Impulse Control Disorders & their genetics

31st January 2018

Department of Clinical Neuroscience,Institute of Neurology

Dr Richard Rees

Richard Rees | Impulse control disorders and their genetics | 1 of 11

Derek

Richard Rees | Impulse control disorders and their genetics | 2 of 11

What are we talking about?Impulse control disorders & Impulse related behaviours

Pathological gambling

Hypersexuality

Compulsive eating

Compulsive shopping

Punding

Hobbyism

Walkabout

Dopamine dysregulation syndrome

Richard Rees | Impulse control disorders and their genetics | 3 of 11

Who’s at risk?

On Parkinson's Treatment

Younger age

Male

Smoker

SingleAnxiety

High novelty seeking

FHx of addictive disorders

Richard Rees | Impulse control disorders and their genetics | 4 of 11

Where does Tracking Parkinson’s fit?

Clinical data

Longitudinal

QUIP

Drug data

Demographic data

Genetics

Candidate Gene Study

Genome Wide Association

Richard Rees | Impulse control disorders and their genetics | 5 of 11

Prevalence in PRoBaNDLax• ICD only

– 27%• IRB only

– 29%• Any behaviour

– 42%

Strict• ICD only

– 11%• IRB only

– 27%• Any behaviour

– 31%

Richard Rees | Impulse control disorders and their genetics | 6 of 11

Richard Rees | Impulse control disorders and their genetics | 7 of 11

GWAS

Richard Rees | Impulse control disorders and their genetics | 8 of 11

GWAS

Richard Rees | Impulse control disorders and their genetics | 9 of 11

Why does this matter?• What can I do next?

– Be aware of ICD in PD– Ask about key behaviours– Highlight to study groups

• Future work– Using rich longitudinal data– Replication in other cohorts (IPDGC/UK)– Personalised medicine

Richard Rees | Impulse control disorders and their genetics | 10 of 11

richard.n.rees@ucl.ac.ukRichard Rees | Impulse control disorders and their genetics | 11 of 11