marihuana and Its Surrogates, 23, 263-380
Neurohumoral Transmission, 6,3-132
Regulation of Catecholamine Metabolism in theSympathetic Nervous System, 24, 163-431
Workshop on Cellular and Molecular Toxicology,30, 333-616
Synapseadrenergic
central, 18, 717
junction potential at, 18, 481
ganglionic, motor endplate and, transmission at, 6,71
nerve-muscle, acetylcholine receptors and acetyl-cholinesterase accumulation at newlyformed, 30, 411
Synaptic mechanisms in autonomic ganglia, modifi-cation by drugs, 18, 839
Synergism and potentiation, with reference to combi-nation of structural analogues, 8, 339
Synthesisdegradation and, of catecholamine, application of
immunological techniques to regulating en-zymes, 24, 349
Synthesisepinephrine, adrenocortical control of, 23, 1metabolism and, ofcatecholamines, influence of spe-
cific nutrients on, 24,349norepinephrine
effect ofneuronal activity and nerve growth factoron, 24, 255
in intact tissue, modification by drugs and during
short-term adrenergic nerve stimulation, 24,
203
protein. See Protein synthesis
Systems and organs, exchanges of potassium relatedto, 3, 42
Temperature regulation, physiology and pharmacol-
ogy of, 13, 361
Tetrahydrocannabinol(s)
biological disposition of, 23, 273
derivatives, synthetic, pharmacological actions of,23, 295
synthetic derivatives, central nervous system ac-
tions of, 23, 317
i�9-Tetrahydrocannabinol, metabolism and dispositionof, in man, 23, 371
Tetrahydropteridines, phenylalanime and tyrosine hy-
droxylases and, 18, 61
Tetrodotoxin and saxitoxin, significance in the study
of excitation phenomena, 18, 997THAM. See Tria(hydroxymethyl)aminomethane
Thirst and hunger, physiological and pharmacologicalaspects of the control of, 13, 1
Thromboxane A2 and prostacydlin, prostaglandin en-doperoxides, pharmacology and endogenousroles of, 30, 293
Thyroid function, factors controlling, with especialreference of views on antithyroid substances,7, 301
Thyroid tissue. See under Tissue(s)
Tin compounds, toxicology of, 11, 211Tissue(s)
adiposecyclic 3’,5’-AMP and lipolytic effects of hormones
on, 18, 237drug and hormone action on, biochemical aspects
of, 25, 67glucose deprivation effects on sympathetic out-
flow to, 18, 303and blood changes, induced by norepinephrmme-stim-
ulated mobilization of free fatty acid, 18,241chromaffim, 18,453
connective, metabolism of mucopolysaccharides of,7, 1
intact, catecholamine formation in, 11, 358
lungs and, inert gas exchange at, theory and appli-cations of, 3, 1
nervous
acetylcholine metabolism of, 6, 39adrenal medulla and, role ofL-dopa decarboxylase
in the biosynthesis of catecholamines in, 11,
317
neural and retinal, pineal-related, indole derivativesof, 17, 321
noradrenergic, storage particles in, 18, 425pineal and related neural and retinal, indole deriv-
atives of, 17, 321receptors, of circulating insulin and growth hor-
mone, application of radioreceptor assay to,
25, 179
660 SUBJECT INDEX, VOLUMES 1-30
Tissue(s)-continuedretinal and neural, pineal-related, indole derivatives
of, 17, 321
subcutaneous connective, absorption of drugs from,
13, 441
sympathetic, electron microscopy of, 18, 387
thyroid, intermediary metabolism of, and drug ac-tion, 15, 43
transport, control in mammals by sex hormones, 27,207
Toxic action of pyrrolizidine (Senecio) alkaloids, 22,429
Toxicitychronic, experimental methods used in determining,
6, 191
metabolism and, of methanol, 7, 399
pulmonary oxygen, 23, 37Toxicology
application of basic concepts to research in, 30, 605
drug metabolism, implications, 30, 457of herbicides, 14, 225of marihuana, 23, 279new era, 30, 351pharmacology and, of antibiotics, 2, 1
Toxins
bacterial, pharmacology of, 16, 1
ofAmanitaphalloides, chemistry and toxicology of,
11,87
polypeptide, phospholipase A and, pharmacology of,
actions ofsnake venoms on nerve and muscle,17, 393
Transferase, catechol-O-methyl. See Catechol-O-
methyl transferase
Transmitter reactivity, autonomic neuroeffectortrans-mission and, ontogenetic development of, inembryonic and fetal hearts, 29,3
Tranquilizers and anesthetics, membrane actions of,
24, 583Trihydroxyindole method
development and applications of, for catechol-amimes, 11, 262
estimation of epinephrine and norepinephrine con-
centrations in human plasma by, 11, 273
Trihydroxyimdole procedure, techniques to improve
the specificity of, 11, 269Triphosphatase, adenosine. See Adenosine triphos-
phatase
Tris(hydroxymethyl)aminornethane (THAM), phar-macology of, 14,447
Thberculosis
chemotherapy of, wider aspects of, 5, 421drug treatment of, 15, 169
Tumors
catecholamine-producing neural, other than pheo-
chromocytoma, 18,659catecholamine-secreting, chemistry and pharmacol-
ogy of, 18, 645
growth, hormonal regulation of, 9, 367Tyrosine hydroxylase(s) 18,43
dopa decarboxylase and, changes in, induced by
pharmacological agents, 24, 269
tetrahydropteridines and, 18,61
Uric acid, role in biological processes and influence
upon it of physiological, pathological, and
pharmacological agents, 5, 231
Urinary metabolite, 3-methoxy-4-hydroxy-D-mandelic
acid, of norepinephrine and epinephrine, for-
mation of, 11, 394
Urinebile and, secretion of organic anions in formation of,
11, 109
blood andadrenaline and noradrenaline in, 6, 35
catecholamine assays, spectrophotofluorimetricobservations on, 11, 296
estimation of metanephrine, normetamephrine, and3,4-dihydroxymandelic acid in, 18, 331
human, metabolic products of adrenaline and nor-adrenaline in, 11, 416
Uterus, rat, depolarized, calcium and the relaxant ef-
fect of isoproterenol in, 18, 495
Vascular permeability, increased, mediation of, in in-
flammation, 14, 251Vascular smooth muscle. See under Muscle
Vasodilatation, antidromic, in the paw of the cat, 6,99Venoms, snake. See Snake venom(s)Vertebrate mechanoreceptors, effects of drugs on, 16,
341
Vertebrates
evolution of autonomic innervation of visceral andcardiovascular systems in, 21, 247
poikilothermic, invertebrates and, pharmacology of,14, 281
Viral diseaseschemotherapy of, 15, 407
advances in, 19, 209influence of dietary, hormonal, and other factors
in, 8, 199
Virus infections, influence of dietary, hormonal, and
other factors, 8, 199
- Visceral and cardiovascular system, evolution of au-tonomic innervation of, in vertebrates, 21,247
Vitamin A, metabolism of, 19,559Vitamin B5, pharmacological aspects, 16, 113Vitamin E deficiency, influence of antioxidants and
redox substances on, 9, 1Vomiting, physiology and pharmacology of, 5, 193
Weil-Malherbe and Bone ethylenediamine method,suitability of and modifications for quantitat-
ing plasma presser amines, 11, 289