In Vivo Induction of T Regulatory Cells * Schweizerisches Institut für Allergie- und...

In Vivo Induction of T Regulatory Cells

*

Schweizerisches Institut für Allergie- und Asthmaforschung, Davos

Konieczna et al., Gut 2012


IL-10 TNF- IL-17 CRP

Bifidobacterium infantis 35624

Treated

Placebo Treated Increased

Plasma Level

DecreasedPlasma Level

Plasma Biomarkers in Psoriasis Patients

Groeger et al.,Gut Microbes 2013

Diet Determines Microbiome CompositionDiet Determines Microbiome CompositionSchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Roduit et al. JACI 2014

*Diversity score with major food items: vegetables or fruits, any cereals, meat, bread, cake and yogurt

Early Life Food DiversitySchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Roduit et al. JACI 2012

Yoghurt Consumption Early in Life

0.00

0.50

1.00

1.50

*OR

and

95%

CIAll no allergic parents at least one allergic parent

Yogurt

ref= no introduction in the first year of life


Induction of Regulatory Cells by Bacterial MetabolitesInduction of Regulatory Cells by Bacterial MetabolitesShort-Chain Fatty Acids (SCFAs)Short-Chain Fatty Acids (SCFAs)

Thorburn, Macia & MackayImmunity 2014


SCFAs and Respiratory AllergySCFAs and Respiratory AllergySchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Roduit et al., in preperation

TH2 TH17

SCFAs and Respiratory AllergySCFAs and Respiratory AllergySchweizerisches Institut für Allergie- und Asthmaforschung, Davos


Butyrate and Asthma RiskSchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Butyr

ate

<95P

≥95P

0

5

10

15

Prop

ortio

n %


Short-Chain Fatty Acids (SCFAs)Short-Chain Fatty Acids (SCFAs)

Sandin et al., Acta Paediatrica 2009


Arrieta et al., Sci Transl Med 2015

Immunoregulatory Bacterial Biogenic AminesImmunoregulatory Bacterial Biogenic Amines

A biogenic amine is a biogenic substance with one or more amine groups, formed mainly by decarboxylation of amino acids.

Examples include: - histamine, - tyramine, - cadaverine, - 2-phenylethylamine, - spermine, - spermidine, - putrescine, - tryptamine,- agmatine.


O‘Mahony et al., JACI 2011; Frei et al., JACI 2013

Immunoregulatory Activities of Histamine Receptors


H2R Responds to Histamine from Gut BacteriaSchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Ferstl et al., JACI 2014


Ferstl et al., JACI 2014

High Level of Bacterial-Derived Histamine has Negative

Consequences

Increased HDC+ Bacteria in Asthma Patients

Non-Asthma Asthma


Barcik et al., in preperation

Increased HDC+ Bacteria Associated with Atopy

Atopic: Pollen and/or HDM sensitive


Barcik et al., in preperation

TH1

TH2

TH9TH22

T reg

T regT reg

T reg

TH17

Epithelial cells

Metabolites (e.g. SCFAs)

Microbiome – Nutrition – Immune HealthSchweizerisches Institut für Allergie- und Asthmaforschung, Davos

Lifestyle Factors Contribute to Atopy and Allergy

Ruth FerstlRuth FerstlMario ZieglerMario ZieglerRemo FreiRemo FreiWeronika BarcikWeronika BarcikElisa SchiaviElisa SchiaviNoelia RoderiguezNoelia RoderiguezMarina Sabate BrescoMarina Sabate BrescoRay GrantRay GrantDavid GroegerDavid GroegerChristophe WaupotitschChristophe WaupotitschBenoit PuginBenoit Pugin

Beate RückertBeate RückertClaudio RhynerClaudio RhynerReto CrameriReto CrameriMübeccel AkdisMübeccel AkdisCezmi A. AkdisCezmi A. Akdis

Wroclaw Medical UniversityWroclaw Medical UniversityMarek JutelMarek JutelSylwia SmolinskaSylwia Smolinska

Alimentary HealthAlimentary HealthBarry KielyBarry KielyJenny RoperJenny Roper

http://cordis.europa.eu/fp7/mariecurieactions/home_en.html

In Vivo Induction of T Regulatory Cells * Schweizerisches Institut für Allergie- und...

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