Increase in serum S100B after carotid artery stenting and

carotid endarterectomy

Ayman Alserr. MD

Directed by:

Prof. Christos Liapis Attikon University Hospital, Greece

Prof. Hussein Khairy Cairo University Hospital, Egypt

Presented by:

Assoc. Prof. Amr A. Rahim Cairo University Hospital

Disclosure

Speaker name:

..................................Ayman Alserr.....................................

I have the following potential conflicts of interest to report:

Consulting

Employment in industry

Stockholder of a healthcare company

Owner of a healthcare company

Other(s)

I do not have any potential conflict of interest

Introduction

S100B has been introduced as sensitive biomarker of silent cerebral injury.

Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids Temporal changes of TBI

biomarkers Adrian Harel, Finland Oy, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland ENEURO. 2016

Aim of the study

The aim of our study was to assess thedifferences in serum levels of S100B before,during and 24 hours after Carotid Artery Stenting(CAS) and Carotid Endarterectomy (CEA) .

Methods

• Data was collected prospectively concerningatherosclerotic risk factors and duplex ultrasoundcharacteristics in 30 patients underwent CAS (15) andCEA (15) (with primary closure in 80% and dacronpatch in 20%) during a 3-month period (April-July2017).

• Serum measurements of S100B in arterial bloodsamples were collected:

1. Before the operation (S100Ba),

2. During the operation (S100Bb); after stenting for CAS and before declamping for CEA and

3. 24 hours After the operation (S100Bc)

Results

Results

Results

Results:Plaque type

P Value

0.048

Results: Cerebral Oximeter In CEA

P=0.043

Conclusion

• Both CAS and CEA may result in silent braininjury, as suggested by increased postoperativelevels of S100B with evidence that CAS is moreinjurious, compared to CEA.

• Plaque type I or II is associated with elevatedS100B protein especially in CAS.

Conclusion

• Contralateral carotid can compensate for theischaemia caused by ipsilateral clamping,reducing silent cerebral injuries.

• Our study is a pilot study that can becontinued on a larger scale of cases.

Thank you very much

OUTCOME OF CAROTID ARTERY STENTING IN PATIENT WITH COMBINED CAROTID AND

CORONARY ARTERY DISEASE

Moh. Reza J. Pasciolly,1

Vishal Rashtogi,2 Atul Mathur,2 Ashok Seth,2

1 Former Fellowship Cardiovascular Intervention Fortis Escort Heart Institute and Research Center, New Delhi, India - Now Attending Intervention Cardiologist

Department Cardiology and Vascular Medicine, Al Ihsan Government General Hospital, Bandung, West Java Province, Indonesia.

2 Fortis Escorts Heart Institute, New Delhi, India