IMPROVING ONLINE ACCESS TO DRUG-RELATED INFORMATION

JIAO LI, RITU KHARE, ZHIYONG LU

NCBI/NLM

1 2SEARCH INTEGRATED

ACCESS

ASSIGNING BRAND NAMES TO DRUG MONOGRAPHS

1SEARCH

Advil

Mortin

Tylenol

Ibuprofen

Acetaminophen

Consumers use brand names as search keywords

Editors describe the drug information in terms of active ingredient names

Input: Drug Monograph

Advil

Brand Name (BN)

Ibuprofen

Ingredient (IN)

Advil 100 MG Oral Tablet [Obsolete=N] [Veterinary=N]

Branded Drug or Package (SBD)

Oral Tablet

Dosage Form (DF)

has_ingredient

ingredient_of

has_dose_form

dose_form_of

has_tradename tradename_of

Output: Up-to-date Brand names

RxNorm Concepts and Relationships• Ingredient Normalization• Dosage Form Normalization• Obsolescence• Reformulation• Veterinary

METHODS:

INTEGRATING DRUG-DISEASE RELATIONSHIPS FROM MULTIPLE SOURCES

2INTEGRATED

ACCESS

• Filter drug-disease relationships• Statistics-based filter• Domain-knowledge based filter

• Rank the disease for each drug• Ranking function based on

evidence confidence

METHODS: